EP0599888A1 - Agents contre les incrustations sur des surfaces humides - Google Patents

Agents contre les incrustations sur des surfaces humides

Info

Publication number
EP0599888A1
EP0599888A1 EP92916595A EP92916595A EP0599888A1 EP 0599888 A1 EP0599888 A1 EP 0599888A1 EP 92916595 A EP92916595 A EP 92916595A EP 92916595 A EP92916595 A EP 92916595A EP 0599888 A1 EP0599888 A1 EP 0599888A1
Authority
EP
European Patent Office
Prior art keywords
acid
water
organic
organic acid
hydrogen peroxide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP92916595A
Other languages
German (de)
English (en)
Inventor
Horst Felsch
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
PREGENZER Bruno
Original Assignee
PREGENZER Bruno
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by PREGENZER Bruno filed Critical PREGENZER Bruno
Publication of EP0599888A1 publication Critical patent/EP0599888A1/fr
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
    • C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
    • C02F5/00—Softening water; Preventing scale; Adding scale preventatives or scale removers to water, e.g. adding sequestering agents
    • C02F5/08—Treatment of water with complexing chemicals or other solubilising agents for softening, scale prevention or scale removal, e.g. adding sequestering agents
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/16—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing the group; Thio analogues thereof
    • C—CHEMISTRY; METALLURGY
    • C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
    • C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
    • C02F1/00—Treatment of water, waste water, or sewage
    • C02F1/72—Treatment of water, waste water, or sewage by oxidation
    • C02F1/722—Oxidation by peroxides

Definitions

  • the invention relates to an agent against deposits, in particular against biofilms, on wetted surfaces, which contains at least one water-soluble, weakly dissociating, organic acid.
  • Wet surfaces are primarily understood to mean inner surfaces of pipeline systems or containers in which water or water-containing media are transported and stored. If, for example, hose systems are flowed through by media containing water or water, deposits are formed on the inner surfaces. Since this effect can also be seen in ultrapure water systems, the deposits not only contain deposits of constituents of the flowing medium.
  • Chemical-microbiological analyzes show that this coating is a biofilm which comprises a gel which mainly consists of extracellular, polymeric substances, in particular polysaccharides, and microorganisms which are embedded therein. In technical terms, this biofilm is called "Glycocalyx". The proportion of these extracellular substances ranges between 50% and 90% of the total biofilm. The formation of biofilms is called biofouling in English.
  • biofilms have already been studied very well: in ultrapure water systems, it is very often microorganisms of the pseudo onas species that use the carbon dioxide dissolved in the water as a carbon source and the oxygen dissolved in the water as a respiratory source and synthesize sugar-like molecules from them to be close to a glycose molecule. Linking such sugar molecules ultimately creates water-insoluble gels, which are usually Adhere very well to the surface of hose systems. Once the gel is glued to the wall of the tube, the microorganisms slip into the protective layer and cannot be rinsed away again by the flow of the liquid carried in the tube. The formation of the biofilms thus serves as protection and therefore with a better multiplication of the microorganisms.
  • the ultrapure water systems themselves supply sterile water, which must also be filled into the ampoules in sterile form. If this does not succeed, long microorganisms get into the ampoules and these then have to be sterilized physically. However, the microorganisms killed in the process are able to form fibrinogens which can cause fever-like diseases in humans.
  • Another example is dental units. For the high-speed turbines, the dentist also needs water to rinse out for the patient, which is then warmed up in the dental unit. The water is withdrawn at intervals as required; there is no withdrawal at all during the night. These are ideal conditions for the formation of bio films and other coverings.
  • AT-PS 382 310 describes a method for decalcifying, disinfecting and cleaning mouth showers, toothbrushes, cleaning cups, humidifiers and respiratory and inhalation devices.
  • the means for carrying out the method corresponding to the type mentioned at the outset consist of a mixture of 15 to 80% by weight of lactic, glycolic, wine, lemon, formic, acetic and / or propionic acid with the addition of 10 to 60% by weight of ethanol, isopropanol and / or n- Propanol, 5% by weight of water and, if appropriate, traces of essential oils, which should act on the surfaces for about 8 to 12 hours.
  • a sufficient limescale content of the wetting water is a prerequisite for the effectiveness of this anti-coating agent, since limescale is incorporated into the biofilm, which the acids contained in the medium dissolve. It leaves gaps in the biofilm into which the agent with microbicidal properties can penetrate.
  • the acids can act against the microorganisms.
  • the antimicrobial effect of these acids is only mediocre, but they have the decisive advantage that they are completely biodegradable and can be degraded without residue, ie they are decomposed into carbon dioxide and water. Regular use of the agent keeps the formation of biofilms behind.
  • Another advantage is that these acids can also be used in the food sector or are already present.
  • lemonades and other carbonated soft drinks contain lactic or citric acid.
  • Propionic acid is present in sauerkraut and also protects it from icrobial spoilage. About 5% to 7% of acetic acid is contained in the vinegar.
  • the optimum of the antimicrobial activity of the organic acids mentioned is in the acidic pH range between 3 and 5.
  • microorganisms Their activity against bacteria is usually better than that against fungi.
  • the microorganisms are killed primarily by precipitation of the species' own protein, as a result of which the microorganism is primarily damaged in its external appearance.
  • metabolic functions and enzyme systems in the interior of the attacked microorganisms are also inhibited or destroyed.
  • the acid can penetrate through the semipermeable membrane of the microorganisms. Since this is only possible for very small molecules, only the undissociated acid molecule can penetrate, the proportion of which is very high with the specified organic acids. On the one hand, these dissociate so far in water that the at least optimal pH range between 3 and 5 is reached, but on the other hand so little that the required acid molecules are retained.
  • the biofilm is cooled in such a way that the water contained in the biofilm (up to 95%) is converted into long and sharp ice crystals.
  • the surface of the bio film is broken open, and after thawing, the biofilm can be partially washed away by the flowing medium.
  • the method can only be used to a very limited extent, since temperatures between -8 * and -19 * C and a corresponding outlay on equipment are necessary for this.
  • the invention has now set itself the task of improving the anti-fouling agent mentioned at the outset in such a way that it is also effective against biofilms without lime inclusions and thus eliminates existing ones and prevents their formation.
  • this is achieved with an agent in which the weakly dissociating organic acid is mixed with at least one water-soluble, weakly dissociating organic peracid.
  • Peroxyethanoic acid have antimicrobial effects and can be used as disinfectants. Above all, the antimicrobial effect of peroxyacetic acid is extremely strong even in very low concentrations. Their optimal effect unfolds in the range between pH 2.5 and 4. Thus, at a concentration of 0.2%, influenza, Newcastle and Rotaviruses inactivated. Adenoviruses, vaccine viruses and enteroviruses are inactivated after a few minutes. In addition to viruses, the disinfectant effectiveness of peroxyacetic acid also affects bacteria and fungi. With the bacteria, a concentration of 20 to 50 micrograms per milliliter is sufficient with an exposure time of two minutes. This means that a 0.002 to 0.005% peroxyacetic acid is able to kill practically all germs within two minutes. It is known that the effect of peroxyacetic acid can be further increased by adding about 33% alcohol.
  • the biofilms are thus exposed to a long-term attack by nascent oxygen Oxygen bubbles act mechanically on the attacked coating, so that it ultimately detaches itself from the inner surface of the hose line or the container.
  • Oxygen bubbles act mechanically on the attacked coating, so that it ultimately detaches itself from the inner surface of the hose line or the container.
  • the reasons for the surprising long-term effect have not yet been fully clarified. They should be due to the mixture with the organic weakly dissociating acid and thus ultimately in the pH range of about 3 - 5.
  • Another advantage of the agent according to the invention is that peroxyacetic acid ultimately breaks down into the sub-compounds acetic acid, oxygen and water, that is to say three physiologically completely harmless compounds are formed.
  • the agent according to the invention thus acts simultaneously in several ways: 1.
  • the long-term release of nascent oxygen causes substantial damage to a microorganism-protecting gel.
  • the fine oxygen bubbles which are formed over a long period, act mechanically on already damaged bio films and detach them.
  • the mixture according to the invention in particular of lactic acid and peroxyacetic acid, also prevents this spontaneous reaction, presumably due to the depot effect described above.
  • Peroxyacetic acid molecules that are still active have a destructive effect on the ferment catalase, so that catalysis-related oxygen elimination no longer takes place.
  • the experiment shows that only a brief foaming of a mixture of lactic acid and peracetic acid can be observed when it comes into contact with blood. Thereafter, the evolution of oxygen is completely eliminated since the catalase is destroyed. While maintaining one It is therefore sometimes not necessary to add additional defoamers to the minimum concentration.
  • Peroxycarboxylic acids as high-energy compounds disintegrate very quickly, especially in highly dilute aqueous solution.
  • the reaction equation given above also shows that water is particularly favorable for the cleavage.
  • the agent used according to the invention contains hardly any water, since all acids are highly concentrated, as mentioned 80-90% high-viscosity lactic acid is preferably used.
  • the stabilization can be increased further if the organic peracid is contained in a mixture which contains a second water-soluble organic acid and hydrogen peroxide.
  • the second organic acid is preferably the carboxylic acid corresponding to the peroxycarboxylic acid.
  • Peroxyacetic acid is preferably mixed with almost 100% acetic acid (glacial acetic acid) and hydrogen peroxide. Thus the molecule water is hardly available for the decomposition reaction. Peroxyacetic acid-acetic acid-hydrogen peroxide-lactic acid mixtures are therefore considerably more stable than peroxyacetic acid-water mixtures.
  • the mixture contains peroxyacetic acid, acetic acid and hydrogen peroxide in the weight ratio of the equilibrium reaction.
  • the agent consists of two components which are miscible before use, of which the first component comprises the first organic acid and any additives which may be present, and the second component comprises the organic peracid , the second organic acid, the hydrogen peroxide and optionally the ethylenediaminetetraacetic acid.
  • the user receives a concentrate in which the peroxyacetic acid in
  • Disinfection of water treatment systems can be used because such a physiological mixture can remain in the water. It can also get into the mouth of a dental patient.
  • the water glass contained in the rinsing 30 but not tastes slightly sour, unpleasant. In terms of taste, this is in any case better than with the usual addition of hydrogen peroxide solutions.
  • For fresh water treatment equation also has an effect that a dilution of 1: 100 also has a lime-removing effect.
  • the concentrate can either be used undiluted or diluted up to 1:20.
  • the agent may also get into the patient's mouth. It neither tastes unpleasant nor is it toxicologically harmful.
  • Example 5 For applications in which the coagulation of the blood is important, 1 kg contains: 930.6 g 80% lactic acid 50 g solid citric acid 10 g 40% peroxyacetic acid 3.2 g glacial acetic acid
  • compositions are:
  • an anti-foaming agent can also be incorporated. 1 kg then contain:
  • the ethylenediaminetetraacetic acid is used to bind complex metal traces of black metal, which would otherwise catalyze the decay of the acetic acid.
  • the agent according to the invention provides for the first time a highly effective anti-coating agent, the components of which on the one hand are biodegradable and residue-free, and on the other hand are completely physiological or disintegrate into physiological substances without toxicologically harmful decomposition products after they have taken effect.
  • the synergistic antibacterial effect, the long-lasting release of the oxygen which is split off and the destruction of the catalase permit a very varied use of the agent in which the different acids mixed together form a buffer system which, even at a dilution of 1: 500, always still contains pH values around 3.5.
  • the area of use itself can be determined by producing a concentrate and choosing the dilution option. Higher concentrations serve to remove existing deposits, and lower concentrations are sufficient as a deposit-inhibiting additive to water treatment systems.

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Hydrology & Water Resources (AREA)
  • Environmental & Geological Engineering (AREA)
  • Water Supply & Treatment (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Health & Medical Sciences (AREA)
  • Dentistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

Un agent contre les incrustations, notamment les biofilms, sur des surfaces humides contient un mélange à base d'au moins un acide organique soluble dans l'eau et se dissociant faiblement et d'au moins un peracide organique soluble dans l'eau et se dissociant faiblement.
EP92916595A 1991-08-05 1992-08-03 Agents contre les incrustations sur des surfaces humides Ceased EP0599888A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AT155091 1991-08-05
AT1550/91 1991-08-05
PCT/AT1992/000104 WO1993002973A1 (fr) 1991-08-05 1992-08-03 Agents contre les incrustations sur des surfaces humides

Publications (1)

Publication Number Publication Date
EP0599888A1 true EP0599888A1 (fr) 1994-06-08

Family

ID=3515814

Family Applications (1)

Application Number Title Priority Date Filing Date
EP92916595A Ceased EP0599888A1 (fr) 1991-08-05 1992-08-03 Agents contre les incrustations sur des surfaces humides

Country Status (2)

Country Link
EP (1) EP0599888A1 (fr)
WO (1) WO1993002973A1 (fr)

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JP3197371B2 (ja) * 1992-11-04 2001-08-13 稲畑香料株式会社 芳香を有する過酢酸系殺菌剤組成物及び漂白剤組成物
US5409713A (en) * 1993-03-17 1995-04-25 Ecolab Inc. Process for inhibition of microbial growth in aqueous transport streams
US5393781A (en) * 1993-07-08 1995-02-28 Fmc Corporation Method for controlling zebra mussels
EP0711253B1 (fr) * 1993-07-28 1998-01-21 Heimo Wessollek Utilisation d'un agent reducteur de l'indice de germination et de stabilisation d'eau potable et d'eau pour usages sanitaires
US5543150A (en) * 1993-09-15 1996-08-06 Columbia Laboratories, Inc. Method of progesterone delivery and affect thereof
FR2728171B1 (fr) * 1994-12-14 1997-01-24 Chemoxal Sa Production de formulations desinfectantes biocides, a base d'ions peracetiques
GB2297976A (en) * 1995-02-01 1996-08-21 Reckitt & Colmann Prod Ltd Improvements in or relating to a bleaching process
DE19531241A1 (de) * 1995-08-25 1997-02-27 Degussa Verfahren zur Desinfektion wäßriger Lösungen
NL1003316C2 (nl) * 1996-04-17 1997-10-21 Schaefers Thomas Johannes Samenstelling en werkwijze voor het bereiden van deze samenstelling alsmede een werkwijze voor het ontsmetten van grondstoffen, producten en productiemiddelen.
GB2318349A (en) * 1996-10-15 1998-04-22 Gyre Ltd Biocidal composition for wet environment
WO1999057980A1 (fr) * 1998-05-13 1999-11-18 Oxyster S.N.C. Di Skepetaris & C. Preparation desinfectante stabilisee contenant des peroxydes
DE19925425A1 (de) * 1999-06-02 2000-12-07 Wessollek Heimo Mittel zur Entkeimung bzw. keimreduzierenden Gestaltung von Reinigungs-, Sanitär- und Toilettenartikeln sowie kosmetischen Artikeln, Körperpflegeartikeln und dergleichen verkeimungsgefährdeten Gegenständen
EP1269844B1 (fr) * 2001-06-20 2005-08-31 CASTELLINI S.p.A. Procédé de désinfection et/ou stérilisation d'une unité dentaire
AU2002350397A1 (en) * 2001-11-15 2003-06-10 Heimo Jorg Wessollek Agent for reducing the microbial content in water in order to achieve quality of consumption
KR20110033981A (ko) * 2008-06-24 2011-04-04 프레쉬 익스프레스 인코포레이티드 과산 및 2-히드록시 유기 산 조성물 및 농산물을 처리하는 방법
EP2479148A1 (fr) * 2011-01-25 2012-07-25 Kardag AG Procédé de réduction des coûts de rinçage de systèmes de drainage
DE102014209336A1 (de) * 2014-05-16 2015-11-19 Carela Gmbh Verfahren zur Hygienisierung von mobilen Trinkwasseranlagen und Reagenzienset zur Durchführung des Verfahrens
ES2717798B2 (es) * 2017-12-22 2020-09-22 Univ Jaen Composición desinfectante
US11820737B2 (en) 2020-01-31 2023-11-21 Ecolab Usa Inc. Generation of peroxyhydroxycarboxylic acid and the use thereof
DE102020127330B3 (de) * 2020-10-16 2022-01-05 Knieler & Team Gmbh Tücher oder Mopps getränkt mit einer wässrigen Desinfektionsmittelzusammensetzung enthaltend Peressigsäure
EP4284777A1 (fr) 2021-01-29 2023-12-06 Ecolab USA Inc. Compositions solides de génération d'acide peroxyalphahydroxycarboxylique et leur utilisation

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Also Published As

Publication number Publication date
WO1993002973A1 (fr) 1993-02-18

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