US5977144A
(en)
*
|
1992-08-31 |
1999-11-02 |
University Of Florida |
Methods of use and compositions for benzylidene- and cinnamylidene-anabaseines
|
US7214686B2
(en)
|
1997-06-30 |
2007-05-08 |
Targacept, Inc. |
Pharmaceutical compositions and methods for effecting dopamine release
|
US6632823B1
(en)
*
|
1997-12-22 |
2003-10-14 |
Merck & Co., Inc. |
Substituted pyridine compounds useful as modulators of acetylcholine receptors
|
US6277870B1
(en)
*
|
1998-05-04 |
2001-08-21 |
Astra Ab |
Use
|
FR2804430B1
(fr)
*
|
2000-01-28 |
2002-03-22 |
Sanofi Synthelabo |
Derives de 4-heteroaryl-1,4-diazabicyclo[3.2.2] nonane, leur preparation et leur application en therapeutique
|
GB0010955D0
(en)
|
2000-05-05 |
2000-06-28 |
Novartis Ag |
Organic compounds
|
US8914114B2
(en)
|
2000-05-23 |
2014-12-16 |
The Feinstein Institute For Medical Research |
Inhibition of inflammatory cytokine production by cholinergic agonists and vagus nerve stimulation
|
US6492385B2
(en)
|
2000-08-18 |
2002-12-10 |
Pharmacia & Upjohn Company |
Quinuclidine-substituted heteroaryl moieties for treatment of disease
|
WO2002016357A2
(en)
*
|
2000-08-18 |
2002-02-28 |
Pharmacia & Upjohn Company |
Quinuclidine-substituted aryl moieties for treatment of disease (nicotinic acetylcholine receptor ligands)
|
AU2001284645A1
(en)
*
|
2000-08-18 |
2002-03-04 |
Pharmacia And Upjohn Company |
Quinuclidine-substituted aryl compounds for treatment of disease
|
US6479510B2
(en)
|
2000-08-18 |
2002-11-12 |
Pharmacia & Upjohn Company |
Quinuclidine-substituted aryl compounds for treatment of disease
|
US6599916B2
(en)
|
2000-08-21 |
2003-07-29 |
Pharmacia & Upjohn Company |
Quinuclidine-substituted heteroaryl moieties for treatment of disease
|
WO2002017358A2
(en)
*
|
2000-08-21 |
2002-02-28 |
Pharmacia & Upjohn Company |
Quinuclidine-substituted heteroaryl moieties for treatment of disease (nicotinic acetylcholine receptor antagonists)
|
AU2001282910A1
(en)
*
|
2000-08-21 |
2002-03-04 |
Pharmacia And Upjohn Company |
Quinuclidine-substituted heteroaryl moieties for treatment of disease (nicotinic) acetylcholine receptor ligands
|
PE20021019A1
(es)
|
2001-04-19 |
2002-11-13 |
Upjohn Co |
Grupos azabiciclicos sustituidos
|
AR036040A1
(es)
|
2001-06-12 |
2004-08-04 |
Upjohn Co |
Compuestos de heteroarilo multiciclicos sustituidos con quinuclidinas y composiciones farmaceuticas que los contienen
|
AR036041A1
(es)
*
|
2001-06-12 |
2004-08-04 |
Upjohn Co |
Compuestos aromaticos heterociclicos sustituidos con quinuclidina y composiciones farmaceuticas que los contienen
|
EP1419162A1
(en)
*
|
2001-08-24 |
2004-05-19 |
Pharmacia & Upjohn Company |
Substituted-aryl 7-aza 2.2.1]bicycloheptanes for the treatment of disease
|
CA2458375A1
(en)
|
2001-08-24 |
2003-03-06 |
Pharmacia & Upjohn Company |
Substituted-heteroaryl-7-aza¬2.2.1|bicycloheptanes for the treatment of disease
|
US20030105089A1
(en)
*
|
2001-09-12 |
2003-06-05 |
Wishka Donn G. |
Substituted 7-aza[2.2.1]bicycloheptanes for the treatment of disease
|
GEP20063814B
(en)
*
|
2001-10-02 |
2006-05-10 |
Upjohn Co |
Azabicyclic-Substituted Fused-Heteroaryl Compounds for Treatment of DiseaseAzabicyclic-Substituted Fused-Heteroaryl Compounds for Treatment of Disease
|
US6849620B2
(en)
|
2001-10-26 |
2005-02-01 |
Pfizer Inc |
N-(azabicyclo moieties)-substituted hetero-bicyclic aromatic compounds for the treatment of disease
|
US6919359B2
(en)
|
2001-11-08 |
2005-07-19 |
Pfizer Inc |
Azabicyclic-substituted-heteroaryl compounds for the treatment of disease
|
JP2005510523A
(ja)
*
|
2001-11-09 |
2005-04-21 |
ファルマシア アンド アップジョン カンパニー リミティド ライアビリティー カンパニー |
アザ二環式フェニル縮合複素環式化合物、及びα7NACHRリガンドとしての当該化合物の使用
|
BR0214929A
(pt)
|
2001-12-14 |
2006-05-30 |
Targacept Inc |
métodos e composições para o tratamento de distúrbios do sistema nervoso central
|
DE10164139A1
(de)
|
2001-12-27 |
2003-07-10 |
Bayer Ag |
2-Heteroarylcarbonsäureamide
|
BR0307714A
(pt)
|
2002-02-15 |
2005-02-09 |
Upjohn Co |
Benzoilamidas substituìdas com azabiciclo e tioamidas para tratamento de distúrbios relacionados ao cns
|
US6894042B2
(en)
*
|
2002-02-19 |
2005-05-17 |
Pharmacia & Upjohn Company |
Azabicyclic compounds for the treatment of disease
|
US6858613B2
(en)
*
|
2002-02-19 |
2005-02-22 |
Pfizer Inc. |
Fused bicyclic-N-bridged-heteroaromatic carboxamides for the treatment of disease
|
US7001900B2
(en)
*
|
2002-02-20 |
2006-02-21 |
Pfizer Inc. |
Azabicyclic compounds for the treatment of disease
|
DE10211415A1
(de)
*
|
2002-03-15 |
2003-09-25 |
Bayer Ag |
Bicyclische N-Biarylamide
|
DE10211416A1
(de)
*
|
2002-03-15 |
2003-09-25 |
Bayer Ag |
Essig- und Propionsäureamide
|
EP1542999A1
(en)
|
2002-08-01 |
2005-06-22 |
Pharmacia & Upjohn Company LLC |
1h-pyrazole and 1h-pyrrole-azabicyclic compounds with alfa-7 nachr activity
|
EP2298759A1
(en)
|
2002-08-30 |
2011-03-23 |
Memory Pharmaceuticals Corporation |
Anabaseine derivatives useful in the treatment of neurodegenerative diseases
|
GB0220581D0
(en)
|
2002-09-04 |
2002-10-09 |
Novartis Ag |
Organic Compound
|
US7429664B2
(en)
|
2002-09-25 |
2008-09-30 |
Memory Pharmaceuticals Corporation |
Indazoles, benzothiazoles, and benzoisothiazoles, and preparation and uses thereof
|
AU2003269401A1
(en)
*
|
2002-11-01 |
2004-05-25 |
Pharmacia & Upjohn Company Llc |
Compounds having both alpha7 nachr agonist and 5ht antagonist activity for treatment of cns diseases
|
PT1949901E
(pt)
*
|
2002-12-06 |
2014-05-23 |
The Feinstein Inst Medical Res |
Método para a determinação de um agonista colinérgico selectivo para um receptor nicotínico alfa 7
|
US7238715B2
(en)
|
2002-12-06 |
2007-07-03 |
The Feinstein Institute For Medical Research |
Treatment of pancreatitis using alpha 7 receptor-binding cholinergic agonists
|
MXPA05010496A
(es)
*
|
2003-03-28 |
2005-11-16 |
Pharmacia & Upjohn Co Llc |
Moduladores alostericos positivos del receptor de acetilcolina nicotinico.
|
GB0310867D0
(en)
|
2003-05-12 |
2003-06-18 |
Novartis Ag |
Organic compounds
|
DE10334724A1
(de)
|
2003-07-30 |
2005-02-24 |
Bayer Healthcare Ag |
N-Biarylamide
|
PL1678172T3
(pl)
|
2003-10-15 |
2010-05-31 |
Targacept Inc |
Związki azabicykliczne do łagodzenia bólu oraz leczenia zaburzeń centralnego układu nerwowego
|
NZ548228A
(en)
|
2003-12-22 |
2009-04-30 |
Memory Pharm Corp |
Indoles, 1H-indazoles, 1,2-benzisoxazoles, and 1,2-benzisothiazoles, and preparation and uses thereof
|
US20050137217A1
(en)
*
|
2003-12-22 |
2005-06-23 |
Jianguo Ji |
Spirocyclic quinuclidinic ether derivatives
|
US10912712B2
(en)
|
2004-03-25 |
2021-02-09 |
The Feinstein Institutes For Medical Research |
Treatment of bleeding by non-invasive stimulation
|
BRPI0508771A
(pt)
|
2004-03-25 |
2007-08-14 |
Memory Pharm Corp |
indazóis, benzotiazóis, benzoisotiazóis, benzisoxazóis, e a preparação e usos dos mesmos
|
DE602005024677D1
(de)
|
2004-04-22 |
2010-12-23 |
Memory Pharm Corp |
Indole, 1h-indazole, 1,2-benzisoxazole, 1,2-benzoisothiazole, deren herstellung und verwendungen
|
KR20070015607A
(ko)
|
2004-05-07 |
2007-02-05 |
메모리 파마슈티칼스 코포레이션 |
1h-인다졸, 벤조티아졸, 1,2-벤조이속사졸,1,2-벤조이소티아졸, 및 크로몬 및 그의 제조법 및 용도
|
PE20060437A1
(es)
|
2004-06-18 |
2006-06-08 |
Novartis Ag |
COMPUESTOS AZA-BICICLONONANOS COMO LIGANDOS COLINERGICOS DE nAChR
|
GB0415746D0
(en)
|
2004-07-14 |
2004-08-18 |
Novartis Ag |
Organic compounds
|
GB0424564D0
(en)
*
|
2004-11-05 |
2004-12-08 |
Novartis Ag |
Organic compounds
|
ATE455776T1
(de)
|
2004-12-22 |
2010-02-15 |
Memory Pharm Corp |
Nikotinische alpha-7-rezeptorliganden gegen erkrankungen des zns
|
CA2593079C
(en)
|
2004-12-27 |
2014-08-19 |
North Shore-Long Island Jewish Research Institute |
Treating inflammatory disorders by electrical vagus nerve stimulation
|
US11207518B2
(en)
|
2004-12-27 |
2021-12-28 |
The Feinstein Institutes For Medical Research |
Treating inflammatory disorders by stimulation of the cholinergic anti-inflammatory pathway
|
AU2006283453A1
(en)
|
2005-08-22 |
2007-03-01 |
Targacept, Inc. |
Heteroaryl-substituted diazatricycloalkanes, methods for its preparation and use thereof
|
US8106066B2
(en)
|
2005-09-23 |
2012-01-31 |
Memory Pharmaceuticals Corporation |
Indazoles, benzothiazoles, benzoisothiazoles, benzisoxazoles, pyrazolopyridines, isothiazolopyridines, and preparation and uses thereof
|
GB0521508D0
(en)
|
2005-10-21 |
2005-11-30 |
Novartis Ag |
Organic compounds
|
US8316104B2
(en)
|
2005-11-15 |
2012-11-20 |
California Institute Of Technology |
Method and apparatus for collaborative system
|
GB0525672D0
(en)
|
2005-12-16 |
2006-01-25 |
Novartis Ag |
Organic compounds
|
GB0525673D0
(en)
|
2005-12-16 |
2006-01-25 |
Novartis Ag |
Organic compounds
|
TWI404532B
(zh)
*
|
2006-11-02 |
2013-08-11 |
Targacept Inc |
菸鹼乙醯膽鹼受體亞型選擇性之二氮雜雙環烷類醯胺
|
TW200901974A
(en)
|
2007-01-16 |
2009-01-16 |
Wyeth Corp |
Compounds, compositions, and methods of making and using them
|
EP2119716A4
(en)
*
|
2007-02-09 |
2011-06-01 |
Astellas Pharma Inc |
AZA BRIDGE CYCLE COMPOUND
|
WO2009013535A1
(en)
*
|
2007-07-23 |
2009-01-29 |
Astrazeneca Ab |
2-azabicyclo(2.2.2)octane derivatives as modulators of the glycine transporter i receptor
|
SA08290475B1
(ar)
|
2007-08-02 |
2013-06-22 |
Targacept Inc |
(2s، 3r)-n-(2-((3-بيردينيل)ميثيل)-1-آزا بيسيكلو[2، 2، 2]أوكت-3-يل)بنزو فيوران-2-كربوكساميد، وصور أملاحه الجديدة وطرق استخدامه
|
WO2009029614A1
(en)
|
2007-08-27 |
2009-03-05 |
The Feinstein Institute For Medical Research |
Devices and methods for inhibiting granulocyte activation by neural stimulation
|
CN101883771A
(zh)
|
2007-10-01 |
2010-11-10 |
科门蒂斯公司 |
作为α7-烟碱乙酰胆碱受体配体用于治疗阿尔茨海默氏病的奎宁环-4-基甲基1H-吲哚-3-甲酸酯衍生物
|
BRPI0907570A2
(pt)
|
2008-02-13 |
2019-09-24 |
Targacept Inc |
agonistas alfa7 nicotínico e antipsicóticos
|
WO2009146030A1
(en)
|
2008-03-31 |
2009-12-03 |
The Feinstein Institute For Medical Research |
Methods and systems for reducing inflammation by neuromodulation of t-cell activity
|
US9662490B2
(en)
|
2008-03-31 |
2017-05-30 |
The Feinstein Institute For Medical Research |
Methods and systems for reducing inflammation by neuromodulation and administration of an anti-inflammatory drug
|
ME01516B
(me)
|
2008-06-20 |
2014-04-20 |
Astrazeneca Ab |
DERIVAT DIBENZOTIAZEPINA l NJEGOVA UPOTREBA
|
CN102215909B
(zh)
|
2008-11-18 |
2014-09-10 |
赛博恩特医疗器械公司 |
优化用于消炎刺激的电极放置的装置和方法
|
TW201031664A
(en)
|
2009-01-26 |
2010-09-01 |
Targacept Inc |
Preparation and therapeutic applications of (2S,3R)-N-2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)-3,5-difluorobenzamide
|
JP2012516326A
(ja)
*
|
2009-01-28 |
2012-07-19 |
アストラゼネカ・アクチエボラーグ |
2−アザ−ビシクロ[2.2.1]ヘプタン化合物及びそれらの使用
|
US8996116B2
(en)
|
2009-10-30 |
2015-03-31 |
Setpoint Medical Corporation |
Modulation of the cholinergic anti-inflammatory pathway to treat pain or addiction
|
US9211410B2
(en)
|
2009-05-01 |
2015-12-15 |
Setpoint Medical Corporation |
Extremely low duty-cycle activation of the cholinergic anti-inflammatory pathway to treat chronic inflammation
|
WO2010144578A2
(en)
|
2009-06-09 |
2010-12-16 |
Setpoint Medical Corporation |
Nerve cuff with pocket for leadless stimulator
|
FR2948368B1
(fr)
*
|
2009-07-21 |
2011-07-22 |
Servier Lab |
Nouveaux composes piperidiniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
|
US11051744B2
(en)
|
2009-11-17 |
2021-07-06 |
Setpoint Medical Corporation |
Closed-loop vagus nerve stimulation
|
US9833621B2
(en)
|
2011-09-23 |
2017-12-05 |
Setpoint Medical Corporation |
Modulation of sirtuins by vagus nerve stimulation
|
EP3636314B1
(en)
|
2009-12-23 |
2021-09-08 |
Setpoint Medical Corporation |
Neural stimulation devices and systems for treatment of chronic inflammation
|
SI3029039T1
(en)
|
2010-05-17 |
2018-04-30 |
Forum Pharmaceuticals Inc. |
Pharmaceutical formulations containing crystalline forms of (R) -7-chloro-N- (quinuclidin-3-yl) benzo (b) thiophene-2-carboxamide hydrochloride monohydrate
|
BR112013003847A8
(pt)
|
2010-08-19 |
2017-12-26 |
Buck Institute For Age Res |
métodos de tratar a deterioração cognitiva moderada (mci) e os distúrbios relacionados
|
CN103619405B
(zh)
|
2011-05-09 |
2015-11-25 |
赛博恩特医疗器械公司 |
用于治疗慢性炎症的胆碱能抗炎通路的单个脉冲激活
|
GB201111705D0
(en)
|
2011-07-07 |
2011-08-24 |
Takeda Pharmaceutical |
Compounds and their use
|
GB201111704D0
(en)
|
2011-07-07 |
2011-08-24 |
Takeda Pharmaceutical |
Novel compounds
|
JO3115B1
(ar)
|
2011-08-22 |
2017-09-20 |
Takeda Pharmaceuticals Co |
مركبات بيريدازينون واستخدامها كمثبطات daao
|
US9572983B2
(en)
|
2012-03-26 |
2017-02-21 |
Setpoint Medical Corporation |
Devices and methods for modulation of bone erosion
|
WO2013169646A1
(en)
|
2012-05-08 |
2013-11-14 |
Envivo Pharmaceuticals, Inc. |
Methods of maintaining, treating or improving cognitive function
|
GB201209587D0
(en)
|
2012-05-30 |
2012-07-11 |
Takeda Pharmaceutical |
Therapeutic compounds
|
MA37975B2
(fr)
*
|
2012-09-11 |
2021-03-31 |
Genzyme Corp |
Inhibiteurs de synthase de glucosylcéramide
|
WO2014122474A1
(en)
|
2013-02-07 |
2014-08-14 |
Takeda Pharmaceutical Company Limited |
Piperidin-1 -yl and azepin-1 -yl carboxylates as muscarinic m4 receptor agonists
|
EP2970251B1
(en)
|
2013-03-15 |
2019-02-27 |
Genzyme Corporation |
Method of preparing glucosylceramide synthase inhibitors
|
CN105324372B
(zh)
|
2013-06-21 |
2018-03-06 |
武田药品工业株式会社 |
作为前动力蛋白受体调节剂的1‑磺酰基哌啶衍生物
|
GB201314286D0
(en)
|
2013-08-08 |
2013-09-25 |
Takeda Pharmaceutical |
Therapeutic Compounds
|
GB201318222D0
(en)
|
2013-10-15 |
2013-11-27 |
Takeda Pharmaceutical |
Novel compounds
|
GB201320905D0
(en)
|
2013-11-27 |
2014-01-08 |
Takeda Pharmaceutical |
Therapeutic compounds
|
TW201613864A
(en)
|
2014-02-20 |
2016-04-16 |
Takeda Pharmaceutical |
Novel compounds
|
US9434724B2
(en)
|
2014-07-11 |
2016-09-06 |
Alpharmagen, Llc |
Quinuclidines for modulating alpha 7 activity
|
US11311725B2
(en)
|
2014-10-24 |
2022-04-26 |
Setpoint Medical Corporation |
Systems and methods for stimulating and/or monitoring loci in the brain to treat inflammation and to enhance vagus nerve stimulation
|
US11406833B2
(en)
|
2015-02-03 |
2022-08-09 |
Setpoint Medical Corporation |
Apparatus and method for reminding, prompting, or alerting a patient with an implanted stimulator
|
US9724340B2
(en)
|
2015-07-31 |
2017-08-08 |
Attenua, Inc. |
Antitussive compositions and methods
|
US10596367B2
(en)
|
2016-01-13 |
2020-03-24 |
Setpoint Medical Corporation |
Systems and methods for establishing a nerve block
|
US10314501B2
(en)
|
2016-01-20 |
2019-06-11 |
Setpoint Medical Corporation |
Implantable microstimulators and inductive charging systems
|
US11471681B2
(en)
|
2016-01-20 |
2022-10-18 |
Setpoint Medical Corporation |
Batteryless implantable microstimulators
|
WO2017127756A1
(en)
|
2016-01-20 |
2017-07-27 |
Setpoint Medical Corporation |
Control of vagal stimulation
|
US10583304B2
(en)
|
2016-01-25 |
2020-03-10 |
Setpoint Medical Corporation |
Implantable neurostimulator having power control and thermal regulation and methods of use
|
GB201616839D0
(en)
|
2016-10-04 |
2016-11-16 |
Takeda Pharmaceutical Company Limited |
Therapeutic compounds
|
GB201619514D0
(en)
|
2016-11-18 |
2017-01-04 |
Takeda Pharmaceuticals Co |
Novel compounds
|
DE102017210141A1
(de)
|
2017-06-16 |
2018-12-20 |
Henkel Ag & Co. Kgaa |
Portion zur Bereitstellung tensidhaltiger Flotten
|
US11173307B2
(en)
|
2017-08-14 |
2021-11-16 |
Setpoint Medical Corporation |
Vagus nerve stimulation pre-screening test
|
US11660443B2
(en)
|
2018-04-20 |
2023-05-30 |
The Feinstein Institutes For Medical Research |
Methods and apparatuses for reducing bleeding via electrical trigeminal nerve stimulation
|
US11260229B2
(en)
|
2018-09-25 |
2022-03-01 |
The Feinstein Institutes For Medical Research |
Methods and apparatuses for reducing bleeding via coordinated trigeminal and vagal nerve stimulation
|
WO2021096241A1
(en)
*
|
2019-11-15 |
2021-05-20 |
Yuhan Corporation |
Novel compounds having inhibitory activity against glucosylceramide synthase or pharmaceutically acceptable salt thereof, processes for preparing the same, and pharmaceutical compositions comprising the same
|
KR20210059632A
(ko)
*
|
2019-11-15 |
2021-05-25 |
주식회사유한양행 |
신규의 2,3-다이하이드로-1h-인덴 또는 2,3-다이하이드로벤조퓨란 모이어티를 갖는 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법, 및 이를 포함하는 약학 조성물
|
AU2021215396A1
(en)
|
2020-02-03 |
2022-09-29 |
Genzyme Corporation |
Methods for treating neurological symptoms associated with lysosomal storage diseases
|
JP2021138648A
(ja)
|
2020-03-04 |
2021-09-16 |
武田薬品工業株式会社 |
経口固形製剤
|
JP2023526080A
(ja)
|
2020-05-21 |
2023-06-20 |
ザ・フェインステイン・インスティチュート・フォー・メディカル・リサーチ |
迷走神経刺激のためのシステムおよび方法
|
US11857512B2
(en)
|
2020-07-24 |
2024-01-02 |
Genzyme Corporation |
Pharmaceutical compositions comprising venglustat
|
IL306116A
(en)
*
|
2021-05-11 |
2023-11-01 |
Yuhan Corp |
New compounds with inhibitory activity against glucosylceramide synthase or an acceptable pharmaceutical salt thereof, processes for their preparation and pharmaceutical preparations containing them
|
WO2024090919A1
(en)
*
|
2022-10-24 |
2024-05-02 |
Yuhan Corporation |
Improved processes for preparing dimethyl-2,3-dihydro-1h-indene derivatives
|
WO2024090917A1
(en)
*
|
2022-10-24 |
2024-05-02 |
Yuhan Corporation |
Novel salt of dimethyl-2,3-dihydro-1h-indene derivative and processes for preparing the same
|