EA201991126A1 - Снижение вирулентности бактерий путем снижения транспорта фолата у бактерий - Google Patents

Снижение вирулентности бактерий путем снижения транспорта фолата у бактерий

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Publication number
EA201991126A1
EA201991126A1 EA201991126A EA201991126A EA201991126A1 EA 201991126 A1 EA201991126 A1 EA 201991126A1 EA 201991126 A EA201991126 A EA 201991126A EA 201991126 A EA201991126 A EA 201991126A EA 201991126 A1 EA201991126 A1 EA 201991126A1
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Eurasian Patent Office
Prior art keywords
bacteria
transport
present
folat
decreasing
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EA201991126A
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English (en)
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Publication of EA201991126A1 publication Critical patent/EA201991126A1/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
    • A61K39/092—Streptococcus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/522—Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541—Mucosal route
    • A61K2039/542—Mucosal route oral/gastrointestinal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • A61K2039/552—Veterinary vaccine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/46—Streptococcus ; Enterococcus; Lactococcus

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Настоящее изобретение относится к бактериальным инфекциям, вакцинам против этих инфекций и бактериальным вакцинам. Более конкретно, настоящее изобретение относится к вакцинам, направленным против стрептококковых инфекций у свиней. В настоящем изобретении предложен мутант ∆FolT бактерии, обладающий сниженной способностью транспортировать фолат, причем указанная способность была снижена путем функционального удаления функции транспортера фолата (FolT). В настоящем изобретении также предложен способ снижения вирулентности бактерии, включающий снижение способности указанной бактерии транспортировать фолат.
EA201991126A 2016-11-11 2017-11-10 Снижение вирулентности бактерий путем снижения транспорта фолата у бактерий EA201991126A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP16198361 2016-11-11
PCT/US2017/061170 WO2018089841A1 (en) 2016-11-11 2017-11-10 Attenuating bacterial virulence by attenuating bacterial folate transport

Publications (1)

Publication Number Publication Date
EA201991126A1 true EA201991126A1 (ru) 2019-11-29

Family

ID=57396264

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201991126A EA201991126A1 (ru) 2016-11-11 2017-11-10 Снижение вирулентности бактерий путем снижения транспорта фолата у бактерий

Country Status (20)

Country Link
US (1) US11684663B2 (ru)
EP (2) EP3538143B1 (ru)
JP (2) JP6982616B2 (ru)
KR (1) KR20190084097A (ru)
CN (1) CN110582296B (ru)
AU (1) AU2017357813A1 (ru)
BR (1) BR112019009399A2 (ru)
CA (1) CA3043039A1 (ru)
CL (1) CL2019001275A1 (ru)
DK (1) DK3538143T3 (ru)
EA (1) EA201991126A1 (ru)
ES (1) ES2926543T3 (ru)
HU (1) HUE060176T2 (ru)
MX (2) MX2019005499A (ru)
MY (1) MY201256A (ru)
PH (1) PH12019501019A1 (ru)
PL (1) PL3538143T3 (ru)
PT (1) PT3538143T (ru)
RS (1) RS63524B1 (ru)
WO (1) WO2018089841A1 (ru)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2017357813A1 (en) * 2016-11-11 2019-06-27 Boehringer Ingelheim Vetmedica Gmbh Attenuating bacterial virulence by attenuating bacterial folate transport
WO2021035421A1 (en) * 2019-08-23 2021-03-04 Chifeng Pharmaceutical Co., Ltd. Folate producing strain and the preparation and application thereof
AU2021285044A1 (en) 2020-06-03 2022-12-08 Institute For Research In Biomedicine Combination of an ATP-hydrolyzing enzyme and an immune checkpoint modulator and uses thereof
JP2023529399A (ja) 2020-06-08 2023-07-10 エムヴィ バイオセラピューティクス エスエー ディスバイオーシスの処置に有用なａｔｐ加水分解酵素
CN112813085B (zh) * 2021-03-05 2023-03-31 昆明理工大学 焦磷酸酶基因的用途
CN112961878B (zh) * 2021-03-08 2023-04-25 昆明理工大学 一种植物乳杆菌的基因在叶酸生物生成中的应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6229001B1 (en) 1997-01-03 2001-05-08 Southern Research Institute Mycobacterium fol a gene that encodes for the enzyme dihydrofolate reductase
US5882898A (en) 1997-08-29 1999-03-16 Smithkline Beecham Corporation Streptococcus pneumoniae polynucleotides which encode folyl-polyglutamate synthetase (FPGS) polypeptides
PL204863B1 (pl) * 1998-07-22 2010-02-26 Stichting Dienst Landbouwkundi Zastosowanie mutanta Streptococcus, szczepionka i sposoby kontrolowania lub eliminowania choroby paciorkowcowej w populacji
EP1205552A1 (en) 2000-11-09 2002-05-15 ID-Lelystad, Instituut voor Dierhouderij en Diergezondheid B.V. Virulence of streptococci, involving ORFs from Streptococcus suis
DE102005049527B4 (de) * 2005-10-17 2013-05-08 Forschungszentrum Jülich GmbH Verfahren zur Herstellung von L-Serin, Gensequenz, Vektoren sowie Mikroorganismus
CN106085936B (zh) * 2016-06-14 2019-02-26 华中农业大学 一种猪链球菌2型10基因缺失株及应用
AU2017357813A1 (en) * 2016-11-11 2019-06-27 Boehringer Ingelheim Vetmedica Gmbh Attenuating bacterial virulence by attenuating bacterial folate transport

Also Published As

Publication number Publication date
ES2926543T3 (es) 2022-10-26
PH12019501019A1 (en) 2019-12-16
CN110582296B (zh) 2024-02-06
EP3538143B1 (en) 2022-06-22
CL2019001275A1 (es) 2019-09-06
RS63524B1 (sr) 2022-09-30
JP2019533710A (ja) 2019-11-21
JP6982616B2 (ja) 2021-12-17
EP4159231A1 (en) 2023-04-05
PT3538143T (pt) 2022-09-06
JP2022036982A (ja) 2022-03-08
DK3538143T3 (da) 2022-08-29
US20220226456A1 (en) 2022-07-21
WO2018089841A1 (en) 2018-05-17
CN110582296A (zh) 2019-12-17
EP3538143A1 (en) 2019-09-18
WO2018089841A9 (en) 2018-09-07
US20240115687A1 (en) 2024-04-11
MX2022014984A (es) 2023-01-04
HUE060176T2 (hu) 2023-01-28
MY201256A (en) 2024-02-14
KR20190084097A (ko) 2019-07-15
PL3538143T3 (pl) 2022-10-17
CA3043039A1 (en) 2018-05-17
US11684663B2 (en) 2023-06-27
BR112019009399A2 (pt) 2019-10-08
MX2019005499A (es) 2019-07-04
AU2017357813A1 (en) 2019-06-27

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