ECSP23017158A - Derivados de espiropiperidinilo sustituidos con heteroarilo y usos farmacéuticos de los mismos - Google Patents
Derivados de espiropiperidinilo sustituidos con heteroarilo y usos farmacéuticos de los mismosInfo
- Publication number
- ECSP23017158A ECSP23017158A ECSENADI202317158A ECDI202317158A ECSP23017158A EC SP23017158 A ECSP23017158 A EC SP23017158A EC SENADI202317158 A ECSENADI202317158 A EC SENADI202317158A EC DI202317158 A ECDI202317158 A EC DI202317158A EC SP23017158 A ECSP23017158 A EC SP23017158A
- Authority
- EC
- Ecuador
- Prior art keywords
- heteroaryl
- derivatives
- pharmaceutical uses
- substituted spiropiperidinyl
- spiropiperidinyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/537—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines spiro-condensed or forming part of bridged ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Abstract
La presente invención proporciona un compuesto de la fórmula (I) o una sal farmacéuticamente aceptable del mismo; (I) en donde R1 R2, R4 y X1 han sido definidos en la presente, a un método de elaboración de los compuestos de la invención, y a sus usos terapéuticos. La presente invención además proporciona una combinación de agentes farmacológicamente activos y una composición farmacéutica.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP20191191 | 2020-08-14 |
Publications (1)
Publication Number | Publication Date |
---|---|
ECSP23017158A true ECSP23017158A (es) | 2023-04-28 |
Family
ID=72088005
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ECSENADI202317158A ECSP23017158A (es) | 2020-08-14 | 2023-03-10 | Derivados de espiropiperidinilo sustituidos con heteroarilo y usos farmacéuticos de los mismos |
Country Status (20)
Country | Link |
---|---|
US (2) | US11708366B2 (es) |
EP (1) | EP4196478A1 (es) |
JP (1) | JP2023537357A (es) |
KR (1) | KR20230051227A (es) |
CN (1) | CN116157404A (es) |
AR (1) | AR123241A1 (es) |
AU (2) | AU2021325431B2 (es) |
BR (1) | BR112023002031A2 (es) |
CA (1) | CA3185469A1 (es) |
CL (1) | CL2023000418A1 (es) |
CO (1) | CO2023002940A2 (es) |
CR (1) | CR20230125A (es) |
DO (1) | DOP2023000028A (es) |
EC (1) | ECSP23017158A (es) |
IL (1) | IL299091A (es) |
MX (1) | MX2023001725A (es) |
PE (1) | PE20230855A1 (es) |
TW (1) | TW202220990A (es) |
UY (1) | UY39377A (es) |
WO (1) | WO2022034529A1 (es) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11932630B2 (en) | 2021-04-16 | 2024-03-19 | Novartis Ag | Heteroaryl aminopropanol derivatives |
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GB9913083D0 (en) | 1999-06-04 | 1999-08-04 | Novartis Ag | Organic compounds |
KR20040038899A (ko) | 2001-09-28 | 2004-05-08 | 교와 핫꼬 고교 가부시끼가이샤 | 수용체 길항제 |
PE20050130A1 (es) | 2002-08-09 | 2005-03-29 | Novartis Ag | Compuestos organicos |
NL2000323C2 (nl) | 2005-12-20 | 2007-11-20 | Pfizer Ltd | Pyrimidine-derivaten. |
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JP5987220B2 (ja) | 2011-07-19 | 2016-09-07 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ロイコトリエンa4ヒドロラーゼの阻害剤としてのアリールピラゾールエーテル |
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-
2021
- 2021-08-12 BR BR112023002031A patent/BR112023002031A2/pt unknown
- 2021-08-12 AR ARP210102276A patent/AR123241A1/es unknown
- 2021-08-12 US US17/400,458 patent/US11708366B2/en active Active
- 2021-08-12 CA CA3185469A patent/CA3185469A1/en active Pending
- 2021-08-12 PE PE2023000248A patent/PE20230855A1/es unknown
- 2021-08-12 CN CN202180060257.4A patent/CN116157404A/zh active Pending
- 2021-08-12 KR KR1020237008311A patent/KR20230051227A/ko active Search and Examination
- 2021-08-12 TW TW110129822A patent/TW202220990A/zh unknown
- 2021-08-12 WO PCT/IB2021/057427 patent/WO2022034529A1/en active Application Filing
- 2021-08-12 IL IL299091A patent/IL299091A/en unknown
- 2021-08-12 JP JP2023507892A patent/JP2023537357A/ja active Pending
- 2021-08-12 CR CR20230125A patent/CR20230125A/es unknown
- 2021-08-12 AU AU2021325431A patent/AU2021325431B2/en active Active
- 2021-08-12 EP EP21755587.9A patent/EP4196478A1/en active Pending
- 2021-08-12 MX MX2023001725A patent/MX2023001725A/es unknown
- 2021-08-12 UY UY0001039377A patent/UY39377A/es unknown
-
2023
- 2023-02-10 DO DO2023000028A patent/DOP2023000028A/es unknown
- 2023-02-10 CL CL2023000418A patent/CL2023000418A1/es unknown
- 2023-03-10 EC ECSENADI202317158A patent/ECSP23017158A/es unknown
- 2023-03-10 CO CONC2023/0002940A patent/CO2023002940A2/es unknown
- 2023-05-18 US US18/319,585 patent/US20240043425A1/en active Pending
-
2024
- 2024-01-04 AU AU2024200054A patent/AU2024200054A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
US20240043425A1 (en) | 2024-02-08 |
UY39377A (es) | 2022-03-31 |
AU2021325431B2 (en) | 2024-01-18 |
US11708366B2 (en) | 2023-07-25 |
CL2023000418A1 (es) | 2023-09-29 |
CR20230125A (es) | 2023-05-11 |
US20220048909A1 (en) | 2022-02-17 |
BR112023002031A2 (pt) | 2023-03-07 |
MX2023001725A (es) | 2023-02-22 |
TW202220990A (zh) | 2022-06-01 |
CA3185469A1 (en) | 2022-02-17 |
DOP2023000028A (es) | 2023-03-15 |
IL299091A (en) | 2023-02-01 |
AU2021325431A1 (en) | 2023-01-19 |
CN116157404A (zh) | 2023-05-23 |
CO2023002940A2 (es) | 2023-03-17 |
KR20230051227A (ko) | 2023-04-17 |
JP2023537357A (ja) | 2023-08-31 |
AU2024200054A1 (en) | 2024-01-25 |
WO2022034529A1 (en) | 2022-02-17 |
AR123241A1 (es) | 2022-11-09 |
EP4196478A1 (en) | 2023-06-21 |
PE20230855A1 (es) | 2023-05-29 |
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