EE9900581A - LAG-3 pleissimisteisendid - Google Patents

LAG-3 pleissimisteisendid

Info

Publication number
EE9900581A
EE9900581A EEP199900581A EEP9900581A EE9900581A EE 9900581 A EE9900581 A EE 9900581A EE P199900581 A EEP199900581 A EE P199900581A EE P9900581 A EEP9900581 A EE P9900581A EE 9900581 A EE9900581 A EE 9900581A
Authority
EE
Estonia
Prior art keywords
lag
nucleotidic
seq
code
sequences
Prior art date
Application number
EEP199900581A
Other languages
English (en)
Inventor
Triebel Frdric
Mastrangeli Renato
Romagnani Sergio
Original Assignee
Institut National De La Sante Et De La Recherche Medicale (Inserm)
Institut Gustave Roussy
Applied Research Systems Ars Holding N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Institut National De La Sante Et De La Recherche Medicale (Inserm), Institut Gustave Roussy, Applied Research Systems Ars Holding N.V. filed Critical Institut National De La Sante Et De La Recherche Medicale (Inserm)
Publication of EE9900581A publication Critical patent/EE9900581A/et
Publication of EE04378B1 publication Critical patent/EE04378B1/et

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
EEP199900581A 1997-06-18 1998-06-03 LAG-3 pleissimisteisendid EE04378B1 (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP97401404A EP0900841A1 (en) 1997-06-18 1997-06-18 LAG-3 splice variants
PCT/EP1998/003307 WO1998058059A1 (en) 1997-06-18 1998-06-03 Lag-3 splice variants

Publications (2)

Publication Number Publication Date
EE9900581A true EE9900581A (et) 2000-08-15
EE04378B1 EE04378B1 (et) 2004-10-15

Family

ID=8229784

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP199900581A EE04378B1 (et) 1997-06-18 1998-06-03 LAG-3 pleissimisteisendid

Country Status (18)

Country Link
EP (2) EP0900841A1 (et)
JP (1) JP2002505582A (et)
KR (1) KR100552526B1 (et)
CN (1) CN1181201C (et)
AT (1) ATE274057T1 (et)
AU (1) AU740147B2 (et)
BR (1) BR9810925A (et)
CA (1) CA2293735A1 (et)
DE (1) DE69825741T2 (et)
DK (1) DK0977856T3 (et)
EA (1) EA003086B1 (et)
EE (1) EE04378B1 (et)
ES (1) ES2227862T3 (et)
HK (1) HK1027377A1 (et)
IL (2) IL133544A0 (et)
NO (1) NO996097L (et)
PT (1) PT977856E (et)
WO (1) WO1998058059A1 (et)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030100359A1 (en) * 2000-10-04 2003-05-29 Loose Timothy C. Audio network for gaming machines
EP1295895B1 (en) * 2001-09-19 2011-08-10 Institut Gustave Roussy Peptides and proteins binding to glu-pro motifs, therapeutical compositions containing the same and applications thereof
SE0103423D0 (sv) * 2001-10-12 2001-10-12 Astrazeneca Ab Polymorphism
CA2476518A1 (en) * 2002-02-22 2003-09-04 Genentech, Inc. Compositions and methods for the treatment of immune related diseases
US7364508B2 (en) 2003-01-16 2008-04-29 Wms Gaming, Inc. Gaming machine environment having controlled audio and visual media presentation
US7367886B2 (en) 2003-01-16 2008-05-06 Wms Gaming Inc. Gaming system with surround sound
US7867085B2 (en) 2003-01-16 2011-01-11 Wms Gaming Inc. Gaming machine environment having controlled audio and visual media presentation
US8313374B2 (en) 2003-02-14 2012-11-20 Wms Gaming Inc. Gaming machine having improved audio control architecture
ES2439580T3 (es) * 2003-02-28 2014-01-23 The Johns Hopkins University Regulación de células T
FR2902101B1 (fr) * 2006-06-12 2012-12-28 Scras Peptides a activite anti-proliferative
WO2008063391A2 (en) 2006-11-10 2008-05-29 Wms Gaming Inc. Wagering games using multi-level gaming structure
AR072999A1 (es) 2008-08-11 2010-10-06 Medarex Inc Anticuerpos humanos que se unen al gen 3 de activacion linfocitaria (lag-3) y los usos de estos
AR091649A1 (es) 2012-07-02 2015-02-18 Bristol Myers Squibb Co Optimizacion de anticuerpos que se fijan al gen de activacion de linfocitos 3 (lag-3) y sus usos
RS64268B1 (sr) 2013-09-20 2023-07-31 Bristol Myers Squibb Co Kombinacija anti-lag-3 antitela i anti-pd-1 antitela za lečenje tumora
US9412222B2 (en) 2013-09-20 2016-08-09 Igt Coordinated gaming machine attract via gaming machine cameras
JOP20200094A1 (ar) 2014-01-24 2017-06-16 Dana Farber Cancer Inst Inc جزيئات جسم مضاد لـ pd-1 واستخداماتها
MX2016011993A (es) 2014-03-14 2016-12-09 Novartis Ag Moleculas de anticuerpo que se unen a lag-3 y usos de las mismas.
TWI693232B (zh) 2014-06-26 2020-05-11 美商宏觀基因股份有限公司 與pd-1和lag-3具有免疫反應性的共價結合的雙抗體和其使用方法
JO3663B1 (ar) 2014-08-19 2020-08-27 Merck Sharp & Dohme الأجسام المضادة لمضاد lag3 وأجزاء ربط الأنتيجين
TWI773646B (zh) 2015-06-08 2022-08-11 美商宏觀基因股份有限公司 結合lag-3的分子和其使用方法
HRP20211645T1 (hr) 2015-07-30 2022-02-04 Macrogenics, Inc. Molekule za vezanje pd-1 i postupci za njihovu uporabu
TWI756187B (zh) 2015-10-09 2022-03-01 美商再生元醫藥公司 抗ｌａｇ３抗體及其用途
BR112018011781A2 (pt) 2015-12-14 2018-12-04 Macrogenics Inc molécula biespecífica possuindo um ou mais sítios de ligação a epítopo capazes de ligação imunoespecífica a (um) epítopo(s) de pd-1 e um ou mais sítios de ligação a epítopo capazes de ligação imunoespecífica a (um) epítopo(s) de ctla-4, e composição farmacêutica
BR112018012352A2 (pt) 2015-12-16 2018-12-11 Merck Sharp & Dohme Corp. anticorpos anti-lag3 e fragmentos de ligação ao antígeno
CA3053348A1 (en) 2017-02-10 2018-08-16 Regeneron Pharmaceuticals, Inc. Radiolabeled anti-lag3 antibodies for immuno-pet imaging
WO2018222718A1 (en) 2017-05-30 2018-12-06 Bristol-Myers Squibb Company Treatment of lag-3 positive tumors
CA3065304A1 (en) 2017-05-30 2018-12-06 Bristol-Myers Squibb Company Compositions comprising an anti-lag-3 antibody or an anti-lag-3 antibody and an anti-pd-1 or anti-pd-l1 antibody
US20220249659A1 (en) 2019-05-13 2022-08-11 Regeneron Pharmaceuticals, Inc. Combination of pd-1 inhibitors and lag-3 inhibitors for enhanced efficacy in treating cancer

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU616639B2 (en) * 1986-08-21 1991-11-07 Trustees Of Columbia University In The City Of New York, The Dna encoding the t cell surface protein t4 and use of fragments of t4 in the treatment of aids
FR2656800B1 (fr) * 1990-01-08 1992-05-15 Roussy Inst Gustave Nouvelles proteines produits par les lymphocytes humains, sequence d'adn codant pour ces proteines et applications pharmaceutiques et biologiques.
CA2189657C (fr) * 1994-05-06 2002-03-12 Florence Faure Fractions polypeptidiques solubles de la proteine lag-3; procede de production; composition therapeutique; anticorps anti-idiotype

Also Published As

Publication number Publication date
BR9810925A (pt) 2000-08-15
CN1260833A (zh) 2000-07-19
EE04378B1 (et) 2004-10-15
HK1027377A1 (en) 2001-01-12
KR100552526B1 (ko) 2006-02-14
EA200000038A1 (ru) 2000-06-26
ATE274057T1 (de) 2004-09-15
EP0900841A1 (en) 1999-03-10
ES2227862T3 (es) 2005-04-01
DE69825741T2 (de) 2005-09-01
NO996097L (no) 2000-02-17
IL133544A (en) 2006-12-31
AU740147B2 (en) 2001-11-01
DE69825741D1 (de) 2004-09-23
EA003086B1 (ru) 2002-12-26
JP2002505582A (ja) 2002-02-19
DK0977856T3 (da) 2004-12-20
IL133544A0 (en) 2001-04-30
PT977856E (pt) 2005-01-31
EP0977856A1 (en) 2000-02-09
EP0977856B1 (en) 2004-08-18
WO1998058059A1 (en) 1998-12-23
KR20010013539A (ko) 2001-02-26
NO996097D0 (no) 1999-12-09
CA2293735A1 (en) 1998-12-23
AU8435598A (en) 1999-01-04
CN1181201C (zh) 2004-12-22

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Legal Events

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KB4A Valid patent at the end of a year

Effective date: 20041231

KB4A Valid patent at the end of a year

Effective date: 20051231

KB4A Valid patent at the end of a year

Effective date: 20061231

KB4A Valid patent at the end of a year

Effective date: 20071231

KB4A Valid patent at the end of a year

Effective date: 20081231

MM4A Lapsed by not paying the annual fees

Effective date: 20090603