EP0590094A1 - 4-aryl-3-(heteroarylureido)quinoline derivatives - Google Patents

4-aryl-3-(heteroarylureido)quinoline derivatives

Info

Publication number
EP0590094A1
EP0590094A1 EP92923349A EP92923349A EP0590094A1 EP 0590094 A1 EP0590094 A1 EP 0590094A1 EP 92923349 A EP92923349 A EP 92923349A EP 92923349 A EP92923349 A EP 92923349A EP 0590094 A1 EP0590094 A1 EP 0590094A1
Authority
EP
European Patent Office
Prior art keywords
ureido
chlorophenyl
bis
quinoline
methylthio
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP92923349A
Other languages
German (de)
English (en)
French (fr)
Inventor
Ernest S. Hamanaka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Publication of EP0590094A1 publication Critical patent/EP0590094A1/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/36—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
EP92923349A 1991-04-26 1992-03-16 4-aryl-3-(heteroarylureido)quinoline derivatives Withdrawn EP0590094A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US69232391A 1991-04-26 1991-04-26
PCT/US1992/001801 WO1992019614A1 (en) 1991-04-26 1992-03-16 4-aryl-3-(heteroarylureido)quinoline derivatives
US692323 2003-10-23

Publications (1)

Publication Number Publication Date
EP0590094A1 true EP0590094A1 (en) 1994-04-06

Family

ID=24780107

Family Applications (1)

Application Number Title Priority Date Filing Date
EP92923349A Withdrawn EP0590094A1 (en) 1991-04-26 1992-03-16 4-aryl-3-(heteroarylureido)quinoline derivatives

Country Status (20)

Country Link
EP (1) EP0590094A1 (zh)
JP (1) JPH0776215B2 (zh)
CN (1) CN1066068A (zh)
AU (1) AU1879792A (zh)
BR (1) BR9205939A (zh)
CA (1) CA2108014A1 (zh)
CZ (1) CZ395592A3 (zh)
DE (1) DE9290049U1 (zh)
FI (1) FI934710A0 (zh)
HU (1) HUT65748A (zh)
IE (1) IE921330A1 (zh)
IL (1) IL101627A0 (zh)
MX (1) MX9201916A (zh)
NO (1) NO933837L (zh)
NZ (1) NZ242493A (zh)
PT (1) PT100426A (zh)
TW (1) TW197436B (zh)
WO (1) WO1992019614A1 (zh)
YU (1) YU44592A (zh)
ZA (1) ZA922976B (zh)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2125325T3 (es) * 1992-01-23 1999-03-01 Pfizer Derivados de 4-fenil-3-(heteroarilureido)-1,2-dihidro-2-oxoquinolina como agentes antihipercolesterolemicos y antiateroscleroticos.
US5565472A (en) * 1992-12-21 1996-10-15 Pfizer Inc. 4-aryl-3-(heteroarylureido)-1,2-dihydro-2-oxo-quinoline derivatives as antihypercholesterolemic and antiatherosclerotic agents
NZ264063A (en) * 1993-08-13 1995-11-27 Nihon Nohyaku Co Ltd N-(2-phenylpyrid-3-yl)- and n-(4-phenylpyrimidin-5-yl)-n'-phenylurea derivatives and pharmaceutical compositions
US5843957A (en) * 1995-05-19 1998-12-01 Sumitomo Pharmaceuticals Company, Ltd. Naphthyridine derivatives
CN1065243C (zh) * 1995-05-31 2001-05-02 住友制药株式会社 新的二氮杂萘衍生物
CA2272068A1 (en) * 1996-11-26 1998-06-04 Masami Muraoka Novel naphthyridine derivatives
US6452008B2 (en) 1998-02-25 2002-09-17 Sumitomo Pharmaceuticals Company, Limited Pyridone derivatives and process for preparing the same
EP1086948A4 (en) 1998-02-25 2004-03-10 Sumitomo Pharma PYRIDONE DERIVATIVES AND THEIR MANUFACTURING PROCESS
BRPI0417543A (pt) * 2003-12-12 2007-03-27 Wyeth Corp quinolinas úteis no tratamento de doença cardiovascular
CN103601677B (zh) * 2013-11-19 2015-11-18 清华大学 制备2-烷硫基喹啉衍生物的方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE892088L (en) * 1988-07-12 1990-01-12 William Henry Deryk Morris Quinoline derivatives, their production and use
MX22406A (es) * 1989-09-15 1994-01-31 Pfizer Nuevos derivados de n-aril y n-heteroarilamidas y urea como inhibidores de acil coenzima a: acil transferasa del colesterol (acat).
TW205037B (zh) * 1989-10-06 1993-05-01 Takeda Pharm Industry Co Ltd

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO9219614A1 *

Also Published As

Publication number Publication date
DE9290049U1 (de) 1994-01-05
NZ242493A (en) 1994-08-26
CZ395592A3 (en) 1994-02-16
WO1992019614A1 (en) 1992-11-12
HU9303025D0 (en) 1994-01-28
NO933837L (no) 1993-10-25
ZA922976B (en) 1993-10-25
JPH0776215B2 (ja) 1995-08-16
MX9201916A (es) 1992-11-01
CN1066068A (zh) 1992-11-11
PT100426A (pt) 1993-08-31
AU1879792A (en) 1992-12-21
FI934710A (fi) 1993-10-25
IL101627A0 (en) 1992-12-30
YU44592A (sh) 1994-12-28
HUT65748A (en) 1994-07-28
JPH06501025A (ja) 1994-01-27
TW197436B (zh) 1993-01-01
BR9205939A (pt) 1994-09-27
FI934710A0 (fi) 1993-10-25
CA2108014A1 (en) 1992-10-27
IE921330A1 (en) 1992-11-04

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 19931008

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH DE DK ES FR GB GR IT LI LU NL SE

17Q First examination report despatched

Effective date: 19960605

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 19981229