EP0763476A1 - Capuchon de fermeture pour un récipient - Google Patents

Capuchon de fermeture pour un récipient Download PDF

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Publication number
EP0763476A1
EP0763476A1 EP96114504A EP96114504A EP0763476A1 EP 0763476 A1 EP0763476 A1 EP 0763476A1 EP 96114504 A EP96114504 A EP 96114504A EP 96114504 A EP96114504 A EP 96114504A EP 0763476 A1 EP0763476 A1 EP 0763476A1
Authority
EP
European Patent Office
Prior art keywords
seal
cap
particular according
wall
annular space
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP96114504A
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German (de)
English (en)
Inventor
Paul Stepanek
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pohl GmbH and Co KG
Original Assignee
Pohl GmbH and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19539897A external-priority patent/DE19539897A1/de
Application filed by Pohl GmbH and Co KG filed Critical Pohl GmbH and Co KG
Publication of EP0763476A1 publication Critical patent/EP0763476A1/fr
Withdrawn legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D51/00—Closures not otherwise provided for
    • B65D51/002—Closures to be pierced by an extracting-device for the contents and fixed on the container by separate retaining means

Definitions

  • the invention relates to a closure for a container with a pharmaceutical content in particular, with a shell of a cap placed on the container and firmly connected to it and with a seal which can be pierced with a hollow mandrel on the end face and which is connected to the inner wall of the cap.
  • Such pharmaceutical contents for example infusion or transfusion solutions, are generally to be kept sterile and used. From this arises the requirement that the content does not come into contact with the non-sterile environment even when it is used.
  • solutions have been developed in which a cap firmly connected to the container holds a seal which, after at least partial removal of the cap, can be pierced by means of an injection needle or a hollow mandrel to remove the contents from the container .
  • DE-A 32 41 283 shows a pierceable stopper that can be inserted into a container opening in the form of a bottle neck. There it is held by a cap covering it, which in turn has an opening covered by a seal.
  • the seal After removing the seal, the seal can be pierced through this opening by means of, for example, a hollow mandrel. Since the seal is directly connected to the container content in this closure, the container content was completely encapsulated in a further development, particularly in the case of plastic bottles. As a result, provision must also be made to pierce a closure wall of the container by means of the hollow mandrel in the region of the penetrable seal. The remaining space between the cap and the closure wall is often filled by an inserted sealing disk which closes again after being punctured.
  • sealing washers are inserted as precisely as possible, so that no cavities remain in which, for example, bacterial cultures could settle (DE-A 33 10 265, DE-A 23 27 553).
  • DE-A 33 10 265, DE-A 23 27 553 shows two development directions for avoiding such cavities. It is known from DE 25 09 504 to use a sealing washer made of a thermoelastic plastic, which softens at the sterilization temperature and then forms on the inside of the cap housing.
  • DE 23 27 553 shows an alternative closure option, namely pouring or injecting hot sealing material, for example a rubber compound at a temperature of 130 degrees Celsius, into a plastic cap.
  • the cap closure is designed to provide an annular space between the seal and the jacket on the inside of the cap, into which the seal can elastically deflect when the hollow mandrel is pierced.
  • the forces caused by elastic deformation are primarily available for reclosing the seal.
  • this annular space By connecting the seal to the inner wall, this annular space remains in its originally sterile state even after being punctured, since even then it does not come into contact with the non-sterile environment.
  • the shape of the cross section of the annular space can vary, but preferably the width of the annular space between the inner surface of the casing and the circumferential surface of the seal delimiting the annular space is to be kept substantially constant or, alternatively, the width of the annular space is to be increased in the direction of penetration, i.e. in the direction of the end of the cap towards the container. This is ensures that there is a maximum width in the area of the maximum elastic deflection of the seal when puncturing. This maximum deflection is given on the underside of the seal.
  • the width should be about 1 / 3-2 / 3 times the thickness of the seal in the direction of penetration, which also provides sufficient space for an elastic deflection of the seal Puncturing with a hollow mandrel of relatively large cross section, for example 6 mm in diameter, is given.
  • the thickness of the seal is limited - depending on the material - to enable puncturing. For example, in the case of a seal made of thermoelastic plastic, it can be 5 mm and an annular space with a width of approximately 2.2 mm can then be provided.
  • connection of the seal has a tongue and groove connection.
  • a tongue and groove connection increases the connection of the seal to the inner wall, for example through the geometry of the tongue and groove connection with undercuts.
  • the common contact area between the inner wall and the subsequent seal is enlarged, for example for gluing, etc. It is also advantageous that the position of the seal and cap relative to one another is geometrically fixed by this measure, and in this way the annular space is inevitably formed exactly.
  • the seal preferably co-forms the spring with an annular circumference.
  • the seal has on its upper side adjoining the front inner wall of the cap one of these protruding tongue, which engages in a groove of the front inner wall.
  • the peripheral surface of the seal merges directly into the spring, which is overlapped by a groove edge of the end wall, which borders a piercing opening in the end wall.
  • the transverse dimensions of the jacket are also determined by the subsequent annular space. This also reduces the material required for the cap.
  • the seal on its circumferential surface opposite the inner wall of the cap formed by the casing and delimiting the annular space has a protruding spring which engages in a groove in the inner wall of the casing.
  • the top of the seal merges directly into the spring, which is overlapped by a groove edge of the cap which surrounds at least one end opening.
  • the cap itself no longer has an end wall covering the seal. The face of the seal is largely exposed, with the exception of the spring being covered by the groove.
  • the seal is bonded to the inner wall in the area of the tongue and groove engagement, namely for example by the geometric shape with undercuts or by gluing and the like.
  • This connection serves, as it were, as a counter-bearing for the forces which occur when it is pierced, so that this connection must be correspondingly firm.
  • the groove edge has one of the bulges projecting on the end face, which surrounds the at least one piercing opening in a ring, which is preferably designed to be final in one plane.
  • the cap can also have a constant material thickness and therefore constant stability in the region of the groove, and the bead can simultaneously be the carrier of a seal covering the through opening.
  • a plurality of penetration openings can also be provided in the cap.
  • each penetration opening can be underlaid by a seal in the manner described or all penetration openings are closed by a common seal.
  • the seal has a web on the upper side, which ends with the plane of the bead, and that seals lying on the bead and web are detachably attached.
  • the piercing opening is divided into at least two piercing areas. These can be used independently of one another, since when a seal of one piercing area is inserted, the other piercing area remains sterile under the second seal, also separated from the environment by the web. For good handling, it is ultimately provided that the seal extends in the longitudinal direction of the web projecting opposite tongues protruding over the jacket.
  • cap closures are known in which a cap was first injected, into which a sealing compound is then injected, optionally held by one and the same tool. This method is extremely efficient and safely prevents gaps between the inner wall of the cap and the seal.
  • this type of procedure creates internal stresses when the injected, hot sealing material cools down. The deformations of the cap caused thereby can on the one hand impair its connection to the container and on the other hand the sealing of a container closure wall can be of low quality in that after the injection process this sealing surface no longer has the desired shape.
  • a spraying method is provided according to the invention in which a seal is prefabricated from an elastic, preferably thermoplastic material and that the seal is molded onto the cap.
  • the seal is received in a pot-shaped holder, the upper ring wall edge of which is formed, for example, with the top of the seal, so that only one spring of the seal protrudes from the ring wall edge, and that to those in the bracket received seal, the cap is injected, a later free annular space between a jacket inner surface of the cap and a peripheral surface of the seal being determined by the ring wall thickness.
  • the upper edge of the ring wall ends on the underside of the essentially radially extending spring. Points of contact between the cap and the seal are then only provided in the area of the gating of the seal and here in particular only in the area of the tongue and groove connection.
  • the molded cap is largely spaced from the seal.
  • the holding space forms the annular space of the cap according to the invention in an advantageous manner, which has a constant width or increases in the direction of penetration of the seal for good demolding.
  • the seal is held in the holder by a counter-punch seated on its upper side, the transverse dimensions of which determine a later opening in the cap. If several piercing openings are provided, several corresponding counter-punches can also be provided.
  • the seal is also injected into the holder.
  • the seal can be punched out or cut out of an elastic, preferably thermoplastic, flat material.
  • the container 1 shown in FIG. 1 for a pharmaceutical content can be used, for example, with a rigid wall 2 or as a bag to hold a fusion solution, when it is removed it can be attached to a gallows by means of an eyelet 3.
  • this has a cap closure 4.
  • An outer cap 5 with an end wall 6 and a jacket 7 projecting therefrom is firmly connected to the container 1 here.
  • the free edge of the jacket 7 has a flange 8 which is, for example, firmly glued or welded to a counter flange 9 of the container 1.
  • a seal 10 On the outside on the outside, a seal 10 is also provided which can be torn off, on the end of which a piercing opening 11 of the end wall 6 is released. On the inside of the cap, this push-through opening is closed by a push-through seal 12 which, for example, has markings or, like here, two depressions 13 for the attachment of a hollow mandrel.
  • the seal 12 is firmly connected to the front inner wall 14, see FIGS. 3 and 4.
  • connection of the seal 12 to the front inner wall 14 has a tongue and groove connection, for which purpose the seal 12 has on its upper side 15 one of these protruding springs 16 which engages in a groove 17 of the inner wall 14.
  • the groove 17 runs in a groove edge 18 of the end wall 6, which on the one hand overlaps the spring 16 and on the other hand borders the penetration opening 11. Since the peripheral surface 19 of the seal 12 merges directly into the spring 16, the seal 12 is connected to the inner wall 14 exclusively in the area of the tongue and groove connection 16, 17, which provides a sufficient surface area for gluing or welding .
  • the groove edge projects with a bulge 20 of the end wall 6 and closes in a plane which corresponds to the underside 21 of the seal 10.
  • the seal 10 can be attached in a simple manner above the penetration opening 11.
  • the seal 12 can be pierced by means of a hollow mandrel 22.
  • the seal 12 is held on the one hand by the connection to the inner wall 14 of the cap 5.
  • the cap lies sealingly on a closure wall 24 of the container, which must also be pierced by the hollow mandrel 22.
  • the asymmetrical penetration shown here naturally also causes an asymmetrical, elastic deflection of the seal 12 into the annular space 26 according to FIG. 4.
  • the elastic forces stored in the seal 12 are also of sufficient magnitude after removal of the hollow mandrel 22 by the piercing to securely close the resulting hole.
  • a seal 30 is received in a cup-shaped holder 31.
  • This holder can be made in one piece or, if appropriate, in multiple pieces.
  • the upper edge 32 of the ring wall 33 of the holder 31 terminates with the upper side 34 of the seal 30, a spring 35 of the seal 30 still protruding from the ring wall edge 32.
  • the seal 30 itself can preferably be injection-molded or, if appropriate, inserted as a stamped or cut-out part.
  • the seal 30 is preferably held in the holder 31 by a counter-punch 36 seated on its upper side 34. This arrangement is surrounded by a further molded part 37, in which the seal 30 is now made of an elastic, preferably thermoplastic, after completion Material a cap is molded onto the seal 30.
  • the ring wall thickness determines the later free annular space between an inner surface of the cap and a peripheral surface of the seal. Due to the transverse dimension of the counter-punch, the later piercing opening or piercing openings in the cap are determined immediately during the spraying process, so that no complex measures are still necessary to create them.
  • the holder 31, counter-punch 36 and molded part 37 are only shown schematically. Depending on the shape requirements or injection molding conditions, these shapes can be combined or can be made in several parts, as is required for the exemplary embodiment described below.
  • FIGS. 6 to 9 An alternative embodiment to the cap closure for the container according to FIG. 1 is shown in FIGS. 6 to 9.
  • the section according to FIG. 6 shows a cap 50, the jacket 51 of which has a flange 52 on the container side for fastening to a counter flange on the container side, cf. 1 also shows this.
  • a seal 55 is connected via a spring 49 in a circumferential groove 53 in the inner wall 54 of the casing.
  • the spring 49 projects from the circumferential surface 57 delimiting an annular space 56, the upper side 58 of the seal 55 merging directly into the spring 49.
  • a groove edge 59 of the cap 50 engages over the spring 49 and surrounds a piercing opening 60, which largely corresponds to the inner surface of the cap 50 surrounded by the jacket 51.
  • the groove edge 59 also has a bead 61 which terminates in a plane 62.
  • the seal 55 has a web 63 projecting into the penetration opening 60 and also terminating with the plane 62.
  • Seals 64, 65 are provided in the plane 62, lying on the bead 61 and the web 63 and detachably attached there.
  • the seals 64, 65 have tongues 66, 67 protruding beyond the jacket 51, on which they can be easily torn off. Two piercing areas 68, 69 are thus created.
  • Figures 6 and 8 show a dovetail-shaped undercut of the tongue and groove connection 53/49.
  • Such an undercut is easy to achieve by injection molding by means of a divided, pot-shaped holder, in which the seal 55 is received, even if the seal 55 is sprayed out in this holder.
  • the division can then take place in such a way that an outer annular slide is simply displaced relative to the lower plane of the spring 49.
  • one of the projections 81 protrudes, which increases the width of the annular space 56 in the direction of penetration.
  • connection of the web to the bead two variants of the connection of the web to the bead are explained in more detail in order to obtain two piercing areas 85, 86.
  • the connection of the web is to be supplemented by symmetry with respect to the center lines 87, 87 '.
  • the connection of the web 88 shown in the upper half in FIG. 10 corresponds to the left side of the image in FIG. 11. It is the web 88 extended in such a way that it ends directly with the extension of the inner wall 90 through the bead 91 with its narrow face 89.
  • the closure is of a type which maintains the sterility of the second piercing area when the seal of the first piercing area has been removed.
  • FIG. 10 shows an alternative embodiment of a connection of a web 88 '.
  • the inner wall 90 'of the jacket protrudes 92, which overlaps the spring 93 to the narrow side 89' of the web 88 '.
  • the circumferential bead 91 ' branches and also adjoins the narrow side 89' of the web 88 ', so that here too the sterility is maintained by a seal, for example, glued on.
  • the outer section 94 of the bead 91 'between the branching points can also be omitted if necessary.
  • the piercing areas can be marked in the usual way, for example by depressions.
  • Figures 12 to 14 show different embodiments for this and for the approach of the spring.
  • Fig. 12 shows first that the spring 70 does not necessarily have to end with the top 71 of a seal 72 in one plane. However, care should be taken to ensure a sufficient height of the annular space 73 so that the elastic deformation, cf. Fig. 4, is guaranteed.
  • the section according to FIG. 12 through the seal 72 shows opposite trough-like depressions 74, 75 which mark piercing areas in a manner known per se.
  • FIG. 13 shows a seal 76 with a continuous surface 77, which also extends over the spring 78.
  • the spring 78 also only has an undercut on the underside.

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  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Closures For Containers (AREA)
EP96114504A 1995-09-13 1996-09-11 Capuchon de fermeture pour un récipient Withdrawn EP0763476A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE19533813 1995-09-13
DE19533813 1995-09-13
DE19539897A DE19539897A1 (de) 1995-09-13 1995-10-26 Kappenverschluß für einen Behälter
DE19539897 1995-10-26

Publications (1)

Publication Number Publication Date
EP0763476A1 true EP0763476A1 (fr) 1997-03-19

Family

ID=26018519

Family Applications (1)

Application Number Title Priority Date Filing Date
EP96114504A Withdrawn EP0763476A1 (fr) 1995-09-13 1996-09-11 Capuchon de fermeture pour un récipient

Country Status (1)

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EP (1) EP0763476A1 (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1070241A1 (fr) * 1998-03-06 2001-01-24 LEVY, Abner Modele perfectionne de flacon a urine et mode d'emploi
WO2014064548A1 (fr) 2012-10-23 2014-05-01 Copan Italia S.P.A. Élément de fermeture de récipient pour liquides organiques
WO2014067597A1 (fr) * 2012-10-31 2014-05-08 Kocher-Plastik Maschinenbau Gmbh Ensemble d'étanchéité et récipient associé à un tel ensemble
WO2016015742A1 (fr) * 2014-07-29 2016-02-04 Kocher-Plastik Maschinenbau Gmbh Récipient pourvu d'une pièce de tête qui est ou peut être rempli avec un fluide

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2969158A (en) * 1959-03-02 1961-01-24 Baxter Laboratories Inc Parenteral solution equipment
DE3241283A1 (de) * 1981-11-13 1983-05-19 Manufacture Lyonnaise de Bouchage, 69008 Lyon Verschluss fuer behaelter beinhaltend ein injektionsgut
DE8613068U1 (de) * 1986-05-14 1986-06-26 Matthias Faensen KG, 5190 Stolberg Flaschenverschluß für medizinische Glasflaschen
GB2203118A (en) * 1987-04-07 1988-10-12 Fuso Pharmaceutical Ind Plastics transfusion containers
EP0364783A1 (fr) * 1988-10-20 1990-04-25 Pharma-Gummi Wimmer West GmbH Fermeture pour une bouteille à usage médical et son procédé de préparation
EP0623523A1 (fr) * 1993-05-06 1994-11-09 Becton, Dickinson and Company Dispositif de fermeture comportant au bouchon et un capuchon protecteur

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2969158A (en) * 1959-03-02 1961-01-24 Baxter Laboratories Inc Parenteral solution equipment
DE3241283A1 (de) * 1981-11-13 1983-05-19 Manufacture Lyonnaise de Bouchage, 69008 Lyon Verschluss fuer behaelter beinhaltend ein injektionsgut
DE8613068U1 (de) * 1986-05-14 1986-06-26 Matthias Faensen KG, 5190 Stolberg Flaschenverschluß für medizinische Glasflaschen
GB2203118A (en) * 1987-04-07 1988-10-12 Fuso Pharmaceutical Ind Plastics transfusion containers
EP0364783A1 (fr) * 1988-10-20 1990-04-25 Pharma-Gummi Wimmer West GmbH Fermeture pour une bouteille à usage médical et son procédé de préparation
EP0623523A1 (fr) * 1993-05-06 1994-11-09 Becton, Dickinson and Company Dispositif de fermeture comportant au bouchon et un capuchon protecteur

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1070241A1 (fr) * 1998-03-06 2001-01-24 LEVY, Abner Modele perfectionne de flacon a urine et mode d'emploi
EP1070241A4 (fr) * 1998-03-06 2004-10-13 Abner Levy Modele perfectionne de flacon a urine et mode d'emploi
WO2014064548A1 (fr) 2012-10-23 2014-05-01 Copan Italia S.P.A. Élément de fermeture de récipient pour liquides organiques
JP2016501786A (ja) * 2012-10-31 2016-01-21 コッヒャー−プラスティック マシーネンバウ ゲゼルシャフト ミット ベシュレンクテル ハフツング シーリング装置及びこれに割り当てられた容器
KR20150079902A (ko) * 2012-10-31 2015-07-08 코허-플라스틱 마쉬넨바우 게엠베하 밀봉 장치 및 그와 결합되는 용기
CN104870329A (zh) * 2012-10-31 2015-08-26 科赫尔塑料机械制造有限公司 密封系统以及配置给该密封系统的容器
WO2014067597A1 (fr) * 2012-10-31 2014-05-08 Kocher-Plastik Maschinenbau Gmbh Ensemble d'étanchéité et récipient associé à un tel ensemble
RU2643432C2 (ru) * 2012-10-31 2018-02-01 Кохер-Пластик Машиненбау Гмбх Закупоривающее устройство и способ изготовления такого устройства
US10098814B2 (en) 2012-10-31 2018-10-16 Kocher-Plastik Maschinenbau Gmbh Sealing arrangement and container associated with same
WO2016015742A1 (fr) * 2014-07-29 2016-02-04 Kocher-Plastik Maschinenbau Gmbh Récipient pourvu d'une pièce de tête qui est ou peut être rempli avec un fluide
RU2675782C2 (ru) * 2014-07-29 2018-12-24 Кохер-Пластик Машиненбау Гмбх Контейнер, имеющий головку контейнера, который заполнен или может быть заполнен веществом
AU2014401981B2 (en) * 2014-07-29 2019-08-29 Kocher-Plastik Maschinenbau Gmbh Container having a head piece, which container can be or is filled with a medium
US11046474B2 (en) 2014-07-29 2021-06-29 Kocher-Plastick Maschinebau Gmbh Container having a head piece, which container can be or is filled with a medium

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