EA201491965A1 - Слитые белки для облегчения отбора клеток, инфицированных рекомбинантным вирусом осповакцины с геном специфического иммуноглобулина - Google Patents

Слитые белки для облегчения отбора клеток, инфицированных рекомбинантным вирусом осповакцины с геном специфического иммуноглобулина

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EA201491965A1
EA201491965A1 EA201491965A EA201491965A EA201491965A1 EA 201491965 A1 EA201491965 A1 EA 201491965A1 EA 201491965 A EA201491965 A EA 201491965A EA 201491965 A EA201491965 A EA 201491965A EA 201491965 A1 EA201491965 A1 EA 201491965A1
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selection
relates
ospovaccine
proteins
slip
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EA201491965A
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EA028164B1 (ru
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Эрнест С. Смит
Трэйси Пандина
Лесли А. Крой
Марк Пэрис
Морис Заудерер
Ангелика Мокса
Рене Кирк
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Вэксинекс, Инк.
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Publication of EA201491965A1 publication Critical patent/EA201491965A1/ru
Publication of EA028164B1 publication Critical patent/EA028164B1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/522—CH1 domain
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    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
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    • C12N2710/00011—Details
    • C12N2710/24011—Poxviridae
    • C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
    • C12N2710/24122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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    • C12N2710/24011—Poxviridae
    • C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
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    • C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
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    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
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  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Изобретение относится к высокоэффективному способу экспрессии молекул иммуноглобулинов в эукариотических клетках. Изобретение, кроме того, относится к способу получения библиотек тяжелых и легких цепей иммуноглобулинов, в частности, с использованием способа тримолекулярной рекомбинации для экспрессии в эукариотических клетках. Изобретение, кроме того, относится к способам отбора и скрининга антигенспецифических молекул иммуноглобулинов, и их антигенспецифических фрагментов. Изобретение относится также к наборам для получения, скрининга и отбора антигенспецифических молекул иммуноглобулинов. Наконец, изобретение относится к молекулам иммуноглобулинов и их антигенспецифических фрагментам, полученным способами, представленными в настоящем документе.
EA201491965A 2012-04-26 2013-04-26 Слитые белки для облегчения отбора клеток, инфицированных рекомбинантным вирусом осповакцины с геном специфического иммуноглобулина EA028164B1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201261639046P 2012-04-26 2012-04-26
US201261732776P 2012-12-03 2012-12-03
US13/844,388 US9708601B2 (en) 2012-04-26 2013-03-15 Fusion proteins to facilitate selection of cells infected with specific immunoglobulin gene recombinant vaccinia virus
PCT/US2013/038497 WO2013163602A1 (en) 2012-04-26 2013-04-26 Fusion proteins to facilitate selection of cells infected with specific immunoglobulin gene recombinant vaccinia virus

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EA201491965A1 true EA201491965A1 (ru) 2015-03-31
EA028164B1 EA028164B1 (ru) 2017-10-31

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US (3) US9708601B2 (ru)
EP (1) EP2841606B1 (ru)
JP (2) JP6498599B2 (ru)
KR (1) KR102108589B1 (ru)
CN (1) CN104520444B (ru)
AU (1) AU2013251371B2 (ru)
CA (1) CA2871597C (ru)
DK (1) DK2841606T3 (ru)
EA (1) EA028164B1 (ru)
ES (1) ES2725673T3 (ru)
IL (1) IL235323B (ru)
NZ (1) NZ630854A (ru)
PL (1) PL2841606T3 (ru)
PT (1) PT2841606T (ru)
SG (1) SG11201406974YA (ru)
WO (1) WO2013163602A1 (ru)

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ES2725673T3 (es) 2019-09-26
CA2871597C (en) 2021-04-20
NZ630854A (en) 2017-03-31
US9708601B2 (en) 2017-07-18
WO2013163602A1 (en) 2013-10-31
KR102108589B1 (ko) 2020-05-07
EA028164B1 (ru) 2017-10-31
AU2013251371A1 (en) 2014-11-13
JP6498599B2 (ja) 2019-04-10
DK2841606T3 (da) 2019-05-06
JP2015514811A (ja) 2015-05-21
EP2841606B1 (en) 2019-01-23
US20160152971A1 (en) 2016-06-02
CA2871597A1 (en) 2013-10-31
IL235323B (en) 2020-01-30
EP2841606A1 (en) 2015-03-04
KR20150009560A (ko) 2015-01-26
US20170306318A1 (en) 2017-10-26
SG11201406974YA (en) 2014-11-27
US20130288927A1 (en) 2013-10-31
CN104520444A (zh) 2015-04-15
CN104520444B (zh) 2017-12-12
EP2841606A4 (en) 2015-12-30
US10662422B2 (en) 2020-05-26
PT2841606T (pt) 2019-05-17
AU2013251371B2 (en) 2018-01-04
PL2841606T3 (pl) 2019-07-31
JP2019055956A (ja) 2019-04-11
US9701958B2 (en) 2017-07-11
IL235323A0 (en) 2014-12-31

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