EE200200225A - L-pantolaktoon-hüdrolaas ja meetod D-pantolaktooni saamiseks - Google Patents

L-pantolaktoon-hüdrolaas ja meetod D-pantolaktooni saamiseks

Info

Publication number
EE200200225A
EE200200225A EEP200200225A EEP200200225A EE200200225A EE 200200225 A EE200200225 A EE 200200225A EE P200200225 A EEP200200225 A EE P200200225A EE P200200225 A EEP200200225 A EE P200200225A EE 200200225 A EE200200225 A EE 200200225A
Authority
EE
Estonia
Prior art keywords
pantolactone
producing
hydrolase
pantolactone hydrolase
Prior art date
Application number
EEP200200225A
Other languages
English (en)
Inventor
Kesseler Maria
Hauer Bernhard
Friedrich Thomas
Mattes Ralf
Original Assignee
Basf Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19952501A external-priority patent/DE19952501A1/de
Priority claimed from DE10029194A external-priority patent/DE10029194A1/de
Application filed by Basf Aktiengesellschaft filed Critical Basf Aktiengesellschaft
Publication of EE200200225A publication Critical patent/EE200200225A/et

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/04—Oxygen as only ring hetero atoms containing a five-membered hetero ring, e.g. griseofulvin, vitamin C
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18—Carboxylic ester hydrolases (3.1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
    • C12P41/005—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of carboxylic acid groups in the enantiomers or the inverse reaction

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
EEP200200225A 1999-10-29 2000-10-20 L-pantolaktoon-hüdrolaas ja meetod D-pantolaktooni saamiseks EE200200225A (et)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19952501A DE19952501A1 (de) 1999-10-29 1999-10-29 L-Pantolacton-Hydrolase und ein Verfahren zur Herstellung von D-Pantolacton
DE10029194A DE10029194A1 (de) 2000-06-19 2000-06-19 L-Pantolacton-Hydrolase und ein Verfahren zur Herstellung von D-Pantolacton
PCT/EP2000/010320 WO2001032890A1 (de) 1999-10-29 2000-10-20 L-pantolacton-hydrolase und ein verfahren zur herstellung von d-pantolacton

Publications (1)

Publication Number Publication Date
EE200200225A true EE200200225A (et) 2003-06-16

Family

ID=26006072

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP200200225A EE200200225A (et) 1999-10-29 2000-10-20 L-pantolaktoon-hüdrolaas ja meetod D-pantolaktooni saamiseks

Country Status (17)

Country Link
US (1) US6998258B1 (et)
EP (1) EP1224296A1 (et)
JP (1) JP2003530080A (et)
KR (1) KR20020043254A (et)
CN (1) CN1384880A (et)
AU (1) AU782517B2 (et)
BR (1) BR0015114A (et)
CA (1) CA2389064A1 (et)
CZ (1) CZ20021449A3 (et)
EE (1) EE200200225A (et)
HU (1) HUP0203704A3 (et)
IL (1) IL148973A0 (et)
MX (1) MXPA02003417A (et)
NO (1) NO20021931L (et)
PL (1) PL355487A1 (et)
RU (1) RU2002114044A (et)
WO (1) WO2001032890A1 (et)

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US20030194798A1 (en) * 2001-05-24 2003-10-16 Surber Mark W. Minicell compositions and methods
EP1570060B1 (de) 2002-12-02 2007-08-01 Basf Aktiengesellschaft L-rhamnose-induzierbare expressionssysteme
GB2413329B (en) * 2003-03-28 2007-09-19 Dsm Ip Assets Bv Novel Enzymes
DE112007001179T5 (de) * 2006-05-16 2009-04-02 Dsm Ip Assets B.V. Verfahren zur Herstellung von Panthenol
AU2007277081B2 (en) * 2006-07-27 2014-02-06 Wyeth Llc High-cell density fed-batch fermentation process for producing recombinant protein
US8399866B2 (en) 2008-05-22 2013-03-19 Vladimir Balakin Charged particle extraction apparatus and method of use thereof
US9044600B2 (en) * 2008-05-22 2015-06-02 Vladimir Balakin Proton tomography apparatus and method of operation therefor
US9498649B2 (en) 2008-05-22 2016-11-22 Vladimir Balakin Charged particle cancer therapy patient constraint apparatus and method of use thereof
US9095040B2 (en) 2008-05-22 2015-07-28 Vladimir Balakin Charged particle beam acceleration and extraction method and apparatus used in conjunction with a charged particle cancer therapy system
US8569717B2 (en) * 2008-05-22 2013-10-29 Vladimir Balakin Intensity modulated three-dimensional radiation scanning method and apparatus
US8129699B2 (en) 2008-05-22 2012-03-06 Vladimir Balakin Multi-field charged particle cancer therapy method and apparatus coordinated with patient respiration
US10029122B2 (en) 2008-05-22 2018-07-24 Susan L. Michaud Charged particle—patient motion control system apparatus and method of use thereof
US9056199B2 (en) 2008-05-22 2015-06-16 Vladimir Balakin Charged particle treatment, rapid patient positioning apparatus and method of use thereof
US8089054B2 (en) 2008-05-22 2012-01-03 Vladimir Balakin Charged particle beam acceleration and extraction method and apparatus used in conjunction with a charged particle cancer therapy system
US8642978B2 (en) 2008-05-22 2014-02-04 Vladimir Balakin Charged particle cancer therapy dose distribution method and apparatus
US8718231B2 (en) 2008-05-22 2014-05-06 Vladimir Balakin X-ray tomography method and apparatus used in conjunction with a charged particle cancer therapy system
US8288742B2 (en) * 2008-05-22 2012-10-16 Vladimir Balakin Charged particle cancer therapy patient positioning method and apparatus
US9579525B2 (en) 2008-05-22 2017-02-28 Vladimir Balakin Multi-axis charged particle cancer therapy method and apparatus
US8969834B2 (en) 2008-05-22 2015-03-03 Vladimir Balakin Charged particle therapy patient constraint apparatus and method of use thereof
US9744380B2 (en) 2008-05-22 2017-08-29 Susan L. Michaud Patient specific beam control assembly of a cancer therapy apparatus and method of use thereof
US9855444B2 (en) 2008-05-22 2018-01-02 Scott Penfold X-ray detector for proton transit detection apparatus and method of use thereof
US9616252B2 (en) 2008-05-22 2017-04-11 Vladimir Balakin Multi-field cancer therapy apparatus and method of use thereof
US10070831B2 (en) 2008-05-22 2018-09-11 James P. Bennett Integrated cancer therapy—imaging apparatus and method of use thereof
US8373146B2 (en) * 2008-05-22 2013-02-12 Vladimir Balakin RF accelerator method and apparatus used in conjunction with a charged particle cancer therapy system
US9155911B1 (en) 2008-05-22 2015-10-13 Vladimir Balakin Ion source method and apparatus used in conjunction with a charged particle cancer therapy system
US9910166B2 (en) 2008-05-22 2018-03-06 Stephen L. Spotts Redundant charged particle state determination apparatus and method of use thereof
US8378311B2 (en) 2008-05-22 2013-02-19 Vladimir Balakin Synchrotron power cycling apparatus and method of use thereof
US9682254B2 (en) 2008-05-22 2017-06-20 Vladimir Balakin Cancer surface searing apparatus and method of use thereof
US8309941B2 (en) * 2008-05-22 2012-11-13 Vladimir Balakin Charged particle cancer therapy and patient breath monitoring method and apparatus
US8198607B2 (en) * 2008-05-22 2012-06-12 Vladimir Balakin Tandem accelerator method and apparatus used in conjunction with a charged particle cancer therapy system
US10684380B2 (en) 2008-05-22 2020-06-16 W. Davis Lee Multiple scintillation detector array imaging apparatus and method of use thereof
US9737734B2 (en) 2008-05-22 2017-08-22 Susan L. Michaud Charged particle translation slide control apparatus and method of use thereof
US9937362B2 (en) 2008-05-22 2018-04-10 W. Davis Lee Dynamic energy control of a charged particle imaging/treatment apparatus and method of use thereof
US9177751B2 (en) 2008-05-22 2015-11-03 Vladimir Balakin Carbon ion beam injector apparatus and method of use thereof
US9737733B2 (en) 2008-05-22 2017-08-22 W. Davis Lee Charged particle state determination apparatus and method of use thereof
US8188688B2 (en) * 2008-05-22 2012-05-29 Vladimir Balakin Magnetic field control method and apparatus used in conjunction with a charged particle cancer therapy system
US8378321B2 (en) * 2008-05-22 2013-02-19 Vladimir Balakin Charged particle cancer therapy and patient positioning method and apparatus
US9168392B1 (en) 2008-05-22 2015-10-27 Vladimir Balakin Charged particle cancer therapy system X-ray apparatus and method of use thereof
US8637833B2 (en) 2008-05-22 2014-01-28 Vladimir Balakin Synchrotron power supply apparatus and method of use thereof
US9782140B2 (en) 2008-05-22 2017-10-10 Susan L. Michaud Hybrid charged particle / X-ray-imaging / treatment apparatus and method of use thereof
US20090314960A1 (en) * 2008-05-22 2009-12-24 Vladimir Balakin Patient positioning method and apparatus used in conjunction with a charged particle cancer therapy system
US8436327B2 (en) * 2008-05-22 2013-05-07 Vladimir Balakin Multi-field charged particle cancer therapy method and apparatus
US8907309B2 (en) 2009-04-17 2014-12-09 Stephen L. Spotts Treatment delivery control system and method of operation thereof
US8374314B2 (en) 2008-05-22 2013-02-12 Vladimir Balakin Synchronized X-ray / breathing method and apparatus used in conjunction with a charged particle cancer therapy system
US10143854B2 (en) 2008-05-22 2018-12-04 Susan L. Michaud Dual rotation charged particle imaging / treatment apparatus and method of use thereof
US10092776B2 (en) 2008-05-22 2018-10-09 Susan L. Michaud Integrated translation/rotation charged particle imaging/treatment apparatus and method of use thereof
US8178859B2 (en) 2008-05-22 2012-05-15 Vladimir Balakin Proton beam positioning verification method and apparatus used in conjunction with a charged particle cancer therapy system
US9981147B2 (en) 2008-05-22 2018-05-29 W. Davis Lee Ion beam extraction apparatus and method of use thereof
US9974978B2 (en) 2008-05-22 2018-05-22 W. Davis Lee Scintillation array apparatus and method of use thereof
US10548551B2 (en) 2008-05-22 2020-02-04 W. Davis Lee Depth resolved scintillation detector array imaging apparatus and method of use thereof
US8624528B2 (en) * 2008-05-22 2014-01-07 Vladimir Balakin Method and apparatus coordinating synchrotron acceleration periods with patient respiration periods
US8373143B2 (en) * 2008-05-22 2013-02-12 Vladimir Balakin Patient immobilization and repositioning method and apparatus used in conjunction with charged particle cancer therapy
US8975600B2 (en) 2008-05-22 2015-03-10 Vladimir Balakin Treatment delivery control system and method of operation thereof
US8368038B2 (en) 2008-05-22 2013-02-05 Vladimir Balakin Method and apparatus for intensity control of a charged particle beam extracted from a synchrotron
US9737272B2 (en) 2008-05-22 2017-08-22 W. Davis Lee Charged particle cancer therapy beam state determination apparatus and method of use thereof
US8598543B2 (en) * 2008-05-22 2013-12-03 Vladimir Balakin Multi-axis/multi-field charged particle cancer therapy method and apparatus
US8373145B2 (en) * 2008-05-22 2013-02-12 Vladimir Balakin Charged particle cancer therapy system magnet control method and apparatus
US7939809B2 (en) * 2008-05-22 2011-05-10 Vladimir Balakin Charged particle beam extraction method and apparatus used in conjunction with a charged particle cancer therapy system
US8519365B2 (en) * 2008-05-22 2013-08-27 Vladimir Balakin Charged particle cancer therapy imaging method and apparatus
US8710462B2 (en) * 2008-05-22 2014-04-29 Vladimir Balakin Charged particle cancer therapy beam path control method and apparatus
US8625739B2 (en) 2008-07-14 2014-01-07 Vladimir Balakin Charged particle cancer therapy x-ray method and apparatus
US8627822B2 (en) * 2008-07-14 2014-01-14 Vladimir Balakin Semi-vertical positioning method and apparatus used in conjunction with a charged particle cancer therapy system
US8229072B2 (en) * 2008-07-14 2012-07-24 Vladimir Balakin Elongated lifetime X-ray method and apparatus used in conjunction with a charged particle cancer therapy system
EP2438182B1 (de) 2009-06-05 2018-10-10 Basf Se Biokatalytische herstellung von ambroxan
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US10556126B2 (en) 2010-04-16 2020-02-11 Mark R. Amato Automated radiation treatment plan development apparatus and method of use thereof
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US10179250B2 (en) 2010-04-16 2019-01-15 Nick Ruebel Auto-updated and implemented radiation treatment plan apparatus and method of use thereof
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US10518109B2 (en) 2010-04-16 2019-12-31 Jillian Reno Transformable charged particle beam path cancer therapy apparatus and method of use thereof
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US10589128B2 (en) 2010-04-16 2020-03-17 Susan L. Michaud Treatment beam path verification in a cancer therapy apparatus and method of use thereof
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US10188877B2 (en) 2010-04-16 2019-01-29 W. Davis Lee Fiducial marker/cancer imaging and treatment apparatus and method of use thereof
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KR20180006970A (ko) * 2015-06-19 2018-01-19 바스프 에스이 판토락톤의 제조
US9907981B2 (en) 2016-03-07 2018-03-06 Susan L. Michaud Charged particle translation slide control apparatus and method of use thereof
US10037863B2 (en) 2016-05-27 2018-07-31 Mark R. Amato Continuous ion beam kinetic energy dissipater apparatus and method of use thereof
CA3116477A1 (en) 2018-10-18 2020-04-23 Basf Se Method for the production of acrylic acid or salts thereof
CN110452861B (zh) * 2019-07-10 2021-02-09 杭州师范大学 一种基因重组工程菌及其在催化合成d-泛酰内酯中的应用

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JPS5572182A (en) * 1978-11-28 1980-05-30 Sagami Chem Res Center Optical resolution of pantolactone
JPH0667320B2 (ja) * 1986-06-13 1994-08-31 三菱化成株式会社 Ｄ−パントラクトンの製造法
JPH0655156B2 (ja) * 1986-06-13 1994-07-27 三菱化成株式会社 Ｄｌ−パントラクトンの光学分割法
JP2844354B2 (ja) 1989-08-03 1999-01-06 富士薬品工業株式会社 Ｄ―パントラクトンの製造法
DE4005150A1 (de) 1990-02-17 1991-08-22 Hoechst Ag Verfahren zur enzymatischen racematspaltung von pantolacton
JP3011449B2 (ja) 1990-10-05 2000-02-21 富士薬品工業株式会社 Ｄ―パントラクトン加水分解酵素およびその製造法
CA2064676A1 (en) 1991-04-02 1992-10-03 Manfred Schneider Immobilized biocatalyst, its preparation and use for ester synthesis in a column reactor
DE4126580A1 (de) 1991-08-12 1993-02-18 Degussa D-2,4-dihydroxy-3,3-dimethylbutansaeurenitril, seine herstellung und verwendung
CA2125785A1 (en) 1992-10-15 1994-04-28 Tsuguhiko Nakagawa Method of continuously carburizing metal strip
US6406898B1 (en) 1995-09-13 2002-06-18 Daiichi Fine Chemical Co., Ltd. D-pantolactone hydrolase and gene encoding the same
CN1354795A (zh) 1998-11-10 2002-06-19 诺沃奇梅兹生物技术有限公司 具有内酯水解酶活性的多肽和编码该多肽的核酸
US6395529B1 (en) * 1998-11-10 2002-05-28 Novozymes Biotech, Inc. Polypeptides having lactonohydrolase activity and nucleic acids encoding same

Also Published As

Publication number Publication date
PL355487A1 (en) 2004-05-04
EP1224296A1 (de) 2002-07-24
HUP0203704A2 (hu) 2003-03-28
RU2002114044A (ru) 2004-03-27
AU782517B2 (en) 2005-08-04
AU1141601A (en) 2001-05-14
CA2389064A1 (en) 2001-05-10
CN1384880A (zh) 2002-12-11
NO20021931D0 (no) 2002-04-24
KR20020043254A (ko) 2002-06-08
IL148973A0 (en) 2002-11-10
CZ20021449A3 (cs) 2002-10-16
HUP0203704A3 (en) 2006-03-28
US6998258B1 (en) 2006-02-14
NO20021931L (no) 2002-04-24
BR0015114A (pt) 2002-07-16
MXPA02003417A (es) 2002-08-20
JP2003530080A (ja) 2003-10-14
WO2001032890A1 (de) 2001-05-10

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