EG17879A - Non-toxinogenic vibrio cholerae nutants - Google Patents

Non-toxinogenic vibrio cholerae nutants

Info

Publication number
EG17879A
EG17879A EG266/84A EG26684A EG17879A EG 17879 A EG17879 A EG 17879A EG 266/84 A EG266/84 A EG 266/84A EG 26684 A EG26684 A EG 26684A EG 17879 A EG17879 A EG 17879A
Authority
EG
Egypt
Prior art keywords
vibrio cholerae
nutants
toxinogenic
peptide
modified strains
Prior art date
Application number
EG266/84A
Other languages
English (en)
Original Assignee
Harvard College
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Harvard College filed Critical Harvard College
Application granted granted Critical
Publication of EG17879A publication Critical patent/EG17879A/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/107—Vibrio
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/28—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Vibrionaceae (F)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/01—Preparation of mutants without inserting foreign genetic material therein; Screening processes therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/522—Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/909—Vibrio

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Plant Pathology (AREA)
  • Mycology (AREA)
  • Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
EG266/84A 1983-04-29 1984-04-28 Non-toxinogenic vibrio cholerae nutants EG17879A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/489,958 US4882278A (en) 1983-04-29 1983-04-29 Non-toxinogenic vibrio cholerae mutants

Publications (1)

Publication Number Publication Date
EG17879A true EG17879A (en) 1991-08-30

Family

ID=23945983

Family Applications (1)

Application Number Title Priority Date Filing Date
EG266/84A EG17879A (en) 1983-04-29 1984-04-28 Non-toxinogenic vibrio cholerae nutants

Country Status (20)

Country Link
US (1) US4882278A (fr)
EP (1) EP0125228B1 (fr)
JP (1) JPH0740921B2 (fr)
AT (1) ATE35152T1 (fr)
AU (1) AU585481B2 (fr)
CA (1) CA1326218C (fr)
DE (1) DE3472114D1 (fr)
DK (1) DK213784A (fr)
DZ (1) DZ634A1 (fr)
EG (1) EG17879A (fr)
ES (1) ES8600649A1 (fr)
GR (1) GR81986B (fr)
IE (1) IE57266B1 (fr)
IL (1) IL71652A (fr)
PH (1) PH25301A (fr)
PT (1) PT78478B (fr)
YU (1) YU45616B (fr)
ZA (1) ZA843142B (fr)
ZM (1) ZM2884A1 (fr)
ZW (1) ZW6884A1 (fr)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5882653A (en) * 1983-03-04 1999-03-16 The University Of Maryland System Vibrio cholerae 01 (CVD111) and non-01 (CVD112 and CVD112RM) serogroup vaccine strains, methods of making same and products thereof
US5399494A (en) * 1983-03-04 1995-03-21 The University Of Maryland System Vibrio cholerae strain CVD103Hgr, method of making same, and vaccines derived therefrom
US5470729A (en) * 1983-03-04 1995-11-28 University Of Maryland At Baltimore Method of isolating restriction fragment deletions in Vibrio cholerae, and products thereof
US5135862A (en) * 1983-03-04 1992-08-04 University Of Maryland Method of isolating restriction fragment deletions in vibrio cholerae, products thereof
US5308835A (en) * 1984-07-09 1994-05-03 Praxis Biologics, Inc. Production of the E. coli LT-B enterotoxin subunit
CA1340372C (fr) * 1984-07-09 1999-02-02 John D. Clements Production d'une sous-unite d'enterotoxine lt-b d'e. coli
US4808700A (en) * 1984-07-09 1989-02-28 Praxis Biologics, Inc. Immunogenic conjugates of non-toxic E. coli LT-B enterotoxin subunit and capsular polymers
EP0249449A1 (fr) * 1986-06-11 1987-12-16 Enterovax Research Pty. Ltd. Souche bactérienne pour vaccins vivants
SE462285B (sv) * 1988-09-16 1990-05-28 Jan Roland Holmgren Expression av koleratoxinets bindande subenhet med hjaelp av fraemmande promotor- och/eller ledarpeptidstrukturer
US6043057A (en) * 1988-09-16 2000-03-28 Vitec Aktiebolag Recombinant systems for expression of the cholera B-sub-unit with the aid of foreign promoters and/or leader peptides
AU656730B2 (en) * 1990-06-05 1995-02-16 University Of Maryland At Baltimore Method of isolating restriction fragment deletions in vibrio cholerae, and products thereof
IL101715A (en) * 1991-05-02 2005-06-19 Amgen Inc Recombinant dna-derived cholera toxin subunit analogs
AU4660893A (en) * 1992-07-06 1994-01-31 President And Fellows Of Harvard College Deletion mutants as vaccines for cholera
US5874088A (en) * 1992-07-06 1999-02-23 President And Fellows Of Harvard College Deletion mutants of cholera vaccines expressing heterologous antigens
EP0692031B1 (fr) * 1993-02-22 2007-04-11 The General Hospital Corporation Antigenes heterologues presents dans des souches vaccinales a cellules vivantes
US6203799B1 (en) 1993-07-01 2001-03-20 Presidents And Fellows Of Harvard College Vibrio cholerae mutants which are soft-agar penetration defective and lack a functional CtxA subunit
WO1997049289A1 (fr) * 1996-06-27 1997-12-31 President And Fellows Of Harvard College Vibrio cholerae a sensibilite accrue aux antibiotiques
US6036953A (en) * 1996-11-29 2000-03-14 The General Hospital Corporation Heterologous antigens in live cell V. cholerae strains
JP4086945B2 (ja) * 1996-12-10 2008-05-14 カウンシル・オブ・サイエンティフィック・アンド・インダストリアル・リサーチ 非毒性Ｖ．Ｃｈｏｌｅｒａｅ株の単離法およびその株由来のコレラワクチンの製造法
EP0928831B1 (fr) * 1997-12-10 2006-05-03 Council of Scientific and Industrial Research Organismes cholerae, vaccins et leur préparation
WO1999041369A2 (fr) * 1998-02-11 1999-08-19 Maxygen, Inc. Vecteurs de vaccins mis au point par genie genetique
US6541011B2 (en) 1998-02-11 2003-04-01 Maxygen, Inc. Antigen library immunization
US7390619B1 (en) 1998-02-11 2008-06-24 Maxygen, Inc. Optimization of immunomodulatory properties of genetic vaccines
US6686339B1 (en) * 1998-08-20 2004-02-03 Aventis Pasteur Limited Nucleic acid molecules encoding inclusion membrane protein C of Chlamydia
AU5366099A (en) 1998-08-20 2000-03-14 Connaught Laboratories Limited Nucleic acid molecules encoding inclusion membrane protein of (chlamydia)
US6693087B1 (en) 1998-08-20 2004-02-17 Aventis Pasteur Limited Nucleic acid molecules encoding POMP91A protein of Chlamydia
JP4540033B2 (ja) 1999-10-22 2010-09-08 サノフィ パストゥール リミテッド 腫瘍抗原に対する免疫応答を誘発および／または増強する方法
EP1792995A3 (fr) 2000-05-08 2007-06-13 Sanofi Pasteur Limited Antigènes de chlamydia et fragments d'adn correspondants, et utilisations de ceux-ci
ATE513913T1 (de) 2000-05-10 2011-07-15 Sanofi Pasteur Ltd Durch mage minigene kodierte immunogene polypeptide und ihre verwendungen
CN1484700A (zh) * 2000-11-02 2004-03-24 �¼��¹�����ѧ aopB基因,蛋白,同系物,片段和它们的变体,以及它们在细胞表面展示方面的应用
AU2003223527B2 (en) 2002-04-09 2009-01-15 Sanofi Pasteur Limited Modified CEA nucleic acid and expression vectors
CN1705492A (zh) * 2002-08-29 2005-12-07 新加坡国立大学 用于诱发抗过敏原保护性免疫应答的重组核酸
US20060099229A1 (en) * 2004-11-05 2006-05-11 Universiti Sains Malaysia Vibrio cholerae strains VCUSM1 and VCUSM4, method of producing same, and vaccine derivatives thereof
CN101124327A (zh) * 2003-10-08 2008-02-13 圣诺菲·帕斯图尔公司 经修饰的cea/b7载体

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4264737A (en) * 1978-09-21 1981-04-28 President And Fellows Of Harvard College Method of making genetically stable mutants of vibrio cholerae
US4328209A (en) * 1979-04-11 1982-05-04 Board Of Regents, The University Of Texas System Cholera vaccine
JPS5893837A (ja) * 1981-11-30 1983-06-03 Toyota Motor Corp 複合材料及びその製造方法
US4666837A (en) * 1982-05-24 1987-05-19 Smithkline-Rit DNA sequences, recombinant DNA molecules and processes for producing the A and B subunits of cholera toxin and preparations containing so-obtained subunit or subunits
US5135862A (en) * 1983-03-04 1992-08-04 University Of Maryland Method of isolating restriction fragment deletions in vibrio cholerae, products thereof
ZA841557B (en) * 1983-03-04 1984-10-31 Univ Maryland Method of isolating restriction fragment deletions in vibrio chlolerae,and products thereof

Also Published As

Publication number Publication date
GR81986B (fr) 1984-12-12
EP0125228B1 (fr) 1988-06-15
IE841043L (en) 1984-10-29
IL71652A0 (en) 1984-07-31
AU2727084A (en) 1984-11-01
YU45616B (sh) 1992-07-20
ES531986A0 (es) 1985-09-01
ZM2884A1 (en) 1985-04-22
YU76384A (en) 1989-08-31
US4882278A (en) 1989-11-21
DK213784A (da) 1984-10-30
JPS6037980A (ja) 1985-02-27
PT78478B (en) 1986-05-27
EP0125228A1 (fr) 1984-11-14
ZA843142B (en) 1985-03-27
DE3472114D1 (en) 1988-07-21
AU585481B2 (en) 1989-06-22
PT78478A (en) 1984-05-01
ZW6884A1 (en) 1984-09-19
DK213784D0 (da) 1984-04-27
ES8600649A1 (es) 1985-09-01
DZ634A1 (fr) 2004-09-13
JPH0740921B2 (ja) 1995-05-10
CA1326218C (fr) 1994-01-18
PH25301A (en) 1991-04-30
ATE35152T1 (de) 1988-07-15
IE57266B1 (en) 1992-07-01
IL71652A (en) 1988-11-30

Similar Documents

Publication Publication Date Title
EG17879A (en) Non-toxinogenic vibrio cholerae nutants
ES8705036A1 (es) Procedimiento para preparar una vacuna que comprende un polipeptido fijado a una membrana
DK219087A (da) Vektorsystem til brug ved transformation af trichoderma, transformerede trichodermastammer og fremgangsmaade til fremstilling af proteiner heri
GB2303854B (en) Helicobacter proteins and vaccines
AU2785089A (en) Chimeric glycoproteins containing immunogenic segments of the glycoproteins of human respiratory syncytial virus
AU6733487A (en) Mammalian interleukin-4
IL65565A (en) Plasmids coding for b.thuringiensis crystal protein,their production and their use in creating genetically engineered bacterial strains
DE3266201D1 (en) Infectious-bronchitis vaccines for poultry, combined infectious-bronchitis vaccines, process for preparing such vaccines and infectious-bronchitis virus strain
KR970009347B1 (en) Chimeric glycoproteins containing immunogenic segments of human parainfluenza virus type 3
GR80840B (en) Novel polypeptide with a - amylase inhibiting effect, method for the preparation thereof, use and pharmaceutical preparations thereof
FI851859L (fi) Antigenpreparat och isolering av saodana preparat.
AU5280186A (en) Canine parvovirus vaccines
IT1212111B (it) Procedimento per preparare fluoroelastomeri insaturi.
DE3585578D1 (de) Hepatitisoberflaechenantigenpartikelvakzin.
FI102544B1 (fi) Menetelmä E.coli-kannan valmistamiseksi
AU2403188A (en) Infectious bovine rhinotracheitis virus mutants, vaccines containing same, methods for the production of same and methods for the use of same
HUT44609A (en) Process for preparing new polypeptides
DK160565C (da) Plasmid p sg 2, fremgangsmaade til dets fremstilling og dets anvendelse
JO1343B1 (en) Non-toxic gene variant strains of vibro cholera
FI905055A0 (fi) Ett p1-bakteriofagkloningssystem foer sao stora dna-fragment som 95 kb.
IL85759A0 (en) The cloning of malaria-specific dna sequences,isolation of the gene for the 140 kd protein
AR224831A1 (es) Un procedimiento para la elaboracion de preparados de paredes celulares o preparaciones de celulas completas de propionibacterium granulosum dsm 1773,propionibacterium avidum dms 1772 y/o propionibacterium acnes atcc 6919
SU1380209A1 (ru) РЕКОМБИНАНТНАЯ ПЛАЗМИДНАЯ ДНК PUR 291-HAV 22, КОДИРУЮЩАЯ СИНТЕЗ ГИБРИДНОГО ПОЛИПЕПТИДА АНТИГЕННЫХ ДЕТЕРМИНАНТ ВИРУСА ГЕПАТИТА А С β -ГАЛАКТОЗИДАЗОЙ
AU2713488A (en) Process for manufacturing antigens, vaccines and sera to combat bacterial or viral diseases and composition for implementing said process
AU7384387A (en) Avirulent bacterial strains used in live vaccine preparation