EA201600235A1 - Циклические пептидомиметические соединения в качестве иммуномодуляторов - Google Patents

Циклические пептидомиметические соединения в качестве иммуномодуляторов

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Publication number
EA201600235A1
EA201600235A1 EA201600235A EA201600235A EA201600235A1 EA 201600235 A1 EA201600235 A1 EA 201600235A1 EA 201600235 A EA201600235 A EA 201600235A EA 201600235 A EA201600235 A EA 201600235A EA 201600235 A1 EA201600235 A1 EA 201600235A1
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EA
Eurasian Patent Office
Prior art keywords
cyclic
compounds
peptidomymetic
immunomodulators
therapeutic agents
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EA201600235A
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English (en)
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EA031325B1 (ru
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Потайил Говиндан Наир Сасикумар
Муралидхара Рамачандра
Сизарамайах Сетти Сударшан Наремаддепалли
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Ауриген Дискавери Текнолоджиз Лимитед
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Application filed by Ауриген Дискавери Текнолоджиз Лимитед filed Critical Ауриген Дискавери Текнолоджиз Лимитед
Publication of EA201600235A1 publication Critical patent/EA201600235A1/ru
Publication of EA031325B1 publication Critical patent/EA031325B1/ru

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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
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    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/26—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one amino group bound to the carbon skeleton, e.g. lysine
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  • Chemical & Material Sciences (AREA)
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  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Настоящее изобретение относится к циклическим пептидомиметическим соединениям в качестве терапевтических средств, способных ингибировать сигнальный путь программируемой смерти клеток - 1 (PD1). Изобретение также относится к производным этих терапевтических средств. Кроме того, изобретение относится к применению указанных терапевтических средств и их производных для лечения расстройств посредством иммуностимуляции, включающей ингибирование иммуносупрессивного сигнала, индуцированного вследствие PD-1, PD-L1 или PD-L2, а также к терапии или лечению с их помощью.
EA201600235A 2013-09-06 2014-09-05 Циклические пептидомиметические соединения в качестве иммуномодуляторов EA031325B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN4010CH2013 2013-09-06
PCT/IB2014/064283 WO2015033303A1 (en) 2013-09-06 2014-09-05 Cyclic peptidomimetic compounds as immunomodulators

Publications (2)

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EA201600235A1 true EA201600235A1 (ru) 2016-08-31
EA031325B1 EA031325B1 (ru) 2018-12-28

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EA201600235A EA031325B1 (ru) 2013-09-06 2014-09-05 Циклические пептидомиметические соединения в качестве иммуномодуляторов
EA201891818A EA201891818A3 (ru) 2013-09-06 2014-09-05 Способ получения соединений, используемых при получении циклических пептидомиметических соединений

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EA201891818A EA201891818A3 (ru) 2013-09-06 2014-09-05 Способ получения соединений, используемых при получении циклических пептидомиметических соединений

Country Status (24)

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US (2) US20160113901A1 (ru)
EP (2) EP3041468B1 (ru)
JP (1) JP6474412B2 (ru)
KR (1) KR20160075506A (ru)
CN (1) CN105813640A (ru)
AU (2) AU2014316686B2 (ru)
CA (1) CA2922982A1 (ru)
CU (1) CU24363B1 (ru)
CY (1) CY1120747T1 (ru)
DK (1) DK3041468T3 (ru)
EA (2) EA031325B1 (ru)
ES (1) ES2683356T3 (ru)
HR (1) HRP20181271T1 (ru)
HU (1) HUE039012T2 (ru)
IL (2) IL244388A0 (ru)
LT (1) LT3041468T (ru)
MX (1) MX2016002970A (ru)
PH (1) PH12016500413B1 (ru)
PL (1) PL3041468T3 (ru)
PT (1) PT3041468T (ru)
RS (1) RS57628B1 (ru)
SG (1) SG11201601685TA (ru)
SI (1) SI3041468T1 (ru)
WO (1) WO2015033303A1 (ru)

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