EA201490627A1 - Соединения для улучшенной вирусной трансдукции - Google Patents

Соединения для улучшенной вирусной трансдукции

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Publication number
EA201490627A1
EA201490627A1 EA201490627A EA201490627A EA201490627A1 EA 201490627 A1 EA201490627 A1 EA 201490627A1 EA 201490627 A EA201490627 A EA 201490627A EA 201490627 A EA201490627 A EA 201490627A EA 201490627 A1 EA201490627 A1 EA 201490627A1
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Prior art keywords
methods
compounds
viral transduction
compositions
stem cells
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EA201490627A
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English (en)
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EA032699B1 (ru
Inventor
Гарретт Коллинс Хеффнер
Абрахам Исаак Бассан
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Блубёрд Био, Инк.
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Application filed by Блубёрд Био, Инк. filed Critical Блубёрд Био, Инк.
Publication of EA201490627A1 publication Critical patent/EA201490627A1/ru
Publication of EA032699B1 publication Critical patent/EA032699B1/ru

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Abstract

В настоящем изобретении предложены способы и композиции для улучшения эффективности трансдукции клеток. В частности, в настоящем изобретении предложены способы и материалы, применимые для безопасного и гарантированного повышения эффективности способов трансдукции клеток, таких как кроветворные стволовые клетки человека (HSC), вирусами и/или вирусными векторами. Композиции и способы применимы при терапевтических показаниях, когда целесообразна генная терапия с использованием кроветворных стволовых клеток.
EA201490627A 2011-09-30 2012-09-28 Способ повышения эффективности трансдукции кроветворных клеток лентивирусом EA032699B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161541736P 2011-09-30 2011-09-30
PCT/US2012/057987 WO2013049615A1 (en) 2011-09-30 2012-09-28 Compounds for improved viral transduction

Publications (2)

Publication Number Publication Date
EA201490627A1 true EA201490627A1 (ru) 2014-11-28
EA032699B1 EA032699B1 (ru) 2019-07-31

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Family Applications (1)

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EA201490627A EA032699B1 (ru) 2011-09-30 2012-09-28 Способ повышения эффективности трансдукции кроветворных клеток лентивирусом

Country Status (19)

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US (4) US9988644B2 (ru)
EP (4) EP4095236A1 (ru)
JP (2) JP6285863B2 (ru)
KR (1) KR102011532B1 (ru)
CN (2) CN108220246B (ru)
AU (1) AU2012315699B2 (ru)
BR (1) BR112014007782B1 (ru)
CA (1) CA2850484C (ru)
CY (1) CY1122654T1 (ru)
DK (2) DK3269802T3 (ru)
EA (1) EA032699B1 (ru)
ES (3) ES2913633T3 (ru)
IL (2) IL231812B (ru)
IN (1) IN2014CN02518A (ru)
MX (2) MX359398B (ru)
PT (2) PT2760994T (ru)
SG (2) SG10201602423TA (ru)
UA (1) UA114796C2 (ru)
WO (1) WO2013049615A1 (ru)

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