EA201792269A1 - Полипептиды, нацеленные на слияние вич - Google Patents
Полипептиды, нацеленные на слияние вичInfo
- Publication number
- EA201792269A1 EA201792269A1 EA201792269A EA201792269A EA201792269A1 EA 201792269 A1 EA201792269 A1 EA 201792269A1 EA 201792269 A EA201792269 A EA 201792269A EA 201792269 A EA201792269 A EA 201792269A EA 201792269 A1 EA201792269 A1 EA 201792269A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- polypeptides
- hiv
- merger
- aimed
- protein
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 5
- 229920001184 polypeptide Polymers 0.000 title abstract 3
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 3
- 239000012634 fragment Substances 0.000 abstract 3
- 102000004169 proteins and genes Human genes 0.000 abstract 3
- 108090000623 proteins and genes Proteins 0.000 abstract 3
- 108010067306 Fibronectins Proteins 0.000 abstract 2
- 102000016359 Fibronectins Human genes 0.000 abstract 2
- 101800001690 Transmembrane protein gp41 Proteins 0.000 abstract 2
- 239000002835 hiv fusion inhibitor Substances 0.000 abstract 2
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/76—Albumins
- C07K14/765—Serum albumin, e.g. HSA
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/79—Transferrins, e.g. lactoferrins, ovotransferrins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
- C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Virology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- AIDS & HIV (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Immunology (AREA)
Abstract
Изобретение направлено на полипептиды, содержащие CD4-связывающий фрагмент, gp41-связывающий фрагмент, фрагмент пептидного ингибитора слияния ВИЧ, и их комбинации. Более конкретно, настоящее изобретение относится к полипептидам, содержащим фибронектиновый каркасный доменный белок, который связывается с CD4, фибронектиновый каркасный доменный белок, который связывается с доменом N17 белка gp41, и пептидный ингибитор слияния ВИЧ или их комбинациям. Данное изобретение также относится к использованию новых белков в терапевтическом применении в лечении ВИЧ.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562152271P | 2015-04-24 | 2015-04-24 | |
US201562257474P | 2015-11-19 | 2015-11-19 | |
PCT/US2016/027424 WO2016171980A1 (en) | 2015-04-24 | 2016-04-14 | Polypeptides targeting hiv fusion |
Publications (2)
Publication Number | Publication Date |
---|---|
EA201792269A1 true EA201792269A1 (ru) | 2018-04-30 |
EA035332B1 EA035332B1 (ru) | 2020-05-28 |
Family
ID=55809237
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201792269A EA035332B1 (ru) | 2015-04-24 | 2016-04-14 | Полипептиды, нацеленные на слияние вич |
Country Status (25)
Country | Link |
---|---|
US (2) | US10407490B2 (ru) |
EP (2) | EP3985020A1 (ru) |
JP (3) | JP6894846B2 (ru) |
KR (1) | KR20170138558A (ru) |
CN (1) | CN107922474A (ru) |
AU (2) | AU2016252008B2 (ru) |
BR (1) | BR112017022790A2 (ru) |
CA (1) | CA2983276A1 (ru) |
CL (1) | CL2017002687A1 (ru) |
CO (1) | CO2017011583A2 (ru) |
CR (1) | CR20170482A (ru) |
DO (1) | DOP2017000246A (ru) |
EA (1) | EA035332B1 (ru) |
ES (1) | ES2884267T3 (ru) |
HK (1) | HK1243432A1 (ru) |
IL (1) | IL255122A0 (ru) |
MA (2) | MA41943A (ru) |
MX (1) | MX2017013687A (ru) |
PE (1) | PE20180162A1 (ru) |
PH (1) | PH12017501914A1 (ru) |
PT (1) | PT3286212T (ru) |
SG (1) | SG11201708441RA (ru) |
TW (1) | TW201643185A (ru) |
UY (1) | UY36650A (ru) |
WO (1) | WO2016171980A1 (ru) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106755100A (zh) * | 2017-02-20 | 2017-05-31 | 李因传 | 可控性hiv‑1基因组靶向编辑系统和其靶向载运系统 |
WO2019123262A1 (en) | 2017-12-18 | 2019-06-27 | VIIV Healthcare UK (No.5) Limited | Antigen binding polypeptides |
CN114605505B (zh) * | 2018-08-09 | 2023-01-31 | 东莞市朋志生物科技有限公司 | 用于检测hiv-1的合成肽 |
WO2021081515A2 (en) * | 2019-10-25 | 2021-04-29 | Cidara Therapeutics, Inc. | Compositions and methods for the treatment of human immunodeficiency virus |
CA3230492A1 (en) * | 2021-08-30 | 2023-03-09 | Kanglin Biotechnology (Hangzhou) Co., Ltd. | Gene sequence construct for gene therapy for hiv infection |
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AU2265701A (en) * | 1999-12-16 | 2001-06-25 | Tanox, Inc. | Anti-hiv-1 conjugates for treatment of hiv disease |
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EA035150B1 (ru) | 2011-09-27 | 2020-05-06 | Янссен Байотек, Инк. | Способ получения белковых каркасов на основе фибронектинового домена типа iii с альтернативными поверхностями связывания |
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CN103333255A (zh) * | 2013-06-28 | 2013-10-02 | 复旦大学 | 一种长效hiv‐1膜融合抑制剂 |
-
2016
- 2016-04-14 MX MX2017013687A patent/MX2017013687A/es unknown
- 2016-04-14 MA MA041943A patent/MA41943A/fr unknown
- 2016-04-14 CR CR20170482A patent/CR20170482A/es unknown
- 2016-04-14 CN CN201680036930.XA patent/CN107922474A/zh active Pending
- 2016-04-14 MA MA056222A patent/MA56222A/fr unknown
- 2016-04-14 BR BR112017022790-8A patent/BR112017022790A2/pt not_active IP Right Cessation
- 2016-04-14 EP EP21176464.2A patent/EP3985020A1/en active Pending
- 2016-04-14 EA EA201792269A patent/EA035332B1/ru not_active IP Right Cessation
- 2016-04-14 PT PT167188176T patent/PT3286212T/pt unknown
- 2016-04-14 US US15/568,830 patent/US10407490B2/en active Active
- 2016-04-14 ES ES16718817T patent/ES2884267T3/es active Active
- 2016-04-14 EP EP16718817.6A patent/EP3286212B1/en active Active
- 2016-04-14 CA CA2983276A patent/CA2983276A1/en not_active Abandoned
- 2016-04-14 JP JP2017555557A patent/JP6894846B2/ja active Active
- 2016-04-14 PE PE2017002311A patent/PE20180162A1/es unknown
- 2016-04-14 WO PCT/US2016/027424 patent/WO2016171980A1/en active Application Filing
- 2016-04-14 AU AU2016252008A patent/AU2016252008B2/en not_active Ceased
- 2016-04-14 SG SG11201708441RA patent/SG11201708441RA/en unknown
- 2016-04-14 KR KR1020177033985A patent/KR20170138558A/ko unknown
- 2016-04-22 UY UY0001036650A patent/UY36650A/es not_active Application Discontinuation
- 2016-04-22 TW TW105112708A patent/TW201643185A/zh unknown
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2017
- 2017-10-18 IL IL255122A patent/IL255122A0/en unknown
- 2017-10-19 PH PH12017501914A patent/PH12017501914A1/en unknown
- 2017-10-23 CL CL2017002687A patent/CL2017002687A1/es unknown
- 2017-10-23 DO DO2017000246A patent/DOP2017000246A/es unknown
- 2017-11-14 CO CONC2017/0011583A patent/CO2017011583A2/es unknown
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2018
- 2018-02-28 HK HK18102882.7A patent/HK1243432A1/zh unknown
-
2019
- 2019-08-07 US US16/533,941 patent/US11155602B2/en active Active
- 2019-09-06 AU AU2019226255A patent/AU2019226255A1/en not_active Abandoned
-
2020
- 2020-10-16 JP JP2020174288A patent/JP2021035951A/ja active Pending
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2023
- 2023-02-03 JP JP2023014947A patent/JP7465378B2/ja active Active
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG TJ TM |