EP0812135A1 - Astaxanthin suspension - Google Patents

Astaxanthin suspension

Info

Publication number
EP0812135A1
EP0812135A1 EP96902947A EP96902947A EP0812135A1 EP 0812135 A1 EP0812135 A1 EP 0812135A1 EP 96902947 A EP96902947 A EP 96902947A EP 96902947 A EP96902947 A EP 96902947A EP 0812135 A1 EP0812135 A1 EP 0812135A1
Authority
EP
European Patent Office
Prior art keywords
astaxanthin
suspension
oil
feed
particle size
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP96902947A
Other languages
German (de)
English (en)
French (fr)
Inventor
Peter Moldt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
NTG Nordic Transport Group AS
Original Assignee
Neurosearch AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurosearch AS filed Critical Neurosearch AS
Publication of EP0812135A1 publication Critical patent/EP0812135A1/en
Withdrawn legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C403/00Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
    • C07C403/24Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by six-membered non-aromatic rings, e.g. beta-carotene
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23KFODDER
    • A23K20/00Accessory food factors for animal feeding-stuffs
    • A23K20/10Organic substances
    • A23K20/179Colouring agents, e.g. pigmenting or dyeing agents
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23KFODDER
    • A23K50/00Feeding-stuffs specially adapted for particular animals
    • A23K50/80Feeding-stuffs specially adapted for particular animals for aquatic animals, e.g. fish, crustaceans or molluscs
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L5/00Preparation or treatment of foods or foodstuffs, in general; Food or foodstuffs obtained thereby; Materials therefor
    • A23L5/40Colouring or decolouring of foods
    • A23L5/42Addition of dyes or pigments, e.g. in combination with optical brighteners
    • A23L5/43Addition of dyes or pigments, e.g. in combination with optical brighteners using naturally occurring organic dyes or pigments, their artificial duplicates or their derivatives
    • A23L5/44Addition of dyes or pigments, e.g. in combination with optical brighteners using naturally occurring organic dyes or pigments, their artificial duplicates or their derivatives using carotenoids or xanthophylls

Definitions

  • This invention relates to a stable oil suspension of astaxanthin with high bioavailability, and the use thereof.
  • Astaxanthin belongs to the carotenoids, which is a group of compounds exhibiting a wide range of yellow to red colour nuances. Carotenoids give rise to several of the colour characteristics of plants, and aquatic animals, for example.
  • Carotenoids are insoluble in water and are only slightly fat soluble which means that solutions of carotenoids for direct application are unavailable. Furthermore, carotenoids are very sensible to oxidation.
  • Astaxanthin is used in fish-farming to impart a pink colour to shrimp, trout, salmon etc.
  • the invention comprises thus the following:
  • the suspension according to the invention can be prepared by milling of astaxanthin, if desired in the presence of oil.
  • astaxanthin is milled without oil, whereafter oil is added and the milling continued, if desired. Oxidation of astaxanthin during the dry milling operation can be reduced by the application of an inert gas atmosphere.
  • the astaxanthin particles in the suspension of the invention have a particle size less than 2 ⁇ m, especially less than 1 ⁇ m. More preferred is an astaxanthin particle size less than 0.5 ⁇ m, especially less than 0J ⁇ m.
  • the oil can be any animal or vegetable oil suitable for use in feed for aquatic animals.
  • oil includes fish oil, such as for example mackerel oil, sprat oil and launce oil.
  • Antioxidants such as for example tocopherols, especially ⁇ -tocopherol, butylhydroxyanisole (BHA), butylhydroxytoluene (BHT), ascorbylpalmitate or ethoxyquin, can be added to the suspension to avoid oxidation.
  • tocopherols especially ⁇ -tocopherol, butylhydroxyanisole (BHA), butylhydroxytoluene (BHT), ascorbylpalmitate or ethoxyquin
  • BHA butylhydroxyanisole
  • BHT butylhydroxytoluene
  • ascorbylpalmitate or ethoxyquin can be added to the suspension to avoid oxidation.
  • Feed for aquatic animals suitably contains 15-30 % fat. Fat can be added by absorption of oil into the feed after extrusion, if desired using vacuum.
  • the oil suspension of the invention could suitably be added to the feed using the same procedure, whereby an addition of fat and astaxanthin is obtained in one step.
  • the suspension of the invention has a high concentration of astaxanthin and is diluted with additional oil before use.
  • the final concentration of astaxanthin in fish feed is suitable between 25 and 100 ppm.
  • Astaxanthin OJ g is milled for one hour totally in a Fritsen planetary micro mill pulverisette 7, speed 6. 5 ml of Launce oil ( Esbjerg Fiskeindustri ) is added and milling is continued for 15 min, speed 1.5. Particle size is measured by microscopy and found to be less than 2 ⁇ m for the majority of the particles. This suspension is poured on to a glass and placed in the dark at room temperature for 14 days.
  • the small particles show a tendency to agglomeration but nothing indicates that the particles grow when standing. There is no sedimentation of astaxanthin.
  • Launce oil solidifies at -18°C.

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Animal Husbandry (AREA)
  • Zoology (AREA)
  • Nutrition Science (AREA)
  • Health & Medical Sciences (AREA)
  • Insects & Arthropods (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Birds (AREA)
  • Feed For Specific Animals (AREA)
  • Fodder In General (AREA)
EP96902947A 1995-01-31 1996-01-30 Astaxanthin suspension Withdrawn EP0812135A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DK10895 1995-01-31
DK10895 1995-01-31
PCT/EP1996/000373 WO1996023420A1 (en) 1995-01-31 1996-01-30 Astaxanthin suspension

Publications (1)

Publication Number Publication Date
EP0812135A1 true EP0812135A1 (en) 1997-12-17

Family

ID=8089837

Family Applications (1)

Application Number Title Priority Date Filing Date
EP96902947A Withdrawn EP0812135A1 (en) 1995-01-31 1996-01-30 Astaxanthin suspension

Country Status (8)

Country Link
EP (1) EP0812135A1 (fi)
JP (1) JPH10511270A (fi)
AU (1) AU4715696A (fi)
CA (1) CA2211107A1 (fi)
FI (1) FI972961A (fi)
NO (1) NO973473D0 (fi)
NZ (1) NZ301672A (fi)
WO (1) WO1996023420A1 (fi)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19649062A1 (de) * 1996-11-27 1998-05-28 Basf Ag Flüssige, mit Öl mischbare Carotinoid-Zubereitungen
US7105176B2 (en) * 2000-11-29 2006-09-12 Basf Aktiengesellschaft Production of solid preparations of water-soluble, sparingly water-soluble or water-insoluble active compounds
GB0218932D0 (en) * 2002-08-14 2002-09-25 Zoolife Internat Ltd Composition for dietary enrichment
EP1802279A1 (en) 2004-09-29 2007-07-04 Michael Ary Bos Caratenoid composition and method for preparation thereof
CA2609160C (en) * 2005-05-23 2013-01-08 Phares Pharmaceutical Research N.V. Direct dissolution
ES2304835B1 (es) * 2005-12-29 2009-10-23 Universidad De Las Palmas De Gran Canaria Pienso y procedimiento de alimentacion para peces de piel color rosado-rojiza procedentes de la acuicultura, para obtener en los mismos una coloracion y apariencia externa semejante a dichos organismos cuando son obtenidos directamente del mar mediante pesca extractiva.
DK2111125T4 (en) 2007-01-16 2017-02-27 Basf Se LIQUID FORMULATIONS CONTAINING CAROTINOIDS
WO2009065928A1 (de) * 2007-11-23 2009-05-28 Basf Se Verfahren zur herstellung von carotinoidlösungen
CL2008003485A1 (es) * 2007-11-23 2010-06-11 Basf Se Procedimiento para la preparacion de soluciones de carotenoides en un aceite comestible.
EP2224823B2 (de) 2007-11-29 2021-11-17 Basf Se Pulverförmige carotinoidzubereitung für die färbung von getränken
CN102176833B (zh) 2008-10-07 2018-03-16 巴斯夫欧洲公司 即用型稳定乳液
EP2792246A1 (de) 2013-04-17 2014-10-22 Basf Se Verfahren zur Herstellung einer Astaxanthin-Suspension

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3611229A1 (de) * 1986-04-04 1987-10-08 Basf Ag Verfahren zur herstellung von feinverteilten, pulverfoermigen carotinoidpraeparaten
DK199887D0 (da) * 1987-04-15 1987-04-15 Danisco Bioteknologi As Gaerstamme
US4871551A (en) * 1988-02-08 1989-10-03 Microbio Resources, Inc. Pigmentation supplements for animal feed compositions
DK546289D0 (da) * 1989-11-02 1989-11-02 Danochemo As Carotenoidpulvere
DE4200728A1 (de) * 1992-01-14 1993-07-15 Basf Ag Stabile, fluessige praeparate fettloeslicher substanzen
DE69319758T2 (de) * 1992-01-24 1998-11-26 Gist-Brocades N.V., Delft Verfahren zur Herstellung von Futterpellets

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO9623420A1 *

Also Published As

Publication number Publication date
JPH10511270A (ja) 1998-11-04
FI972961A (fi) 1997-07-31
NO973473L (no) 1997-07-28
NO973473D0 (no) 1997-07-28
FI972961A0 (fi) 1997-07-11
WO1996023420A1 (en) 1996-08-08
AU4715696A (en) 1996-08-21
NZ301672A (en) 1997-12-19
CA2211107A1 (en) 1996-08-08

Similar Documents

Publication Publication Date Title
WO1996023420A1 (en) Astaxanthin suspension
DE69006362T2 (de) Verfahren zur herstellung eines wasserdispergierbaren hydrophobischen oder aerophilen festkörpers.
US5084289A (en) Method for the inhibition of oxidation of edible oils utilizing a fat soluble anti-oxidant and a water soluble anti-oxdant in a reverse micelle system
US7173145B2 (en) Process for extraction and purification of lutein, zeaxanthin and rare carotenoids from marigold flowers and plants
CA2544902C (en) A process for isolating, purifying and formulating a stable, commercial grade lutein paste from oleoresin
JP2002543263A (ja) キサントフィルの安定した水性分散液及び水に分散可能な安定した乾燥粉末、並びにその製造及び使用
DE19838636A1 (de) Carotinoid-Formulierungen, enthaltend ein Gemisch aus beta-Carotin, Lycopin und Lutein
DE102004046026A1 (de) Verfahren zur Herstellung von Trockenpulvern eines oder mehrerer Carotinoide
DE202006020886U1 (de) Algen- und Algenextrakt-Nahrungsergänzungszusammensetzung
EP1713746A2 (de) Verfahren zur herstellung von trockenpulvern eines oder mehrerer carotinoide
JP4227409B2 (ja) 安定なルテインおよびルテイン誘導体の組成物を得るためのプロセス
EP1219292A1 (de) Verfahren zur Herstellung von Trockenpulvern eines oder mehrerer Sauerstoff-haltiger Carotinoide
EP2403362B1 (de) Pulverförmige zusammensetzungen von astaxanthin-derivaten ii
GB2215981A (en) Encapsulated food containing dunaliella algae and process for the production thereof
US2562840A (en) Vitamin preparations
WO2004012707A1 (de) Suspensionen von salzen der ascorbinsäure und ihre verwendung als antioxidantien
DE10042833A1 (de) Feste Zubereitungen mit einer Multi-Kern Struktur
DE10147035A1 (de) Verfahren zur Herstellung öliger Suspensionen wasserlöslicher Enzyme
WO1994014336A1 (en) Granular colorant and formula feed containing the same
DE3005874C2 (fi)
US3227561A (en) Coloring agent containing carotenoid pigment, and preparation of such agent
DE10233738A1 (de) Suspensionen von Salzen der Ascorbinsäure und ihre Verwendung als Antioxidantien
EP1559766A1 (de) Verfahren zur Stabilisierung carotinoidhaltiger Biomasse
AT253465B (de) Antioxydativ verwendbare Verbindungen
CN116420718A (zh) 斜纹夜蛾诱集性信息素

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 19970718

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE

AX Request for extension of the european patent

Free format text: LT PAYMENT 970718;LV PAYMENT 970718;SI PAYMENT 970718

17Q First examination report despatched

Effective date: 19990126

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: NEUROSEARCH A/S

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 19990608