EP0693291B1 - Compositions pour le traitement des plaies - Google Patents

Compositions pour le traitement des plaies Download PDF

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Publication number
EP0693291B1
EP0693291B1 EP95111523A EP95111523A EP0693291B1 EP 0693291 B1 EP0693291 B1 EP 0693291B1 EP 95111523 A EP95111523 A EP 95111523A EP 95111523 A EP95111523 A EP 95111523A EP 0693291 B1 EP0693291 B1 EP 0693291B1
Authority
EP
European Patent Office
Prior art keywords
polysaccharide
cross
linked
composition
wound treatment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
EP95111523A
Other languages
German (de)
English (en)
Other versions
EP0693291A3 (fr
EP0693291A2 (fr
Inventor
Elliott A. Gruskin
Ying Jiang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
United States Surgical Corp
Original Assignee
United States Surgical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by United States Surgical Corp filed Critical United States Surgical Corp
Publication of EP0693291A2 publication Critical patent/EP0693291A2/fr
Publication of EP0693291A3 publication Critical patent/EP0693291A3/fr
Application granted granted Critical
Publication of EP0693291B1 publication Critical patent/EP0693291B1/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • A61L26/0023—Polysaccharides

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  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Materials Engineering (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Materials For Medical Uses (AREA)

Claims (20)

  1. Composition comprenant :
    un traitement hydrolysable des plaies comprenant un polysaccharide oxydé qui est réticulé et a une charge chimiquement induite et un véhicule de distribution, le polysaccharide modifié et le véhicule de distribution étant en une condition dans laquelle le polysaccharide oxydé ne s'hydrolysera sensiblement pas avant application à un site d'une plaie.
  2. Composition selon la revendication 1, où le polysaccharide est du dextrane.
  3. Composition selon les revendications 1 ou 2, où la charge chimiquement induite est produite par des groupes DEAE sur le polysaccharide.
  4. Composition selon l'une quelconque des revendications 1 à 3, où le véhicule de distribution comprend un fluide non polaire.
  5. Composition selon l'une quelconque des revendications 1 à 4 comprenant de plus une substance thérapeutiquement active.
  6. Composition comprenant un traitement stérile contre les plaies contenant un polysaccharide oxydé réticulé, hydrolysable, ayant une charge chimiquement induite.
  7. Méthode de préparation d'une composition de traitement des plaies consistant à :
    prévoir un polysaccharide réticulé ayant une charge qui y est chimiquement induite ; et
    oxyder le polysaccharide réticulé.
  8. Méthode selon la revendication 7, où le polysaccharide réticulé est du dextrane réticulé.
  9. Méthode selon les revendications 7 ou 8, où la charge sur le polysaccharide réticulé est produite par des groupes DEAE.
  10. Méthode selon l'une quelconque des revendications 7 à 9 où l'étape d'oxydation comprend la mise en contact du polysaccharide réticulé avec un agent oxydant sélectionné dans le consistant en acide periodique, sels periodiques, chlorite de sodium, hypochlorite de sodium, bromite de sodium et hypobromite de sodium.
  11. Méthode selon l'une quelconque des revendications 7 à 10, où l'étape d'oxydation comprend l'oxydation du polysaccharide par réaction avec l'ion periodate et de plus l'oxydation du polysaccharide par réaction du chlorite de sodium.
  12. Utilisation d'un polysaccharide oxydé, réticulé ayant une charge qui y est chimiquement induite, dans la fabrication d'une composition de traitement stérile des plaies efficace dans le traitement d'un site d'une plaie.
  13. Utilisation selon la revendication 12, où la composition de traitement des plaies est une poudre.
  14. Utilisation selon les revendications 12 ou 13, où la composition de traitement des plaies contient également un véhicule de distribution.
  15. Utilisation selon la revendication 14, où la composition de traitement des plaies est un gel.
  16. Utilisation selon l'une quelconque des revendications 12 à 15, où le polysaccharide réticulé est un detrane réticulé.
  17. Utilisation selon l'une quelconque des revendications 12 à 16, où la charge chimiquement induite est produite par des groupes DEAE sur le polysaccharide.
  18. Composition de traitement des plaies comprenant un dextrane réticulé où au moins une portion des unités monosaccharides a été oxydée en un groupe ayant la formule suivante :
    Figure 00200001
  19. Composition de traitement des plaies selon la revendication 18, où le dextrane réticulé a une charge qui y est chimiquement induite.
  20. Composition de traitement des plaies selon la revendication 19, où la charge chimique est produite par des groupes DEAE sur le dextrane réticulé.
EP95111523A 1994-07-22 1995-07-21 Compositions pour le traitement des plaies Expired - Lifetime EP0693291B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/278,778 US5502042A (en) 1994-07-22 1994-07-22 Methods and compositions for treating wounds
US278778 1994-07-22

Publications (3)

Publication Number Publication Date
EP0693291A2 EP0693291A2 (fr) 1996-01-24
EP0693291A3 EP0693291A3 (fr) 1999-09-15
EP0693291B1 true EP0693291B1 (fr) 2001-12-19

Family

ID=23066328

Family Applications (1)

Application Number Title Priority Date Filing Date
EP95111523A Expired - Lifetime EP0693291B1 (fr) 1994-07-22 1995-07-21 Compositions pour le traitement des plaies

Country Status (4)

Country Link
US (1) US5502042A (fr)
EP (1) EP0693291B1 (fr)
CA (1) CA2154124C (fr)
DE (1) DE69524682T2 (fr)

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US8034048B2 (en) 2003-05-05 2011-10-11 Boston Scientific Scimed, Inc. Tissue patches and related delivery systems and methods
WO2005027834A2 (fr) * 2003-09-12 2005-03-31 Z-Medica Corporation Agent hemostatique partiellement hydrate
US7758654B2 (en) 2004-05-20 2010-07-20 Kensey Nash Corporation Anti-adhesion device
EP1796746B1 (fr) 2004-10-07 2011-05-04 E.I. Du Pont De Nemours And Company Adhesif tissulaire polymere a base de polysaccharide destine a un usage medical
US20060178609A1 (en) 2005-02-09 2006-08-10 Z-Medica, Llc Devices and methods for the delivery of molecular sieve materials for the formation of blood clots
KR20070117589A (ko) 2005-02-15 2007-12-12 버지니아 커먼웰스 유니버시티 급성 지혈 및 급성 상처와 만성 궤양의 치료를 위한 광물기술
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US7604819B2 (en) 2006-05-26 2009-10-20 Z-Medica Corporation Clay-based hemostatic agents and devices for the delivery thereof
US7968114B2 (en) 2006-05-26 2011-06-28 Z-Medica Corporation Clay-based hemostatic agents and devices for the delivery thereof
CN101541857B (zh) * 2006-11-27 2012-12-12 阿克塔马克斯手术器材有限责任公司 多官能聚环氧烷、水凝胶和组织粘合剂
WO2008157536A2 (fr) * 2007-06-21 2008-12-24 Z-Medica Corporation Éponge hémostatique et procédé de fabrication
US20090035249A1 (en) * 2007-08-02 2009-02-05 Bhatia Sujata K Method of inhibiting proliferation of Escherichia coli
EP2214731B1 (fr) * 2007-11-14 2014-05-14 Actamax Surgical Materials LLC Adhésif tissulaire polymère à base de polysaccharide cationique oxydé, à usage médical
US20100015231A1 (en) * 2008-07-17 2010-01-21 E.I. Du Pont De Nemours And Company Low swell, long-lived hydrogel sealant
US8551136B2 (en) 2008-07-17 2013-10-08 Actamax Surgical Materials, Llc High swell, long-lived hydrogel sealant
US8466327B2 (en) 2008-11-19 2013-06-18 Actamax Surgical Materials, Llc Aldehyde-functionalized polyethers and method of making same
WO2010059279A2 (fr) * 2008-11-19 2010-05-27 E. I. Du Pont De Nemours And Company Adhésif de type hydrogel pour tissus formés à partir de polysaccharide aminé et de polyéther à plusieurs bras fonctionnalisé par aldéhyde
US20100160960A1 (en) * 2008-12-19 2010-06-24 E. I. Du Pont De Nemours And Company Hydrogel tissue adhesive having increased degradation time
EP2416811B1 (fr) 2009-04-09 2015-09-09 Actamax Surgical Materials LLC Adhésif de type hydrogel pour tissus, ayant un temps de dégradation réduit
US8580951B2 (en) 2009-07-02 2013-11-12 Actamax Surgical Materials, Llc Aldehyde-functionalized polysaccharides
US8580950B2 (en) 2009-07-02 2013-11-12 Actamax Surgical Materials, Llc Aldehyde-functionalized polysaccharides
US8796242B2 (en) 2009-07-02 2014-08-05 Actamax Surgical Materials, Llc Hydrogel tissue adhesive for medical use
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US20160145567A1 (en) * 2010-05-27 2016-05-26 Corning Incorporated Cell culture article and methods thereof
US8858969B2 (en) 2010-09-22 2014-10-14 Z-Medica, Llc Hemostatic compositions, devices, and methods
JP2012107033A (ja) * 2012-02-02 2012-06-07 Medafor Inc 局所適用される凝血材料
KR102037150B1 (ko) 2012-06-22 2019-10-28 지-메디카 엘엘씨 지혈 장치
US8859705B2 (en) 2012-11-19 2014-10-14 Actamax Surgical Materials Llc Hydrogel tissue adhesive having decreased gelation time and decreased degradation time
EP3027659B1 (fr) 2013-07-29 2020-12-09 Actamax Surgical Materials LLC Adhésif pour tissu à faible gonflement et formulations d'obturant
IL267432B1 (en) * 2016-12-22 2024-03-01 Omrix Biopharmaceuticals Ltd A hemostatic preparation containing an anion exchanger and a calcium salt
IL249725A0 (en) 2016-12-22 2017-03-30 Omrix Biopharmaceuticals Ltd A hemostatic preparation containing an anion exchanger and a calcium salt
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Also Published As

Publication number Publication date
CA2154124A1 (fr) 1996-01-23
US5502042A (en) 1996-03-26
DE69524682T2 (de) 2002-08-14
EP0693291A3 (fr) 1999-09-15
EP0693291A2 (fr) 1996-01-24
CA2154124C (fr) 2010-01-12
DE69524682D1 (de) 2002-01-31

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