EP0640014A1 - Separation method - Google Patents
Separation methodInfo
- Publication number
- EP0640014A1 EP0640014A1 EP93909823A EP93909823A EP0640014A1 EP 0640014 A1 EP0640014 A1 EP 0640014A1 EP 93909823 A EP93909823 A EP 93909823A EP 93909823 A EP93909823 A EP 93909823A EP 0640014 A1 EP0640014 A1 EP 0640014A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- catalyst
- acid
- reaction mixture
- solid
- reaction
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J38/00—Regeneration or reactivation of catalysts, in general
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J37/00—Processes, in general, for preparing catalysts; Processes, in general, for activation of catalysts
- B01J37/009—Preparation by separation, e.g. by filtration, decantation, screening
Definitions
- the immobilized enzyme is an ampicillin hydrolase.
- a solid product produced in a process in which the starting material(s) is (are) fully dissolved in the reaction mixture is separated continuously from the catalyst during the reaction by leading the filtrate from the filter which retains the catalyst only to a filter which retains the solid product synthesized and recirculating the filtrate from this filter to the catalyst.
- the invention relates to a method of separating an immobilized enzyme used for catalyzing acylation of the 7-amino group in 7-amino- desacetoxycephalosporanic acid from the remainder of the reaction mixture.
- ZAPM can be further processed to aspartame by methods known per se (removal of the N-protection group of the aspartic moiety, crystallization etc.).
Landscapes
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Catalysts (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK641/92 | 1992-05-14 | ||
DK64192A DK64192D0 (da) | 1992-05-14 | 1992-05-14 | Separationsmetode |
PCT/DK1993/000159 WO1993023164A1 (en) | 1992-05-14 | 1993-05-13 | Separation method |
Publications (1)
Publication Number | Publication Date |
---|---|
EP0640014A1 true EP0640014A1 (en) | 1995-03-01 |
Family
ID=8095895
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP93909823A Withdrawn EP0640014A1 (en) | 1992-05-14 | 1993-05-13 | Separation method |
Country Status (10)
Country | Link |
---|---|
EP (1) | EP0640014A1 (es) |
JP (1) | JPH07507959A (es) |
CN (1) | CN1081929A (es) |
AU (1) | AU4061393A (es) |
BR (1) | BR9306349A (es) |
DK (1) | DK64192D0 (es) |
MX (1) | MX9302724A (es) |
SK (1) | SK134294A3 (es) |
TW (1) | TW304886B (es) |
WO (1) | WO1993023164A1 (es) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW555855B (en) * | 1996-07-26 | 2003-10-01 | Bristol Myers Squibb Co | Synthesis of beta-lactam antibacterials using soluble side chain esters and enzyme acylase |
DE10211449A1 (de) * | 2002-03-15 | 2003-09-25 | Basf Ag | Katalysator-Precursor für die Herstellung von Maleinsäureanhydrid und Verfahren zu dessen Herstellung |
WO2017186864A1 (en) * | 2016-04-27 | 2017-11-02 | Sandoz Ag | Enzymatic process for the production of beta-lactam antibiotics in the presence of particulate inoculum |
-
1992
- 1992-05-14 DK DK64192A patent/DK64192D0/da not_active Application Discontinuation
-
1993
- 1993-05-10 MX MX9302724A patent/MX9302724A/es unknown
- 1993-05-11 TW TW82103667A patent/TW304886B/zh active
- 1993-05-13 AU AU40613/93A patent/AU4061393A/en not_active Abandoned
- 1993-05-13 JP JP5519788A patent/JPH07507959A/ja active Pending
- 1993-05-13 BR BR9306349A patent/BR9306349A/pt not_active Application Discontinuation
- 1993-05-13 EP EP93909823A patent/EP0640014A1/en not_active Withdrawn
- 1993-05-13 WO PCT/DK1993/000159 patent/WO1993023164A1/en not_active Application Discontinuation
- 1993-05-13 CN CN 93107082 patent/CN1081929A/zh active Pending
- 1993-05-13 SK SK1342-94A patent/SK134294A3/sk unknown
Non-Patent Citations (1)
Title |
---|
See references of WO9323164A1 * |
Also Published As
Publication number | Publication date |
---|---|
SK134294A3 (en) | 1995-07-11 |
WO1993023164A1 (en) | 1993-11-25 |
MX9302724A (es) | 1994-08-31 |
BR9306349A (pt) | 1998-06-30 |
AU4061393A (en) | 1993-12-13 |
CN1081929A (zh) | 1994-02-16 |
TW304886B (es) | 1997-05-11 |
DK64192D0 (da) | 1992-05-14 |
JPH07507959A (ja) | 1995-09-07 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 19941214 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI LU NL PT SE |
|
17Q | First examination report despatched |
Effective date: 19960909 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION HAS BEEN WITHDRAWN |
|
18W | Application withdrawn |
Withdrawal date: 19970705 |