EP0233418B1 - Conditionnement étanche sous forme de plaquette alvéolaire permettant des échanges gazeux entre les alvéoles - Google Patents

Conditionnement étanche sous forme de plaquette alvéolaire permettant des échanges gazeux entre les alvéoles Download PDF

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Publication number
EP0233418B1
EP0233418B1 EP86401152A EP86401152A EP0233418B1 EP 0233418 B1 EP0233418 B1 EP 0233418B1 EP 86401152 A EP86401152 A EP 86401152A EP 86401152 A EP86401152 A EP 86401152A EP 0233418 B1 EP0233418 B1 EP 0233418B1
Authority
EP
European Patent Office
Prior art keywords
compartments
tablets
card
packaging according
packaging
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
EP86401152A
Other languages
German (de)
English (en)
French (fr)
Other versions
EP0233418A1 (fr
Inventor
Jacques Dauphin
Alain Cuine
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ADIR SARL
Original Assignee
ADIR SARL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ADIR SARL filed Critical ADIR SARL
Priority to AT86401152T priority Critical patent/ATE39905T1/de
Publication of EP0233418A1 publication Critical patent/EP0233418A1/fr
Application granted granted Critical
Publication of EP0233418B1 publication Critical patent/EP0233418B1/fr
Expired legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
    • B65D81/24—Adaptations for preventing deterioration or decay of contents; Applications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants
    • B65D81/26—Adaptations for preventing deterioration or decay of contents; Applications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants with provision for draining away, or absorbing, or removing by ventilation, fluids, e.g. exuded by contents; Applications of corrosion inhibitors or desiccators
    • B65D81/266—Adaptations for preventing deterioration or decay of contents; Applications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants with provision for draining away, or absorbing, or removing by ventilation, fluids, e.g. exuded by contents; Applications of corrosion inhibitors or desiccators for absorbing gases, e.g. oxygen absorbers or desiccants
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D75/00—Packages comprising articles or materials partially or wholly enclosed in strips, sheets, blanks, tubes, or webs of flexible sheet material, e.g. in folded wrappers
    • B65D75/28—Articles or materials wholly enclosed in composite wrappers, i.e. wrappers formed by associating or interconnecting two or more sheets or blanks
    • B65D75/30—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding
    • B65D75/32—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents
    • B65D75/325—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents one sheet being recessed, and the other being a flat not- rigid sheet, e.g. puncturable or peelable foil
    • B65D75/327—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents one sheet being recessed, and the other being a flat not- rigid sheet, e.g. puncturable or peelable foil and forming several compartments
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D75/00—Packages comprising articles or materials partially or wholly enclosed in strips, sheets, blanks, tubes, or webs of flexible sheet material, e.g. in folded wrappers
    • B65D75/28—Articles or materials wholly enclosed in composite wrappers, i.e. wrappers formed by associating or interconnecting two or more sheets or blanks
    • B65D75/30—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding
    • B65D75/32—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents
    • B65D75/325—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents one sheet being recessed, and the other being a flat not- rigid sheet, e.g. puncturable or peelable foil
    • B65D75/327—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents one sheet being recessed, and the other being a flat not- rigid sheet, e.g. puncturable or peelable foil and forming several compartments
    • B65D75/328—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents one sheet being recessed, and the other being a flat not- rigid sheet, e.g. puncturable or peelable foil and forming several compartments the compartments being interconnected, e.g. by small channels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D2585/00—Containers, packaging elements or packages specially adapted for particular articles or materials
    • B65D2585/56—Containers, packaging elements or packages specially adapted for particular articles or materials for medicinal tablets or pills

Definitions

  • the present invention relates to a sealed package in the form of a blister card allowing gas exchanges between the cells.
  • This packaging which can be used for any product requiring waterproof packaging for its conservation, is particularly suitable for the pharmaceutical industry.
  • the packaging which is the subject of the present invention differs from the already existing packaging for the pharmaceutical forms and offers particularly advantageous advantages over the latter.
  • the packaging which allows gas exchanges are either closed bottles with an absorber or a gas generator, or blister packs overwrapped in a second sealed packaging containing an absorber or a gas generator, or packaging as described in the preamble of claim 1.
  • the bottle does not constitute a security packaging, in the sense that access to all of the content is facilitated.
  • the overwrapped blister pack requires the overlapping of two packaging operations.
  • the new packaging offered is a unique packaging which individualizes each pharmaceutical form while allowing gas exchanges. It combines both the stability of medication storage, guaranteed until then by the use of absorbent bottles, with the safety of use, presented by conventional blisters, and is therefore particularly interesting.
  • Patent GB-A 1 073 786 describes a unique sealed packaging which is in the form of a blister card allowing gas exchanges between the blisters and used for divided solid pharmaceutical forms.
  • the proximity of the pharmaceutical form to be stored and the dehydrating product entails the risk of expulsion of the latter at the same time as the pharmaceutical product when it is desired to release the latter; risk which does not exist with the blister packs of the present invention where the pharmaceutical product to be stored and the dehydrating product are each in very distinct blisters, separated by canaliculi.
  • Patent DE-A 2 224 965 describes a device in the form of a plate constituted in its lower part by a waterproof film in which cells are connected together by canaliculi. Such a device is used for the sterilization of packages external to this device which, at the end of use is intended to be immersed in an aqueous medium; the canaliculi then serving to establish a liquid contact between the different alveoli; which is never the case in the invention of the present application where the wafer as a whole is used to ensure the safety of the storage of the only pharmaceutical products which it contains, without any exchange with a fluid or an external packaging, nor via the canaliculi, nor at the level of the alveoli.
  • the present invention particularly relates to a gas-impermeable packaging in the form of a wafer consisting in its upper part of a waterproof fusible film and in its lower part of a waterproof film in which cells connected together by canaliculi are formed by stamping or thermoforming, or both.
  • the cells of the same wafer can be of different size.
  • One or more cells contain a gas absorber or generator, the other cells contain divided solid pharmaceutical forms (tablets, capsules, lyocs ).
  • the gas exchanges inside the wafer are made by canaliculi connecting the alveoli together. They can be of variable size according to the desired gas exchanges.
  • carrier materials, such as for example polypropylene or co-extrudates based on polyvinyl alcohol resin, can also be used.
  • Blister for packaging tablets based on a product sensitive to humidity Blister for packaging tablets based on a product sensitive to humidity.
  • the face in is formed by a polyethylene-aluminum-polyethylene complex; the upper side with a fusible aluminum film.
  • Such a plate comprises in its upper part a cell (A), receptacle for the absorbent product, to which is connected a double row of cells (C) intended to receive the tablets.
  • the cells (C) are grouped in pairs on either side of a canaliculus connecting them to each other and to the cell (A) containing the absorbent product.
  • Such a pack contains the medication valid for a 10-day treatment at the rate of 2 tablets / day.
  • the packaging method described above ensures the stability of the tablets during long-term storage, at the manufacturer or the wholesaler for example.
  • the title of the tablets in percentage relative to the initial title, after three months at 37 ° C. and 75% relative humidity, is as follows:
  • the blister pack shown schematically in Annex 1/2 therefore provides the packaged tablets with greater stability than that provided by conventional blisters, even overpackaged. It offers the same guarantee of stability of the tablets as the pillbox with absorber, but presents compared to the latter the advantages of a presentation for a sequential treatment particularly appreciated in the treatment of patients at high risk.
  • the title of the tablets in percentage compared to the initial title, after three months at 37 ° C and 75% relative humidity, is as follows:
  • the underside is formed by the polyvinyl chloride + polyethylene + polyvinylidene chloride assembly; the upper side with a fusible aluminum film.
  • Such a wafer comprises five alveolar groups each formed by a central alveolus (A) intended to contain the absorbent product connected, on either side, by a canaliculus to two alveoli receiving the tablets.
  • A central alveolus
  • Such a pack contains the medication valid for a treatment of 5 days at a dose of 2 tablets / day.

Landscapes

  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Chemical & Material Sciences (AREA)
  • Composite Materials (AREA)
  • Food Science & Technology (AREA)
  • Packages (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Laminated Bodies (AREA)
  • Medicinal Preparation (AREA)
  • Processing Of Solid Wastes (AREA)
  • Rigid Containers With Two Or More Constituent Elements (AREA)
  • Heat Sensitive Colour Forming Recording (AREA)
  • Structure Of Emergency Protection For Nuclear Reactors (AREA)
EP86401152A 1986-01-22 1986-05-30 Conditionnement étanche sous forme de plaquette alvéolaire permettant des échanges gazeux entre les alvéoles Expired EP0233418B1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AT86401152T ATE39905T1 (de) 1986-01-22 1986-05-30 Undurchlaessige zellenfoermige schalenverpackung, die den gasaustausch zwischen den zellen zulaesst.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8600837A FR2593152B1 (fr) 1986-01-22 1986-01-22 Conditionnement etanche sous forme de plaquettes alveolaire permettant des echanges gazeux entre les alveoles.
FR8600837 1986-01-22

Publications (2)

Publication Number Publication Date
EP0233418A1 EP0233418A1 (fr) 1987-08-26
EP0233418B1 true EP0233418B1 (fr) 1989-01-11

Family

ID=9331356

Family Applications (1)

Application Number Title Priority Date Filing Date
EP86401152A Expired EP0233418B1 (fr) 1986-01-22 1986-05-30 Conditionnement étanche sous forme de plaquette alvéolaire permettant des échanges gazeux entre les alvéoles

Country Status (15)

Country Link
US (1) US4753352A (ja)
EP (1) EP0233418B1 (ja)
JP (1) JPS62182073A (ja)
AT (1) ATE39905T1 (ja)
AU (1) AU597254B2 (ja)
DE (1) DE3661717D1 (ja)
DK (1) DK163050C (ja)
ES (1) ES2000557A6 (ja)
FR (1) FR2593152B1 (ja)
GR (1) GR861400B (ja)
IE (1) IE57511B1 (ja)
NZ (1) NZ216349A (ja)
OA (1) OA08333A (ja)
PT (1) PT82687B (ja)
ZA (1) ZA864013B (ja)

Families Citing this family (33)

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US5231521A (en) * 1989-10-30 1993-07-27 The University Of Colorado Foundation, Inc. Chiral smectic liquid crystal polarization interference filters
US5243455A (en) * 1990-05-11 1993-09-07 The University Of Colorado Foundation, Inc. Chiral smectic liquid crystal polarization interference filters
FR2660634B1 (fr) * 1990-04-06 1992-10-16 Airsec Ind Sa Conditionnement pour produits necessitant l'usage d'un agent deshydratant.
JPH0471560A (ja) * 1990-07-10 1992-03-06 Mect Corp 包装体
US5293996A (en) * 1992-05-14 1994-03-15 Motorola, Inc. Container having an observation window
GB9401893D0 (en) * 1994-02-01 1994-03-30 Aquasol Ltd New packages
US6499597B2 (en) 1994-02-01 2002-12-31 Aquasol Limited Skin package
CH687615A5 (de) * 1994-09-07 1997-01-15 R W Johnson Pharmaceutical Res Tropen-Verpackung.
US6279736B1 (en) * 1995-04-19 2001-08-28 Capitol Specialty Plastics, Inc. Barrier pack having an absorbing agent applied to the interior of the pack
US6180708B1 (en) 1996-06-28 2001-01-30 W. R. Grace & Co.-Conn. Thermoplastic adsorbent compositions containing wax and insulating glass units containing such compositions
US6112888A (en) * 1996-06-28 2000-09-05 W. R. Grace & Co.-Conn. Non-reclosable packages containing desiccant matrix
JP4037464B2 (ja) * 1997-04-01 2008-01-23 シーマ・ラブス・インコーポレイテッド ブリスタパッケージ及びパッケージタブレット
US6131738A (en) * 1999-01-22 2000-10-17 Valley Design Inc. Breakage prevention device for blister packs
US6905016B2 (en) * 2000-03-14 2005-06-14 Noven Pharmaceuticals, Inc. Packaging system for transdermal drug delivery systems
ATE418979T2 (de) † 2000-06-09 2009-01-15 Lek Pharmaceuticals Stabilisiertes arzneimittel und arzneizubereitung
US6799572B2 (en) 2000-12-22 2004-10-05 Chrysalis Technologies Incorporated Disposable aerosol generator system and methods for administering the aerosol
US7077130B2 (en) * 2000-12-22 2006-07-18 Chrysalis Technologies Incorporated Disposable inhaler system
AU779458B2 (en) 2000-12-28 2005-01-27 Manrex Pty. Limited Improvements in blister sheets
EP1243524A3 (en) * 2001-03-16 2004-04-07 Pfizer Products Inc. Pharmaceutical kit for oxygen-sensitive drugs
WO2002091987A2 (en) * 2001-05-15 2002-11-21 E-Medication Aps A medicine dispenser
SE0401654D0 (sv) * 2004-06-24 2004-06-24 Astrazeneca Ab A support structure for a medicament
CA2659558A1 (en) * 2006-08-03 2008-02-07 Merck Patent Gesellschaft Mit Beschraenkter Haftung Pack containing pharmaceutical administration forms
DK200601302A (da) * 2006-10-06 2008-04-07 O2 Tabs Gmbh Blisteremballage til tabletter
AU2008269201B2 (en) 2007-06-21 2011-08-18 Gen-Probe Incorporated Instrument and receptacles for use in performing processes
EP2098249B1 (en) * 2008-03-05 2012-10-24 Rivopharm SA Nicorandil carriers with enhanced stability
EP2127628A1 (en) * 2008-05-27 2009-12-02 Ranbaxy Laboratories Limited Unit dose pack
EP2376348A4 (en) * 2008-12-10 2012-09-05 Merck Sharp & Dohme PACKAGING FOR OXYGEN-SENSITIVE PHARMACEUTICAL PRODUCTS
AU2009100522A4 (en) * 2009-05-28 2009-08-06 Manrex Pty. Ltd. Blister Package Stiffening
ES2381422T3 (es) * 2009-05-30 2012-05-28 Bayer Innovation Gmbh Producto con materiales de soporte biorreabsorbibles y envase
US20140000223A1 (en) * 2010-11-10 2014-01-02 Boehringer Ingelheim Microparts Gmbh Method for filling a blister packaging with liquid, and blister packaging with a cavity for filling with liquid
JP6040940B2 (ja) * 2010-12-16 2016-12-07 ベーリンガー インゲルハイム マイクロパーツ ゲゼルシャフト ミット ベシュレンクテル ハフツングＢｏｅｈｒｉｎｇｅｒ Ｉｎｇｅｌｈｅｉｍ ｍｉｃｒｏＰａｒｔｓ ＧｍｂＨ キャビティ、特にブリスタ包装材のブリスタに液体を充填する方法及びかかる方法で用いられる半完成品
WO2017184584A1 (en) * 2016-04-19 2017-10-26 Ascent Pharmaceuticals, Inc. Stable packaging system for moisture and oxygen sensitive pharmaceutical dosage forms
WO2020092651A1 (en) 2018-10-30 2020-05-07 Verinetics An integrated device and system for drug dispensing

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DE224965C (ja) *
FR1182739A (fr) * 1957-02-23 1959-06-29 Walli Kommanditgesellschaft H Serviette de toilette conservant l'humidité et procédé de fabrication
BE640751A (ja) * 1963-12-03 1964-04-01
FR1398104A (fr) * 1964-03-26 1965-05-07 Participations Et Procedes Ind éléments déshydratants et leur procédé de fabrication
US3567085A (en) * 1968-12-02 1971-03-02 James G Flores Neck-supported pill container
GB1249050A (en) * 1969-12-09 1971-10-06 Grace W R & Co Improvements relating to desiccant packages
US4040515A (en) * 1971-01-22 1977-08-09 Stewart-Hall Chemical Co. Chemical dispensing apparatus
JPS5239859B2 (ja) * 1972-09-29 1977-10-07
JO984B1 (en) * 1977-10-11 1979-12-01 بيتشام غروب ليمتد A dry pharmaceutical compound with a suitable dosage unit for oral administration
US4211326A (en) * 1978-10-10 1980-07-08 American Can Company Blister package
DE3040959A1 (de) * 1980-10-30 1982-05-27 Siemens AG, 1000 Berlin und 8000 München Verpackung fuer elektrische bauelemente
US4444316A (en) * 1982-09-03 1984-04-24 Olin Corporation Gas scavenger agents for containers of solid chloroisocyanurates
GB8334503D0 (en) * 1983-12-24 1984-02-01 Proprietary Ass Great Britain Strip packaging

Also Published As

Publication number Publication date
US4753352A (en) 1988-06-28
ATE39905T1 (de) 1989-01-15
GR861400B (en) 1986-10-02
PT82687A (pt) 1986-11-28
DE3661717D1 (en) 1989-02-16
IE861433L (en) 1987-07-22
FR2593152B1 (fr) 1988-12-23
NZ216349A (en) 1988-04-29
AU5809686A (en) 1987-07-23
IE57511B1 (en) 1992-10-07
FR2593152A1 (fr) 1987-07-24
DK163050C (da) 1992-06-09
DK252686A (da) 1987-07-23
JPS62182073A (ja) 1987-08-10
OA08333A (fr) 1988-02-29
ES2000557A6 (es) 1988-03-01
PT82687B (pt) 1992-11-30
EP0233418A1 (fr) 1987-08-26
AU597254B2 (en) 1990-05-31
DK252686D0 (da) 1986-05-29
DK163050B (da) 1992-01-13
ZA864013B (en) 1987-01-28

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