EP0456792B1 - SYSTEME TRANSDERMIQUE AMELIORE D'APPLICATION DE COMPOSES PHARMACOLOGIQUEMENT ACTIFS AVEC UN pH CONTROLE - Google Patents

SYSTEME TRANSDERMIQUE AMELIORE D'APPLICATION DE COMPOSES PHARMACOLOGIQUEMENT ACTIFS AVEC UN pH CONTROLE Download PDF

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Publication number
EP0456792B1
EP0456792B1 EP90917612A EP90917612A EP0456792B1 EP 0456792 B1 EP0456792 B1 EP 0456792B1 EP 90917612 A EP90917612 A EP 90917612A EP 90917612 A EP90917612 A EP 90917612A EP 0456792 B1 EP0456792 B1 EP 0456792B1
Authority
EP
European Patent Office
Prior art keywords
skin
active substance
clenbuterol
additive
active ingredient
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
EP90917612A
Other languages
German (de)
English (en)
Other versions
EP0456792A1 (fr
Inventor
Arun Rajaram Gupte
Uwe Rohr
Bernd Zierenberg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
Boehringer Ingelheim International GmbH
Boehringer Ingelheim Pharma GmbH and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim International GmbH, Boehringer Ingelheim Pharma GmbH and Co KG filed Critical Boehringer Ingelheim International GmbH
Publication of EP0456792A1 publication Critical patent/EP0456792A1/fr
Application granted granted Critical
Publication of EP0456792B1 publication Critical patent/EP0456792B1/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/44—Medicaments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M35/00—Devices for applying media, e.g. remedies, on the human body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin

Claims (4)

  1. Utilisation de bases faibles, d'acides faibles, de sels organiques et inorganiques, qui forment un système tampon avec la surface de la peau ou de mélanges tampons comme additif dans un système thérapeutique transdermique (STT) contenant un principe actif, qui contient une couche dorsale imperméable au principe actif, un réservoir contenant le principe actif, des moyens pour la fixation sur la peau et éventuellement une membrane pour la commande de la libération du principe actif, pour régler le pH de la surface de la peau dans un domaine qui correspond au flux maximal [µg/cm2h] du principe actif cité ci-dessus.
  2. Utilisation selon la revendication 1 caractérisée en ce que le principe actif et l'additif sont incorporés dans une matrice polymère, de préférence constituée par un polyacrylate polymérisé en émulsion.
  3. Utilisation selon l'une des revendications 1 et 2 caractérisée en ce que la quantité de l'additif est située entre 2 et 10%-en masse par rapport à la masse de la matrice polymère contenant le principe actif.
  4. Utilisation selon l'une des revendications 1 à 3 caractérisée en ce que le principe actif est le clenbutérol.
EP90917612A 1989-12-01 1990-11-29 SYSTEME TRANSDERMIQUE AMELIORE D'APPLICATION DE COMPOSES PHARMACOLOGIQUEMENT ACTIFS AVEC UN pH CONTROLE Expired - Lifetime EP0456792B1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE3939703A DE3939703C2 (de) 1989-12-01 1989-12-01 Verbesserte transdermale Applikation von pharmakologisch aktiven Verbindungen
DE3939703 1989-12-01
PCT/EP1990/002052 WO1991007998A1 (fr) 1989-12-01 1990-11-29 SYSTEME TRANSDERMIQUE AMELIORE D'APPLICATION DE COMPOSES PHARMACOLOGIQUEMENT ACTIFS AVEC UN pH REGLE

Publications (2)

Publication Number Publication Date
EP0456792A1 EP0456792A1 (fr) 1991-11-21
EP0456792B1 true EP0456792B1 (fr) 1999-10-13

Family

ID=6394557

Family Applications (1)

Application Number Title Priority Date Filing Date
EP90917612A Expired - Lifetime EP0456792B1 (fr) 1989-12-01 1990-11-29 SYSTEME TRANSDERMIQUE AMELIORE D'APPLICATION DE COMPOSES PHARMACOLOGIQUEMENT ACTIFS AVEC UN pH CONTROLE

Country Status (20)

Country Link
EP (1) EP0456792B1 (fr)
JP (1) JPH04506811A (fr)
KR (1) KR0143549B1 (fr)
AT (1) ATE185492T1 (fr)
AU (1) AU637861B2 (fr)
CA (1) CA2046337C (fr)
DE (2) DE3939703C2 (fr)
DK (1) DK0456792T3 (fr)
ES (1) ES2139570T3 (fr)
FI (1) FI107707B (fr)
GR (1) GR3032175T3 (fr)
HU (1) HU206993B (fr)
IE (1) IE904322A1 (fr)
IL (1) IL96506A (fr)
NO (1) NO302156B1 (fr)
NZ (1) NZ236280A (fr)
PT (1) PT96045B (fr)
RU (1) RU1834665C (fr)
WO (1) WO1991007998A1 (fr)
ZA (1) ZA909624B (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6057133A (en) * 1992-11-24 2000-05-02 G. D. Searle Multivariant human IL-3 fusion proteins and their recombinant production
JP3526887B2 (ja) * 1993-04-23 2004-05-17 帝國製薬株式会社 消炎鎮痛外用貼付剤
US6395292B2 (en) 1996-02-02 2002-05-28 Alza Corporation Sustained delivery of an active agent using an implantable system
EP1455849B1 (fr) 2001-12-21 2005-11-23 Coloplast A/S Dispositif de traitement de plaie
KR20190092313A (ko) * 2018-01-30 2019-08-07 닛토덴코 가부시키가이샤 경피 흡수형 제제

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3598122A (en) * 1969-04-01 1971-08-10 Alza Corp Bandage for administering drugs
US4756710A (en) * 1985-04-05 1988-07-12 Merck & Co., Inc. pH-Mediated drug delivery system
US4645502A (en) * 1985-05-03 1987-02-24 Alza Corporation Transdermal delivery of highly ionized fat insoluble drugs
US4690683A (en) * 1985-07-02 1987-09-01 Rutgers, The State University Of New Jersey Transdermal varapamil delivery device
US4830856A (en) * 1987-01-27 1989-05-16 Peppers James M Chelation product
EP0356382B1 (fr) * 1988-08-02 1994-02-16 Ciba-Geigy Ag Pansement à plusieurs couches
WO1990006120A1 (fr) * 1988-12-01 1990-06-14 Schering Corporation Compositions d'administration transdermique d'estradiol
DE3843557A1 (de) * 1988-12-23 1990-06-28 Beiersdorf Ag Transdermales therapeutisches system zur verabreichung von clenbuterol

Also Published As

Publication number Publication date
GR3032175T3 (en) 2000-04-27
EP0456792A1 (fr) 1991-11-21
NO912985D0 (no) 1991-07-31
KR920700704A (ko) 1992-08-10
PT96045B (pt) 1998-01-30
DE3939703C2 (de) 1998-07-02
PT96045A (pt) 1991-09-13
AU637861B2 (en) 1993-06-10
DK0456792T3 (da) 2000-04-03
IL96506A (en) 1996-01-19
FI107707B (fi) 2001-09-28
AU6875791A (en) 1991-06-26
RU1834665C (ru) 1993-08-15
CA2046337C (fr) 2004-05-25
HUT59615A (en) 1992-06-29
WO1991007998A1 (fr) 1991-06-13
KR0143549B1 (ko) 1998-07-01
IE904322A1 (en) 1991-06-05
DE59010885D1 (de) 1999-11-18
ES2139570T3 (es) 2000-02-16
CA2046337A1 (fr) 1991-06-02
NZ236280A (en) 1994-06-27
JPH04506811A (ja) 1992-11-26
HU912638D0 (en) 1992-01-28
ZA909624B (en) 1992-08-26
ATE185492T1 (de) 1999-10-15
HU206993B (en) 1993-03-01
NO912985L (no) 1991-07-31
DE3939703A1 (de) 1991-06-06
NO302156B1 (no) 1998-02-02
FI913645A0 (fi) 1991-07-31
IL96506A0 (en) 1991-08-16

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