EP0640014A1 - Procede de separation - Google Patents

Procede de separation

Info

Publication number
EP0640014A1
EP0640014A1 EP93909823A EP93909823A EP0640014A1 EP 0640014 A1 EP0640014 A1 EP 0640014A1 EP 93909823 A EP93909823 A EP 93909823A EP 93909823 A EP93909823 A EP 93909823A EP 0640014 A1 EP0640014 A1 EP 0640014A1
Authority
EP
European Patent Office
Prior art keywords
catalyst
acid
reaction mixture
solid
reaction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP93909823A
Other languages
German (de)
English (en)
Inventor
Svend Gunnar Kaasgaard
Camilla Helene Ulrich
Kim Clausen
Thomas Lisbjerg Jensen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novo Nordisk AS
Original Assignee
Novo Nordisk AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk AS filed Critical Novo Nordisk AS
Publication of EP0640014A1 publication Critical patent/EP0640014A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J38/00—Regeneration or reactivation of catalysts, in general
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J37/00—Processes, in general, for preparing catalysts; Processes, in general, for activation of catalysts
    • B01J37/009—Preparation by separation, e.g. by filtration, decantation, screening

Definitions

  • the immobilized enzyme is an ampicillin hydrolase.
  • a solid product produced in a process in which the starting material(s) is (are) fully dissolved in the reaction mixture is separated continuously from the catalyst during the reaction by leading the filtrate from the filter which retains the catalyst only to a filter which retains the solid product synthesized and recirculating the filtrate from this filter to the catalyst.
  • the invention relates to a method of separating an immobilized enzyme used for catalyzing acylation of the 7-amino group in 7-amino- desacetoxycephalosporanic acid from the remainder of the reaction mixture.
  • ZAPM can be further processed to aspartame by methods known per se (removal of the N-protection group of the aspartic moiety, crystallization etc.).

Landscapes

  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Catalysts (AREA)

Abstract

La présente invention concerne un procédé de séparation d'un catalyseur particulaire solide à partir d'un mélange réactionnel chimique contenant par ailleurs au moins un autre composant solide, et cela soit durant la réaction, soit après la réaction.
EP93909823A 1992-05-14 1993-05-13 Procede de separation Withdrawn EP0640014A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DK641/92 1992-05-14
DK64192A DK64192D0 (da) 1992-05-14 1992-05-14 Separationsmetode
PCT/DK1993/000159 WO1993023164A1 (fr) 1992-05-14 1993-05-13 Procede de separation

Publications (1)

Publication Number Publication Date
EP0640014A1 true EP0640014A1 (fr) 1995-03-01

Family

ID=8095895

Family Applications (1)

Application Number Title Priority Date Filing Date
EP93909823A Withdrawn EP0640014A1 (fr) 1992-05-14 1993-05-13 Procede de separation

Country Status (10)

Country Link
EP (1) EP0640014A1 (fr)
JP (1) JPH07507959A (fr)
CN (1) CN1081929A (fr)
AU (1) AU4061393A (fr)
BR (1) BR9306349A (fr)
DK (1) DK64192D0 (fr)
MX (1) MX9302724A (fr)
SK (1) SK134294A3 (fr)
TW (1) TW304886B (fr)
WO (1) WO1993023164A1 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW555855B (en) * 1996-07-26 2003-10-01 Bristol Myers Squibb Co Synthesis of beta-lactam antibacterials using soluble side chain esters and enzyme acylase
DE10211449A1 (de) * 2002-03-15 2003-09-25 Basf Ag Katalysator-Precursor für die Herstellung von Maleinsäureanhydrid und Verfahren zu dessen Herstellung
WO2017186864A1 (fr) * 2016-04-27 2017-11-02 Sandoz Ag Procédé enzymatique pour la production d'antibiotiques bêta-lactames en présence d'inoculum particulaire

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO9323164A1 *

Also Published As

Publication number Publication date
TW304886B (fr) 1997-05-11
AU4061393A (en) 1993-12-13
BR9306349A (pt) 1998-06-30
DK64192D0 (da) 1992-05-14
CN1081929A (zh) 1994-02-16
MX9302724A (es) 1994-08-31
WO1993023164A1 (fr) 1993-11-25
SK134294A3 (en) 1995-07-11
JPH07507959A (ja) 1995-09-07

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Legal Events

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