EG21235A - Process for the preparation of a b-lactam antibiotic - Google Patents

Process for the preparation of a b-lactam antibiotic

Info

Publication number
EG21235A
EG21235A EG125898A EG125898A EG21235A EG 21235 A EG21235 A EG 21235A EG 125898 A EG125898 A EG 125898A EG 125898 A EG125898 A EG 125898A EG 21235 A EG21235 A EG 21235A
Authority
EG
Egypt
Prior art keywords
acylation
beta
reaction
lactam nucleus
preparation
Prior art date
Application number
EG125898A
Other languages
English (en)
Inventor
Van Dooren
Original Assignee
Dsm Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dsm Nv filed Critical Dsm Nv
Application granted granted Critical
Publication of EG21235A publication Critical patent/EG21235A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
    • C12P35/04—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin by acylation of the substituent in the 7 position
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P37/00—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin
    • C12P37/04—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin by acylation of the substituent in the 6 position
EG125898A 1997-10-17 1998-10-17 Process for the preparation of a b-lactam antibiotic EG21235A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NL1007302A NL1007302C2 (nl) 1997-10-17 1997-10-17 Werkwijze voor de bereiding van een ß-lactam antibioticum.

Publications (1)

Publication Number Publication Date
EG21235A true EG21235A (en) 2001-03-31

Family

ID=19765855

Family Applications (1)

Application Number Title Priority Date Filing Date
EG125898A EG21235A (en) 1997-10-17 1998-10-17 Process for the preparation of a b-lactam antibiotic

Country Status (13)

Country Link
US (1) US6287799B1 (de)
EP (1) EP1023454B1 (de)
KR (1) KR100516271B1 (de)
CN (1) CN1165626C (de)
AT (1) ATE234934T1 (de)
AU (1) AU9560198A (de)
BR (1) BR9813079A (de)
EG (1) EG21235A (de)
ES (1) ES2195400T3 (de)
IN (1) IN188152B (de)
NL (1) NL1007302C2 (de)
TR (1) TR200000991T2 (de)
WO (1) WO1999020786A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL1006266C2 (nl) 1997-06-10 1998-12-14 Chemferm Vof Werkwijze voor de bereiding van ampicilline.
EP1394262A1 (de) * 2002-08-30 2004-03-03 Bioferma Murcia, S.A. Enzymatischer Prozess zur Herstellung von beta-Lactamverbindungen
KR101203287B1 (ko) * 2004-12-27 2012-11-20 디에스엠 시노켐 파마슈티칼스 네덜란드 비.브이. 세파클로르의 합성 방법
ES2609633T3 (es) * 2006-05-19 2017-04-21 Dsm Sinochem Pharmaceuticals Netherlands B.V. Proceso para la cristalización de cefadroxilo monohidrato
CN101525603B (zh) * 2008-03-04 2013-12-25 中国医药集团总公司四川抗菌素工业研究所 固定化α-氨基酸酯水解酶及其制备与应用
WO2012175585A1 (en) 2011-06-23 2012-12-27 Dsm Sinochem Pharmaceuticals Netherlands B.V. Process for preparing 3'-thiosubstituted cephalosporins employing a penicillin g acylase
CN103635586A (zh) 2011-06-23 2014-03-12 中化帝斯曼制药有限公司荷兰公司 结晶头孢氧哌唑中间体、其制备方法及其制药用途
CN103467493B (zh) * 2013-10-16 2016-01-20 华北制药集团先泰药业有限公司 无水氨苄西林的制备方法
CN103757085B (zh) * 2013-11-28 2016-06-15 湖南福来格生物技术有限公司 头孢克洛及其合成方法
CN103937692B (zh) * 2014-04-30 2016-03-23 江南大学 一株丝枝霉菌株及其生产β-葡萄糖苷酶的方法
US20170101660A1 (en) 2015-10-07 2017-04-13 Gwangju Institute Of Science And Technology Enzyme-immobilized porous membrane and preparation method of antibiotics using the same

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0537255B1 (de) * 1990-07-04 2006-02-15 DSM IP Assets B.V. Verfahren zur herstellung von beta-lactamen
WO1996002663A1 (en) * 1994-07-18 1996-02-01 Gist-Brocades B.V. PROCESS FOR PREPARATION OF β-LACTAMS AT CONSTANTLY HIGH CONCENTRATION OF REACTANTS
BE1009071A3 (nl) * 1995-02-02 1996-11-05 Dsm Nv Werkwijze voor de bereiding van een beta-lactam antibioticum.
US5770272A (en) * 1995-04-28 1998-06-23 Massachusetts Institute Of Technology Matrix-bearing targets for maldi mass spectrometry and methods of production thereof
DE69626842D1 (de) * 1995-12-08 2003-04-24 Dsm Nv Verfahren zur herstellung eines anitibiotkums

Also Published As

Publication number Publication date
KR20010024519A (ko) 2001-03-26
EP1023454B1 (de) 2003-03-19
TR200000991T2 (tr) 2000-07-21
CN1282377A (zh) 2001-01-31
US6287799B1 (en) 2001-09-11
IN188152B (de) 2002-08-24
KR100516271B1 (ko) 2005-09-20
ES2195400T3 (es) 2003-12-01
CN1165626C (zh) 2004-09-08
WO1999020786A1 (en) 1999-04-29
BR9813079A (pt) 2000-08-15
AU9560198A (en) 1999-05-10
EP1023454A1 (de) 2000-08-02
ATE234934T1 (de) 2003-04-15
NL1007302C2 (nl) 1999-04-20

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