EA202092799A1 - Модифицированные стерол-ацилтрансферазы - Google Patents
Модифицированные стерол-ацилтрансферазыInfo
- Publication number
- EA202092799A1 EA202092799A1 EA202092799A EA202092799A EA202092799A1 EA 202092799 A1 EA202092799 A1 EA 202092799A1 EA 202092799 A EA202092799 A EA 202092799A EA 202092799 A EA202092799 A EA 202092799A EA 202092799 A1 EA202092799 A1 EA 202092799A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- vitamin
- sterol acyltransferase
- modified
- modified sterol
- relates
- Prior art date
Links
- 102000057234 Acyl transferases Human genes 0.000 title abstract 2
- 108700016155 Acyl transferases Proteins 0.000 title abstract 2
- 229930182558 Sterol Natural products 0.000 title abstract 2
- 150000003432 sterols Chemical class 0.000 title abstract 2
- 235000003702 sterols Nutrition 0.000 title abstract 2
- QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 abstract 5
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 abstract 3
- 235000005282 vitamin D3 Nutrition 0.000 abstract 3
- 239000011647 vitamin D3 Substances 0.000 abstract 3
- 229940021056 vitamin d3 Drugs 0.000 abstract 3
- UCTLRSWJYQTBFZ-UHFFFAOYSA-N Dehydrocholesterol Natural products C1C(O)CCC2(C)C(CCC3(C(C(C)CCCC(C)C)CCC33)C)C3=CC=C21 UCTLRSWJYQTBFZ-UHFFFAOYSA-N 0.000 abstract 2
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 abstract 1
- 230000010933 acylation Effects 0.000 abstract 1
- 238000005917 acylation reaction Methods 0.000 abstract 1
- 238000013452 biotechnological production Methods 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000002207 metabolite Substances 0.000 abstract 1
- 239000002243 precursor Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1025—Acyltransferases (2.3)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1025—Acyltransferases (2.3)
- C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P33/00—Preparation of steroids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y103/00—Oxidoreductases acting on the CH-CH group of donors (1.3)
- C12Y103/01—Oxidoreductases acting on the CH-CH group of donors (1.3) with NAD+ or NADP+ as acceptor (1.3.1)
- C12Y103/01072—DELTA24-sterol reductase (1.3.1.72)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y203/00—Acyltransferases (2.3)
- C12Y203/01—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
- C12Y203/01026—Sterol O-acyltransferase (2.3.1.26)
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH6272018 | 2018-05-22 | ||
| PCT/EP2019/063076 WO2019224187A1 (en) | 2018-05-22 | 2019-05-21 | Modified sterol acyltransferases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EA202092799A1 true EA202092799A1 (ru) | 2021-03-01 |
Family
ID=67003439
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA202092799A EA202092799A1 (ru) | 2018-05-22 | 2019-05-21 | Модифицированные стерол-ацилтрансферазы |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US12227772B2 (https=) |
| EP (1) | EP3797159A1 (https=) |
| JP (1) | JP7460540B2 (https=) |
| CN (1) | CN112752841B (https=) |
| BR (1) | BR112020023394A2 (https=) |
| EA (1) | EA202092799A1 (https=) |
| WO (1) | WO2019224187A1 (https=) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114606147B (zh) * | 2022-03-15 | 2022-12-16 | 江南大学 | 一种同时增强和抑制酿酒酵母7-脱氢胆固醇合成中多个关键基因的方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100854607B1 (ko) | 1999-08-30 | 2008-08-27 | 몬산토 테크놀로지 엘엘씨 | 식물 스테롤 아실전달효소 |
| DE10203352A1 (de) | 2002-01-29 | 2003-07-31 | Basf Ag | Verfahren zur Herstellung von 7-Dehydrocholesterol und/oder dessen biosynthetischen Zwischen- und/oder Folgeprodukten in transgenen Organismen |
| BRPI0417533B1 (pt) | 2003-12-24 | 2016-03-01 | Danisco | enzima variante glicolipídio aciltransferase, uso e método para sua produção, método para o preparo de um produto alimentício e produto assado de farinha, processo de refinamento enzimático |
| ES2607891T3 (es) | 2004-07-16 | 2017-04-04 | Dsm Ip Assets B.V. | Ingeniería metabólica de células eucariotas que fermentan xilosa |
| HRP20140315T1 (hr) | 2007-07-26 | 2014-05-09 | Amgen Inc. | Modificirani enzimi lecitin-kolesterol aciltransferaze |
| EP2292741A1 (en) | 2009-08-26 | 2011-03-09 | OrganoBalance GmbH | Genetically modified organisms for the production of lipids |
| US9624521B2 (en) | 2009-12-03 | 2017-04-18 | Dsm Ip Assets B.V. | Production of non-yeast sterols by yeast |
| JP2012024084A (ja) | 2010-06-25 | 2012-02-09 | Mitsubishi Chemicals Corp | 新規酵母およびそれを用いたδ５，７−ステロール及びハイドロコルチゾンの製造方法 |
| AU2012346662B2 (en) | 2011-11-30 | 2016-07-28 | Danisco Us Inc. | Yeast strains engineered to produce ethanol from acetic acid and glycerol |
| CN109154015B (zh) | 2015-12-23 | 2022-03-15 | 帝斯曼知识产权资产管理有限公司 | 在经修饰的酵母中生产甾醇 |
-
2019
- 2019-05-21 CN CN201980033817.XA patent/CN112752841B/zh active Active
- 2019-05-21 JP JP2020557258A patent/JP7460540B2/ja active Active
- 2019-05-21 BR BR112020023394-3A patent/BR112020023394A2/pt unknown
- 2019-05-21 EP EP19729429.1A patent/EP3797159A1/en active Pending
- 2019-05-21 EA EA202092799A patent/EA202092799A1/ru unknown
- 2019-05-21 WO PCT/EP2019/063076 patent/WO2019224187A1/en not_active Ceased
- 2019-05-21 US US17/050,603 patent/US12227772B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP3797159A1 (en) | 2021-03-31 |
| US20210115412A1 (en) | 2021-04-22 |
| WO2019224187A1 (en) | 2019-11-28 |
| JP7460540B2 (ja) | 2024-04-02 |
| JP2021523692A (ja) | 2021-09-09 |
| CN112752841B (zh) | 2024-04-05 |
| CN112752841A (zh) | 2021-05-04 |
| US12227772B2 (en) | 2025-02-18 |
| BR112020023394A2 (pt) | 2021-02-09 |
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