EP0888138A1 - Formulations topiques pour traiter le psoriasis de l'ongle - Google Patents
Formulations topiques pour traiter le psoriasis de l'ongleInfo
- Publication number
- EP0888138A1 EP0888138A1 EP97905085A EP97905085A EP0888138A1 EP 0888138 A1 EP0888138 A1 EP 0888138A1 EP 97905085 A EP97905085 A EP 97905085A EP 97905085 A EP97905085 A EP 97905085A EP 0888138 A1 EP0888138 A1 EP 0888138A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- formulation
- formulation according
- spreading
- film former
- treatment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7015—Drug-containing film-forming compositions, e.g. spray-on
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/44—Medicaments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
Definitions
- Dithranol (local), PUVA, glucocorticoids and vitamin D analogues (local) or systemic methotrexate, retinoids, cyclosporin A treated.
- EP 0 634 170 describes formulations for the treatment of psoriasis.
- the invention aims to provide a formulation which does not have the disadvantages described above or has them only to a minor extent.
- the object is achieved by using a formulation which consists of the active ingredient, at least one spreading solvent, a volatile solvent and a water-insoluble film former for the manufacture of a medicament for the treatment of nail psoriasis.
- Spreading solvents are understood to mean compounds which are found in a test system, as in Pharm. Research / Drug Res. 31 (II), 8a, p. 1 334, 1981, give the formulations according to the invention a higher spread number than Example 12 from EP 0 226 984.
- Volatile solvents are understood to mean compounds which have a boiling point which is below 80 ° C.
- active ingredients come e.g. in question: leflunomide and its metabolite A 77 1726, propentofylline, pentoxifylline, cyclosporin A or glucocorticoids, e.g. Alclometasone dipropionate, amcinonide, beclomethasone dipropionate, Bendacort, betamethasone benzoate, betamethasone dipropionate, betamethasone valerate, budesonide, chlorquinaldol, clioquinol, clobetasol propionate, clobetasone butyrate, desonide, desoximetasone, dexamethasone, dichlorisone, diflorasone diacetate, diflucortolone, difluprednate, fluazacort, flucinolone acetonide, fluclorolone, fludroxycortide, Flumathasonpivalat, Fluocinolonacetonide, Fluocino
- Penetration-promoting substances are also used in these formulations, e.g. Oleyl oleate, n-octanol, N-methylpyrrolidone, hexyl laurate.
- Suitable film formers are, for example, substances based on cellulose nitrate or physiologically harmless polymers, as are customary, for example, in cosmetics, preferably as a mixture with cellulose nitrate.
- Examples include polyvinyl acetate and partially saponified polyvinyl acetate, copolymers of vinyl acetate on the one hand and acrylic acid or crotonic acid or Monoalkyl maleates on the other hand, tertiary copolymers of vinyl acetate on the one hand and crotonic acid and vinyl neodecanoate, or crotonic acid and vinyl propionate on the other hand, copolymers of methyl vinyl ether and monoalkyl maleate, in particular as monobutyl maleate, copolymers of Fettklavinylester and acrylic acid or methacrylic acid, copolymers of N-vinylpyrrolidone, methacrylic acid and alkyl methacrylate, copolymers of acrylic acid and methacrylic acid
- Suitable physiologically acceptable solvents are substances such as hydrocarbons, alcohols, ethers, ketones and esters customary in cosmetics, in particular ethanol, isopropanol or acetic acid esters of monohydric alcohols, such as ethyl and butyl acetate.
- the formulations according to the invention can furthermore contain additives customary in cosmetics, such as phthalate or camphor-based plasticizers, dyes or colored pigments, pearlescent agents, sedimentation retardants, sulfonamide resins, silicates, fragrances, surface-active substances, for example wetting agents such as sodium dioctylsulfosuccinate (DONS) and / or PEG-400 monolaurate, Tween ® 80, lanolin derivatives, photoprotective agents such as 2-hydroxy-4-methoxybenzophenone, antibacterial and antimycotic active substances, substances with a keratolytic and / or keratoplastic action, such as ammonium sulfite, esters and salts of thioglycolic acid, urea, allantoin, enzymes, Salicylic acid, complexing agents such as edetic acid and its salts and pH-adjusting substances.
- Colored or pigmented formulations have the advantage, for example, that they can be
- the total concentration of the antipsoriatic active ingredients is from 0.1 to 10 percent by weight (hereinafter abbreviated as%), in particular from 0.5% to 5%.
- the concentration of the spreading solvent is from 0.1% to 10%.
- the concentration of the film former is from 3.0% to 35%.
- the total concentration of volatile solvents is from 50% to 90%.
- compositions according to the invention have the following compositions:
- silica gel layer determined according to the method given in Pharmaceutical Research / Drug Res. 31 (II), 8a, p. 1334, 1981, which was modified for measuring liquid formulations as follows.
- the liquid formulation to be examined was applied into the inner lumen of a glass ring which was placed in the center of the thin-layer plate. In each case 100 ⁇ l were applied at 21 ° C.
- the total area of the spreading capacity - idealized as a circular area - was determined by determining the final value of Z.
- Relative spreading capacity spreading capacity of the formulation divided by spreading capacity of the comparison formulation.
- IPP isopropyl palmitate
- An anhydrous, volatile solvent or solvent mixture is introduced and, with stirring, a spreading solvent, a film former and an antipsoriatic active ingredient are added in succession so that a solution or a suspension is formed.
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Materials Engineering (AREA)
- Birds (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
L'invention concerne des formulations appropriées pour traiter le psoriasis de l'ongle et contenant un principe actif antipsoriasique, au moins un solvant d'étalement, au moins un solvant volatil et un agent filmogène.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19610482 | 1996-03-16 | ||
DE19610482 | 1996-03-16 | ||
PCT/EP1997/000905 WO1997034644A1 (fr) | 1996-03-16 | 1997-02-26 | Formulations topiques pour traiter le psoriasis de l'ongle |
Publications (1)
Publication Number | Publication Date |
---|---|
EP0888138A1 true EP0888138A1 (fr) | 1999-01-07 |
Family
ID=7788561
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP97905085A Withdrawn EP0888138A1 (fr) | 1996-03-16 | 1997-02-26 | Formulations topiques pour traiter le psoriasis de l'ongle |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP0888138A1 (fr) |
JP (1) | JP2000512265A (fr) |
KR (1) | KR20000064607A (fr) |
AU (1) | AU1876797A (fr) |
BR (1) | BR9708081A (fr) |
CA (1) | CA2248977A1 (fr) |
WO (1) | WO1997034644A1 (fr) |
ZA (1) | ZA972180B (fr) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RO118174B1 (ro) * | 1997-08-21 | 2003-03-28 | Aventis Pharma Deutschland Gmbh | Lac de unghii şi utilizarea acestuia |
TR200600888T1 (tr) * | 2003-08-25 | 2006-08-21 | Bioequal Ag | Farmasötik ve kozmetik formülasyonlar. |
CA2610755A1 (fr) * | 2005-06-10 | 2006-12-14 | Galderma S.A. | Methode de liberation controlee d'un medicament a travers la peau |
CA2775393C (fr) * | 2012-05-02 | 2014-04-29 | Samy Saad | Formulations pharmaceutiques topiques non aqueuses |
KR102327827B1 (ko) | 2019-11-01 | 2021-11-18 | 한국과학기술연구원 | 강황 추출물을 유효성분으로 포함하고 자외선 처리를 포함하는 건선 개선용 조성물 |
KR102461001B1 (ko) | 2020-09-14 | 2022-11-01 | 한국과학기술연구원 | 술패랭이꽃 추출물을 유효성분으로 포함하는 건선 개선용 조성물 |
KR102451304B1 (ko) | 2020-09-14 | 2022-10-07 | 한국과학기술연구원 | 꿩의다리속 추출물을 유효성분으로 포함하는 건선 개선용 조성물 |
KR102527907B1 (ko) | 2020-09-14 | 2023-05-03 | 한국과학기술연구원 | 무산상자 추출물을 유효성분으로 포함하는 건선 개선용 조성물 |
KR20230041257A (ko) | 2021-09-17 | 2023-03-24 | 한국과학기술연구원 | 시미시푸고라이드 에이를 유효성분으로 포함하는 건선 개선용 조성물 |
KR20230041255A (ko) | 2021-09-17 | 2023-03-24 | 한국과학기술연구원 | 눈개승마 추출물을 유효성분으로 포함하는 건선 개선용 조성물 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2002795B (en) * | 1977-07-15 | 1982-03-17 | Mallinckrodt Inc | Nail enamel compositions their preparation and use |
GB2085297B (en) * | 1980-10-08 | 1984-06-13 | Bernstein Joel Edward | Composition for treating psoriasis of the fingernails |
DE3045914A1 (de) * | 1980-12-05 | 1982-07-22 | Bayer Ag, 5090 Leverkusen | Antimykotische mittel mit hoher wirkstoff-freisetzung in form von elastischen fluessig-pflastern |
ATE84208T1 (de) * | 1985-11-04 | 1993-01-15 | Owen Galderma Lab Inc | Filmbildende arzneimitteltraeger zur verabreichung von arzneimitteln an naegeln; verfahren zur verwendung. |
HU219480B (hu) * | 1991-05-23 | 2001-04-28 | Novartis Ag. | Eljárás gombás körömmegbetegségek ellen helyileg alkalmazható, allil-amin-származékot tartalmazó gyógyászati készítmények előállítására |
EP0711181A1 (fr) * | 1993-07-28 | 1996-05-15 | Pfizer Inc. | Traitement du psoriasis |
DK128494A (da) * | 1994-11-08 | 1996-05-09 | Edel K Seidenschnur | Behandling af keratinøse og psoriatiske sygdomstilstande med neglelak indeholdende vitamin D metabolit, eller derivat, og/eller vitamin A derivat |
-
1997
- 1997-02-26 EP EP97905085A patent/EP0888138A1/fr not_active Withdrawn
- 1997-02-26 JP JP09533072A patent/JP2000512265A/ja active Pending
- 1997-02-26 WO PCT/EP1997/000905 patent/WO1997034644A1/fr not_active Application Discontinuation
- 1997-02-26 CA CA002248977A patent/CA2248977A1/fr not_active Abandoned
- 1997-02-26 KR KR1019980707296A patent/KR20000064607A/ko not_active Application Discontinuation
- 1997-02-26 BR BR9708081A patent/BR9708081A/pt not_active Application Discontinuation
- 1997-02-26 AU AU18767/97A patent/AU1876797A/en not_active Abandoned
- 1997-03-13 ZA ZA9702180A patent/ZA972180B/xx unknown
Non-Patent Citations (1)
Title |
---|
See references of WO9734644A1 * |
Also Published As
Publication number | Publication date |
---|---|
KR20000064607A (ko) | 2000-11-06 |
WO1997034644A1 (fr) | 1997-09-25 |
BR9708081A (pt) | 1999-07-27 |
ZA972180B (en) | 1997-09-16 |
CA2248977A1 (fr) | 1997-09-25 |
AU1876797A (en) | 1997-10-10 |
JP2000512265A (ja) | 2000-09-19 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 19981016 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE |
|
AX | Request for extension of the european patent |
Free format text: LT PAYMENT 981016;LV PAYMENT 981016;SI PAYMENT 981016 |
|
17Q | First examination report despatched |
Effective date: 20000516 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20000927 |