EA200000038A1 - Сплайсинговые варианты lag-3 - Google Patents
Сплайсинговые варианты lag-3Info
- Publication number
- EA200000038A1 EA200000038A1 EA200000038A EA200000038A EA200000038A1 EA 200000038 A1 EA200000038 A1 EA 200000038A1 EA 200000038 A EA200000038 A EA 200000038A EA 200000038 A EA200000038 A EA 200000038A EA 200000038 A1 EA200000038 A1 EA 200000038A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- lag
- nucleotidic
- seq
- code
- sequences
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Plant Pathology (AREA)
- Toxicology (AREA)
- Cell Biology (AREA)
- Physics & Mathematics (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Mechanical Coupling Of Light Guides (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Branch Pipes, Bends, And The Like (AREA)
- Oscillators With Electromechanical Resonators (AREA)
Abstract
Настоящее изобретение касается выделенных нуклеотидных последовательностей, выбираемых из группы, которая включает: 1) нуклеотидные последовательности SEQ ID NO I, SEQ ID NO 3 и SEQ ID NO 5; 2) нуклеотидные последовательности, которые гибридизуются в жёстких условиях с любой из последовательностей, определённых в п. (1) и которые кодируют полипептид, являющийся вариантом молекулы LAG-3; 3) нуклеотидные последовательности, являющиеся модифицированными в результате вырожденности генетического кода по отношению к нуклеотидным последовательностям, определённым в пп. (1) и (2) у которых кодируют полипептид, являющийся генетическим вариантом молекулы LAG-3.Международная заявка была опубликована вместе с отчетом о международном поиске.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP97401404A EP0900841A1 (en) | 1997-06-18 | 1997-06-18 | LAG-3 splice variants |
| PCT/EP1998/003307 WO1998058059A1 (en) | 1997-06-18 | 1998-06-03 | Lag-3 splice variants |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA200000038A1 true EA200000038A1 (ru) | 2000-06-26 |
| EA003086B1 EA003086B1 (ru) | 2002-12-26 |
Family
ID=8229784
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA200000038A EA003086B1 (ru) | 1997-06-18 | 1998-06-03 | ПОЛИПЕПТИДЫ LAG-3V1, LAG-3V2 И LAG-3V3 И КОДИРУЮЩИЕ ИХ кДНК |
Country Status (18)
| Country | Link |
|---|---|
| EP (2) | EP0900841A1 (ru) |
| JP (1) | JP2002505582A (ru) |
| KR (1) | KR100552526B1 (ru) |
| CN (1) | CN1181201C (ru) |
| AT (1) | ATE274057T1 (ru) |
| AU (1) | AU740147B2 (ru) |
| BR (1) | BR9810925A (ru) |
| CA (1) | CA2293735A1 (ru) |
| DE (1) | DE69825741T2 (ru) |
| DK (1) | DK0977856T3 (ru) |
| EA (1) | EA003086B1 (ru) |
| EE (1) | EE04378B1 (ru) |
| ES (1) | ES2227862T3 (ru) |
| HK (1) | HK1027377A1 (ru) |
| IL (2) | IL133544A0 (ru) |
| NO (1) | NO996097L (ru) |
| PT (1) | PT977856E (ru) |
| WO (1) | WO1998058059A1 (ru) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030100359A1 (en) * | 2000-10-04 | 2003-05-29 | Loose Timothy C. | Audio network for gaming machines |
| EP1295895B1 (en) * | 2001-09-19 | 2011-08-10 | Institut Gustave Roussy | Peptides and proteins binding to glu-pro motifs, therapeutical compositions containing the same and applications thereof |
| SE0103423D0 (sv) * | 2001-10-12 | 2001-10-12 | Astrazeneca Ab | Polymorphism |
| EP2388265A1 (en) * | 2002-02-22 | 2011-11-23 | Genentech, Inc. | Compositions and methods for the treatment of immune related diseases |
| US7367886B2 (en) | 2003-01-16 | 2008-05-06 | Wms Gaming Inc. | Gaming system with surround sound |
| US7867085B2 (en) | 2003-01-16 | 2011-01-11 | Wms Gaming Inc. | Gaming machine environment having controlled audio and visual media presentation |
| US7364508B2 (en) | 2003-01-16 | 2008-04-29 | Wms Gaming, Inc. | Gaming machine environment having controlled audio and visual media presentation |
| US8313374B2 (en) | 2003-02-14 | 2012-11-20 | Wms Gaming Inc. | Gaming machine having improved audio control architecture |
| SI1897548T1 (sl) | 2003-02-28 | 2013-12-31 | The Johns Hopkins University | Regulacija celic T |
| FR2902101B1 (fr) * | 2006-06-12 | 2012-12-28 | Scras | Peptides a activite anti-proliferative |
| WO2008063391A2 (en) | 2006-11-10 | 2008-05-29 | Wms Gaming Inc. | Wagering games using multi-level gaming structure |
| AR072999A1 (es) | 2008-08-11 | 2010-10-06 | Medarex Inc | Anticuerpos humanos que se unen al gen 3 de activacion linfocitaria (lag-3) y los usos de estos |
| UY34887A (es) | 2012-07-02 | 2013-12-31 | Bristol Myers Squibb Company Una Corporacion Del Estado De Delaware | Optimización de anticuerpos que se fijan al gen de activación de linfocitos 3 (lag-3) y sus usos |
| US9412222B2 (en) | 2013-09-20 | 2016-08-09 | Igt | Coordinated gaming machine attract via gaming machine cameras |
| HUE044730T2 (hu) | 2013-09-20 | 2019-11-28 | Bristol Myers Squibb Co | Anti-LAG-3 antitestek és Anti-PD-1 antitestek kombinációja tumorok kezelésére |
| JOP20200094A1 (ar) | 2014-01-24 | 2017-06-16 | Dana Farber Cancer Inst Inc | جزيئات جسم مضاد لـ pd-1 واستخداماتها |
| TWI777174B (zh) | 2014-03-14 | 2022-09-11 | 瑞士商諾華公司 | 針對lag-3之抗體分子及其用途 |
| TWI693232B (zh) | 2014-06-26 | 2020-05-11 | 美商宏觀基因股份有限公司 | 與pd-1和lag-3具有免疫反應性的共價結合的雙抗體和其使用方法 |
| JO3663B1 (ar) | 2014-08-19 | 2020-08-27 | Merck Sharp & Dohme | الأجسام المضادة لمضاد lag3 وأجزاء ربط الأنتيجين |
| TWI773646B (zh) | 2015-06-08 | 2022-08-11 | 美商宏觀基因股份有限公司 | 結合lag-3的分子和其使用方法 |
| PE20231958A1 (es) | 2015-07-30 | 2023-12-06 | Macrogenics Inc | Moleculas de union a pd-1 y metodos de uso de las mismas |
| TWI756187B (zh) | 2015-10-09 | 2022-03-01 | 美商再生元醫藥公司 | 抗ｌａｇ３抗體及其用途 |
| TW202208440A (zh) | 2015-12-14 | 2022-03-01 | 美商宏觀基因股份有限公司 | 對於pd-1和ctla-4具有免疫反應性的雙特異性分子及其使用方法 |
| MX2018007406A (es) | 2015-12-16 | 2018-08-15 | Merck Sharp & Dohme | Anticuerpos anti-lag3 y fragmentos de enlace al antigeno. |
| EA201991673A1 (ru) | 2017-02-10 | 2020-01-17 | Регенерон Фармасьютикалз, Инк. | Меченные радиоактивным изотопом антитела к lag3 для иммуно-пэт-визуализации |
| CN110678200B (zh) | 2017-05-30 | 2024-05-17 | 百时美施贵宝公司 | 包含抗lag-3抗体或抗lag-3抗体和抗pd-1或抗pd-l1抗体的组合物 |
| BR112019020610A2 (pt) | 2017-05-30 | 2020-04-22 | Bristol-Myers Squibb Company | tratamento de tumores positivos para o lag-3 |
| CA3136568A1 (en) | 2019-05-13 | 2020-11-19 | Regeneron Pharmaceuticals, Inc. | Combination of pd-1 inhibitors and lag-3 inhibitors for enhanced efficacy in treating cancer |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0280710B1 (en) * | 1986-08-21 | 1996-03-20 | The Trustees Of Columbia University In The City Of New York | Dna encoding the t cell surface protein t4 and use of fragments of t4 in the treatment of aids |
| FR2656800B1 (fr) * | 1990-01-08 | 1992-05-15 | Roussy Inst Gustave | Nouvelles proteines produits par les lymphocytes humains, sequence d'adn codant pour ces proteines et applications pharmaceutiques et biologiques. |
| EP0758383B1 (fr) * | 1994-05-06 | 2007-01-24 | Institut Gustave Roussy | Fractions polypeptidiques solubles de la proteine lag-3; procede de production; composition therapeutique; anticorps anti-idiotype |
-
1997
- 1997-06-18 EP EP97401404A patent/EP0900841A1/en not_active Withdrawn
-
1998
- 1998-06-03 PT PT98934908T patent/PT977856E/pt unknown
- 1998-06-03 EP EP98934908A patent/EP0977856B1/en not_active Expired - Lifetime
- 1998-06-03 IL IL13354498A patent/IL133544A0/xx active IP Right Grant
- 1998-06-03 CA CA002293735A patent/CA2293735A1/en not_active Abandoned
- 1998-06-03 WO PCT/EP1998/003307 patent/WO1998058059A1/en active IP Right Grant
- 1998-06-03 KR KR1019997011546A patent/KR100552526B1/ko not_active IP Right Cessation
- 1998-06-03 CN CNB988061384A patent/CN1181201C/zh not_active Expired - Fee Related
- 1998-06-03 EE EEP199900581A patent/EE04378B1/xx not_active IP Right Cessation
- 1998-06-03 ES ES98934908T patent/ES2227862T3/es not_active Expired - Lifetime
- 1998-06-03 DK DK98934908T patent/DK0977856T3/da active
- 1998-06-03 DE DE69825741T patent/DE69825741T2/de not_active Expired - Fee Related
- 1998-06-03 JP JP50365799A patent/JP2002505582A/ja not_active Ceased
- 1998-06-03 EA EA200000038A patent/EA003086B1/ru not_active IP Right Cessation
- 1998-06-03 AU AU84355/98A patent/AU740147B2/en not_active Ceased
- 1998-06-03 AT AT98934908T patent/ATE274057T1/de not_active IP Right Cessation
- 1998-06-03 BR BR9810925-1A patent/BR9810925A/pt not_active Application Discontinuation
-
1999
- 1999-12-09 NO NO19996097A patent/NO996097L/no unknown
- 1999-12-16 IL IL133544A patent/IL133544A/en not_active IP Right Cessation
-
2000
- 2000-10-11 HK HK00106456A patent/HK1027377A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EA003086B1 (ru) | 2002-12-26 |
| KR100552526B1 (ko) | 2006-02-14 |
| DE69825741T2 (de) | 2005-09-01 |
| NO996097L (no) | 2000-02-17 |
| ES2227862T3 (es) | 2005-04-01 |
| EP0977856B1 (en) | 2004-08-18 |
| EE9900581A (xx) | 2000-08-15 |
| IL133544A (en) | 2006-12-31 |
| CN1260833A (zh) | 2000-07-19 |
| EP0977856A1 (en) | 2000-02-09 |
| AU8435598A (en) | 1999-01-04 |
| KR20010013539A (ko) | 2001-02-26 |
| NO996097D0 (no) | 1999-12-09 |
| EP0900841A1 (en) | 1999-03-10 |
| EE04378B1 (xx) | 2004-10-15 |
| AU740147B2 (en) | 2001-11-01 |
| PT977856E (pt) | 2005-01-31 |
| DK0977856T3 (da) | 2004-12-20 |
| IL133544A0 (en) | 2001-04-30 |
| ATE274057T1 (de) | 2004-09-15 |
| DE69825741D1 (de) | 2004-09-23 |
| CA2293735A1 (en) | 1998-12-23 |
| JP2002505582A (ja) | 2002-02-19 |
| CN1181201C (zh) | 2004-12-22 |
| HK1027377A1 (en) | 2001-01-12 |
| WO1998058059A1 (en) | 1998-12-23 |
| BR9810925A (pt) | 2000-08-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EA200000038A1 (ru) | Сплайсинговые варианты lag-3 | |
| AU7550098A (en) | System for expressing hyperthermostable protein | |
| CY1110982T1 (el) | Συνθεσεις και μεθοδοι για την αυξηση της ασβεστοποιησεως των οστων | |
| ATE460429T1 (de) | Polypeptide enthaltend extrazellulären domäne von il-20ra und/oderr il-20rb | |
| ATE534742T1 (de) | Polypeptide und nukleinsäuren von phorphorymonas gingivalis | |
| CY1106978T1 (el) | Ενζυμα φωσφοδιεστερασης | |
| NZ508439A (en) | Novel endometriosis-associated gene | |
| DK0870833T3 (da) | Gener for ultrathermostabile proteaser | |
| EP1006126A3 (en) | Osteogenic peptides | |
| DE60015042D1 (de) | Nukleotidsequenzen, welche für das dapF-Gen kodieren | |
| DK0811071T3 (da) | Amplifikeringssekvenser hidrørende fra desmin-genet, vektorer indeholdende disse sekvenser og anvendelse heraf til fremstilling af proteiner | |
| ES2124694T3 (es) | Clonacion de la n-metil-hidantoinasa. | |
| HUP0001969A2 (hu) | Az NNT-1 neurotróf faktor | |
| SE9801098D0 (sv) | Receptors | |
| DE60036676D1 (de) | G-protein-gekoppelter rezeptor-ähnliche proteine | |
| ES2133275T3 (es) | N-carbamoil-sarcosina-amidohidrolasa clonada. | |
| DE69831584D1 (de) | Polypeptide mit wasserkanalaktivität und dna sequenzen | |
| ATE301199T1 (de) | Beta-primeverosidase gen | |
| WO1999060117A3 (fr) | Polypeptide prax-1 | |
| TH14326A (th) | โปรตีเอสและสารประกอบดีเอนเอที่เกี่ยวข้อง | |
| TH19876A (th) | จีนที่ประมวลรหัสและวิธีสำหรับแสดงลักษณะเอนไซม์ชนิดใหม่ |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG MD TJ TM RU |