EP0575526A4 - - Google Patents

Info

Publication number
EP0575526A4
EP0575526A4 EP19920908816 EP92908816A EP0575526A4 EP 0575526 A4 EP0575526 A4 EP 0575526A4 EP 19920908816 EP19920908816 EP 19920908816 EP 92908816 A EP92908816 A EP 92908816A EP 0575526 A4 EP0575526 A4 EP 0575526A4
Authority
EP
European Patent Office
Prior art keywords
alkyl
group
aralkyl
phenyl
nr2r3
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP19920908816
Other languages
English (en)
Other versions
EP0575526A1 (en
Inventor
A. Paul Krapcho
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Vermont
Original Assignee
University of Vermont
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Vermont filed Critical University of Vermont
Publication of EP0575526A1 publication Critical patent/EP0575526A1/en
Publication of EP0575526A4 publication Critical patent/EP0575526A4/xx
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/08—Aza-anthracenes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
EP92908816A 1991-03-08 1992-03-09 6,9 BIS(SUBSTITUTED-AMINO)BENZO g]ISOQUINOLINE-5,10-DIONES Pending EP0575526A1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US66595491A 1991-03-08 1991-03-08
US665954 1991-03-08
US82730292A 1992-01-29 1992-01-29
US827302 1992-01-29

Publications (2)

Publication Number Publication Date
EP0575526A1 EP0575526A1 (en) 1993-12-29
EP0575526A4 true EP0575526A4 (zh) 1994-03-30

Family

ID=27099336

Family Applications (2)

Application Number Title Priority Date Filing Date
EP92104004A Expired - Lifetime EP0503537B1 (en) 1991-03-08 1992-03-09 6,9 Bis(substituted-amino)benzo-[g]isoquinoline-5,10-diones
EP92908816A Pending EP0575526A1 (en) 1991-03-08 1992-03-09 6,9 BIS(SUBSTITUTED-AMINO)BENZO g]ISOQUINOLINE-5,10-DIONES

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EP92104004A Expired - Lifetime EP0503537B1 (en) 1991-03-08 1992-03-09 6,9 Bis(substituted-amino)benzo-[g]isoquinoline-5,10-diones

Country Status (22)

Country Link
EP (2) EP0503537B1 (zh)
JP (1) JP3009465B2 (zh)
KR (1) KR100193593B1 (zh)
AT (1) ATE153018T1 (zh)
AU (1) AU663494B2 (zh)
BR (1) BR9205740A (zh)
CA (1) CA2104582A1 (zh)
CZ (1) CZ286180B6 (zh)
DE (1) DE69219646T2 (zh)
DK (1) DK0503537T3 (zh)
ES (1) ES2104753T3 (zh)
FI (1) FI103575B (zh)
GR (1) GR3024436T3 (zh)
HU (1) HU215967B (zh)
IE (1) IE920754A1 (zh)
IL (1) IL102087A (zh)
MX (1) MX9201020A (zh)
NZ (1) NZ241868A (zh)
RU (1) RU2129546C1 (zh)
SG (1) SG66252A1 (zh)
TW (1) TW201735B (zh)
WO (1) WO1992015300A1 (zh)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5519029A (en) * 1992-09-08 1996-05-21 Boehringer Mannheim Italia, S.P.A. 2-aminoalkyl-5-aminoalkylamino substituted-isoquinoindazole-6(2H)-ones
ZA936396B (en) * 1992-09-08 1994-06-13 Univ Vermont 4-Substituted 6,9-bis(substituted-amino)benzo[g] isoquinoline-5,10,diones
US5506232A (en) * 1994-03-28 1996-04-09 Boehringer Mannheim Italia S.P.A. 6,9-bis[(2-aminoethyl)amino]benzo[g]isoquinoline-5,10-dione and its dimaleate salt
US5587382A (en) * 1994-03-28 1996-12-24 Boehringer Mannheim Italia, Spa 6,9-bis[(2-aminoethyl) amino]benzo [g]isoquinoline-5,10- dione dimaleate; an aza-anthracenedione with reduced cardiotoxicity
US6747039B2 (en) 2002-03-12 2004-06-08 Albany Molecular Research, Inc. Aza-benzothiopyranoindazoles with antitumor activity
ITMI20021040A1 (it) 2002-05-16 2003-11-17 Novuspharma Spa Composizioni farmaceutiche iniettabili di un derivato antracenedionico ad attivita' antitumorale
US20050222190A1 (en) * 2004-03-30 2005-10-06 Curd John G 1,4-bis-N-oxide azaanthracenediones and the use thereof
WO2008103320A1 (en) * 2007-02-16 2008-08-28 Novacea, Inc. Methods of treating ophthalmic disorders with anthraquinones
US8173621B2 (en) 2008-06-11 2012-05-08 Gilead Pharmasset Llc Nucleoside cyclicphosphates
BRPI0922508A8 (pt) 2008-12-23 2016-01-19 Pharmasset Inc Análogos de nucleosídeo
CA2748057C (en) 2008-12-23 2018-07-03 Pharmasset, Inc. Nucleoside phosphoramidates
JP5793084B2 (ja) 2008-12-23 2015-10-14 ギリアド ファーマセット エルエルシー プリンヌクレオシドの合成
CN102858790A (zh) 2010-03-31 2013-01-02 吉利德制药有限责任公司 核苷氨基磷酸酯
CN104513201B (zh) * 2013-09-28 2017-12-26 正大天晴药业集团股份有限公司 马来酸匹杉琼的结晶
CN104557704B (zh) * 2013-10-28 2017-05-10 北京凯莱天成医药科技有限公司 一种匹杉琼马来酸盐的制备方法
CN103787970A (zh) * 2014-01-14 2014-05-14 北京万全德众医药生物技术有限公司 一锅煮法制备6，9-二氟苯并异喹啉-5，10-二酮的工艺

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2000029A (en) * 1977-07-22 1979-01-04 Allied Chem Anthraquinones for Cancer Therapy
US4197249A (en) * 1977-08-15 1980-04-08 American Cyanamid Company 1,4-Bis(substituted-amino)-5,8-dihydroxyanthraquinones and leuco bases thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2051005A (en) * 1933-09-19 1936-08-11 Gen Aniline Works Inc Process of producing n-substitution products of 1, 4-diaminoanthraquinones
US2552263A (en) * 1947-09-27 1951-05-08 Eastman Kodak Co alpha-anthrapyridinequinone compounds
EP0270306B1 (en) * 1986-12-01 1991-03-27 Sumitomo Chemical Company, Limited Anthrapyridone compounds, their production process and their use

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2000029A (en) * 1977-07-22 1979-01-04 Allied Chem Anthraquinones for Cancer Therapy
US4197249A (en) * 1977-08-15 1980-04-08 American Cyanamid Company 1,4-Bis(substituted-amino)-5,8-dihydroxyanthraquinones and leuco bases thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
M. CROISY-DELCEY ET AL: "Aminoalkylamino derivatives of dihydroxy-benzo[g]isoquinoline dione and of trihydroxy-naphtho[2,3-g]isoquinoline dione:synthesis and anti-tumor evaluation", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 23, no. 1, January 1988 (1988-01-01), PARIS FR, pages 101 - 106 *

Also Published As

Publication number Publication date
BR9205740A (pt) 1994-09-27
KR100193593B1 (ko) 1999-06-15
NZ241868A (en) 1995-05-26
EP0503537A1 (en) 1992-09-16
CZ184793A3 (en) 1994-06-15
HU215967B (hu) 1999-03-29
RU2129546C1 (ru) 1999-04-27
EP0503537B1 (en) 1997-05-14
IE920754A1 (en) 1992-09-09
MX9201020A (es) 1993-11-01
CA2104582A1 (en) 1992-09-17
IL102087A (en) 1996-09-12
TW201735B (zh) 1993-03-11
DK0503537T3 (da) 1997-12-15
FI103575B1 (fi) 1999-07-30
GR3024436T3 (en) 1997-11-28
FI103575B (fi) 1999-07-30
DE69219646D1 (de) 1997-06-19
WO1992015300A1 (en) 1992-09-17
AU1580392A (en) 1992-10-06
EP0575526A1 (en) 1993-12-29
CZ286180B6 (cs) 2000-02-16
FI933895A (fi) 1993-09-07
DE69219646T2 (de) 1997-10-02
HUT68649A (en) 1995-07-28
AU663494B2 (en) 1995-10-12
ES2104753T3 (es) 1997-10-16
ATE153018T1 (de) 1997-05-15
JP3009465B2 (ja) 2000-02-14
FI933895A0 (fi) 1993-09-07
JPH06511230A (ja) 1994-12-15
SG66252A1 (en) 1999-07-20

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 19930908

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH DE DK ES FR GB GR IT LI LU NL SE

RHK1 Main classification (correction)

Ipc: C07D221/08

A4 Supplementary search report drawn up and despatched

Effective date: 19940210

AK Designated contracting states

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Designated state(s): AT BE CH DE DK ES FR GB GR IT LI LU NL SE

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: PROCEEDINGS CLOSED FOLLOWING CONSOLIDATION WITH EP92104004.4

XX Miscellaneous (additional remarks)

Free format text: VERFAHREN ABGESCHLOSSEN INFOLGE VERBINDUNG MIT 92104004.4/0503537 (EUROPAEISCHE ANMELDENUMMER/VEROEFFENTLICHUNGSNUMMER) DURCH ENTSCHEIDUNG VOM 28.08.95.

RTI1 Title (correction)

Free format text: 6,9 BIS(SUBSTITUTED-AMINO)BENZO G ISOQUINOLINE-5,10-DIONES