EP0477289A1 - Suspension liquide et anhydre a base d'huile servant a liberer un medicament - Google Patents

Suspension liquide et anhydre a base d'huile servant a liberer un medicament

Info

Publication number
EP0477289A1
EP0477289A1 EP90910225A EP90910225A EP0477289A1 EP 0477289 A1 EP0477289 A1 EP 0477289A1 EP 90910225 A EP90910225 A EP 90910225A EP 90910225 A EP90910225 A EP 90910225A EP 0477289 A1 EP0477289 A1 EP 0477289A1
Authority
EP
European Patent Office
Prior art keywords
liquid suspension
delivery system
medicament
oil
aqueous liquid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP90910225A
Other languages
German (de)
English (en)
Other versions
EP0477289A4 (en
Inventor
Akwete L. Adjei
Saul Borodkin
Richard B. Doyle
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Publication of EP0477289A1 publication Critical patent/EP0477289A1/fr
Publication of EP0477289A4 publication Critical patent/EP0477289A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Supports de libération de médicaments sous forme de suspension liquide et non aqueuse à base d'huile, aptes à libérer des médicaments sensibles à l'eau ou ayant un goût désagréable, et comprenant une huile comestible, un sucre et un agent de suspension. La taille moyenne des particules de tous les constituants solides de la formulation est égale ou inférieure à 30 mu, ce qui permet d'obtenir des formulations qui présentent une stabilité physique excellente, c'est-à-dire par exemple une résistance à l'agglomération particulaire, à la sédimentation et à l'agglutination.
EP19900910225 1989-06-13 1990-06-08 Anhydrous oil-based liquid suspension for delivering a medicament Withdrawn EP0477289A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US36540989A 1989-06-13 1989-06-13
US365409 1989-06-13

Publications (2)

Publication Number Publication Date
EP0477289A1 true EP0477289A1 (fr) 1992-04-01
EP0477289A4 EP0477289A4 (en) 1992-07-22

Family

ID=23438802

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19900910225 Withdrawn EP0477289A4 (en) 1989-06-13 1990-06-08 Anhydrous oil-based liquid suspension for delivering a medicament

Country Status (10)

Country Link
EP (1) EP0477289A4 (fr)
JP (1) JPH04506216A (fr)
KR (1) KR920702616A (fr)
AU (1) AU639004B2 (fr)
CA (1) CA2060501A1 (fr)
GR (1) GR1001028B (fr)
IE (1) IE902109A1 (fr)
IL (1) IL94710A (fr)
PT (1) PT94372A (fr)
WO (1) WO1991008734A1 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5736151A (en) * 1996-12-09 1998-04-07 Pharmacia & Upjohn Company Antibiotic oil suspensions
JP2001240534A (ja) * 2000-02-29 2001-09-04 Bio Kagaku Kk 液状組成物
UA80682C2 (en) * 2001-08-06 2007-10-25 Pharmacia Corp Orally deliverable stabilized oral suspension formulation and process for the incresaing physical stability of thixotropic pharmaceutical composition
US20040202696A1 (en) * 2003-04-14 2004-10-14 Cts Chemical Industries Ltd. Administration form for veterinary use
WO2006008640A1 (fr) * 2004-07-15 2006-01-26 Pharmacia & Upjohn Company Llc Suspension non aqueuse contenant un medicament a gout desagreable

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0257288A1 (fr) * 1986-08-19 1988-03-02 Oratech Pharmaceutical Development Corporation Compositions analgésiques liquides stabilisées
EP0302370A1 (fr) * 1987-08-07 1989-02-08 Abbott Laboratories Formulations d'erythromycine pour l'administration orale
EP0310801A1 (fr) * 1987-09-14 1989-04-12 Abbott Laboratories Suspension liquide anhydre à base d'huile pour délivrer un médicament

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2238973A (en) * 1940-07-26 1941-04-22 American Cyanamid Co Sulphonamide compound in oil
US2951014A (en) * 1957-01-03 1960-08-30 Upjohn Co Process for a stable oil suspension
US2867565A (en) * 1957-08-12 1959-01-06 Feinstone Wolffe Harry Sulfonamide composition comprising a lipid-aqueous emulsion carrier
US3996355A (en) * 1975-01-02 1976-12-07 American Home Products Corporation Permanent suspension pharmaceutical dosage form
IE59934B1 (en) * 1987-06-19 1994-05-04 Elan Corp Plc Liquid suspension for oral administration

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0257288A1 (fr) * 1986-08-19 1988-03-02 Oratech Pharmaceutical Development Corporation Compositions analgésiques liquides stabilisées
EP0302370A1 (fr) * 1987-08-07 1989-02-08 Abbott Laboratories Formulations d'erythromycine pour l'administration orale
EP0310801A1 (fr) * 1987-09-14 1989-04-12 Abbott Laboratories Suspension liquide anhydre à base d'huile pour délivrer un médicament

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
P.H. LIST ET AL 'HAGERS HANDBUCH DER PHARMAZEUTISCHEN PRAXIS' September 1970 , SPRINGER VERLAG , BERLIN-HEIDELBERG-NEW YORK *
See also references of WO9108734A1 *

Also Published As

Publication number Publication date
AU639004B2 (en) 1993-07-15
AU5934290A (en) 1991-07-18
GR900100441A (en) 1991-11-15
IL94710A (en) 1995-05-26
PT94372A (pt) 1991-02-08
KR920702616A (ko) 1992-10-06
IL94710A0 (en) 1991-04-15
CA2060501A1 (fr) 1990-12-14
WO1991008734A1 (fr) 1991-06-27
JPH04506216A (ja) 1992-10-29
EP0477289A4 (en) 1992-07-22
IE902109A1 (en) 1991-01-02
IE902109L (en) 1990-12-13
GR1001028B (el) 1993-03-31

Similar Documents

Publication Publication Date Title
CA2019863C (fr) Suspension aqueuse pharmaceutique pour des ingredients actifs pharmaceutiques peu hydrosolubles
US5409907A (en) Aqueous pharmaceutical suspension for pharmaceutical actives
US6214386B1 (en) Prompt-release oral pharmaceutical compositions for extemporaneous suspensions
EP0620001A1 (fr) Suspension pharmaceutique aqueuse et procédé pour sa préparation
KR20000048819A (ko) 맛이 차폐된 마이크로캡슐 조성물 및 이것의 제조 방법
US5730997A (en) Tastemasked liquid pharmaceutical delivery system
CA2800235A1 (fr) Suspension de rifaximine prete a l'emploi
CA2071141A1 (fr) Formule d'acetate de megestrol
WO2000030619A1 (fr) Solution d'ibuprofene auto-emulsifiante et sa capsule de gelatine souple
JP3774975B2 (ja) ゲル状徐放性組成物
Kimura et al. Pharmaceutical evaluation of Ibuprofen fast‐absorbed syrup containing low‐molecular‐weight gelatin
US20020028794A1 (en) Megestrol acetate suspension
JP2000500477A (ja) 即時放出型の薬学的組成物
EP2741750A1 (fr) Composition pharmaceutique comprenant du céfuroxime
AU639004B2 (en) Anhydrous oil-based liquid suspension for delivering a medicament
EP0310801A1 (fr) Suspension liquide anhydre à base d'huile pour délivrer un médicament
JP2005516943A (ja) 経口投与に適した医薬品懸濁液
JP2001509175A (ja) 味覚的に口に合わない製剤用味隠蔽組成物
US20030198679A1 (en) Flocculated pharmaceutical suspensions and methods for actives
JP2024519421A (ja) カルバメート化合物を含む経口用水性懸濁液製剤
JP2001106641A (ja) 口内薬
JP2001072594A (ja) 内服用液剤
HRP990030A2 (en) Oral liquid formulations of benzoxazinones hiv reverse transcriptase inhibitors
MXPA99003082A (en) Taste-masked microcapsule compositions and methods of manufacture
IE893287A1 (en) Novel drug delivery system

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 19911204

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH DE DK ES FR GB IT LI LU NL SE

A4 Supplementary search report drawn up and despatched

Effective date: 19920603

AK Designated contracting states

Kind code of ref document: A4

Designated state(s): AT BE CH DE DK ES FR GB IT LI LU NL SE

17Q First examination report despatched

Effective date: 19950329

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 19970610