EP0698481A1 - Procédé de commande floue pour assurer la qualité dans la fabrication de comprimés - Google Patents

Procédé de commande floue pour assurer la qualité dans la fabrication de comprimés Download PDF

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Publication number
EP0698481A1
EP0698481A1 EP94250211A EP94250211A EP0698481A1 EP 0698481 A1 EP0698481 A1 EP 0698481A1 EP 94250211 A EP94250211 A EP 94250211A EP 94250211 A EP94250211 A EP 94250211A EP 0698481 A1 EP0698481 A1 EP 0698481A1
Authority
EP
European Patent Office
Prior art keywords
pressing force
weight
control
height
hardness
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP94250211A
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German (de)
English (en)
Other versions
EP0698481B2 (fr
EP0698481B1 (fr
Inventor
Wolfgang Dr. Linke
Walter Hegel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Korsch AG
Original Assignee
Korsch Pressen GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25925811&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EP0698481(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to DE4315680A priority Critical patent/DE4315680C2/de
Application filed by Korsch Pressen GmbH filed Critical Korsch Pressen GmbH
Priority to EP94250211A priority patent/EP0698481B2/fr
Priority to DE59407774T priority patent/DE59407774D1/de
Priority to ES94250211T priority patent/ES2130350T5/es
Publication of EP0698481A1 publication Critical patent/EP0698481A1/fr
Application granted granted Critical
Publication of EP0698481B1 publication Critical patent/EP0698481B1/fr
Publication of EP0698481B2 publication Critical patent/EP0698481B2/fr
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Expired - Lifetime legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B30—PRESSES
    • B30B—PRESSES IN GENERAL
    • B30B11/00—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses
    • B30B11/005—Control arrangements

Definitions

  • the invention relates to a method for quality assurance in tablet production by pressing according to the preamble of claim 1.
  • An important quality parameter for tablet production is compliance with the specified tablet weight, which ensures compliance with the limits for the content of active ingredients if the mixing quality is sufficient.
  • the basis for any automatic Controlling a tableting machine is the relationship between the measured maximum compressive force of a tablet and the mass of the goods filled into the die (tablet weight). There is a direct relationship between the tablet weight and the pressing force required to manufacture the controlled tablet. This relationship is used for the use of automatic monitoring and control devices on rotary presses. Depending on the material to be pressed, each tablet weight is assigned a specific pressing force with a tablet shape predetermined by the pressing tools and a set tablet height. If the filling quantity and thus the tablet weight fluctuate at a constant tablet height, this results in a direct dependence on a change in the pressing force.
  • the parameters of weight, height and hardness of the tablet are measured discontinuously, whereby deviations from the target values lead to the specification of a new pressing force target value.
  • the new pressure force setpoint is adjusted by adjusting the height of the web.
  • EP-0.261.358 B1 describes a method for quality assurance in the manufacture of tablets. Thereafter, during the production of the tablets, samples are taken which consist of a large number of tablets, the common actual weight value of which is compared with the desired weight value, and in which the tabletting machine corresponds to the difference between the actual value and the intended value. Value is adjusted in order to bring the tablet weight to the SET value. Before readjusting the tablet machine, the weights of the individual tablets of the sample are measured and compared. If one or more tablets of the sample differ significantly in weight from the target value, the statistics are corrected by means of a correction calculation and the corrected value is used for readjustment.
  • the invention is therefore based on the object to develop a method for quality assurance in tablet manufacture by pressing, according to which all the necessary control mechanisms for keeping the tablet weight, the tablet height and hardness run so that a quick correction of deviations is guaranteed and after the limit values can also be optimized automatically.
  • the invention is based on an embodiment of the method for quality assurance in tablet manufacture shown in the drawing by a modern high-performance rotary press explained in more detail.
  • the single figure shows a controller model for the simultaneous control of the tablet parameters weight, height and hardness.
  • the control system is divided into control circuits R1 to R5, which are connected to one another in such a way that they run parallel and nested one inside the other.
  • the first control loop R1 causes a stabilization of the actual pressing force PK IST on the value of the target pressing force PK SOLL by a Dose modification ⁇ D.
  • the actual pressing force PF actual is the rigid or floating mean value of several Einzelpreß manufacturedn to the die stations of the press.
  • the first input to the first control circuit R1 is the value of ⁇ Preßkraftabweichung PK between the target pressing force PK SOLL and the actual pressing force PK IST.
  • the control circuit R1 is acted upon by a second input variable, which is formed by the sensitivity of the pressing force dosing dPK / dD.
  • the sensitivity dPK / dD determines the accuracy of the pressing force control as a function of the change in dosage ⁇ D and is adjusted to the control during operation of the press, ie the sensitivity dPK / dD is adaptive.
  • the weight G, the height T and the hardness H of the tablets are measured continuously and a moving average is calculated.
  • a new value for the SET pressing force PK SOLL is calculated in the second control circuit R2, which in turn generates a dosage change ⁇ D in the first control circuit R1, whereby the weight deviation ⁇ G is compensated for.
  • the variation of the target pressing force PK SOLL is determined by the value ⁇ PK SOLL.
  • a sensitivity weight dG / dPF which determines the accuracy of weight control as a function of ⁇ Preßkraft Sung PK SOLL. This sensitivity dG / dPK is also adaptive and is adapted to the regulation during the tablet production process.
  • the values for the height deviation ⁇ T and for the sensitivity height dT / dh are applied as input variables to the third control circuit R3, the values for the hardness deviation ⁇ H and the sensitivity hardness dH / dh are applied to the input of the fourth control circuit R4 created.
  • the sensitivities dT / dh and dH / dh are again adaptive.
  • a deviation between the SET pressing force web height PK SOLLST and the ACTUAL pressing force PK IST is corrected by a height adjustment by the value ⁇ ST.
  • the second input variable on the fifth control circuit R5 is the sensitivity-compression force web height dPK / ie with adaptive properties.
  • control loops R1 and R5 work alternatively. All control loops R1 to R5 work continuously. Current values are constantly available due to a preferably moving averaging of the individual control variables.
  • the control loops R1 to R5 can also each be divided into several sub-loops, which have different characteristics, for example, depending on the control deviation.
  • the limit values for the pressing force PK upon reaching which the press is stopped and / or tablets are sorted out, are adaptively determined by using the data measured during operation to determine the relationship between the pressing force PK and the weight G, the height T and the hardness H is determined. This determination can also be made on a stamp basis. With given limits for the weight G, the height T and the hardness H, the associated press force limits can be determined from this connection.
  • the technical variables of the controller model are fuzzyfied by converting them into linguistic variables, for example weight deviation, sensitivity-weight, height deviation, etc. Terms such as “low, medium, high” are assigned to these linguistic variables, these terms in each case unsharp quantities represent.
  • the terms are assigned membership functions, with the aid of which it is possible to determine the degree of membership for each value of the linguistic variables to determine individual terms. For example, a weight deviation of 5 mg fulfills the condition "medium deviation" to grade 0.2, the condition "high deviation” to grade 0.7.
  • the variables are linked using FUZZY operators, e.g. "Minimum operator, maximum operator, gamma operator” or the like.
  • the fuzzy information is processed using production rules that are processed using methods of FUZZY inference, for example MAX-MIN / MAX-PROD inference or FAM / inference and others.
  • the output variables which are now available as "FUZZY values"
  • the area center of gravity method is preferably used as the defuzzification method, but other methods such as maximum mean method, maximum center of gravity method and others are also possible.

Landscapes

  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Medicinal Preparation (AREA)
  • Glanulating (AREA)
EP94250211A 1993-05-05 1994-08-24 Procédé de commande floue pour assurer la qualité dans la fabrication de comprimés Expired - Lifetime EP0698481B2 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
DE4315680A DE4315680C2 (de) 1993-05-05 1993-05-05 Regelung von Tablettenparametern bei der Herstellung auf Rundlauf-Pressen
EP94250211A EP0698481B2 (fr) 1993-05-05 1994-08-24 Procédé de commande floue pour assurer la qualité dans la fabrication de comprimés
DE59407774T DE59407774D1 (de) 1993-05-05 1994-08-24 Fuzzysteuerungsverfahren zur Qualitätssicherung bei der Tablettenherstellung
ES94250211T ES2130350T5 (es) 1993-05-05 1994-08-24 Procedimiento para asegurar la calidad en la fabricacion de tabletas.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4315680A DE4315680C2 (de) 1993-05-05 1993-05-05 Regelung von Tablettenparametern bei der Herstellung auf Rundlauf-Pressen
EP94250211A EP0698481B2 (fr) 1993-05-05 1994-08-24 Procédé de commande floue pour assurer la qualité dans la fabrication de comprimés

Publications (3)

Publication Number Publication Date
EP0698481A1 true EP0698481A1 (fr) 1996-02-28
EP0698481B1 EP0698481B1 (fr) 1999-02-03
EP0698481B2 EP0698481B2 (fr) 2003-03-19

Family

ID=25925811

Family Applications (1)

Application Number Title Priority Date Filing Date
EP94250211A Expired - Lifetime EP0698481B2 (fr) 1993-05-05 1994-08-24 Procédé de commande floue pour assurer la qualité dans la fabrication de comprimés

Country Status (3)

Country Link
EP (1) EP0698481B2 (fr)
DE (2) DE4315680C2 (fr)
ES (1) ES2130350T5 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8361360B2 (en) 2006-05-15 2013-01-29 Courtoy Nv Method for controlling a tablet press

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19828004B4 (de) * 1998-06-24 2005-10-13 Korsch Ag Verfahren zur Erzielung einer konstanten Preßkraft bei Tablettiermaschinen
DE19955196A1 (de) * 1999-11-16 2001-05-23 Korsch Pressen Ag Verfahren zum Konstanthalten der Bruchhärte von Tabletten
DE19958999A1 (de) * 1999-12-08 2001-04-26 Henkel Kgaa Verfahren und Vorrichtung zur Regelung von Tablettenpressen
ES2242141T3 (es) 2003-02-10 2005-11-01 Korsch Ag Metodo y dispositivo para el control de una maquina rotativa para la fabricacion de tabletas.
DE102006017196B4 (de) 2006-04-12 2008-09-11 Fette Gmbh Verfahren zur Regelung der Wirkstoffmenge von Tabletten während der Produktion in einer Rundläufertablettenpresse
DE102009004620A1 (de) * 2009-01-15 2010-07-22 Gkn Sinter Metals Holding Gmbh Verfahren zum Betrieb einer Pressvorrichtung zur Herstellung von Presslingen konstanter Höhe aus pulverförmigen Stoffen, Steuergerät für eine derartige Pressvorrichtung und Pressvorrichtung
CN102438578A (zh) 2009-05-07 2012-05-02 基伊埃制药系统有限公司 药片生产模块和用于连续生产药片的方法
DE102017004803A1 (de) * 2017-05-18 2018-11-22 Cosateq Gmbh Verfahren zum Betrieb einer Pulverpresse mit Lagenregelung und Pulverpresse zur Ausführung des Verfahrens
DE102018113220A1 (de) * 2018-06-04 2019-12-05 Thilo Kraemer Verfahren zum automatischen Ermitteln von Grenzwerten von mindestens einem Parameter von kleinvolumigen Schüttgütern eines bestimmten Typs

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2252917A1 (fr) * 1973-11-30 1975-06-27 Kikusui Seisakusho Ltd
JPS61111799A (ja) * 1984-11-02 1986-05-29 Hata Tekkosho:Kk ロ−タリ−式粉末圧縮成形機
FR2607441A1 (fr) * 1986-12-02 1988-06-03 Commissariat Energie Atomique Installation de fabrication de comprimes de masse lineique constante

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3628757A1 (de) * 1986-08-23 1988-03-03 Fette Wilhelm Gmbh Verfahren zur qualitaetssicherung bei der herstellung von tabletten

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2252917A1 (fr) * 1973-11-30 1975-06-27 Kikusui Seisakusho Ltd
JPS61111799A (ja) * 1984-11-02 1986-05-29 Hata Tekkosho:Kk ロ−タリ−式粉末圧縮成形機
FR2607441A1 (fr) * 1986-12-02 1988-06-03 Commissariat Energie Atomique Installation de fabrication de comprimes de masse lineique constante

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
PATENT ABSTRACTS OF JAPAN vol. 10, no. 299 (M - 524)<2355> 11 October 1986 (1986-10-11) *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8361360B2 (en) 2006-05-15 2013-01-29 Courtoy Nv Method for controlling a tablet press

Also Published As

Publication number Publication date
DE4315680C2 (de) 1996-02-29
DE4315680A1 (de) 1994-11-10
EP0698481B2 (fr) 2003-03-19
ES2130350T3 (es) 1999-07-01
ES2130350T5 (es) 2003-11-16
EP0698481B1 (fr) 1999-02-03
DE59407774D1 (de) 1999-03-18

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