EA201690402A1 - Способ количественного определения уровнейac в композицияхra - Google Patents

Способ количественного определения уровнейac в композицияхra

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Publication number
EA201690402A1
EA201690402A1 EA201690402A EA201690402A EA201690402A1 EA 201690402 A1 EA201690402 A1 EA 201690402A1 EA 201690402 A EA201690402 A EA 201690402A EA 201690402 A EA201690402 A EA 201690402A EA 201690402 A1 EA201690402 A1 EA 201690402A1
Authority
EA
Eurasian Patent Office
Prior art keywords
quantitative determination
column
compositions
levels
passing
Prior art date
Application number
EA201690402A
Other languages
English (en)
Inventor
Гро Элизабет Хьеллум
Original Assignee
Байер Ас
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Байер Ас filed Critical Байер Ас
Publication of EA201690402A1 publication Critical patent/EA201690402A1/ru

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Classifications

    • G—PHYSICS
    • G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
    • G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
    • G21G1/00—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes
    • G21G1/0005—Isotope delivery systems
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/15—Medicinal preparations ; Physical properties thereof, e.g. dissolubility
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
    • B01D15/1864—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns using two or more columns
    • B01D15/1871—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns using two or more columns placed in series
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01F—COMPOUNDS OF THE METALS BERYLLIUM, MAGNESIUM, ALUMINIUM, CALCIUM, STRONTIUM, BARIUM, RADIUM, THORIUM, OR OF THE RARE-EARTH METALS
    • C01F13/00—Compounds of radium
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/0093—Radioactive materials
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01T—MEASUREMENT OF NUCLEAR OR X-RADIATION
    • G01T1/00—Measuring X-radiation, gamma radiation, corpuscular radiation, or cosmic radiation
    • G01T1/36—Measuring spectral distribution of X-rays or of nuclear radiation spectrometry
    • G—PHYSICS
    • G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
    • G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
    • G21G1/00—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes
    • G21G1/001—Recovery of specific isotopes from irradiated targets
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N2030/009—Extraction
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
    • G01N2030/8868—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample elemental analysis, e.g. isotope dilution analysis
    • G—PHYSICS
    • G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
    • G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
    • G21G1/00—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes
    • G21G1/001—Recovery of specific isotopes from irradiated targets
    • G21G2001/0089—Actinium

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • General Physics & Mathematics (AREA)
  • Organic Chemistry (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Molecular Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Geology (AREA)
  • Inorganic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Extraction Or Liquid Replacement (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Способ для количественного определенияАс в композицииRa, включающий прохождение указанной композиции через первую колонку А для твердофазной экстракции, которая при этом содержит торий-специфичную смолу, прохождение элюата из колонки А через вторую колонку В для твердофазной экстракции, которая при этом содержит актиний-специфичную смолу, и извлечение Ас, адсорбированного на смолу в колонке В, и определение его количества.
EA201690402A 2013-08-16 2014-08-13 Способ количественного определения уровнейac в композицияхra EA201690402A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB201314718A GB201314718D0 (en) 2013-08-16 2013-08-16 Quantification method
PCT/EP2014/002222 WO2015022074A1 (en) 2013-08-16 2014-08-13 Method for the quantification of 227ac in 223ra compositions

Publications (1)

Publication Number Publication Date
EA201690402A1 true EA201690402A1 (ru) 2016-07-29

Family

ID=49301831

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201690402A EA201690402A1 (ru) 2013-08-16 2014-08-13 Способ количественного определения уровнейac в композицияхra

Country Status (17)

Country Link
US (2) US9874550B2 (ru)
EP (1) EP3033156A1 (ru)
JP (1) JP6605466B2 (ru)
KR (1) KR102307694B1 (ru)
CN (1) CN105899269B (ru)
AU (1) AU2014308140B2 (ru)
BR (1) BR112016003194B1 (ru)
CA (1) CA2921268A1 (ru)
CL (1) CL2016000351A1 (ru)
EA (1) EA201690402A1 (ru)
GB (1) GB201314718D0 (ru)
IL (1) IL243950B (ru)
MX (1) MX2016002076A (ru)
PE (1) PE20160219A1 (ru)
SG (1) SG11201600904RA (ru)
UA (1) UA120594C2 (ru)
WO (1) WO2015022074A1 (ru)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3174068B1 (en) * 2015-11-30 2018-06-20 Orano Med New method and apparatus for the production of high purity radionuclides
EP3682959A1 (en) * 2019-01-16 2020-07-22 Sck Cen Purification of actinium
CN113066598B (zh) * 2021-03-25 2023-08-08 中国科学院近代物理研究所 一种从高能质子束辐照232Th靶引起的散裂反应中分离纯化223Ra的方法
CN113311468B (zh) * 2021-04-12 2022-08-16 中国辐射防护研究院 一种使用uteva树脂分析气溶胶中铀同位素含量的方法
CN114624364B (zh) * 2022-03-21 2024-05-10 中国工程物理研究院核物理与化学研究所 一种水体中铀钍同步分离及含量测定方法
US20240219592A1 (en) * 2022-12-29 2024-07-04 BWXT Medical Ltd. Method for determination of actinium-227 in actinium-225
CN115869658A (zh) * 2022-12-29 2023-03-31 中国核动力研究设计院 用于制备Ra-223的分离系统及其分离方法、应用和制备方法
CN116594054B (zh) * 2023-07-18 2023-09-26 清华大学 一种233Pa标准γ源及其制备方法和应用

Family Cites Families (15)

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Publication number Priority date Publication date Assignee Title
US5809394A (en) * 1996-12-13 1998-09-15 Battelle Memorial Institute Methods of separating short half-life radionuclides from a mixture of radionuclides
US5854968A (en) * 1997-06-09 1998-12-29 Arch Development Corporation Process and apparatus for the production of BI-213 cations
US7405320B2 (en) * 1998-06-22 2008-07-29 Immunomedics, Inc. Therapeutic and diagnostic conjugates for use with multispecific antibodies
NO310544B1 (no) * 1999-01-04 2001-07-23 Algeta As Opparbeidelse og anvendelse av radium-223 til fremstilling av preparat samt kit til behandling av kalsifisert vev for palliasjon, benkreft-terapi og/eller overflatebehandling av ben
US20040166060A1 (en) * 2000-06-16 2004-08-26 Sloan Kettering Institute For Cancer Research Liposomal encapsulation of alpha particle emittors and uses thereof
NO313180B1 (no) * 2000-07-04 2002-08-26 Anticancer Therapeutic Inv Sa Bensökende alfapartikkel emitterende radiofarmasöytika
JP4495453B2 (ja) * 2001-06-22 2010-07-07 ピージー リサーチ ファンデーション，インコーポレーテッド 自動放射性核種分離システム
AU2003230886B2 (en) * 2002-04-12 2007-07-05 Pg Research Foundation, Inc. Multicolumn selectivity inversion generator for production of ultrapure radionuclides
US7087206B2 (en) * 2002-04-12 2006-08-08 Pg Research Foundation Multicolumn selectivity inversion generator for production of high purity actinium for use in therapeutic nuclear medicine
US7157022B2 (en) * 2002-09-30 2007-01-02 .Pg Research Foundation, Inc. Multivalent metal ion extraction using diglycolamide-coated particles
US7157061B2 (en) * 2004-09-24 2007-01-02 Battelle Energy Alliance, Llc Process for radioisotope recovery and system for implementing same
GB2436508C (en) * 2005-01-14 2011-01-26 Europ Organisation For Nuclear Res Cern Method for production of radioisotope preparationsand their use in life science, research, medical application and industry.
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GB201007353D0 (en) * 2010-04-30 2010-06-16 Algeta Asa Method
GB201007354D0 (en) * 2010-04-30 2010-06-16 Algeta Asa Method

Also Published As

Publication number Publication date
EP3033156A1 (en) 2016-06-22
CN105899269B (zh) 2017-12-01
NZ716837A (en) 2021-08-27
KR102307694B1 (ko) 2021-10-06
CA2921268A1 (en) 2015-02-19
BR112016003194B1 (pt) 2021-10-13
MX2016002076A (es) 2016-08-17
AU2014308140B2 (en) 2019-10-24
JP2016536593A (ja) 2016-11-24
SG11201600904RA (en) 2016-03-30
PE20160219A1 (es) 2016-05-22
WO2015022074A1 (en) 2015-02-19
CN105899269A (zh) 2016-08-24
US20160209387A1 (en) 2016-07-21
IL243950B (en) 2021-05-31
AU2014308140A1 (en) 2016-03-03
JP6605466B2 (ja) 2019-11-13
US9874550B2 (en) 2018-01-23
US20180180585A1 (en) 2018-06-28
BR112016003194A2 (pt) 2020-03-10
GB201314718D0 (en) 2013-10-02
KR20160043039A (ko) 2016-04-20
CL2016000351A1 (es) 2016-10-14
UA120594C2 (uk) 2020-01-10
IL243950A0 (en) 2016-04-21

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