CA2154124C - Methodes et compositions pour le traitement des blessures - Google Patents

Methodes et compositions pour le traitement des blessures Download PDF

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Publication number
CA2154124C
CA2154124C CA002154124A CA2154124A CA2154124C CA 2154124 C CA2154124 C CA 2154124C CA 002154124 A CA002154124 A CA 002154124A CA 2154124 A CA2154124 A CA 2154124A CA 2154124 C CA2154124 C CA 2154124C
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CA
Canada
Prior art keywords
polysaccharide
composition
cross
linked
oxidized
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA002154124A
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English (en)
Other versions
CA2154124A1 (fr
Inventor
Elliott A. Gruskin
Ying Jiang
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United States Surgical Corp
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United States Surgical Corp
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Filing date
Publication date
Application filed by United States Surgical Corp filed Critical United States Surgical Corp
Publication of CA2154124A1 publication Critical patent/CA2154124A1/fr
Application granted granted Critical
Publication of CA2154124C publication Critical patent/CA2154124C/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • A61L26/0023—Polysaccharides

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  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Materials Engineering (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Materials For Medical Uses (AREA)

Abstract

Des compositions de traitement des blessures comprennent un polysaccharide réticulé oxydé qui a une charge induite chimiquement. Les polysaccharides préférés sont des dextranes réticulés. Une charge est fournie de préférence par des groupes de diéthylaminoéthyle (groupes DEAE) ou des groupes de carboxyméthyle. Le polysaccharide réticulé oxydé peut être appliqué sous forme d'une poudre directement à un site de plaie. Dans un autre mode de réalisation, le polysaccharide réticulé oxydé peut être combiné avec un véhicule d'administration pour former un liquide ou appliqué à un site de blessure.
CA002154124A 1994-07-22 1995-07-18 Methodes et compositions pour le traitement des blessures Expired - Lifetime CA2154124C (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/278,778 US5502042A (en) 1994-07-22 1994-07-22 Methods and compositions for treating wounds
US08/278,778 1994-07-22

Publications (2)

Publication Number Publication Date
CA2154124A1 CA2154124A1 (fr) 1996-01-23
CA2154124C true CA2154124C (fr) 2010-01-12

Family

ID=23066328

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002154124A Expired - Lifetime CA2154124C (fr) 1994-07-22 1995-07-18 Methodes et compositions pour le traitement des blessures

Country Status (4)

Country Link
US (1) US5502042A (fr)
EP (1) EP0693291B1 (fr)
CA (1) CA2154124C (fr)
DE (1) DE69524682T2 (fr)

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US7758654B2 (en) * 2004-05-20 2010-07-20 Kensey Nash Corporation Anti-adhesion device
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US20060178609A1 (en) 2005-02-09 2006-08-10 Z-Medica, Llc Devices and methods for the delivery of molecular sieve materials for the formation of blood clots
US11167058B2 (en) 2005-02-15 2021-11-09 Virginia Commonwealth University Hemostasis of wound having high pressure blood flow
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US8414907B2 (en) 2005-04-28 2013-04-09 Warsaw Orthopedic, Inc. Coatings on medical implants to guide soft tissue healing
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US20070248653A1 (en) * 2006-04-20 2007-10-25 Cochrum Kent C Hemostatic compositions and methods for controlling bleeding
US8938898B2 (en) * 2006-04-27 2015-01-27 Z-Medica, Llc Devices for the identification of medical products
US7604819B2 (en) 2006-05-26 2009-10-20 Z-Medica Corporation Clay-based hemostatic agents and devices for the delivery thereof
US7968114B2 (en) 2006-05-26 2011-06-28 Z-Medica Corporation Clay-based hemostatic agents and devices for the delivery thereof
EP2099845B1 (fr) * 2006-11-27 2020-12-23 Actamax Surgical Materials LLC Reactifs a extremites ramifiees et adhesifs tissulaires en hydrogel polymere associes
WO2008157536A2 (fr) * 2007-06-21 2008-12-24 Z-Medica Corporation Éponge hémostatique et procédé de fabrication
US20090035249A1 (en) * 2007-08-02 2009-02-05 Bhatia Sujata K Method of inhibiting proliferation of Escherichia coli
WO2009064963A2 (fr) * 2007-11-14 2009-05-22 E. I. Du Pont De Nemours And Company Adhésif tissulaire polymère à base de polysaccharide cationique oxydé, à usage médical
US20100015231A1 (en) * 2008-07-17 2010-01-21 E.I. Du Pont De Nemours And Company Low swell, long-lived hydrogel sealant
US8551136B2 (en) 2008-07-17 2013-10-08 Actamax Surgical Materials, Llc High swell, long-lived hydrogel sealant
US8466327B2 (en) 2008-11-19 2013-06-18 Actamax Surgical Materials, Llc Aldehyde-functionalized polyethers and method of making same
EP2349357B1 (fr) * 2008-11-19 2012-10-03 Actamax Surgical Materials LLC Adhésif de type hydrogel pour tissus formés à partir de polysaccharide aminé et de polyéther à plusieurs bras fonctionnalisé par aldéhyde
US20100160960A1 (en) * 2008-12-19 2010-06-24 E. I. Du Pont De Nemours And Company Hydrogel tissue adhesive having increased degradation time
JP2012523289A (ja) 2009-04-09 2012-10-04 アクタマックス サージカル マテリアルズ リミテッド ライアビリティ カンパニー 減少した分解時間を有するハイドロゲル組織接着剤
US8580950B2 (en) 2009-07-02 2013-11-12 Actamax Surgical Materials, Llc Aldehyde-functionalized polysaccharides
WO2011002888A2 (fr) 2009-07-02 2011-01-06 E. I. Du Pont De Nemours And Company Adhesif de type hydrogel pour tissu a usage medical
US8796242B2 (en) 2009-07-02 2014-08-05 Actamax Surgical Materials, Llc Hydrogel tissue adhesive for medical use
WO2011002956A1 (fr) 2009-07-02 2011-01-06 E. I. Du Pont De Nemours And Company Polysaccharides fonctionnalisés par aldéhyde
KR101003331B1 (ko) * 2010-05-11 2010-12-23 조강선 피부 충전제 조성물
US20160145567A1 (en) * 2010-05-27 2016-05-26 Corning Incorporated Cell culture article and methods thereof
US8858969B2 (en) 2010-09-22 2014-10-14 Z-Medica, Llc Hemostatic compositions, devices, and methods
JP2012107033A (ja) * 2012-02-02 2012-06-07 Medafor Inc 局所適用される凝血材料
BR112014031439A8 (pt) 2012-06-22 2023-01-31 Z Medica Llc Dispositivos e curativos hemostáticos e para feridas e processos para produzir dispositivo hemostático e para tratar feridas
US8859705B2 (en) 2012-11-19 2014-10-14 Actamax Surgical Materials Llc Hydrogel tissue adhesive having decreased gelation time and decreased degradation time
EP3027659B1 (fr) 2013-07-29 2020-12-09 Actamax Surgical Materials LLC Adhésif pour tissu à faible gonflement et formulations d'obturant
BR112019012531A2 (pt) * 2016-12-22 2019-11-19 Omrix Biopharmaceuticals Ltd composição hemostática compreendendo um trocador de ânions e um sal de cálcio
IL249725A0 (en) * 2016-12-22 2017-03-30 Omrix Biopharmaceuticals Ltd A hemostatic preparation containing an anion exchanger and a calcium salt
CA3079753A1 (fr) * 2017-11-28 2019-06-06 Baxter International Inc. Absorbant pour le traitement des plaies
US11739166B2 (en) 2020-07-02 2023-08-29 Davol Inc. Reactive polysaccharide-based hemostatic agent

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Also Published As

Publication number Publication date
EP0693291A3 (fr) 1999-09-15
DE69524682T2 (de) 2002-08-14
EP0693291A2 (fr) 1996-01-24
CA2154124A1 (fr) 1996-01-23
US5502042A (en) 1996-03-26
DE69524682D1 (de) 2002-01-31
EP0693291B1 (fr) 2001-12-19

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