EA201490905A1 - N-(3-{[(3-{[2-хлор-5-(метокси)фенил]амино}хиноксалин-2-ил)амино]сульфонил}фенил)-2-метилаланинамид как ингибитор фосфатидилинозитол-3-киназы для лечения лимфопролиферативных злокачественных заболеваний - Google Patents

N-(3-{[(3-{[2-хлор-5-(метокси)фенил]амино}хиноксалин-2-ил)амино]сульфонил}фенил)-2-метилаланинамид как ингибитор фосфатидилинозитол-3-киназы для лечения лимфопролиферативных злокачественных заболеваний

Info

Publication number
EA201490905A1
EA201490905A1 EA201490905A EA201490905A EA201490905A1 EA 201490905 A1 EA201490905 A1 EA 201490905A1 EA 201490905 A EA201490905 A EA 201490905A EA 201490905 A EA201490905 A EA 201490905A EA 201490905 A1 EA201490905 A1 EA 201490905A1
Authority
EA
Eurasian Patent Office
Prior art keywords
amino
phosphatidylinosytolinoty
methilaninamide
methilaninamid
lymphproliferative
Prior art date
Application number
EA201490905A
Other languages
English (en)
Inventor
Артур Десиллис
Джоанн Лейджер
Original Assignee
Экселиксис, Инк.
Санофи
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47295148&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201490905(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Экселиксис, Инк., Санофи filed Critical Экселиксис, Инк.
Publication of EA201490905A1 publication Critical patent/EA201490905A1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/233—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
    • C07D241/40—Benzopyrazines
    • C07D241/44—Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Представлены способы лечения лимфопролиферативного злокачественного заболевания у пациента, нуждающегося в таком лечении, включающие введение указанному пациенту эффективного количества соединения А, описанного в настоящем документе.
EA201490905A 2011-11-01 2012-11-01 N-(3-{[(3-{[2-хлор-5-(метокси)фенил]амино}хиноксалин-2-ил)амино]сульфонил}фенил)-2-метилаланинамид как ингибитор фосфатидилинозитол-3-киназы для лечения лимфопролиферативных злокачественных заболеваний EA201490905A1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161553990P 2011-11-01 2011-11-01
US201161568189P 2011-12-08 2011-12-08
PCT/US2012/062999 WO2013067141A1 (en) 2011-11-01 2012-11-01 N- (3- { [ (3- { [2-chloro-5- (methoxy) phenyl] amino} quinoxalin- 2 -yl) amino] sulfonyl} phe nyl) - 2 -methylalaninamide as phosphatidylinositol 3 - kinase inhibitor for the treatment of lymphoproliferative malignancies

Publications (1)

Publication Number Publication Date
EA201490905A1 true EA201490905A1 (ru) 2014-11-28

Family

ID=47295148

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201490905A EA201490905A1 (ru) 2011-11-01 2012-11-01 N-(3-{[(3-{[2-хлор-5-(метокси)фенил]амино}хиноксалин-2-ил)амино]сульфонил}фенил)-2-метилаланинамид как ингибитор фосфатидилинозитол-3-киназы для лечения лимфопролиферативных злокачественных заболеваний

Country Status (21)

Country Link
US (2) US20140303172A1 (ru)
EP (1) EP2773353B1 (ru)
JP (1) JP6013498B2 (ru)
KR (1) KR20140096083A (ru)
CN (2) CN104302294A (ru)
AU (2) AU2012332486A1 (ru)
BR (1) BR112014010492A2 (ru)
CA (1) CA2854159A1 (ru)
CL (1) CL2014001138A1 (ru)
CR (1) CR20140253A (ru)
DO (1) DOP2014000092A (ru)
EA (1) EA201490905A1 (ru)
EC (1) ECSP14002014A (ru)
HK (1) HK1201480A1 (ru)
IL (1) IL232398A0 (ru)
MX (1) MX2014005249A (ru)
NI (1) NI201400037A (ru)
PE (1) PE20141794A1 (ru)
SG (1) SG11201401961UA (ru)
WO (1) WO2013067141A1 (ru)
ZA (1) ZA201403258B (ru)

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AR092501A1 (es) * 2012-09-13 2015-04-22 Sanofi Sa Compuestos cristalinos
CN111904962A (zh) 2012-11-08 2020-11-10 理森制药股份公司 含有PDE4抑制剂和PI3 δ或双重PI3 δ-γ激酶抑制剂的药物组合物

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Also Published As

Publication number Publication date
DOP2014000092A (es) 2015-02-15
WO2013067141A1 (en) 2013-05-10
IL232398A0 (en) 2014-06-30
ZA201403258B (en) 2015-11-25
ECSP14002014A (es) 2015-11-30
US10328069B2 (en) 2019-06-25
CL2014001138A1 (es) 2014-08-01
NI201400037A (es) 2014-12-22
BR112014010492A2 (pt) 2017-04-25
JP2014532709A (ja) 2014-12-08
SG11201401961UA (en) 2014-05-29
CR20140253A (es) 2014-10-28
AU2012332486A1 (en) 2014-06-19
US20170296529A1 (en) 2017-10-19
JP6013498B2 (ja) 2016-10-25
PE20141794A1 (es) 2014-12-17
KR20140096083A (ko) 2014-08-04
HK1201480A1 (en) 2015-09-04
CN104302294A (zh) 2015-01-21
AU2017219131A1 (en) 2017-09-28
CN107375289A (zh) 2017-11-24
EP2773353B1 (en) 2018-09-05
EP2773353A1 (en) 2014-09-10
MX2014005249A (es) 2015-03-05
CA2854159A1 (en) 2013-05-10
US20140303172A1 (en) 2014-10-09

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