EG24669A - Antivral azaindole derivatives - Google Patents

Antivral azaindole derivatives

Info

Publication number
EG24669A
EG24669A EG20010152A EG20010152A EG24669A EG 24669 A EG24669 A EG 24669A EG 20010152 A EG20010152 A EG 20010152A EG 20010152 A EG20010152 A EG 20010152A EG 24669 A EG24669 A EG 24669A
Authority
EG
Egypt
Prior art keywords
antivral
azaindole derivatives
azaindole
derivatives
antivral azaindole
Prior art date
Application number
EG20010152A
Other languages
English (en)
Inventor
Tao Wang
Owen B Wallace
Zhongxing Zhang
Nicholas A Meanwell
John A Bender
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22675206&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EG24669(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Application granted granted Critical
Publication of EG24669A publication Critical patent/EG24669A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EG20010152A 2000-02-22 2001-02-19 Antivral azaindole derivatives EG24669A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US18400400P 2000-02-22 2000-02-22

Publications (1)

Publication Number Publication Date
EG24669A true EG24669A (en) 2010-04-11

Family

ID=22675206

Family Applications (1)

Application Number Title Priority Date Filing Date
EG20010152A EG24669A (en) 2000-02-22 2001-02-19 Antivral azaindole derivatives

Country Status (31)

Country Link
US (1) US20020061892A1 (cg-RX-API-DMAC10.html)
EP (1) EP1257276B1 (cg-RX-API-DMAC10.html)
JP (1) JP3868814B2 (cg-RX-API-DMAC10.html)
KR (1) KR100496574B1 (cg-RX-API-DMAC10.html)
CN (1) CN1404392A (cg-RX-API-DMAC10.html)
AR (1) AR029469A1 (cg-RX-API-DMAC10.html)
AT (1) ATE314072T1 (cg-RX-API-DMAC10.html)
AU (2) AU2001232895B2 (cg-RX-API-DMAC10.html)
BR (1) BRPI0108485B1 (cg-RX-API-DMAC10.html)
CA (1) CA2400700C (cg-RX-API-DMAC10.html)
CO (1) CO5271657A1 (cg-RX-API-DMAC10.html)
CY (1) CY1107460T1 (cg-RX-API-DMAC10.html)
DE (1) DE60116260T2 (cg-RX-API-DMAC10.html)
DK (1) DK1257276T3 (cg-RX-API-DMAC10.html)
EG (1) EG24669A (cg-RX-API-DMAC10.html)
ES (1) ES2254367T3 (cg-RX-API-DMAC10.html)
HU (1) HU229992B1 (cg-RX-API-DMAC10.html)
IL (1) IL150734A0 (cg-RX-API-DMAC10.html)
MX (1) MXPA02008113A (cg-RX-API-DMAC10.html)
MY (1) MY128458A (cg-RX-API-DMAC10.html)
NO (1) NO323564B1 (cg-RX-API-DMAC10.html)
NZ (1) NZ520317A (cg-RX-API-DMAC10.html)
PE (1) PE20020786A1 (cg-RX-API-DMAC10.html)
PL (1) PL357434A1 (cg-RX-API-DMAC10.html)
PT (1) PT1257276E (cg-RX-API-DMAC10.html)
RU (1) RU2259372C2 (cg-RX-API-DMAC10.html)
TR (1) TR200201961T2 (cg-RX-API-DMAC10.html)
TW (1) TWI293629B (cg-RX-API-DMAC10.html)
UY (1) UY26593A1 (cg-RX-API-DMAC10.html)
WO (1) WO2001062255A1 (cg-RX-API-DMAC10.html)
ZA (1) ZA200206073B (cg-RX-API-DMAC10.html)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040110785A1 (en) * 2001-02-02 2004-06-10 Tao Wang Composition and antiviral activity of substituted azaindoleoxoacetic piperazine derivatives
US20030207910A1 (en) * 2001-02-02 2003-11-06 Tao Wang Composition and antiviral activity of substituted azaindoleoxoacetic piperazine derivatives
PL364279A1 (en) * 2001-02-02 2004-12-13 Bristol-Myers Squibb Company Composition and antiviral activity of substituted azaindoleoxoacetic piperazine derivatives
US6825201B2 (en) * 2001-04-25 2004-11-30 Bristol-Myers Squibb Company Indole, azaindole and related heterocyclic amidopiperazine derivatives
US20030236277A1 (en) 2002-02-14 2003-12-25 Kadow John F. Indole, azaindole and related heterocyclic pyrrolidine derivatives
US20040162298A1 (en) * 2002-02-23 2004-08-19 Hsu-Tso Ho Method of treating HIV infection by preventing interaction of CD4 and gp120
US20040063744A1 (en) * 2002-05-28 2004-04-01 Tao Wang Indole, azaindole and related heterocyclic 4-alkenyl piperidine amides
US20050075364A1 (en) * 2003-07-01 2005-04-07 Kap-Sun Yeung Indole, azaindole and related heterocyclic N-substituted piperazine derivatives
JP5138938B2 (ja) 2003-12-19 2013-02-06 プレキシコン インコーポレーテッド Ｒｅｔ調節剤の開発のための化合物および方法
US7745625B2 (en) 2004-03-15 2010-06-29 Bristol-Myers Squibb Company Prodrugs of piperazine and substituted piperidine antiviral agents
CN1953985B (zh) * 2004-03-15 2010-06-09 布里斯托尔-迈尔斯斯奎布公司 哌嗪和取代的哌啶抗病毒药物的前药
US20050252408A1 (en) * 2004-05-17 2005-11-17 Richardson H W Particulate wood preservative and method for producing same
DK1753764T3 (da) 2004-06-09 2009-02-16 Glaxo Group Ltd Pyrrolopyridin-derivater
US7498342B2 (en) 2004-06-17 2009-03-03 Plexxikon, Inc. Compounds modulating c-kit activity
US20060100209A1 (en) * 2004-11-09 2006-05-11 Chong-Hui Gu Formulations of 1-(4-benzoyl-piperazin-1-yl)-2-[4-methoxy-7-(3-methyl-[1,2,4]triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-ethane-1,2-dione
US20060100432A1 (en) * 2004-11-09 2006-05-11 Matiskella John D Crystalline materials of 1-(4-benzoyl-piperazin-1-yl)-2-[4-methoxy-7-(3-methyl-[1,2,4]triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-ethane-1,2-dione
US7183284B2 (en) * 2004-12-29 2007-02-27 Bristol-Myers Squibb Company Aminium salts of 1,2,3-triazoles as prodrugs of drugs including antiviral agents
US7601715B2 (en) 2005-06-22 2009-10-13 Bristol-Myers Squibb Company Process for preparing triazole substituted azaindoleoxoacetic piperazine derivatives and novel salt forms produced therein
EP1910573B1 (en) 2005-07-22 2013-09-04 CytoDyn, Inc. Methods for reducing viral load in hiv-1-infected patients
US7598380B2 (en) * 2005-08-03 2009-10-06 Bristol-Myers Squibb Company Method of preparation of azaindole derivatives
US7396830B2 (en) * 2005-10-04 2008-07-08 Bristol-Myers Squibb Company Piperazine amidines as antiviral agents
US7622466B2 (en) * 2005-11-18 2009-11-24 Hoffman-La Roche Inc. Azaindole-2-carboxamide derivatives
US7851476B2 (en) * 2005-12-14 2010-12-14 Bristol-Myers Squibb Company Crystalline forms of 1-benzoyl-4-[2-[4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-YL)-1-[(phosphonooxy)methyl]-1H-pyrrolo[2,3-C]pyridin-3-YL]-1,2-dioxoethyl]-piperazine
US7807671B2 (en) * 2006-04-25 2010-10-05 Bristol-Myers Squibb Company Diketo-piperazine and piperidine derivatives as antiviral agents
WO2008063888A2 (en) 2006-11-22 2008-05-29 Plexxikon, Inc. Compounds modulating c-fms and/or c-kit activity and uses therefor
MX2009013431A (es) * 2007-06-18 2010-01-15 Sanofi Aventis Derivados de pirrol como antagonistas de p2y12.
JP2010533729A (ja) 2007-07-17 2010-10-28 プレキシコン，インコーポレーテッド キナーゼ調節のための化合物と方法、及びそのための適応
WO2009011912A1 (en) * 2007-07-18 2009-01-22 Bristol-Myers Squibb Company A composition for treating hiv comprising virus-like particles
CA2712701A1 (en) 2008-01-31 2009-08-06 Henning Steinhagen Cyclic azaindole-3-carboxamides, their preparation and their use as pharmaceuticals
CN102143739B (zh) * 2008-09-04 2014-12-17 百时美施贵宝公司 用于最优化传递hiv附着抑制剂的稳定的药用组合物
CA2738573C (en) 2009-04-03 2013-02-19 F. Hoffmann-La Roche Ag Compositions of propane-1 sulfonic acid {3-[5-(4-chloro-phenyl)-1h-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluoro-phenyl}-amide and uses thereof
JP2013510166A (ja) 2009-11-06 2013-03-21 プレキシコン インコーポレーテッド キナーゼ調節のための化合物、方法およびその適用
US8912195B2 (en) 2010-12-02 2014-12-16 Bristol-Myers Squibb Company Alkyl amides as HIV attachment inhibitors
PE20141360A1 (es) 2011-02-07 2014-10-13 Plexxikon Inc Compuestos y metodos para la modulacion de quinasas e indicaciones para los mismos.
TWI558702B (zh) 2011-02-21 2016-11-21 普雷辛肯公司 醫藥活性物質的固態形式
WO2012142080A1 (en) 2011-04-12 2012-10-18 Bristol-Myers Squibb Company Thioamide, amidoxime and amidrazone derivatives as hiv attachment inhibitors
EP2751119B1 (en) 2011-08-29 2016-11-23 VIIV Healthcare UK (No.5) Limited Fused bicyclic diamine derivatives as hiv attachment inhibitors
WO2013033059A1 (en) 2011-08-29 2013-03-07 Bristol-Myers Squibb Company Spiro bicyclic diamine derivatives as hiv attachment inhibitors
US9193725B2 (en) 2012-03-14 2015-11-24 Bristol-Meyers Squibb Company Cyclic hydrazine derivatives as HIV attachment inhibitors
US9150570B2 (en) 2012-05-31 2015-10-06 Plexxikon Inc. Synthesis of heterocyclic compounds
CN102746295B (zh) * 2012-06-20 2014-10-15 上海阿达玛斯试剂有限公司 4位取代-7-氮杂吲哚的制备方法
WO2014025854A1 (en) 2012-08-09 2014-02-13 Bristol-Myers Squibb Company Piperidine amide derivatives as hiv attachment inhibitors
ES2616432T3 (es) 2012-08-09 2017-06-13 VIIV Healthcare UK (No.5) Limited Derivados de alquenos tricíclicos como inhibidores de la unión del VIH
CN109528749B (zh) * 2017-09-22 2023-04-28 上海交通大学医学院附属瑞金医院 长链非编码rna-h19在制备治疗垂体瘤药物中的用途
CA3196620A1 (en) 2020-10-05 2022-04-14 Enliven Therapeutics, Inc. 5- and 6-azaindole compounds for inhibition of bcr-abl tyrosine kinases
CN118515629A (zh) * 2020-11-24 2024-08-20 中国人民解放军海军军医大学 一类取代苯甲酰哌嗪类化合物及其应用
CN115855899B (zh) * 2022-11-24 2025-06-10 常熟理工学院 一种荧光探针检测二氧化硫衍生物的应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX9203454A (es) * 1989-12-28 1992-08-01 Upjohn Co Compuestos anti sida diaromaticos substituidos.
US5424329A (en) * 1993-08-18 1995-06-13 Warner-Lambert Company Indole-2-carboxamides as inhibitors of cell adhesion

Also Published As

Publication number Publication date
PE20020786A1 (es) 2002-09-06
DE60116260T2 (de) 2006-08-31
CA2400700A1 (en) 2001-08-30
HUP0301508A2 (hu) 2003-09-29
RU2002125494A (ru) 2004-03-20
HK1052132A1 (en) 2003-09-05
KR100496574B1 (ko) 2005-06-22
AU3289501A (en) 2001-09-03
TWI293629B (cg-RX-API-DMAC10.html) 2008-02-21
EP1257276B1 (en) 2005-12-28
UY26593A1 (es) 2001-09-28
MY128458A (en) 2007-02-28
PT1257276E (pt) 2006-05-31
NO323564B1 (no) 2007-06-11
CO5271657A1 (es) 2003-04-30
US20020061892A1 (en) 2002-05-23
PL357434A1 (en) 2004-07-26
JP3868814B2 (ja) 2007-01-17
HU229992B1 (hu) 2015-04-28
DK1257276T3 (da) 2006-04-10
HUP0301508A3 (en) 2004-08-30
IL150734A0 (en) 2003-02-12
NO20023981D0 (no) 2002-08-21
AU2001232895B2 (en) 2005-03-17
RU2259372C2 (ru) 2005-08-27
NO20023981L (no) 2002-10-17
NZ520317A (en) 2004-05-28
TR200201961T2 (tr) 2002-12-23
WO2001062255A1 (en) 2001-08-30
AR029469A1 (es) 2003-07-02
MXPA02008113A (es) 2003-01-28
KR20020073598A (ko) 2002-09-27
DE60116260D1 (de) 2006-02-02
CA2400700C (en) 2010-10-26
EP1257276A4 (en) 2004-10-27
ES2254367T3 (es) 2006-06-16
BRPI0108485B1 (pt) 2016-08-23
ZA200206073B (en) 2003-10-30
ATE314072T1 (de) 2006-01-15
CN1404392A (zh) 2003-03-19
CY1107460T1 (el) 2012-12-19
EP1257276A1 (en) 2002-11-20
BR0108485A (pt) 2003-04-22
JP2003523392A (ja) 2003-08-05

Similar Documents

Publication Publication Date Title
AU2001295992A1 (en) Imidazopyridine derivatives
HU229992B1 (hu) Antivirális hatású aza-indol-származékok
HUP0301330A3 (en) 2-aminocarbonyl-9h-purine derivatives
HRP20030055A2 (en) 4-phenyl-pyridine derivatives
IL150841A0 (en) 1h-imidazopyridine derivatives
AU3954702A (en) Substituted imidazopyridines
IL151919A0 (en) Imidazopyridine derivatives and triazolpyrimidine derivatives
IL155974A0 (en) Novel pyridine-substituted pyrazolopyridine derivatives
AU2002216028A1 (en) Novel carbamate-substituted pyrazolopyridine derivatives
AU2002221827A1 (en) Novel lactame-substituted pyrazolopyridine derivatives
AU6030101A (en) Novel phenyl-propargylether derivatives
IL152581A0 (en) Phenylglycine derivatives
PL354600A1 (en) Naphthyridine derivatives
AU1397802A (en) Substituted c-cyclohexylmethylamine derivatives
PL356565A1 (en) Aminosulfonylbiphenyl derivatives
IL150557A0 (en) Substituted aminomethyl-phenyl-cyclohexane derivatives
AU8993701A (en) Substituted 1-aminobutan-3-ol derivatives
EP1316548A4 (en) ACYLSULFONAMIDE DERIVATIVES
IL150558A0 (en) Aminomethyl-phenyl-cyclohexanone derivatives
IL155104A0 (en) 5-amino-1-pentene-3-ol substituted derivatives
IL151598A0 (en) 2-phenylpyran-4-one derivatives
GB0021639D0 (en) Maurotoxin derivatives
SI1246793T1 (en) Substituted aminomethyl-phenyl-cyclohexane derivatives
SI1322590T1 (sl) Substituirani 5-amino-1-penten-3-olni derivati