EE04642B1 - (1H)benso[c]kinolisiin-3-ooni derivaatide sünteesi meetod - Google Patents

(1H)benso[c]kinolisiin-3-ooni derivaatide sünteesi meetod

Info

Publication number
EE04642B1
EE04642B1 EEP200100060A EEP200100060A EE04642B1 EE 04642 B1 EE04642 B1 EE 04642B1 EE P200100060 A EEP200100060 A EE P200100060A EE P200100060 A EEP200100060 A EE P200100060A EE 04642 B1 EE04642 B1 EE 04642B1
Authority
EE
Estonia
Prior art keywords
quinolizin
benzo
derivatives
synthesis
compounds
Prior art date
Application number
EEP200100060A
Other languages
English (en)
Inventor
Guarna Antonio
Serio Mario
Giovanni Occhiato Ernesto
Original Assignee
Applied Research Systems Ars Holding N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Applied Research Systems Ars Holding N.V. filed Critical Applied Research Systems Ars Holding N.V.
Publication of EE200100060A publication Critical patent/EE200100060A/et
Publication of EE04642B1 publication Critical patent/EE04642B1/et

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/03—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/04—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Inorganic Compounds Of Heavy Metals (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Carbon And Carbon Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
EEP200100060A 1998-08-03 1999-07-23 (1H)benso[c]kinolisiin-3-ooni derivaatide sünteesi meetod EE04642B1 (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP98114524 1998-08-03
PCT/EP1999/005277 WO2000008019A1 (en) 1998-08-03 1999-07-23 Process for the synthesis of (1h)-benzo[c]quinolizin-3-ones derivatives

Publications (2)

Publication Number Publication Date
EE200100060A EE200100060A (et) 2002-06-17
EE04642B1 true EE04642B1 (et) 2006-06-15

Family

ID=8232396

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP200100060A EE04642B1 (et) 1998-08-03 1999-07-23 (1H)benso[c]kinolisiin-3-ooni derivaatide sünteesi meetod

Country Status (29)

Country Link
US (1) US6723850B1 (et)
EP (1) EP1102765B1 (et)
JP (1) JP2002522435A (et)
KR (1) KR100624239B1 (et)
CN (1) CN1128148C (et)
AT (1) ATE250057T1 (et)
AU (1) AU751873B2 (et)
BG (1) BG65062B1 (et)
BR (1) BR9912870A (et)
CA (1) CA2338498C (et)
CZ (1) CZ291648B6 (et)
DE (1) DE69911430T2 (et)
DK (1) DK1102765T3 (et)
EA (1) EA003997B1 (et)
EE (1) EE04642B1 (et)
ES (1) ES2203169T3 (et)
HK (1) HK1037368A1 (et)
HU (1) HUP0103241A3 (et)
IL (2) IL141212A0 (et)
NO (1) NO20010559L (et)
NZ (1) NZ509243A (et)
PL (1) PL198963B1 (et)
PT (1) PT1102765E (et)
SI (1) SI1102765T1 (et)
SK (1) SK285438B6 (et)
TR (1) TR200100286T2 (et)
UA (1) UA67787C2 (et)
WO (1) WO2000008019A1 (et)
ZA (1) ZA200100365B (et)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100074949A1 (en) 2008-08-13 2010-03-25 William Rowe Pharmaceutical composition and administration thereof
US8354427B2 (en) 2004-06-24 2013-01-15 Vertex Pharmaceutical Incorporated Modulators of ATP-binding cassette transporters
CN107501099B (zh) 2004-06-24 2021-03-19 沃泰克斯药物股份有限公司 Atp-结合弹夹转运蛋白的调控剂
CN101374849A (zh) * 2005-12-24 2009-02-25 沃泰克斯药物股份有限公司 作为abc转运蛋白调控剂的喹啉-4-酮衍生物
PL1993360T3 (pl) 2005-12-28 2017-08-31 Vertex Pharmaceuticals Incorporated Stałe postacie n-[2,4-bis(1,1-dimetyloetylo)-5-hydroksyfenylo]-1,4- dihydro-4-oksochinolino-3-karboksyamidu
KR101955863B1 (ko) 2009-03-20 2019-03-07 버텍스 파마슈티칼스 인코포레이티드 낭성 섬유증 막횡단 전도도 조절자의 조정자의 제조 방법
US8802700B2 (en) 2010-12-10 2014-08-12 Vertex Pharmaceuticals Incorporated Modulators of ATP-Binding Cassette transporters
EA023571B1 (ru) * 2010-12-14 2016-06-30 Зингента Партисипейшнс Аг Стриголактамовые производные и их применение в качестве регуляторов роста растений
IL265430B2 (en) 2012-02-27 2024-08-01 Vertex Pharma Pharmaceutical preparations containing a solid dispersion of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide and uses thereof
AU2015330923B2 (en) 2014-10-07 2020-03-12 Vertex Pharmaceuticals Incorporated Co-crystals of modulators of cystic fibrosis transmembrane conductance regulator
CN105001216B (zh) * 2015-07-08 2017-03-01 中国科学院兰州化学物理研究所 一种喹嗪酮的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5064961A (en) * 1989-12-18 1991-11-12 E. R. Squibb & Sons, Inc. Process for preparing an optically active cyclobutane nucleoside
FR2696465B1 (fr) * 1992-10-02 1994-12-23 Adir Nouveaux dérivés d'ellipticine, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
IT1286545B1 (it) 1996-02-09 1998-07-15 Antonio Guarna Derivati benzo(c) chinolizinici,loro preparazione ed uso come inibitori delle 5-alfa-riduttasi
JPH09316076A (ja) * 1996-05-24 1997-12-09 Nippon Paper Ind Co Ltd ９−置換プリン誘導体及びその抗ウイルス剤としての用途

Also Published As

Publication number Publication date
DK1102765T3 (da) 2004-02-02
DE69911430T2 (de) 2004-07-22
ATE250057T1 (de) 2003-10-15
UA67787C2 (uk) 2004-07-15
CN1128148C (zh) 2003-11-19
IL141212A (en) 2006-12-31
EA200100213A1 (ru) 2001-08-27
CZ291648B6 (cs) 2003-04-16
NZ509243A (en) 2002-11-26
CA2338498A1 (en) 2000-02-17
PL345802A1 (en) 2002-01-02
CN1311788A (zh) 2001-09-05
BG105198A (en) 2001-12-29
US6723850B1 (en) 2004-04-20
TR200100286T2 (tr) 2001-07-23
JP2002522435A (ja) 2002-07-23
IL141212A0 (en) 2002-03-10
HK1037368A1 (en) 2002-02-08
EA003997B1 (ru) 2003-12-25
HUP0103241A3 (en) 2002-10-28
CZ2001434A3 (cs) 2001-08-15
AU6312399A (en) 2000-02-28
SK1672001A3 (en) 2001-08-06
CA2338498C (en) 2009-05-19
EE200100060A (et) 2002-06-17
PL198963B1 (pl) 2008-08-29
BG65062B1 (bg) 2007-01-31
NO20010559D0 (no) 2001-02-01
PT1102765E (pt) 2003-12-31
AU751873B2 (en) 2002-08-29
KR20010074684A (ko) 2001-08-09
BR9912870A (pt) 2001-10-16
DE69911430D1 (de) 2003-10-23
HUP0103241A2 (hu) 2002-01-28
EP1102765A1 (en) 2001-05-30
KR100624239B1 (ko) 2006-09-13
ES2203169T3 (es) 2004-04-01
SI1102765T1 (en) 2003-12-31
ZA200100365B (en) 2001-07-26
NO20010559L (no) 2001-02-01
WO2000008019A1 (en) 2000-02-17
EP1102765B1 (en) 2003-09-17
SK285438B6 (sk) 2007-01-04

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Legal Events

Date Code Title Description
KB4A Valid patent at the end of a year

Effective date: 20061231

GB1A Change in the ownership or in the address of the owner
KB4A Valid patent at the end of a year

Effective date: 20071231

KB4A Valid patent at the end of a year

Effective date: 20081231

KB4A Valid patent at the end of a year

Effective date: 20101231

MM4A Lapsed by not paying the annual fees

Effective date: 20100723