EA201591373A1 - Изготовление модифицированных внеклеточным матриксом тканеинженерных нервных трансплантатов для восстановления поврежденных периферических нервов - Google Patents

Изготовление модифицированных внеклеточным матриксом тканеинженерных нервных трансплантатов для восстановления поврежденных периферических нервов

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EA201591373A1
EA201591373A1 EA201591373A EA201591373A EA201591373A1 EA 201591373 A1 EA201591373 A1 EA 201591373A1 EA 201591373 A EA201591373 A EA 201591373A EA 201591373 A EA201591373 A EA 201591373A EA 201591373 A1 EA201591373 A1 EA 201591373A1
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Eurasian Patent Office
Prior art keywords
extracellular matrix
manufacturing
peripheral nerves
transplantas
nervous
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EA201591373A
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English (en)
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EA038957B1 (ru
Inventor
Сяосун Гу
Фэй Дин
Юнь Гу
Ченбин Сюэ
Юймин Ян
Юнцзюнь Ван
Лэйлэй Гун
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Наньтун Юниверсити
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Publication of EA201591373A1 publication Critical patent/EA201591373A1/ru
Publication of EA038957B1 publication Critical patent/EA038957B1/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3641—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the site of application in the body
    • A61L27/3675—Nerve tissue, e.g. brain, spinal cord, nerves, dura mater
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
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    • A—HUMAN NECESSITIES
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    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/24—Collagen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A61L27/3633—Extracellular matrix [ECM]
    • A—HUMAN NECESSITIES
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    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
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    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
    • A61L27/3687—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by the use of chemical agents in the treatment, e.g. specific enzymes, detergents, capping agents, crosslinkers, anticalcification agents
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    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3839—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
    • A61L27/3878—Nerve tissue, brain, spinal cord, nerves, dura mater
    • A—HUMAN NECESSITIES
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    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3895—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells using specific culture conditions, e.g. stimulating differentiation of stem cells, pulsatile flow conditions
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Abstract

Тканеинженерный нервный трансплантат для восстановления поврежденных периферических нервов составляют нервный проводник и внеклеточный матрикс (ЕСМ), который выделяется аутогенными или аллогенными поддерживающими клетками и получается посредством децеллюляризации. Способ изготовления модифицированных внеклеточным матриксом тканеинженерных нервных трансплантатов, содержащих поддерживающие клетки и нервный проводник, и изготовление модифицированного внеклеточным матриксом тканеинженерного нервного трансплантата.
EA201591373A 2013-01-25 2013-05-27 Изготовление модифицированных внеклеточным матриксом тканеинженерных нервных трансплантатов для восстановления поврежденных периферических нервов EA038957B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201310028903.6A CN103041450B (zh) 2013-01-25 2013-01-25 用于修复周围神经损伤的细胞基质修饰的组织工程神经移植物及其制备方法
PCT/CN2013/076239 WO2014114043A1 (zh) 2013-01-25 2013-05-27 用于修复周围神经损伤的细胞基质修饰的组织工程神经移植物及其制备方法

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EA201591373A1 true EA201591373A1 (ru) 2016-01-29
EA038957B1 EA038957B1 (ru) 2021-11-15

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US (1) US9492589B2 (ru)
EP (1) EP2949349B1 (ru)
CN (1) CN103041450B (ru)
AU (1) AU2013375655B2 (ru)
BR (1) BR112015017174B1 (ru)
EA (1) EA038957B1 (ru)
WO (1) WO2014114043A1 (ru)

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CN107384862B (zh) * 2017-08-23 2020-08-04 北京再生生物科技研究院有限公司 MSCs来源的雪旺细胞的制备方法及试剂盒
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CN110665059B (zh) * 2019-10-17 2021-09-28 苏州大学 一种组织工程化神经移植体及其制备方法
CN112402697A (zh) * 2020-11-25 2021-02-26 南通大学 皮肤前体细胞诱导的施万细胞来源的囊泡在构建组织工程神经移植物中的应用
CN112755250A (zh) * 2020-12-31 2021-05-07 西安交通大学口腔医院 一种组织工程化周围神经组织及其制备方法
CN113171494A (zh) * 2021-04-20 2021-07-27 武汉理工大学 利用细胞外基质材料制备神经诱导修复导管的方法
CN113151177B (zh) * 2021-05-21 2023-11-03 四川大学华西医院 乳腺或乳腺癌组织脱细胞基质及其制备方法和用途
CN114288478B (zh) * 2021-12-24 2022-11-29 南通大学 一种组织工程神经复合体及其制备方法和应用
CN114306731B (zh) * 2021-12-28 2022-10-14 中国科学院上海硅酸盐研究所 多细胞打印神经化骨再生的活性支架及其制备方法和应用
CN114958745A (zh) * 2022-04-28 2022-08-30 复旦大学附属儿科医院 一种适宜儿童使用的组织工程神经及其制备方法
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JP5930476B2 (ja) * 2010-03-25 2016-06-08 ライフセル コーポレーションＬｉｆｅＣｅｌｌ Ｃｏｒｐｏｒａｔｉｏｎ 再生組織足場の製造
EP2661243B1 (en) * 2011-01-06 2022-10-12 Humacyte, Inc. Tissue-engineered constructs
CN102343114A (zh) * 2011-10-24 2012-02-08 南通大学 组织工程神经移植物及其用途
CN103041450B (zh) * 2013-01-25 2015-06-10 南通大学 用于修复周围神经损伤的细胞基质修饰的组织工程神经移植物及其制备方法

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EP2949349A4 (en) 2016-11-02
AU2013375655A1 (en) 2015-07-23
US9492589B2 (en) 2016-11-15
CN103041450B (zh) 2015-06-10
EA038957B1 (ru) 2021-11-15
EP2949349B1 (en) 2018-10-31
BR112015017174B1 (pt) 2020-09-24
WO2014114043A1 (zh) 2014-07-31
BR112015017174A2 (pt) 2017-07-11
US20150352255A1 (en) 2015-12-10
EP2949349A1 (en) 2015-12-02
AU2013375655B2 (en) 2016-11-17

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