EE9800353A - Pürasinoonidest trombiini inhibiitorid - Google Patents
Pürasinoonidest trombiini inhibiitoridInfo
- Publication number
- EE9800353A EE9800353A EE9800353A EE9800353A EE9800353A EE 9800353 A EE9800353 A EE 9800353A EE 9800353 A EE9800353 A EE 9800353A EE 9800353 A EE9800353 A EE 9800353A EE 9800353 A EE9800353 A EE 9800353A
- Authority
- EE
- Estonia
- Prior art keywords
- pyrazinones
- thrombin inhibitors
- thrombin
- inhibitors
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/20—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1604196P | 1996-04-23 | 1996-04-23 | |
| GBGB9609714.2A GB9609714D0 (en) | 1996-05-09 | 1996-05-09 | Pyridinone thrombin inhibitors |
| US4300997P | 1997-04-14 | 1997-04-14 | |
| PCT/US1997/006744 WO1997040024A1 (fr) | 1996-04-23 | 1997-04-18 | Inhibiteurs de thrombine a base de pyrazinone |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EE9800353A true EE9800353A (et) | 1999-04-15 |
Family
ID=27268274
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EE9800353A EE9800353A (et) | 1996-04-23 | 1997-04-18 | Pürasinoonidest trombiini inhibiitorid |
Country Status (21)
| Country | Link |
|---|---|
| EP (1) | EP0900207B1 (fr) |
| JP (1) | JP3140790B2 (fr) |
| KR (1) | KR20000010650A (fr) |
| AT (1) | ATE209191T1 (fr) |
| AU (1) | AU714985B2 (fr) |
| BG (1) | BG102948A (fr) |
| BR (1) | BR9708859A (fr) |
| CA (1) | CA2252964A1 (fr) |
| CZ (1) | CZ340898A3 (fr) |
| DE (1) | DE69709727T2 (fr) |
| EE (1) | EE9800353A (fr) |
| HR (1) | HRP970211A2 (fr) |
| IL (1) | IL126404A0 (fr) |
| IS (1) | IS4853A (fr) |
| NO (1) | NO984928L (fr) |
| NZ (1) | NZ331993A (fr) |
| PE (1) | PE13399A1 (fr) |
| PL (1) | PL329441A1 (fr) |
| SK (1) | SK145398A3 (fr) |
| TR (1) | TR199802133T2 (fr) |
| WO (1) | WO1997040024A1 (fr) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU746024B2 (en) * | 1996-04-23 | 2002-04-11 | Merck & Co., Inc. | Pyrazinone thrombin inhibitors |
| AU4270297A (en) | 1996-09-16 | 1998-04-02 | Du Pont Pharmaceuticals Company | Pyrazinones and triazinones and their derivatives thereof |
| JP2001518932A (ja) * | 1997-03-24 | 2001-10-16 | メルク エンド カンパニー インコーポレーテッド | トロンビン阻害薬 |
| US6011038A (en) * | 1997-09-05 | 2000-01-04 | Merck & Co., Inc. | Pyrazinone thrombin inhibitors |
| JP2002515434A (ja) * | 1998-05-19 | 2002-05-28 | メルク エンド カムパニー インコーポレーテッド | ピラジノン系トロンビン阻害薬 |
| US6147078A (en) * | 1998-05-19 | 2000-11-14 | Merck & Co., Inc. | Pyrazinone thrombin inhibitors |
| AU742178B2 (en) * | 1998-05-26 | 2001-12-20 | Merck & Co., Inc. | Imidazopyridine thrombin inhibitors |
| EP1589029B1 (fr) | 1998-06-11 | 2010-03-17 | Ortho-McNeil Pharmaceuticals, Inc. | Inhibiteurs de protéase à base de pyrazine |
| DK0997474T3 (da) | 1998-08-14 | 2004-02-09 | Pfizer | Antithrombotiske midler |
| AU758237B2 (en) * | 1998-09-28 | 2003-03-20 | Merck & Co., Inc. | Thrombin inhibitors |
| JP2002528542A (ja) | 1998-10-30 | 2002-09-03 | メルク エンド カムパニー インコーポレーテッド | トロンビン阻害剤 |
| CA2348734A1 (fr) | 1998-10-30 | 2000-05-11 | Merck & Co., Inc. | Inhibiteurs de la thrombine |
| WO2000039102A1 (fr) * | 1998-12-23 | 2000-07-06 | Du Pont Pharmaceuticals Company | INHIBITEURS DE LA THROMBINE OU DU FACTEUR Xa |
| AR023510A1 (es) | 1999-04-21 | 2002-09-04 | Astrazeneca Ab | Un equipo de partes, formulacion farmaceutica y uso de un inhibidor de trombina. |
| US7015230B1 (en) | 1999-05-19 | 2006-03-21 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl uracils useful for selective inhibition of the coagulation cascade |
| US6867217B1 (en) | 1999-05-19 | 2005-03-15 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl pyridones useful for selective inhibition of the coagulation cascade |
| AU775229B2 (en) * | 1999-05-19 | 2004-07-22 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl pyrazinones useful for selective inhibition of the coagulation cascade |
| US6458952B1 (en) | 1999-05-19 | 2002-10-01 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl uracils useful for selective inhibition of the coagulation cascade |
| US6716838B1 (en) | 1999-05-19 | 2004-04-06 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl uracils as anticoagulative agents |
| US6653316B1 (en) | 1999-05-19 | 2003-11-25 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl pyrimidinones useful for selective inhibition of the coagulation cascade |
| US6664255B1 (en) | 1999-05-19 | 2003-12-16 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl pyrazinones useful for selective inhibition of the coagulation cascade |
| EP1586565A1 (fr) * | 1999-05-19 | 2005-10-19 | Pharmacia Corporation | Pyrazinones d'hétéroaryle et d'aryle polycyclique substituées utiles à l'inhibition selective de la coagulation en cascade |
| US6750342B1 (en) | 1999-05-19 | 2004-06-15 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl pyrimidinones useful for selective inhibition of the coagulation cascade |
| UA58636C2 (uk) * | 1999-06-04 | 2003-08-15 | Мерк Енд Ко., Інк. | Піразинонові інгібітори тромбіну, фармацевтична композиція, спосіб інгібування утворення тромбів у крові, спосіб лікування станів, пов'язаних із тромбоутворенням |
| WO2001005772A1 (fr) | 1999-07-19 | 2001-01-25 | Merck Frosst Canada & Co. | Pyrazinones, compositions contenant ces composes |
| AU2044401A (en) * | 1999-11-23 | 2001-06-04 | Merck & Co., Inc. | Pyrazinone thrombin inhibitors |
| US6852761B2 (en) | 2000-03-13 | 2005-02-08 | Pharmacia Corporation | Polycyclic aryl and heteroaryl substituted benzenes useful for selective inhibition of the coagulation cascade |
| JP2003527426A (ja) | 2000-03-23 | 2003-09-16 | メルク エンド カムパニー インコーポレーテッド | トロンビン阻害薬 |
| WO2001077079A2 (fr) | 2000-04-05 | 2001-10-18 | Pharmacia Corporation | Pyridones polycycliques 4-aryl et heteroaryl substituees utiles pour l'inhibition selective de la cascade de coagulation |
| US6875791B2 (en) | 2000-04-05 | 2005-04-05 | Pharmacia Corporation | Polycyclic aryl and heteroaryl substituted 4-pyrones useful for selective inhibition of the coagulation cascade |
| WO2001079193A2 (fr) * | 2000-04-14 | 2001-10-25 | Corvas International, Inc. | Inhibiteurs heteroaromatiques hydrazinyl-substitues de la thrombine |
| US6506761B1 (en) | 2000-04-14 | 2003-01-14 | Corvas International, Inc. | Substituted hydrazinyl heteroaromatic inhibitors of thrombin |
| US6506760B1 (en) | 2000-04-14 | 2003-01-14 | Corvas International, Inc. | Substituted hydrazinyl heteroaromatic inhibitors of thrombin |
| AU2001253363A1 (en) | 2000-04-17 | 2001-10-30 | Pharmacia Corporation | Polycyclic aryl and heteroaryl substituted 1,4-quinones useful for selective inhibition of the coagulation cascade |
| JP2004504305A (ja) * | 2000-07-17 | 2004-02-12 | ３−ディメンショナル ファーマシューティカルズ， インコーポレイテッド | プロテアーゼインヒビターとしての環状オキシグアニジンピラジノン |
| US6710058B2 (en) | 2000-11-06 | 2004-03-23 | Bristol-Myers Squibb Pharma Company | Monocyclic or bicyclic carbocycles and heterocycles as factor Xa inhibitors |
| US7119094B1 (en) | 2000-11-20 | 2006-10-10 | Warner-Lambert Company | Substituted polycyclic aryl and heteroarpyl pyrazinones useful for selective inhibition of the coagulation cascade |
| US7015223B1 (en) | 2000-11-20 | 2006-03-21 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl 1,2,4-triazinones useful for selective inhibition of the coagulation cascade |
| WO2002042272A2 (fr) | 2000-11-20 | 2002-05-30 | Pharmacia Corporation | Aryl-et-heteroaryl-pyridines polycycliques substituees utiles dans l'inhibition selective de la cascade de la coagulation |
| MXPA04003170A (es) | 2001-10-03 | 2004-07-08 | Pharmacia Corp | Compuestos policiclicos, sustituidos, provisto de 5 miembros, utiles para la inhibicion selectiva de la cascada de coagulacion. |
| JP2005519866A (ja) | 2001-10-03 | 2005-07-07 | ファルマシア・コーポレーション | 凝固カスケードの選択阻害に有用な６員複素環式化合物 |
| GEP20063937B (en) | 2002-02-14 | 2006-10-10 | Pharmacia Corp | Substituted pyridinones as modulators of p38 map kinase |
| GB0306615D0 (en) * | 2003-03-22 | 2003-04-30 | Astrazeneca Ab | New use |
| EP1526131A1 (fr) * | 2003-10-22 | 2005-04-27 | Graffinity Pharmaceuticals Aktiengesellschaft | Aminoalkyl-pyrazinones et -pyridones et leur utilisation comme inhibiteurs de la thrombine |
| GB0507577D0 (en) | 2005-04-14 | 2005-05-18 | Novartis Ag | Organic compounds |
| UY29600A1 (es) * | 2005-06-17 | 2007-01-31 | Astrazeneca Ab | Nuevos heterociclos como inhibidores de trombina, composiciones farmacéuticas que los contienen, procedimientos para su preparación y aplicaciones |
| WO2017067670A1 (fr) | 2015-10-23 | 2017-04-27 | Pharmathen S.A. | Nouveau procédé de préparation de tryptamines et de leurs dérivés |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4795486A (en) * | 1986-09-26 | 1989-01-03 | Boehner Beat | Aminopyrazinones and aminotriazinones |
-
1997
- 1997-04-18 WO PCT/US1997/006744 patent/WO1997040024A1/fr not_active Application Discontinuation
- 1997-04-18 SK SK1453-98A patent/SK145398A3/sk unknown
- 1997-04-18 CZ CZ983408A patent/CZ340898A3/cs unknown
- 1997-04-18 EE EE9800353A patent/EE9800353A/xx unknown
- 1997-04-18 JP JP09538296A patent/JP3140790B2/ja not_active Expired - Fee Related
- 1997-04-18 TR TR1998/02133T patent/TR199802133T2/xx unknown
- 1997-04-18 NZ NZ331993A patent/NZ331993A/xx unknown
- 1997-04-18 CA CA002252964A patent/CA2252964A1/fr not_active Abandoned
- 1997-04-18 IL IL12640497A patent/IL126404A0/xx unknown
- 1997-04-18 DE DE69709727T patent/DE69709727T2/de not_active Expired - Fee Related
- 1997-04-18 AT AT97918780T patent/ATE209191T1/de active
- 1997-04-18 BR BR9708859A patent/BR9708859A/pt not_active Application Discontinuation
- 1997-04-18 PL PL97329441A patent/PL329441A1/xx unknown
- 1997-04-18 EP EP97918780A patent/EP0900207B1/fr not_active Expired - Lifetime
- 1997-04-18 KR KR1019980708609A patent/KR20000010650A/ko not_active Application Discontinuation
- 1997-04-18 AU AU26799/97A patent/AU714985B2/en not_active Ceased
- 1997-04-21 HR HR60/043,009A patent/HRP970211A2/xx not_active Application Discontinuation
- 1997-04-23 PE PE1997000308A patent/PE13399A1/es not_active Application Discontinuation
-
1998
- 1998-09-25 IS IS4853A patent/IS4853A/is unknown
- 1998-10-22 NO NO984928A patent/NO984928L/no unknown
- 1998-11-23 BG BG102948A patent/BG102948A/bg unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NO984928L (no) | 1998-12-22 |
| EP0900207A1 (fr) | 1999-03-10 |
| NZ331993A (en) | 2000-04-28 |
| KR20000010650A (ko) | 2000-02-25 |
| AU2679997A (en) | 1997-11-12 |
| DE69709727D1 (de) | 2002-02-21 |
| CA2252964A1 (fr) | 1997-10-30 |
| IL126404A0 (en) | 1999-05-09 |
| EP0900207B1 (fr) | 2001-11-21 |
| DE69709727T2 (de) | 2002-08-08 |
| SK145398A3 (en) | 1999-05-07 |
| BG102948A (bg) | 1999-11-30 |
| HRP970211A2 (en) | 1998-06-30 |
| JP3140790B2 (ja) | 2001-03-05 |
| JP2000508334A (ja) | 2000-07-04 |
| PE13399A1 (es) | 1999-02-11 |
| ATE209191T1 (de) | 2001-12-15 |
| NO984928D0 (no) | 1998-10-22 |
| AU714985B2 (en) | 2000-01-13 |
| IS4853A (is) | 1998-09-25 |
| WO1997040024A1 (fr) | 1997-10-30 |
| PL329441A1 (en) | 1999-03-29 |
| TR199802133T2 (xx) | 2000-09-21 |
| CZ340898A3 (cs) | 1999-02-17 |
| BR9708859A (pt) | 1999-08-03 |
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