DK0977856T3 - LAG-3 splejsningsvarianter - Google Patents

LAG-3 splejsningsvarianter

Info

Publication number
DK0977856T3
DK0977856T3 DK98934908T DK98934908T DK0977856T3 DK 0977856 T3 DK0977856 T3 DK 0977856T3 DK 98934908 T DK98934908 T DK 98934908T DK 98934908 T DK98934908 T DK 98934908T DK 0977856 T3 DK0977856 T3 DK 0977856T3
Authority
DK
Denmark
Prior art keywords
lag
nucleotidic
seq
code
sequences
Prior art date
Application number
DK98934908T
Other languages
Danish (da)
English (en)
Inventor
Frederic Triebel
Renato Mastrangeli
Sergio Romagnani
Original Assignee
Inst Nat Sante Rech Med
Roussy Inst Gustave
Applied Research Systems
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inst Nat Sante Rech Med, Roussy Inst Gustave, Applied Research Systems filed Critical Inst Nat Sante Rech Med
Application granted granted Critical
Publication of DK0977856T3 publication Critical patent/DK0977856T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503Immunoglobulin superfamily
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Plant Pathology (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Mechanical Coupling Of Light Guides (AREA)
  • Branch Pipes, Bends, And The Like (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DK98934908T 1997-06-18 1998-06-03 LAG-3 splejsningsvarianter DK0977856T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP97401404A EP0900841A1 (en) 1997-06-18 1997-06-18 LAG-3 splice variants
EP98934908A EP0977856B1 (en) 1997-06-18 1998-06-03 Lag-3 splice variants

Publications (1)

Publication Number Publication Date
DK0977856T3 true DK0977856T3 (da) 2004-12-20

Family

ID=8229784

Family Applications (1)

Application Number Title Priority Date Filing Date
DK98934908T DK0977856T3 (da) 1997-06-18 1998-06-03 LAG-3 splejsningsvarianter

Country Status (18)

Country Link
EP (2) EP0900841A1 (ru)
JP (1) JP2002505582A (ru)
KR (1) KR100552526B1 (ru)
CN (1) CN1181201C (ru)
AT (1) ATE274057T1 (ru)
AU (1) AU740147B2 (ru)
BR (1) BR9810925A (ru)
CA (1) CA2293735A1 (ru)
DE (1) DE69825741T2 (ru)
DK (1) DK0977856T3 (ru)
EA (1) EA003086B1 (ru)
EE (1) EE04378B1 (ru)
ES (1) ES2227862T3 (ru)
HK (1) HK1027377A1 (ru)
IL (2) IL133544A0 (ru)
NO (1) NO996097L (ru)
PT (1) PT977856E (ru)
WO (1) WO1998058059A1 (ru)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030100359A1 (en) * 2000-10-04 2003-05-29 Loose Timothy C. Audio network for gaming machines
EP1295895B1 (en) * 2001-09-19 2011-08-10 Institut Gustave Roussy Peptides and proteins binding to glu-pro motifs, therapeutical compositions containing the same and applications thereof
SE0103423D0 (sv) * 2001-10-12 2001-10-12 Astrazeneca Ab Polymorphism
EP2388265A1 (en) * 2002-02-22 2011-11-23 Genentech, Inc. Compositions and methods for the treatment of immune related diseases
US7867085B2 (en) 2003-01-16 2011-01-11 Wms Gaming Inc. Gaming machine environment having controlled audio and visual media presentation
US7367886B2 (en) 2003-01-16 2008-05-06 Wms Gaming Inc. Gaming system with surround sound
US7364508B2 (en) 2003-01-16 2008-04-29 Wms Gaming, Inc. Gaming machine environment having controlled audio and visual media presentation
US8313374B2 (en) 2003-02-14 2012-11-20 Wms Gaming Inc. Gaming machine having improved audio control architecture
PT1897548E (pt) * 2003-02-28 2013-11-19 Univ Johns Hopkins Regulação de células t
FR2902101B1 (fr) * 2006-06-12 2012-12-28 Scras Peptides a activite anti-proliferative
WO2008063391A2 (en) 2006-11-10 2008-05-29 Wms Gaming Inc. Wagering games using multi-level gaming structure
AR072999A1 (es) 2008-08-11 2010-10-06 Medarex Inc Anticuerpos humanos que se unen al gen 3 de activacion linfocitaria (lag-3) y los usos de estos
AR091649A1 (es) 2012-07-02 2015-02-18 Bristol Myers Squibb Co Optimizacion de anticuerpos que se fijan al gen de activacion de linfocitos 3 (lag-3) y sus usos
HUE062317T2 (hu) 2013-09-20 2023-10-28 Bristol Myers Squibb Co Anti-LAG-3 antitestek és anti-PD-1 antitestek kombinációja tumorok kezeléséhez
US9412222B2 (en) 2013-09-20 2016-08-09 Igt Coordinated gaming machine attract via gaming machine cameras
JOP20200094A1 (ar) 2014-01-24 2017-06-16 Dana Farber Cancer Inst Inc جزيئات جسم مضاد لـ pd-1 واستخداماتها
ES2770684T3 (es) 2014-03-14 2020-07-02 Novartis Ag Moléculas de anticuerpos contra LAG-3 y usos de los mismos
TWI693232B (zh) 2014-06-26 2020-05-11 美商宏觀基因股份有限公司 與pd-1和lag-3具有免疫反應性的共價結合的雙抗體和其使用方法
JO3663B1 (ar) 2014-08-19 2020-08-27 Merck Sharp & Dohme الأجسام المضادة لمضاد lag3 وأجزاء ربط الأنتيجين
TWI773646B (zh) 2015-06-08 2022-08-11 美商宏觀基因股份有限公司 結合lag-3的分子和其使用方法
AU2016298227B9 (en) 2015-07-30 2019-10-31 Macrogenics, Inc. PD-1-binding molecules and methods of use thereof
TWI756187B (zh) 2015-10-09 2022-03-01 美商再生元醫藥公司 抗lag3抗體及其用途
CR20180318A (es) 2015-12-14 2018-09-19 Macrogenics Inc Moléculas biespecíficas que tienen inmunorreactividad con pd-1 y ctla-4, y métodos de uso de las mismas
MX2018007406A (es) 2015-12-16 2018-08-15 Merck Sharp & Dohme Anticuerpos anti-lag3 y fragmentos de enlace al antigeno.
AU2018219909A1 (en) 2017-02-10 2019-09-12 Regeneron Pharmaceuticals, Inc. Radiolabeled anti-LAG3 antibodies for immuno-PET imaging
BR112019021847A2 (pt) 2017-05-30 2020-06-02 Bristol-Myers Squibb Company Composições compreendendo um anticorpo anti-lag-3 ou um anticorpo anti-lag-3 e um anticorpo anti-pd-1 ou anti-pd-l1
KR20200010501A (ko) 2017-05-30 2020-01-30 브리스톨-마이어스 스큅 컴퍼니 Lag-3 양성 종양의 치료
EA202192528A1 (ru) 2019-05-13 2022-01-27 Регенерон Фармасьютикалз, Инк. Комбинация ингибиторов pd-1 и ингибиторов lag-3 для повышения эффективности при лечении рака

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3751751T2 (de) * 1986-08-21 1996-10-17 Univ Columbia Für das t-zell oberflächenprotein t4 kodierende dna und verwendung von t4-fragmenten bei der behandlung von aids
FR2656800B1 (fr) * 1990-01-08 1992-05-15 Roussy Inst Gustave Nouvelles proteines produits par les lymphocytes humains, sequence d'adn codant pour ces proteines et applications pharmaceutiques et biologiques.
MX9605365A (es) * 1994-05-06 1997-12-31 Roussy Inst Gustave Fracciones polipeptidicas solubles de la proteina lag-3; procedimiento de produccion; composicion terapeutica y anticuerpos ant-idiotipo.

Also Published As

Publication number Publication date
EA003086B1 (ru) 2002-12-26
DE69825741D1 (de) 2004-09-23
PT977856E (pt) 2005-01-31
AU8435598A (en) 1999-01-04
CA2293735A1 (en) 1998-12-23
AU740147B2 (en) 2001-11-01
IL133544A0 (en) 2001-04-30
EA200000038A1 (ru) 2000-06-26
BR9810925A (pt) 2000-08-15
CN1181201C (zh) 2004-12-22
EP0900841A1 (en) 1999-03-10
EP0977856B1 (en) 2004-08-18
EE9900581A (xx) 2000-08-15
NO996097D0 (no) 1999-12-09
CN1260833A (zh) 2000-07-19
DE69825741T2 (de) 2005-09-01
IL133544A (en) 2006-12-31
NO996097L (no) 2000-02-17
WO1998058059A1 (en) 1998-12-23
JP2002505582A (ja) 2002-02-19
KR100552526B1 (ko) 2006-02-14
EP0977856A1 (en) 2000-02-09
KR20010013539A (ko) 2001-02-26
EE04378B1 (xx) 2004-10-15
ES2227862T3 (es) 2005-04-01
HK1027377A1 (en) 2001-01-12
ATE274057T1 (de) 2004-09-15

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