YU45616B - Netoksikogeni genetski stabilan soj vibrio cholerae ogawa 395 - Google Patents

Netoksikogeni genetski stabilan soj vibrio cholerae ogawa 395

Info

Publication number
YU45616B
YU45616B YU76384A YU76384A YU45616B YU 45616 B YU45616 B YU 45616B YU 76384 A YU76384 A YU 76384A YU 76384 A YU76384 A YU 76384A YU 45616 B YU45616 B YU 45616B
Authority
YU
Yugoslavia
Prior art keywords
vibrio cholerae
toxicogenic
genetically stable
stable strain
strain vibrio
Prior art date
Application number
YU76384A
Other languages
English (en)
Other versions
YU76384A (en
Inventor
J.J. Mekalanos
Original Assignee
President And Fellows Of Harvard College
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by President And Fellows Of Harvard College filed Critical President And Fellows Of Harvard College
Publication of YU76384A publication Critical patent/YU76384A/xx
Publication of YU45616B publication Critical patent/YU45616B/sh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/107—Vibrio
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/28—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Vibrionaceae (F)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/01—Preparation of mutants without inserting foreign genetic material therein; Screening processes therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/522—Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/909—Vibrio

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Mycology (AREA)
  • Plant Pathology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

NETOKSIKOGENI GENETSKI STABILAN SOJ VIBRIO CHOLERAE OGAWA 395, koji je naznačen time, što ima mutaciju izostavljanja na obe kopije gena koji kodira za peptid A1 (ctxA1), usled čega dolazi do gubitaka sekvence gena potrebne za ekspresiju otrovnog peptida A1.
YU76384A 1983-04-29 1984-04-27 Netoksikogeni genetski stabilan soj vibrio cholerae ogawa 395 YU45616B (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/489,958 US4882278A (en) 1983-04-29 1983-04-29 Non-toxinogenic vibrio cholerae mutants

Publications (2)

Publication Number Publication Date
YU76384A YU76384A (en) 1989-08-31
YU45616B true YU45616B (sh) 1992-07-20

Family

ID=23945983

Family Applications (1)

Application Number Title Priority Date Filing Date
YU76384A YU45616B (sh) 1983-04-29 1984-04-27 Netoksikogeni genetski stabilan soj vibrio cholerae ogawa 395

Country Status (20)

Country Link
US (1) US4882278A (sh)
EP (1) EP0125228B1 (sh)
JP (1) JPH0740921B2 (sh)
AT (1) ATE35152T1 (sh)
AU (1) AU585481B2 (sh)
CA (1) CA1326218C (sh)
DE (1) DE3472114D1 (sh)
DK (1) DK213784A (sh)
DZ (1) DZ634A1 (sh)
EG (1) EG17879A (sh)
ES (1) ES8600649A1 (sh)
GR (1) GR81986B (sh)
IE (1) IE57266B1 (sh)
IL (1) IL71652A (sh)
PH (1) PH25301A (sh)
PT (1) PT78478B (sh)
YU (1) YU45616B (sh)
ZA (1) ZA843142B (sh)
ZM (1) ZM2884A1 (sh)
ZW (1) ZW6884A1 (sh)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5882653A (en) * 1983-03-04 1999-03-16 The University Of Maryland System Vibrio cholerae 01 (CVD111) and non-01 (CVD112 and CVD112RM) serogroup vaccine strains, methods of making same and products thereof
US5399494A (en) * 1983-03-04 1995-03-21 The University Of Maryland System Vibrio cholerae strain CVD103Hgr, method of making same, and vaccines derived therefrom
US5470729A (en) * 1983-03-04 1995-11-28 University Of Maryland At Baltimore Method of isolating restriction fragment deletions in Vibrio cholerae, and products thereof
US5135862A (en) * 1983-03-04 1992-08-04 University Of Maryland Method of isolating restriction fragment deletions in vibrio cholerae, products thereof
US4808700A (en) * 1984-07-09 1989-02-28 Praxis Biologics, Inc. Immunogenic conjugates of non-toxic E. coli LT-B enterotoxin subunit and capsular polymers
US5308835A (en) * 1984-07-09 1994-05-03 Praxis Biologics, Inc. Production of the E. coli LT-B enterotoxin subunit
CA1340372C (en) * 1984-07-09 1999-02-02 John D. Clements Production of e. coli lt-b enterotoxin subunit
EP0249449A1 (en) * 1986-06-11 1987-12-16 Enterovax Research Pty. Ltd. Bacterial strain for live vaccines
US6043057A (en) * 1988-09-16 2000-03-28 Vitec Aktiebolag Recombinant systems for expression of the cholera B-sub-unit with the aid of foreign promoters and/or leader peptides
SE462285B (sv) * 1988-09-16 1990-05-28 Jan Roland Holmgren Expression av koleratoxinets bindande subenhet med hjaelp av fraemmande promotor- och/eller ledarpeptidstrukturer
ATE145005T1 (de) * 1990-06-05 1996-11-15 Univ Maryland Verfahren zum isolieren von vibrio cholerae- deletionsmutanten und vibrio cholerae enthaltende kulturen
IL101715A (en) * 1991-05-02 2005-06-19 Amgen Inc Recombinant dna-derived cholera toxin subunit analogs
US5874088A (en) * 1992-07-06 1999-02-23 President And Fellows Of Harvard College Deletion mutants of cholera vaccines expressing heterologous antigens
CA2139655C (en) * 1992-07-06 2008-05-13 John J. Mekalanos Deletion mutants as vaccines for cholera
WO1994019482A1 (en) * 1993-02-22 1994-09-01 The General Hospital Corporation Heterologous antigens in live cell vaccine strains
US6203799B1 (en) 1993-07-01 2001-03-20 Presidents And Fellows Of Harvard College Vibrio cholerae mutants which are soft-agar penetration defective and lack a functional CtxA subunit
US5945285A (en) * 1996-06-27 1999-08-31 President And Fellows Of Harvard College Vibrio cholerae having increased sensitivity to antibiotics
AU7410798A (en) * 1996-11-29 1998-06-22 General Hospital Corporation, The Heterologous antigens in live cell V
JP4086945B2 (ja) * 1996-12-10 2008-05-14 カウンシル・オブ・サイエンティフィック・アンド・インダストリアル・リサーチ 非毒性Ｖ．Ｃｈｏｌｅｒａｅ株の単離法およびその株由来のコレラワクチンの製造法
EP0928831B1 (en) * 1997-12-10 2006-05-03 Council of Scientific and Industrial Research Cholera organisms, vaccines and preparation thereof
US6541011B2 (en) 1998-02-11 2003-04-01 Maxygen, Inc. Antigen library immunization
AU2674299A (en) * 1998-02-11 1999-08-30 Maxygen, Inc. Targeting of genetic vaccine vectors
US7390619B1 (en) 1998-02-11 2008-06-24 Maxygen, Inc. Optimization of immunomodulatory properties of genetic vaccines
US6686339B1 (en) 1998-08-20 2004-02-03 Aventis Pasteur Limited Nucleic acid molecules encoding inclusion membrane protein C of Chlamydia
EP1105490A1 (en) 1998-08-20 2001-06-13 Aventis Pasteur Limited Nucleic acid molecules encoding inclusion membrane protein c of chlamydia
US6693087B1 (en) 1998-08-20 2004-02-17 Aventis Pasteur Limited Nucleic acid molecules encoding POMP91A protein of Chlamydia
AU1013601A (en) 1999-10-22 2001-05-08 Aventis Pasteur Limited Method of inducing and/or enhancing an immune response to tumor antigens
EP1792995A3 (en) 2000-05-08 2007-06-13 Sanofi Pasteur Limited Chlamydia secretory locus orf and uses thereof
CA2408328C (en) * 2000-05-10 2012-04-17 Aventis Pasteur Limited Immunogenic polypeptides encoded by mage minigenes and uses thereof
AU1120102A (en) * 2000-11-02 2002-05-15 Univ Singapore AopB gene, protein, homologs, fragments and variants thereof, and their use for cell surface display
US7786278B2 (en) 2002-04-09 2010-08-31 Sanofi Pasteur Limited Modified CEA nucleic acid and expression vectors
CN1705492A (zh) * 2002-08-29 2005-12-07 新加坡国立大学 用于诱发抗过敏原保护性免疫应答的重组核酸
JP4668919B2 (ja) * 2003-10-08 2011-04-13 サノフィ パストゥール インコーポレイテッド 修飾ｃｅａ／ｂ７ベクター
US20060099229A1 (en) * 2004-11-05 2006-05-11 Universiti Sains Malaysia Vibrio cholerae strains VCUSM1 and VCUSM4, method of producing same, and vaccine derivatives thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4264737A (en) * 1978-09-21 1981-04-28 President And Fellows Of Harvard College Method of making genetically stable mutants of vibrio cholerae
US4328209A (en) * 1979-04-11 1982-05-04 Board Of Regents, The University Of Texas System Cholera vaccine
JPS5893837A (ja) * 1981-11-30 1983-06-03 Toyota Motor Corp 複合材料及びその製造方法
US4666837A (en) * 1982-05-24 1987-05-19 Smithkline-Rit DNA sequences, recombinant DNA molecules and processes for producing the A and B subunits of cholera toxin and preparations containing so-obtained subunit or subunits
ZA841557B (en) * 1983-03-04 1984-10-31 Univ Maryland Method of isolating restriction fragment deletions in vibrio chlolerae,and products thereof
US5135862A (en) * 1983-03-04 1992-08-04 University Of Maryland Method of isolating restriction fragment deletions in vibrio cholerae, products thereof

Also Published As

Publication number Publication date
ZA843142B (en) 1985-03-27
IE841043L (en) 1984-10-29
GR81986B (sh) 1984-12-12
DK213784A (da) 1984-10-30
IL71652A0 (en) 1984-07-31
JPH0740921B2 (ja) 1995-05-10
ZW6884A1 (en) 1984-09-19
DZ634A1 (fr) 2004-09-13
AU2727084A (en) 1984-11-01
IE57266B1 (en) 1992-07-01
PH25301A (en) 1991-04-30
DE3472114D1 (en) 1988-07-21
YU76384A (en) 1989-08-31
CA1326218C (en) 1994-01-18
EP0125228B1 (en) 1988-06-15
US4882278A (en) 1989-11-21
AU585481B2 (en) 1989-06-22
ES531986A0 (es) 1985-09-01
IL71652A (en) 1988-11-30
ZM2884A1 (en) 1985-04-22
PT78478B (en) 1986-05-27
DK213784D0 (da) 1984-04-27
PT78478A (en) 1984-05-01
EG17879A (en) 1991-08-30
JPS6037980A (ja) 1985-02-27
ES8600649A1 (es) 1985-09-01
ATE35152T1 (de) 1988-07-15
EP0125228A1 (en) 1984-11-14

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