EP0698481A1 - Procédé de commande floue pour assurer la qualité dans la fabrication de comprimés - Google Patents
Procédé de commande floue pour assurer la qualité dans la fabrication de comprimés Download PDFInfo
- Publication number
- EP0698481A1 EP0698481A1 EP94250211A EP94250211A EP0698481A1 EP 0698481 A1 EP0698481 A1 EP 0698481A1 EP 94250211 A EP94250211 A EP 94250211A EP 94250211 A EP94250211 A EP 94250211A EP 0698481 A1 EP0698481 A1 EP 0698481A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- pressing force
- weight
- control
- height
- hardness
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
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Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B30—PRESSES
- B30B—PRESSES IN GENERAL
- B30B11/00—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses
- B30B11/005—Control arrangements
Definitions
- the invention relates to a method for quality assurance in tablet production by pressing according to the preamble of claim 1.
- An important quality parameter for tablet production is compliance with the specified tablet weight, which ensures compliance with the limits for the content of active ingredients if the mixing quality is sufficient.
- the basis for any automatic Controlling a tableting machine is the relationship between the measured maximum compressive force of a tablet and the mass of the goods filled into the die (tablet weight). There is a direct relationship between the tablet weight and the pressing force required to manufacture the controlled tablet. This relationship is used for the use of automatic monitoring and control devices on rotary presses. Depending on the material to be pressed, each tablet weight is assigned a specific pressing force with a tablet shape predetermined by the pressing tools and a set tablet height. If the filling quantity and thus the tablet weight fluctuate at a constant tablet height, this results in a direct dependence on a change in the pressing force.
- the parameters of weight, height and hardness of the tablet are measured discontinuously, whereby deviations from the target values lead to the specification of a new pressing force target value.
- the new pressure force setpoint is adjusted by adjusting the height of the web.
- EP-0.261.358 B1 describes a method for quality assurance in the manufacture of tablets. Thereafter, during the production of the tablets, samples are taken which consist of a large number of tablets, the common actual weight value of which is compared with the desired weight value, and in which the tabletting machine corresponds to the difference between the actual value and the intended value. Value is adjusted in order to bring the tablet weight to the SET value. Before readjusting the tablet machine, the weights of the individual tablets of the sample are measured and compared. If one or more tablets of the sample differ significantly in weight from the target value, the statistics are corrected by means of a correction calculation and the corrected value is used for readjustment.
- the invention is therefore based on the object to develop a method for quality assurance in tablet manufacture by pressing, according to which all the necessary control mechanisms for keeping the tablet weight, the tablet height and hardness run so that a quick correction of deviations is guaranteed and after the limit values can also be optimized automatically.
- the invention is based on an embodiment of the method for quality assurance in tablet manufacture shown in the drawing by a modern high-performance rotary press explained in more detail.
- the single figure shows a controller model for the simultaneous control of the tablet parameters weight, height and hardness.
- the control system is divided into control circuits R1 to R5, which are connected to one another in such a way that they run parallel and nested one inside the other.
- the first control loop R1 causes a stabilization of the actual pressing force PK IST on the value of the target pressing force PK SOLL by a Dose modification ⁇ D.
- the actual pressing force PF actual is the rigid or floating mean value of several Einzelpreß manufacturedn to the die stations of the press.
- the first input to the first control circuit R1 is the value of ⁇ Preßkraftabweichung PK between the target pressing force PK SOLL and the actual pressing force PK IST.
- the control circuit R1 is acted upon by a second input variable, which is formed by the sensitivity of the pressing force dosing dPK / dD.
- the sensitivity dPK / dD determines the accuracy of the pressing force control as a function of the change in dosage ⁇ D and is adjusted to the control during operation of the press, ie the sensitivity dPK / dD is adaptive.
- the weight G, the height T and the hardness H of the tablets are measured continuously and a moving average is calculated.
- a new value for the SET pressing force PK SOLL is calculated in the second control circuit R2, which in turn generates a dosage change ⁇ D in the first control circuit R1, whereby the weight deviation ⁇ G is compensated for.
- the variation of the target pressing force PK SOLL is determined by the value ⁇ PK SOLL.
- a sensitivity weight dG / dPF which determines the accuracy of weight control as a function of ⁇ Preßkraft Sung PK SOLL. This sensitivity dG / dPK is also adaptive and is adapted to the regulation during the tablet production process.
- the values for the height deviation ⁇ T and for the sensitivity height dT / dh are applied as input variables to the third control circuit R3, the values for the hardness deviation ⁇ H and the sensitivity hardness dH / dh are applied to the input of the fourth control circuit R4 created.
- the sensitivities dT / dh and dH / dh are again adaptive.
- a deviation between the SET pressing force web height PK SOLLST and the ACTUAL pressing force PK IST is corrected by a height adjustment by the value ⁇ ST.
- the second input variable on the fifth control circuit R5 is the sensitivity-compression force web height dPK / ie with adaptive properties.
- control loops R1 and R5 work alternatively. All control loops R1 to R5 work continuously. Current values are constantly available due to a preferably moving averaging of the individual control variables.
- the control loops R1 to R5 can also each be divided into several sub-loops, which have different characteristics, for example, depending on the control deviation.
- the limit values for the pressing force PK upon reaching which the press is stopped and / or tablets are sorted out, are adaptively determined by using the data measured during operation to determine the relationship between the pressing force PK and the weight G, the height T and the hardness H is determined. This determination can also be made on a stamp basis. With given limits for the weight G, the height T and the hardness H, the associated press force limits can be determined from this connection.
- the technical variables of the controller model are fuzzyfied by converting them into linguistic variables, for example weight deviation, sensitivity-weight, height deviation, etc. Terms such as “low, medium, high” are assigned to these linguistic variables, these terms in each case unsharp quantities represent.
- the terms are assigned membership functions, with the aid of which it is possible to determine the degree of membership for each value of the linguistic variables to determine individual terms. For example, a weight deviation of 5 mg fulfills the condition "medium deviation" to grade 0.2, the condition "high deviation” to grade 0.7.
- the variables are linked using FUZZY operators, e.g. "Minimum operator, maximum operator, gamma operator” or the like.
- the fuzzy information is processed using production rules that are processed using methods of FUZZY inference, for example MAX-MIN / MAX-PROD inference or FAM / inference and others.
- the output variables which are now available as "FUZZY values"
- the area center of gravity method is preferably used as the defuzzification method, but other methods such as maximum mean method, maximum center of gravity method and others are also possible.
Landscapes
- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Medicinal Preparation (AREA)
- Glanulating (AREA)
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4315680A DE4315680C2 (de) | 1993-05-05 | 1993-05-05 | Regelung von Tablettenparametern bei der Herstellung auf Rundlauf-Pressen |
DE59407774T DE59407774D1 (de) | 1993-05-05 | 1994-08-24 | Fuzzysteuerungsverfahren zur Qualitätssicherung bei der Tablettenherstellung |
ES94250211T ES2130350T5 (es) | 1993-05-05 | 1994-08-24 | Procedimiento para asegurar la calidad en la fabricacion de tabletas. |
EP94250211A EP0698481B2 (fr) | 1993-05-05 | 1994-08-24 | Procédé de commande floue pour assurer la qualité dans la fabrication de comprimés |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4315680A DE4315680C2 (de) | 1993-05-05 | 1993-05-05 | Regelung von Tablettenparametern bei der Herstellung auf Rundlauf-Pressen |
EP94250211A EP0698481B2 (fr) | 1993-05-05 | 1994-08-24 | Procédé de commande floue pour assurer la qualité dans la fabrication de comprimés |
Publications (3)
Publication Number | Publication Date |
---|---|
EP0698481A1 true EP0698481A1 (fr) | 1996-02-28 |
EP0698481B1 EP0698481B1 (fr) | 1999-02-03 |
EP0698481B2 EP0698481B2 (fr) | 2003-03-19 |
Family
ID=25925811
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP94250211A Expired - Lifetime EP0698481B2 (fr) | 1993-05-05 | 1994-08-24 | Procédé de commande floue pour assurer la qualité dans la fabrication de comprimés |
Country Status (3)
Country | Link |
---|---|
EP (1) | EP0698481B2 (fr) |
DE (2) | DE4315680C2 (fr) |
ES (1) | ES2130350T5 (fr) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8361360B2 (en) | 2006-05-15 | 2013-01-29 | Courtoy Nv | Method for controlling a tablet press |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19828004B4 (de) * | 1998-06-24 | 2005-10-13 | Korsch Ag | Verfahren zur Erzielung einer konstanten Preßkraft bei Tablettiermaschinen |
DE19955196A1 (de) * | 1999-11-16 | 2001-05-23 | Korsch Pressen Ag | Verfahren zum Konstanthalten der Bruchhärte von Tabletten |
DE19958999A1 (de) * | 1999-12-08 | 2001-04-26 | Henkel Kgaa | Verfahren und Vorrichtung zur Regelung von Tablettenpressen |
ES2242141T3 (es) | 2003-02-10 | 2005-11-01 | Korsch Ag | Metodo y dispositivo para el control de una maquina rotativa para la fabricacion de tabletas. |
DE102006017196B4 (de) | 2006-04-12 | 2008-09-11 | Fette Gmbh | Verfahren zur Regelung der Wirkstoffmenge von Tabletten während der Produktion in einer Rundläufertablettenpresse |
DE102009004620A1 (de) * | 2009-01-15 | 2010-07-22 | Gkn Sinter Metals Holding Gmbh | Verfahren zum Betrieb einer Pressvorrichtung zur Herstellung von Presslingen konstanter Höhe aus pulverförmigen Stoffen, Steuergerät für eine derartige Pressvorrichtung und Pressvorrichtung |
DK2427166T3 (da) | 2009-05-07 | 2014-01-27 | Gea Pharma Systems Ltd | Tabletfremstillingsmodul og fremgangsmåde til kontinuerlig fremstilling af tabletter |
DE102017004803A1 (de) * | 2017-05-18 | 2018-11-22 | Cosateq Gmbh | Verfahren zum Betrieb einer Pulverpresse mit Lagenregelung und Pulverpresse zur Ausführung des Verfahrens |
DE102018113220A1 (de) * | 2018-06-04 | 2019-12-05 | Thilo Kraemer | Verfahren zum automatischen Ermitteln von Grenzwerten von mindestens einem Parameter von kleinvolumigen Schüttgütern eines bestimmten Typs |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2252917A1 (fr) * | 1973-11-30 | 1975-06-27 | Kikusui Seisakusho Ltd | |
JPS61111799A (ja) * | 1984-11-02 | 1986-05-29 | Hata Tekkosho:Kk | ロ−タリ−式粉末圧縮成形機 |
FR2607441A1 (fr) * | 1986-12-02 | 1988-06-03 | Commissariat Energie Atomique | Installation de fabrication de comprimes de masse lineique constante |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3628757A1 (de) * | 1986-08-23 | 1988-03-03 | Fette Wilhelm Gmbh | Verfahren zur qualitaetssicherung bei der herstellung von tabletten |
-
1993
- 1993-05-05 DE DE4315680A patent/DE4315680C2/de not_active Expired - Fee Related
-
1994
- 1994-08-24 ES ES94250211T patent/ES2130350T5/es not_active Expired - Lifetime
- 1994-08-24 DE DE59407774T patent/DE59407774D1/de not_active Expired - Lifetime
- 1994-08-24 EP EP94250211A patent/EP0698481B2/fr not_active Expired - Lifetime
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2252917A1 (fr) * | 1973-11-30 | 1975-06-27 | Kikusui Seisakusho Ltd | |
JPS61111799A (ja) * | 1984-11-02 | 1986-05-29 | Hata Tekkosho:Kk | ロ−タリ−式粉末圧縮成形機 |
FR2607441A1 (fr) * | 1986-12-02 | 1988-06-03 | Commissariat Energie Atomique | Installation de fabrication de comprimes de masse lineique constante |
Non-Patent Citations (1)
Title |
---|
PATENT ABSTRACTS OF JAPAN vol. 10, no. 299 (M - 524)<2355> 11 October 1986 (1986-10-11) * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8361360B2 (en) | 2006-05-15 | 2013-01-29 | Courtoy Nv | Method for controlling a tablet press |
Also Published As
Publication number | Publication date |
---|---|
ES2130350T5 (es) | 2003-11-16 |
DE4315680C2 (de) | 1996-02-29 |
EP0698481B2 (fr) | 2003-03-19 |
DE59407774D1 (de) | 1999-03-18 |
EP0698481B1 (fr) | 1999-02-03 |
DE4315680A1 (de) | 1994-11-10 |
ES2130350T3 (es) | 1999-07-01 |
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