WO2002008227A3 - Bicyclic hydantoin derivatives and combinatorial libraries thereof - Google Patents

Bicyclic hydantoin derivatives and combinatorial libraries thereof Download PDF

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Publication number
WO2002008227A3
WO2002008227A3 PCT/EP2001/008322 EP0108322W WO0208227A3 WO 2002008227 A3 WO2002008227 A3 WO 2002008227A3 EP 0108322 W EP0108322 W EP 0108322W WO 0208227 A3 WO0208227 A3 WO 0208227A3
Authority
WO
WIPO (PCT)
Prior art keywords
combinatorial libraries
bicyclic hydantoin
hydantoin derivatives
bicyclic
compounds
Prior art date
Application number
PCT/EP2001/008322
Other languages
French (fr)
Other versions
WO2002008227A2 (en
Inventor
Shao-Po Lu
R Normand Hebert
Original Assignee
Lion Bioscience Ag
Shao-Po Lu
R Normand Hebert
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lion Bioscience Ag, Shao-Po Lu, R Normand Hebert filed Critical Lion Bioscience Ag
Priority to EP01960516A priority Critical patent/EP1301512A2/en
Priority to CA002416654A priority patent/CA2416654A1/en
Priority to AU2001281995A priority patent/AU2001281995A1/en
Publication of WO2002008227A2 publication Critical patent/WO2002008227A2/en
Publication of WO2002008227A3 publication Critical patent/WO2002008227A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention relates to novel bicyclic hydantoin derivative compounds of the following formula (I): wherein R1 to R5 and n have the meanings provided herein. The invention further relates to combinatorial libraries containing two or more such compounds, as well as methods of preparing bicyclic hydantoin derivative compounds.
PCT/EP2001/008322 2000-07-21 2001-07-18 Bicyclic hydantoin derivatives and combinatorial libraries thereof WO2002008227A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP01960516A EP1301512A2 (en) 2000-07-21 2001-07-18 Bicyclic hydantoin derivatives and combinatorial libraries thereof
CA002416654A CA2416654A1 (en) 2000-07-21 2001-07-18 Bicyclic hydantoin derivatives and combinatorial libraries thereof
AU2001281995A AU2001281995A1 (en) 2000-07-21 2001-07-18 Bicyclic hydantoin derivatives and combinatorial libraries thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US62117700A 2000-07-21 2000-07-21
US09/621,177 2000-07-21

Publications (2)

Publication Number Publication Date
WO2002008227A2 WO2002008227A2 (en) 2002-01-31
WO2002008227A3 true WO2002008227A3 (en) 2002-08-29

Family

ID=24489060

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/008322 WO2002008227A2 (en) 2000-07-21 2001-07-18 Bicyclic hydantoin derivatives and combinatorial libraries thereof

Country Status (4)

Country Link
EP (1) EP1301512A2 (en)
AU (1) AU2001281995A1 (en)
CA (1) CA2416654A1 (en)
WO (1) WO2002008227A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6710064B2 (en) 2000-12-01 2004-03-23 Bristol-Myers Squibb Co. Hydantoin compounds useful as anti-inflammatory agents
US7199149B2 (en) 2003-10-01 2007-04-03 Bristol Myers Squibb Company Monocyclic and bicyclic lactams as factor Xa inhibitors
JP5096150B2 (en) 2005-09-02 2012-12-12 日宝化学株式会社 1,3-Diiodohydantoin compound and method for producing the same
WO2008147556A2 (en) * 2007-05-25 2008-12-04 Ipsen Pharma S.A.S. Melanocortin receptor ligands modified with hydantoin
WO2014097787A1 (en) 2012-12-19 2014-06-26 日宝化学株式会社 Production method for halohydrantoin compound and halohydrantoin compound
US9855514B2 (en) 2012-12-19 2018-01-02 Nippoh Chemicals Co., Ltd. Method and apparatus for producing halohydantoin compound, recycling method, and halohydantoin compound

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4198423A (en) * 1979-03-20 1980-04-15 Basf Aktiengesellschaft 1,3-Bis-(trihalomethylsulfenyl)-imidazoline-2,4-diones
EP0493323A1 (en) * 1990-12-18 1992-07-01 Sandoz Ltd. Novel hydantoin compounds
WO1995023509A1 (en) * 1994-03-01 1995-09-08 E.I. Du Pont De Nemours And Company Herbicidal bicyclic hydantoins
WO1997047626A1 (en) * 1996-06-14 1997-12-18 Sagami Chemical Research Center Bicyclic hydantoin derivatives, intermediates for the preparation thereof, process for the preparation of them, and herbicides containing the same as active ingredient
WO1998008813A1 (en) * 1996-08-26 1998-03-05 Eli Lilly And Company Combinatorial process for preparing substituted pyrrolidine libraries
WO1998011107A1 (en) * 1996-09-12 1998-03-19 Sagami Chemical Research Center Bicyclic hydantoin derivatives, process for producing the same, and herbicides containing the same as active ingredient
WO1998033776A1 (en) * 1997-02-04 1998-08-06 Trega Biosciences, Inc. Combinatorial libraries of hydantoin and thiohydantoin derivatives, methods of making the libraries and compounds therein
WO2000077519A1 (en) * 1999-06-15 2000-12-21 Aventis Pharmaceuticals Products Inc. Solid phase synthesis of n,n-disubstituted diazacycloalkylcarboxy derivatives
WO2001030781A2 (en) * 1999-10-20 2001-05-03 Tanabe Seiyaku Co., Ltd. INHIBITORS OF αLβ2 MEDIATED CELL ADHESION

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4198423A (en) * 1979-03-20 1980-04-15 Basf Aktiengesellschaft 1,3-Bis-(trihalomethylsulfenyl)-imidazoline-2,4-diones
EP0493323A1 (en) * 1990-12-18 1992-07-01 Sandoz Ltd. Novel hydantoin compounds
WO1995023509A1 (en) * 1994-03-01 1995-09-08 E.I. Du Pont De Nemours And Company Herbicidal bicyclic hydantoins
WO1997047626A1 (en) * 1996-06-14 1997-12-18 Sagami Chemical Research Center Bicyclic hydantoin derivatives, intermediates for the preparation thereof, process for the preparation of them, and herbicides containing the same as active ingredient
WO1998008813A1 (en) * 1996-08-26 1998-03-05 Eli Lilly And Company Combinatorial process for preparing substituted pyrrolidine libraries
WO1998011107A1 (en) * 1996-09-12 1998-03-19 Sagami Chemical Research Center Bicyclic hydantoin derivatives, process for producing the same, and herbicides containing the same as active ingredient
WO1998033776A1 (en) * 1997-02-04 1998-08-06 Trega Biosciences, Inc. Combinatorial libraries of hydantoin and thiohydantoin derivatives, methods of making the libraries and compounds therein
US5859190A (en) * 1997-02-04 1999-01-12 Trega Biosciences, Inc. Combinatorial libraries of hydantoin and thiohydantoin derivatives, methods of making the libraries and compounds therein
WO2000077519A1 (en) * 1999-06-15 2000-12-21 Aventis Pharmaceuticals Products Inc. Solid phase synthesis of n,n-disubstituted diazacycloalkylcarboxy derivatives
WO2001030781A2 (en) * 1999-10-20 2001-05-03 Tanabe Seiyaku Co., Ltd. INHIBITORS OF αLβ2 MEDIATED CELL ADHESION

Also Published As

Publication number Publication date
CA2416654A1 (en) 2002-01-31
WO2002008227A2 (en) 2002-01-31
EP1301512A2 (en) 2003-04-16
AU2001281995A1 (en) 2002-02-05

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