YU45616B - Netoksikogeni genetski stabilan soj vibrio cholerae ogawa 395 - Google Patents
Netoksikogeni genetski stabilan soj vibrio cholerae ogawa 395Info
- Publication number
- YU45616B YU45616B YU76384A YU76384A YU45616B YU 45616 B YU45616 B YU 45616B YU 76384 A YU76384 A YU 76384A YU 76384 A YU76384 A YU 76384A YU 45616 B YU45616 B YU 45616B
- Authority
- YU
- Yugoslavia
- Prior art keywords
- vibrio cholerae
- toxicogenic
- genetically stable
- stable strain
- strain vibrio
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/107—Vibrio
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/28—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Vibrionaceae (F)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/01—Preparation of mutants without inserting foreign genetic material therein; Screening processes therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/522—Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/909—Vibrio
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Animal Behavior & Ethology (AREA)
- Mycology (AREA)
- Plant Pathology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
NETOKSIKOGENI GENETSKI STABILAN SOJ VIBRIO CHOLERAE OGAWA 395, koji je naznačen time, što ima mutaciju izostavljanja na obe kopije gena koji kodira za peptid A1 (ctxA1), usled čega dolazi do gubitaka sekvence gena potrebne za ekspresiju otrovnog peptida A1.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/489,958 US4882278A (en) | 1983-04-29 | 1983-04-29 | Non-toxinogenic vibrio cholerae mutants |
Publications (2)
Publication Number | Publication Date |
---|---|
YU76384A YU76384A (en) | 1989-08-31 |
YU45616B true YU45616B (sh) | 1992-07-20 |
Family
ID=23945983
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
YU76384A YU45616B (sh) | 1983-04-29 | 1984-04-27 | Netoksikogeni genetski stabilan soj vibrio cholerae ogawa 395 |
Country Status (20)
Country | Link |
---|---|
US (1) | US4882278A (sh) |
EP (1) | EP0125228B1 (sh) |
JP (1) | JPH0740921B2 (sh) |
AT (1) | ATE35152T1 (sh) |
AU (1) | AU585481B2 (sh) |
CA (1) | CA1326218C (sh) |
DE (1) | DE3472114D1 (sh) |
DK (1) | DK213784A (sh) |
DZ (1) | DZ634A1 (sh) |
EG (1) | EG17879A (sh) |
ES (1) | ES8600649A1 (sh) |
GR (1) | GR81986B (sh) |
IE (1) | IE57266B1 (sh) |
IL (1) | IL71652A (sh) |
PH (1) | PH25301A (sh) |
PT (1) | PT78478B (sh) |
YU (1) | YU45616B (sh) |
ZA (1) | ZA843142B (sh) |
ZM (1) | ZM2884A1 (sh) |
ZW (1) | ZW6884A1 (sh) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5882653A (en) * | 1983-03-04 | 1999-03-16 | The University Of Maryland System | Vibrio cholerae 01 (CVD111) and non-01 (CVD112 and CVD112RM) serogroup vaccine strains, methods of making same and products thereof |
US5399494A (en) * | 1983-03-04 | 1995-03-21 | The University Of Maryland System | Vibrio cholerae strain CVD103Hgr, method of making same, and vaccines derived therefrom |
US5470729A (en) * | 1983-03-04 | 1995-11-28 | University Of Maryland At Baltimore | Method of isolating restriction fragment deletions in Vibrio cholerae, and products thereof |
US5135862A (en) * | 1983-03-04 | 1992-08-04 | University Of Maryland | Method of isolating restriction fragment deletions in vibrio cholerae, products thereof |
US4808700A (en) * | 1984-07-09 | 1989-02-28 | Praxis Biologics, Inc. | Immunogenic conjugates of non-toxic E. coli LT-B enterotoxin subunit and capsular polymers |
US5308835A (en) * | 1984-07-09 | 1994-05-03 | Praxis Biologics, Inc. | Production of the E. coli LT-B enterotoxin subunit |
CA1340372C (en) * | 1984-07-09 | 1999-02-02 | John D. Clements | Production of e. coli lt-b enterotoxin subunit |
EP0249449A1 (en) * | 1986-06-11 | 1987-12-16 | Enterovax Research Pty. Ltd. | Bacterial strain for live vaccines |
US6043057A (en) * | 1988-09-16 | 2000-03-28 | Vitec Aktiebolag | Recombinant systems for expression of the cholera B-sub-unit with the aid of foreign promoters and/or leader peptides |
SE462285B (sv) * | 1988-09-16 | 1990-05-28 | Jan Roland Holmgren | Expression av koleratoxinets bindande subenhet med hjaelp av fraemmande promotor- och/eller ledarpeptidstrukturer |
ATE145005T1 (de) * | 1990-06-05 | 1996-11-15 | Univ Maryland | Verfahren zum isolieren von vibrio cholerae- deletionsmutanten und vibrio cholerae enthaltende kulturen |
IL101715A (en) * | 1991-05-02 | 2005-06-19 | Amgen Inc | Recombinant dna-derived cholera toxin subunit analogs |
US5874088A (en) * | 1992-07-06 | 1999-02-23 | President And Fellows Of Harvard College | Deletion mutants of cholera vaccines expressing heterologous antigens |
CA2139655C (en) * | 1992-07-06 | 2008-05-13 | John J. Mekalanos | Deletion mutants as vaccines for cholera |
WO1994019482A1 (en) * | 1993-02-22 | 1994-09-01 | The General Hospital Corporation | Heterologous antigens in live cell vaccine strains |
US6203799B1 (en) | 1993-07-01 | 2001-03-20 | Presidents And Fellows Of Harvard College | Vibrio cholerae mutants which are soft-agar penetration defective and lack a functional CtxA subunit |
US5945285A (en) * | 1996-06-27 | 1999-08-31 | President And Fellows Of Harvard College | Vibrio cholerae having increased sensitivity to antibiotics |
AU7410798A (en) * | 1996-11-29 | 1998-06-22 | General Hospital Corporation, The | Heterologous antigens in live cell V |
JP4086945B2 (ja) * | 1996-12-10 | 2008-05-14 | カウンシル・オブ・サイエンティフィック・アンド・インダストリアル・リサーチ | 非毒性V.Cholerae株の単離法およびその株由来のコレラワクチンの製造法 |
EP0928831B1 (en) * | 1997-12-10 | 2006-05-03 | Council of Scientific and Industrial Research | Cholera organisms, vaccines and preparation thereof |
US6541011B2 (en) | 1998-02-11 | 2003-04-01 | Maxygen, Inc. | Antigen library immunization |
AU2674299A (en) * | 1998-02-11 | 1999-08-30 | Maxygen, Inc. | Targeting of genetic vaccine vectors |
US7390619B1 (en) | 1998-02-11 | 2008-06-24 | Maxygen, Inc. | Optimization of immunomodulatory properties of genetic vaccines |
US6686339B1 (en) | 1998-08-20 | 2004-02-03 | Aventis Pasteur Limited | Nucleic acid molecules encoding inclusion membrane protein C of Chlamydia |
EP1105490A1 (en) | 1998-08-20 | 2001-06-13 | Aventis Pasteur Limited | Nucleic acid molecules encoding inclusion membrane protein c of chlamydia |
US6693087B1 (en) | 1998-08-20 | 2004-02-17 | Aventis Pasteur Limited | Nucleic acid molecules encoding POMP91A protein of Chlamydia |
AU1013601A (en) | 1999-10-22 | 2001-05-08 | Aventis Pasteur Limited | Method of inducing and/or enhancing an immune response to tumor antigens |
EP1792995A3 (en) | 2000-05-08 | 2007-06-13 | Sanofi Pasteur Limited | Chlamydia secretory locus orf and uses thereof |
CA2408328C (en) * | 2000-05-10 | 2012-04-17 | Aventis Pasteur Limited | Immunogenic polypeptides encoded by mage minigenes and uses thereof |
AU1120102A (en) * | 2000-11-02 | 2002-05-15 | Univ Singapore | AopB gene, protein, homologs, fragments and variants thereof, and their use for cell surface display |
US7786278B2 (en) | 2002-04-09 | 2010-08-31 | Sanofi Pasteur Limited | Modified CEA nucleic acid and expression vectors |
CN1705492A (zh) * | 2002-08-29 | 2005-12-07 | 新加坡国立大学 | 用于诱发抗过敏原保护性免疫应答的重组核酸 |
JP4668919B2 (ja) * | 2003-10-08 | 2011-04-13 | サノフィ パストゥール インコーポレイテッド | 修飾cea/b7ベクター |
US20060099229A1 (en) * | 2004-11-05 | 2006-05-11 | Universiti Sains Malaysia | Vibrio cholerae strains VCUSM1 and VCUSM4, method of producing same, and vaccine derivatives thereof |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4264737A (en) * | 1978-09-21 | 1981-04-28 | President And Fellows Of Harvard College | Method of making genetically stable mutants of vibrio cholerae |
US4328209A (en) * | 1979-04-11 | 1982-05-04 | Board Of Regents, The University Of Texas System | Cholera vaccine |
JPS5893837A (ja) * | 1981-11-30 | 1983-06-03 | Toyota Motor Corp | 複合材料及びその製造方法 |
US4666837A (en) * | 1982-05-24 | 1987-05-19 | Smithkline-Rit | DNA sequences, recombinant DNA molecules and processes for producing the A and B subunits of cholera toxin and preparations containing so-obtained subunit or subunits |
ZA841557B (en) * | 1983-03-04 | 1984-10-31 | Univ Maryland | Method of isolating restriction fragment deletions in vibrio chlolerae,and products thereof |
US5135862A (en) * | 1983-03-04 | 1992-08-04 | University Of Maryland | Method of isolating restriction fragment deletions in vibrio cholerae, products thereof |
-
1983
- 1983-04-29 US US06/489,958 patent/US4882278A/en not_active Expired - Lifetime
-
1984
- 1984-04-24 PT PT78478A patent/PT78478B/pt unknown
- 1984-04-25 DZ DZ847164A patent/DZ634A1/fr active
- 1984-04-26 DE DE8484870058T patent/DE3472114D1/de not_active Expired
- 1984-04-26 AU AU27270/84A patent/AU585481B2/en not_active Expired
- 1984-04-26 EP EP84870058A patent/EP0125228B1/en not_active Expired
- 1984-04-26 IL IL71652A patent/IL71652A/xx not_active IP Right Cessation
- 1984-04-26 ZW ZW68/84A patent/ZW6884A1/xx unknown
- 1984-04-26 AT AT84870058T patent/ATE35152T1/de not_active IP Right Cessation
- 1984-04-27 JP JP59087619A patent/JPH0740921B2/ja not_active Expired - Lifetime
- 1984-04-27 YU YU76384A patent/YU45616B/sh unknown
- 1984-04-27 ZA ZA843142A patent/ZA843142B/xx unknown
- 1984-04-27 ZM ZM28/84A patent/ZM2884A1/xx unknown
- 1984-04-27 IE IE1043/84A patent/IE57266B1/en not_active IP Right Cessation
- 1984-04-27 GR GR74529A patent/GR81986B/el unknown
- 1984-04-27 DK DK213784A patent/DK213784A/da not_active Application Discontinuation
- 1984-04-27 ES ES531986A patent/ES8600649A1/es not_active Expired
- 1984-04-27 CA CA000452936A patent/CA1326218C/en not_active Expired - Lifetime
- 1984-04-27 PH PH30609A patent/PH25301A/en unknown
- 1984-04-28 EG EG266/84A patent/EG17879A/xx active
Also Published As
Publication number | Publication date |
---|---|
ZA843142B (en) | 1985-03-27 |
IE841043L (en) | 1984-10-29 |
GR81986B (sh) | 1984-12-12 |
DK213784A (da) | 1984-10-30 |
IL71652A0 (en) | 1984-07-31 |
JPH0740921B2 (ja) | 1995-05-10 |
ZW6884A1 (en) | 1984-09-19 |
DZ634A1 (fr) | 2004-09-13 |
AU2727084A (en) | 1984-11-01 |
IE57266B1 (en) | 1992-07-01 |
PH25301A (en) | 1991-04-30 |
DE3472114D1 (en) | 1988-07-21 |
YU76384A (en) | 1989-08-31 |
CA1326218C (en) | 1994-01-18 |
EP0125228B1 (en) | 1988-06-15 |
US4882278A (en) | 1989-11-21 |
AU585481B2 (en) | 1989-06-22 |
ES531986A0 (es) | 1985-09-01 |
IL71652A (en) | 1988-11-30 |
ZM2884A1 (en) | 1985-04-22 |
PT78478B (en) | 1986-05-27 |
DK213784D0 (da) | 1984-04-27 |
PT78478A (en) | 1984-05-01 |
EG17879A (en) | 1991-08-30 |
JPS6037980A (ja) | 1985-02-27 |
ES8600649A1 (es) | 1985-09-01 |
ATE35152T1 (de) | 1988-07-15 |
EP0125228A1 (en) | 1984-11-14 |
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