AR125594A1 - Moduladores alostéricos negativos novedosos de ciclopenta[c]pirrol de nr2b - Google Patents
Moduladores alostéricos negativos novedosos de ciclopenta[c]pirrol de nr2bInfo
- Publication number
- AR125594A1 AR125594A1 ARP220100708A ARP220100708A AR125594A1 AR 125594 A1 AR125594 A1 AR 125594A1 AR P220100708 A ARP220100708 A AR P220100708A AR P220100708 A ARP220100708 A AR P220100708A AR 125594 A1 AR125594 A1 AR 125594A1
- Authority
- AR
- Argentina
- Prior art keywords
- nr2b
- cyclopenta
- pyrrole
- allosteric modulators
- novel negative
- Prior art date
Links
- 102000034527 Retinoid X Receptors Human genes 0.000 title 1
- 108010038912 Retinoid X Receptors Proteins 0.000 title 1
- 230000003281 allosteric effect Effects 0.000 title 1
- NNHOUIKFCCIVCI-UHFFFAOYSA-N cyclopenta[c]pyrrole Chemical compound N1=CC2=CC=CC2=C1 NNHOUIKFCCIVCI-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000013543 active substance Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4704—2-Quinolinones, e.g. carbostyril
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La presente divulgación proporciona un compuesto de la fórmula (1), o una sal farmacéuticamente aceptable del mismo; un método para fabricar los compuestos de la divulgación y sus usos terapéuticos. La presente descripción proporciona además una combinación de agentes farmacológicamente activos y una composición farmacéutica.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163166516P | 2021-03-26 | 2021-03-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR125594A1 true AR125594A1 (es) | 2023-08-02 |
Family
ID=83396075
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP220100708A AR125594A1 (es) | 2021-03-26 | 2022-03-25 | Moduladores alostéricos negativos novedosos de ciclopenta[c]pirrol de nr2b |
Country Status (16)
| Country | Link |
|---|---|
| EP (1) | EP4313041A1 (es) |
| JP (1) | JP2024509325A (es) |
| KR (1) | KR20230160906A (es) |
| CN (1) | CN117157072A (es) |
| AR (1) | AR125594A1 (es) |
| AU (1) | AU2022244367A1 (es) |
| BR (1) | BR112023018766A2 (es) |
| CA (1) | CA3212203A1 (es) |
| CO (1) | CO2023012711A2 (es) |
| CR (1) | CR20230458A (es) |
| DO (1) | DOP2023000205A (es) |
| EC (1) | ECSP23073082A (es) |
| IL (1) | IL305601A (es) |
| TW (1) | TW202304885A (es) |
| UY (1) | UY39688A (es) |
| WO (1) | WO2022204336A1 (es) |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2879126A1 (en) * | 2012-07-19 | 2014-01-23 | Janssen Pharmaceutica Nv | Octahydro-cyclopentapyrrolyl antagonists of ccr2 |
| JO3579B1 (ar) * | 2014-09-26 | 2020-07-05 | Luc Therapeutics Inc | مُعدِلات تفاغرية سالبة لمستقبل nr2b من المركب n-ألكيل أريل-5-أوكسي أريل-ثامن هيدرو-خماسي الحلقة [c] بيرول |
| CN106565674B (zh) * | 2015-10-13 | 2021-02-05 | 四川海思科制药有限公司 | 一种八氢环戊烷并[c]吡咯衍生物及其制备方法和在医药上的用途 |
-
2022
- 2022-03-24 KR KR1020237036649A patent/KR20230160906A/ko unknown
- 2022-03-24 CA CA3212203A patent/CA3212203A1/en active Pending
- 2022-03-24 UY UY0001039688A patent/UY39688A/es unknown
- 2022-03-24 CN CN202280024529.XA patent/CN117157072A/zh active Pending
- 2022-03-24 TW TW111111135A patent/TW202304885A/zh unknown
- 2022-03-24 IL IL305601A patent/IL305601A/en unknown
- 2022-03-24 JP JP2023558754A patent/JP2024509325A/ja active Pending
- 2022-03-24 WO PCT/US2022/021624 patent/WO2022204336A1/en active Application Filing
- 2022-03-24 CR CR20230458A patent/CR20230458A/es unknown
- 2022-03-24 BR BR112023018766A patent/BR112023018766A2/pt unknown
- 2022-03-24 AU AU2022244367A patent/AU2022244367A1/en active Pending
- 2022-03-24 EP EP22776608.6A patent/EP4313041A1/en active Pending
- 2022-03-25 AR ARP220100708A patent/AR125594A1/es unknown
-
2023
- 2023-09-25 DO DO2023000205A patent/DOP2023000205A/es unknown
- 2023-09-26 EC ECSENADI202373082A patent/ECSP23073082A/es unknown
- 2023-09-26 CO CONC2023/0012711A patent/CO2023012711A2/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN117157072A (zh) | 2023-12-01 |
| IL305601A (en) | 2023-11-01 |
| TW202304885A (zh) | 2023-02-01 |
| CR20230458A (es) | 2023-10-27 |
| CO2023012711A2 (es) | 2023-10-19 |
| KR20230160906A (ko) | 2023-11-24 |
| BR112023018766A2 (pt) | 2023-10-24 |
| AU2022244367A1 (en) | 2023-09-07 |
| UY39688A (es) | 2022-10-31 |
| EP4313041A1 (en) | 2024-02-07 |
| WO2022204336A1 (en) | 2022-09-29 |
| JP2024509325A (ja) | 2024-02-29 |
| ECSP23073082A (es) | 2023-10-31 |
| CA3212203A1 (en) | 2022-09-29 |
| DOP2023000205A (es) | 2023-11-15 |
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