EP0000254B1 - 2-(Gamma-(1-piperidinyl)propyl)1,2-benzisothiazole 3-one antithrombotique, ses sels d'acides pharmaceutiquement acceptables, leur préparation et leurs compositions - Google Patents

2-(Gamma-(1-piperidinyl)propyl)1,2-benzisothiazole 3-one antithrombotique, ses sels d'acides pharmaceutiquement acceptables, leur préparation et leurs compositions Download PDF

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Publication number
EP0000254B1
EP0000254B1 EP78300050A EP78300050A EP0000254B1 EP 0000254 B1 EP0000254 B1 EP 0000254B1 EP 78300050 A EP78300050 A EP 78300050A EP 78300050 A EP78300050 A EP 78300050A EP 0000254 B1 EP0000254 B1 EP 0000254B1
Authority
EP
European Patent Office
Prior art keywords
compound
formula
acid addition
pharmaceutically acceptable
propyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
EP78300050A
Other languages
German (de)
English (en)
Other versions
EP0000254A1 (fr
Inventor
Barbara Nunn
Keith Howard Baggaley
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Publication of EP0000254A1 publication Critical patent/EP0000254A1/fr
Application granted granted Critical
Publication of EP0000254B1 publication Critical patent/EP0000254B1/fr
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)

Claims (4)

1. Le composé 2 - [gamma - (1 - - pipéridinylpropyl] - 1,2 - benzisothiazol - 3 - one ou un sel d'addition avec un acide pharmaceutiquement acceptable de ce composé.
2. Composé suivant la revendication 1, sous la forme de son chlorhydrate.
3. Procédé de préparation d'un composé suivant la revendication 1, caractérisé en ce que:
(a) on fait réagir un composé de formule (III) telle que spécifiée avec un composé de formule (IV) telle que spécifiée;
(b) on fait réagir un composé de formule (V) telle que spécifiée ou un sel de ce composé avec un composé de formule (VI) telle que spécifiée;
(c) on traite un composé de formule (VII) telle que spécifiée soit avec une base, soit avec du chlore ou du brome; ou
(d) on traite un composé de formule (VIII) telle que spécifiée avec une base et, après le stade (a), (b), (c) ou (d), on transforme faculativement en un sel d'addition avec un acide.
4. Composition pharmaceutique caractérisée en ce qu'elle contient un composé suivant la revendication 1, conjointement à au moins un excipient pharmaceutiquement acceptable.
EP78300050A 1977-06-20 1978-06-15 2-(Gamma-(1-piperidinyl)propyl)1,2-benzisothiazole 3-one antithrombotique, ses sels d'acides pharmaceutiquement acceptables, leur préparation et leurs compositions Expired EP0000254B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB2559977 1977-06-20
GB2559977 1977-06-20

Publications (2)

Publication Number Publication Date
EP0000254A1 EP0000254A1 (fr) 1979-01-10
EP0000254B1 true EP0000254B1 (fr) 1981-06-10

Family

ID=10230306

Family Applications (1)

Application Number Title Priority Date Filing Date
EP78300050A Expired EP0000254B1 (fr) 1977-06-20 1978-06-15 2-(Gamma-(1-piperidinyl)propyl)1,2-benzisothiazole 3-one antithrombotique, ses sels d'acides pharmaceutiquement acceptables, leur préparation et leurs compositions

Country Status (16)

Country Link
US (1) US4186203A (fr)
EP (1) EP0000254B1 (fr)
JP (1) JPS549283A (fr)
AR (1) AR216675A1 (fr)
AU (1) AU516003B2 (fr)
CA (1) CA1098447A (fr)
DE (1) DE2860750D1 (fr)
DK (1) DK275478A (fr)
ES (3) ES470977A1 (fr)
FI (1) FI781956A (fr)
IE (1) IE46937B1 (fr)
IL (1) IL54956A0 (fr)
IT (1) IT7849941A0 (fr)
NO (1) NO782129L (fr)
NZ (1) NZ187628A (fr)
ZA (1) ZA783508B (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58177915A (ja) * 1982-04-12 1983-10-18 Green Cross Corp:The 抗血栓剤
FR2583046B1 (fr) * 1985-06-05 1987-07-17 Cird Alkyl ou aralkyl thio-2 cycloalkene-1 carboxamides-1 et leurs sulfoxydes, leurs procedes de preparation et leur application a la synthese de tri et tetramethylene-4,5 isothiazoline-4, ones-3
DE3617976A1 (de) * 1986-05-28 1988-01-14 Alter Sa 1,4-dihydropyridin, verfahren zu dessen herstellung und dessen verwendung in antithrombotischen medikamenten
CA1335289C (fr) * 1987-10-26 1995-04-18 Fujio Antoku Derives piperidinylbenzisoxazole, leur production et leur utilisation pharmaceutique
JP2581739Y2 (ja) * 1990-12-29 1998-09-24 箱竹 株式会社 多目的ラック

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH395094A (de) * 1960-03-24 1965-07-15 Wander Ag Dr A Verfahren zur Herstellung von 6-Chlor-benzisothiazolon
DE1147947B (de) * 1961-07-25 1963-05-02 Knoll Ag Verfahren zur Herstellung neuer 1, 2-Benzisothiazolone
US3661974A (en) * 1970-04-27 1972-05-09 Sherwin Williams Co 2-carbalkoxy-phenyl sulfenamides
NZ182325A (en) * 1975-11-18 1979-03-16 Beecham Group Ltd 2-substituted-1,2-benzisothiazol-3-ones
DE2602643C2 (de) * 1976-01-24 1984-12-20 Bayer Ag, 5090 Leverkusen 1,2-Benzisothiazolinone-3, Verfahren zu ihrer Herstellung sowie Arzneimittel
ZA776857B (en) * 1976-12-04 1978-09-27 Beecham Group Ltd Heterocyclic compounds

Also Published As

Publication number Publication date
IE46937B1 (en) 1983-11-02
NO782129L (no) 1978-12-21
AU516003B2 (en) 1981-05-14
IT7849941A0 (it) 1978-06-20
ES470977A1 (es) 1979-10-01
IE781226L (en) 1978-12-20
AU3729478A (en) 1980-01-03
JPS549283A (en) 1979-01-24
CA1098447A (fr) 1981-03-31
FI781956A (fi) 1978-12-21
EP0000254A1 (fr) 1979-01-10
ES478685A1 (es) 1979-07-01
ZA783508B (en) 1979-06-27
IL54956A0 (en) 1978-08-31
DE2860750D1 (en) 1981-09-17
DK275478A (da) 1978-12-21
ES478686A1 (es) 1979-07-01
NZ187628A (en) 1981-01-23
AR216675A1 (es) 1980-01-15
US4186203A (en) 1980-01-29

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