EP0818986A1 - Selbstbräunungsmittel - Google Patents
SelbstbräunungsmittelInfo
- Publication number
- EP0818986A1 EP0818986A1 EP96908133A EP96908133A EP0818986A1 EP 0818986 A1 EP0818986 A1 EP 0818986A1 EP 96908133 A EP96908133 A EP 96908133A EP 96908133 A EP96908133 A EP 96908133A EP 0818986 A1 EP0818986 A1 EP 0818986A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- dihydroxyacetone
- lecithins
- sterols
- self
- process according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/35—Ketones, e.g. benzophenone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/14—Liposomes; Vesicles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/04—Preparations for care of the skin for chemically tanning the skin
Definitions
- the invention relates to self-tanning agents in liposomal form containing dihydroxyacetone and lecithins, a process for their preparation and the use of lecithins for the liposomal encapsulation of dihydroxyacetone.
- Dihydroxyacetone (1,3-dihydroxypropan-2-one) forms colorless, hygroscopic crystals. Diniers are present in aqueous solution, which disintegrate again when heated. Dihydroxyacetone forms brown-colored compounds with the protein bodies of the skin, which is why it is used in self-tanning products.
- the object of the invention was therefore to provide new self-tanning agents containing dihydroxyacetone which are free from the disadvantages described and to develop a process for stabilizing dihydroxyacetone.
- the invention relates to self-tanning agents containing liposomes, which can be obtained by heating dihydroxyacetone together with lecithins and optionally sterols in aqueous solution.
- the invention includes the knowledge that the liposomes containing the active substance have a very regular vesicular shape and, compared to the polymer spheres of the prior art, have significantly better biodegradability and high dermatological compatibility. As studies with a transmission electron microscope (TEM) show, the agents according to the invention still contain intact liposomes even after storage for 5 months at room temperature.
- Another object of the invention relates to a process for the preparation of self-tanning agents containing liposomes, in which dihydroxyacetone is heated together with lecithins and optionally sterols in aqueous solution.
- the agents according to the invention can contain the dihydroxyacetone in amounts of 1 to 5, preferably 2 to 3% by weight, based on the agents.
- the dihydroxyacetone can be present both as a monomer and as a dimer or as mixtures of the two.
- Lecithins or phosphadylcholines are glycerophospholipids which are formed from glycerol, fatty acids, phosphoric acid and preferably choline by esterification. They have a general structure according to formula (I) .
- R 1 CO and R 1 CO independently of one another for aliphatic acyl radicals with 12 to 22 carbon atoms, and 00 and 02 // ooddeerr 11 bis 44 DDooppppeellbbiinndduunnggeenn u and X for hydrogen, an R CO radical or preferably a Ct ⁇ C ⁇ N ⁇ CH ⁇ rest stand.
- lecithins and the closely related cephalins, to which the invention also extends are 1,2-diacyl-sn-glycerol-3-phosphoric acids and have a ⁇ -configuration.
- ß-lecithins is the phosphoric acid residue esterified with choline bound to the medium-sized hydroxy group of a glycend.
- lecithins preferably soy lecithins of the formula (I) which are largely mixtures of homologues based on fatty acids with 16 to 18 carbon atoms, more precisely, palmitic acid, palmoleic acid, stearic acid, oleic acid, linoleic acid and linolenic acid.
- the lecithins are usually used in amounts of 1 to 10, preferably 2 to 8% by weight, based on the composition.
- sterols (synonymous with sterols) is to be understood as steroids derived from cholesterol which carry a hydroxyl group only in the C-3 position, but no other functional groups.
- the sterols containing 27 to 30 carbon atoms generally have at least one double bond in the S / 6-, 7/8 and / or 8/9 position.
- Typical examples are zoosterols such as cholesterol, lanosterol, spongosterol, stellasterin or phytosterols such as ergosterol, comesterol, stigmasterol and sitosterol as well as vitamin D precursors.
- sterols are preferably used.
- the proportion of sterols in the compositions can usually be from 0.1 to 5, preferably 1 to 3,% by weight, based on the compositions.
- aqueous solution preferably contains a buffer which keeps the pH in the neutral range.
- Known commercial aqueous phosphate buffers for example, are suitable for this purpose.
- antioxidants such as tocopherols, BHT, BHA and the like to the mixtures for stabilization against autoxidation processes.
- dihydroxyacetone in lecithin liposomes, which may also contain sterols, leads to a stabilization of the active ingredient. Since the liposomes have a vesicular structure and are very stable in storage, the dihydroxyacetone can be released particularly evenly when used. Another object of the invention therefore relates to the use of lecithins for stabilizing and liposomal encapsulation of dihydroxyacetone.
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Dermatology (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19512410 | 1995-04-03 | ||
DE19512410 | 1995-04-03 | ||
DE19520104A DE19520104A1 (de) | 1995-04-03 | 1995-06-01 | Selbstbräunungsmittel |
DE19520104 | 1995-06-01 | ||
PCT/EP1996/001301 WO1996031190A1 (de) | 1995-04-03 | 1996-03-25 | Selbstbräunungsmittel |
Publications (1)
Publication Number | Publication Date |
---|---|
EP0818986A1 true EP0818986A1 (de) | 1998-01-21 |
Family
ID=26014075
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP96908133A Withdrawn EP0818986A1 (de) | 1995-04-03 | 1996-03-25 | Selbstbräunungsmittel |
Country Status (3)
Country | Link |
---|---|
EP (1) | EP0818986A1 (ja) |
JP (1) | JPH11503133A (ja) |
WO (1) | WO1996031190A1 (ja) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050238680A1 (en) | 2004-04-21 | 2005-10-27 | Qing Stella | Personal care compositions that deposit hydrophilic benefit agents |
AU2005262369B2 (en) * | 2004-07-01 | 2008-08-28 | E-L Management Corp. | Cosmetic compositions and methods containing a tanning agent and liposome-encapsulated ursolic acid |
WO2009071861A2 (fr) * | 2007-11-29 | 2009-06-11 | Lvmh Recherche | Procede de preparation d'une composition cosmetique contenant de la dha, compositions obtenues selon ce procede, et leurs utilisations |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2597367B1 (fr) * | 1986-04-22 | 1988-07-15 | Oreal | Procede pour faciliter la formation de spherules lipidiques en dispersion dans une phase aqueuse et pour ameliorer leur stabilite et leur taux d'encapsulation, et dispersions correspondantes. |
FR2657607B1 (fr) * | 1990-01-30 | 1992-04-30 | Durand Muriel | Procede de protection de la dihydroxyacetone, dihydroxyacetone protegee par ce procede et produit cosmetique contenant une telle dihydroxyacetone protegee. |
-
1996
- 1996-03-25 WO PCT/EP1996/001301 patent/WO1996031190A1/de not_active Application Discontinuation
- 1996-03-25 EP EP96908133A patent/EP0818986A1/de not_active Withdrawn
- 1996-03-25 JP JP8529935A patent/JPH11503133A/ja active Pending
Non-Patent Citations (1)
Title |
---|
See references of WO9631190A1 * |
Also Published As
Publication number | Publication date |
---|---|
WO1996031190A1 (de) | 1996-10-10 |
JPH11503133A (ja) | 1999-03-23 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 19970925 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): DE ES FR GB IT NL |
|
17Q | First examination report despatched |
Effective date: 19990625 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 19991108 |