EA201490038A1 - Соединения, ингибирующие металлоферменты - Google Patents

Соединения, ингибирующие металлоферменты

Info

Publication number
EA201490038A1
EA201490038A1 EA201490038A EA201490038A EA201490038A1 EA 201490038 A1 EA201490038 A1 EA 201490038A1 EA 201490038 A EA201490038 A EA 201490038A EA 201490038 A EA201490038 A EA 201490038A EA 201490038 A1 EA201490038 A1 EA 201490038A1
Authority
EA
Eurasian Patent Office
Prior art keywords
inhibiting compounds
enzyme inhibiting
metallic
metallic enzyme
compounds
Prior art date
Application number
EA201490038A
Other languages
English (en)
Russian (ru)
Inventor
Уиллиам Дж. Хекстра
Стивен У. Рэфферти
Кристофер М. Йейтс
Роберт Дж. Шотцингер
Майкл Лосо
Майкл Салленбергер
Original Assignee
Вайамет Фармасьютикалс, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Вайамет Фармасьютикалс, Инк. filed Critical Вайамет Фармасьютикалс, Инк.
Publication of EA201490038A1 publication Critical patent/EA201490038A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/54—1,3-Diazines; Hydrogenated 1,3-diazines
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/56—1,2-Diazoles; Hydrogenated 1,2-diazoles
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/64—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
    • A01N43/647—Triazoles; Hydrogenated triazoles
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/64—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
    • A01N43/647—Triazoles; Hydrogenated triazoles
    • A01N43/653—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/713—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with four or more nitrogen atoms as the only ring hetero atoms
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
    • A01N43/74—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,3
    • A01N43/76—1,3-Oxazoles; Hydrogenated 1,3-oxazoles
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
    • A01N43/74—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,3
    • A01N43/78—1,3-Thiazoles; Hydrogenated 1,3-thiazoles
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
    • A01N43/84—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms six-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Environmental Sciences (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Obesity (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Ophthalmology & Optometry (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EA201490038A 2011-06-19 2012-06-19 Соединения, ингибирующие металлоферменты EA201490038A1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201161498571P 2011-06-19 2011-06-19
US201161505949P 2011-07-08 2011-07-08
US201261611880P 2012-03-16 2012-03-16
PCT/US2012/043101 WO2012177608A1 (en) 2011-06-19 2012-06-19 Metalloenzyme inhibitor compounds

Publications (1)

Publication Number Publication Date
EA201490038A1 true EA201490038A1 (ru) 2014-04-30

Family

ID=47391258

Family Applications (2)

Application Number Title Priority Date Filing Date
EA201490038A EA201490038A1 (ru) 2011-06-19 2012-06-19 Соединения, ингибирующие металлоферменты
EA201490036A EA024385B1 (ru) 2011-06-19 2012-06-19 Соединения, ингибирующие металлоферменты

Family Applications After (1)

Application Number Title Priority Date Filing Date
EA201490036A EA024385B1 (ru) 2011-06-19 2012-06-19 Соединения, ингибирующие металлоферменты

Country Status (20)

Country Link
US (4) US8901121B2 (c_deeref_Disk_and_Scratch_Disk_Pools_and_Their_Defaults.html)
EP (2) EP2721020B1 (c_deeref_Disk_and_Scratch_Disk_Pools_and_Their_Defaults.html)
JP (2) JP6159318B2 (c_deeref_Disk_and_Scratch_Disk_Pools_and_Their_Defaults.html)
KR (2) KR20140040235A (c_deeref_Disk_and_Scratch_Disk_Pools_and_Their_Defaults.html)
CN (2) CN103764646A (c_deeref_Disk_and_Scratch_Disk_Pools_and_Their_Defaults.html)
AR (1) AR086988A1 (c_deeref_Disk_and_Scratch_Disk_Pools_and_Their_Defaults.html)
AU (2) AU2012273166A1 (c_deeref_Disk_and_Scratch_Disk_Pools_and_Their_Defaults.html)
BR (1) BR102012015199A2 (c_deeref_Disk_and_Scratch_Disk_Pools_and_Their_Defaults.html)
CA (2) CA2839769A1 (c_deeref_Disk_and_Scratch_Disk_Pools_and_Their_Defaults.html)
CL (1) CL2013003639A1 (c_deeref_Disk_and_Scratch_Disk_Pools_and_Their_Defaults.html)
CO (1) CO6940433A2 (c_deeref_Disk_and_Scratch_Disk_Pools_and_Their_Defaults.html)
CR (1) CR20140024A (c_deeref_Disk_and_Scratch_Disk_Pools_and_Their_Defaults.html)
EA (2) EA201490038A1 (c_deeref_Disk_and_Scratch_Disk_Pools_and_Their_Defaults.html)
EC (1) ECSP14013153A (c_deeref_Disk_and_Scratch_Disk_Pools_and_Their_Defaults.html)
HK (1) HK1198651A1 (c_deeref_Disk_and_Scratch_Disk_Pools_and_Their_Defaults.html)
IN (1) IN2014MN00093A (c_deeref_Disk_and_Scratch_Disk_Pools_and_Their_Defaults.html)
MX (1) MX2013015160A (c_deeref_Disk_and_Scratch_Disk_Pools_and_Their_Defaults.html)
PH (1) PH12013502624A1 (c_deeref_Disk_and_Scratch_Disk_Pools_and_Their_Defaults.html)
UY (1) UY34146A (c_deeref_Disk_and_Scratch_Disk_Pools_and_Their_Defaults.html)
WO (2) WO2012177608A1 (c_deeref_Disk_and_Scratch_Disk_Pools_and_Their_Defaults.html)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012177608A1 (en) * 2011-06-19 2012-12-27 Viamet Pharmaceuticals, Inc. Metalloenzyme inhibitor compounds
JP6247632B2 (ja) * 2011-06-19 2017-12-13 ヴィアメット ファーマスーティカルズ，インコーポレイテッド メタロ酵素阻害剤化合物
KR101964195B1 (ko) * 2011-06-23 2019-04-01 비아멧 파마슈티컬즈(엔씨), 인코포레이티드 금속효소 억제제 화합물
US8598213B2 (en) 2011-07-08 2013-12-03 H. Lundbeck A/S Positive allosteric modulators of nicotinic acetylcholine receptor
WO2013090210A1 (en) 2011-12-11 2013-06-20 Viamet Pharmaceuticals, Inc. Metalloenzyme inhibitor compounds
KR102061137B1 (ko) 2012-01-20 2019-12-31 마이코비아 파마슈티컬즈, 인코포레이티드 금속효소 억제제 화합물
WO2013135674A1 (en) * 2012-03-12 2013-09-19 Syngenta Participations Ag Insecticidal 2-aryl-acetamide compounds
WO2014043376A1 (en) * 2012-09-12 2014-03-20 Dow Agrosciences Llc Metalloenzyme inhibitor compounds
BR112015018547A2 (pt) * 2013-02-04 2017-07-18 Syngenta Participations Ag microbiocidas
BR112015025331A2 (pt) 2013-04-12 2017-07-18 Bayer Cropscience Ag novos derivados de triazolintiona
BR112015025679A8 (pt) * 2013-04-12 2020-02-11 Bayer Cropscience Ag novos derivados de triazol
US9822099B2 (en) * 2013-04-12 2017-11-21 Bayer Cropscience Aktiengesellschaft Triazole derivatives
JP6387401B2 (ja) * 2013-05-28 2018-09-05 ヴィアメット ファーマスーティカルズ（エヌシー），インコーポレイテッド 殺真菌組成物
JP6386035B2 (ja) * 2013-06-12 2018-09-05 ヴィアメット ファーマスーティカルズ（エヌシー），インコーポレイテッド 金属酵素阻害剤化合物
US9981943B2 (en) 2014-03-19 2018-05-29 Mycovia Pharmaceuticals, Inc. Antifungal compound process
AU2015231226B2 (en) 2014-03-19 2019-04-04 Mycovia Pharmaceuticals, Inc. Antifungal compound process
CN106459022B (zh) * 2014-03-19 2019-08-02 北卡罗来纳维亚梅特制药公司 抗真菌化合物的制备方法
EP3119754A4 (en) 2014-03-19 2017-12-13 Viamet Pharmaceuticals, Inc. Antifungal compound process
EP3119749A4 (en) 2014-03-19 2017-12-13 Viamet Pharmaceuticals, Inc. Antifungal compound process
US10017494B2 (en) 2014-03-19 2018-07-10 Mycovia Pharmaceuticals, Inc. Antifungal compound process
JP6633539B2 (ja) * 2014-03-19 2020-01-22 ダウ アグロサイエンシィズ エルエルシー ２−（２，４−ジフルオロフェニル）−１，１−ジフルオロ−１−（５−置換−ピリジン−２−イル）−３−（１ｈ−テトラゾール−１−イル）プロパン−２−オールおよびその調製工程
CA2942972A1 (en) 2014-03-19 2015-09-24 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Antifungal compound process
MX371291B (es) 2014-03-19 2020-01-24 Viamet Pharmaceuticals Nc Inc 2-(2,4-difluorofenil)-1,1-difluoro-1-(5-sustituido-piridin-2-il)- 3-(1h-tetrazol-1-il)propan-2-oles y procedimientos para su preparacion.
JP2017507991A (ja) 2014-03-19 2017-03-23 ヴィアメット ファーマスーティカルズ，インコーポレイテッド 抗真菌化合物の調製方法
US9944664B2 (en) * 2014-04-15 2018-04-17 Dow Agrosciences Llc Metalloenzyme inhibitor compounds as fungicides
EP3164374A4 (en) * 2014-07-02 2017-11-15 Ralco Nutrition, Inc. Agricultural compositions and applications utilizing essential oils
JP2017531636A (ja) 2014-10-02 2017-10-26 バイエル・クロップサイエンス・アクチェンゲゼルシャフト 殺菌剤として有用な新規トリアゾール誘導体
CN107660203A (zh) * 2015-04-02 2018-02-02 拜耳作物科学股份公司 作为杀真菌剂的三唑衍生物
CA2986041C (en) 2015-05-18 2021-06-29 Viamet Pharmaceuticals, Inc. 4-((6-(2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1h-1,2,4-triazol-1-yl)propyl)pyridin-3-yl)oxy)benzonitrile and 4-((6-(2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(5-thioxo-4,5-dihydro-1h-1,2,4-triazol-1-yl)propyl)pyridin-3-yl)oxy)benzonitrile compounds as antifungal agents
AU2016323782B2 (en) 2015-09-18 2020-11-26 Nqp 1598, Ltd. Antifungal compound process
WO2017087643A1 (en) 2015-11-17 2017-05-26 Viamet Pharmaceuticals, Inc. 4-((6-2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1h-1,2,4-triazol-1-yl)propyl)pyridin-3-yl)oxy)benzonitrile and processes of preparation
KR20180101343A (ko) 2015-11-17 2018-09-12 다우 아그로사이언시즈 엘엘씨 4-((6-(2-(2,4-디플루오로페닐)-1,1-디플루오로-2-옥소에틸)피리딘-3-일)옥시)벤조니트릴 및 제조방법
EP3795563B1 (en) 2016-03-31 2024-07-17 Oncternal Therapeutics, Inc. Indoline analogs and uses thereof
AU2017382405B2 (en) 2016-12-22 2021-12-16 Calithera Biosciences, Inc. Compositions and methods for inhibiting arginase activity
CN106866575A (zh) * 2017-03-21 2017-06-20 苏州汉德创宏生化科技有限公司 2‑(1‑哌啶基)‑5‑溴噻唑的合成方法
CN107056690A (zh) * 2017-03-22 2017-08-18 上海康鹏科技有限公司 一种6‑溴吡啶‑3‑甲醛的制备方法
BR112020009446A2 (pt) 2017-11-13 2020-11-03 Bayer Aktiengesellschaft derivados de tetrazólio propila e seu uso como fungicida
CN108358871B (zh) * 2018-02-01 2020-05-22 浙江扬帆新材料股份有限公司 一种2-苄基-2-二甲基氨基-1-(4-吗啉苯基)丁酮的合成方法
CN117069697A (zh) * 2022-05-16 2023-11-17 上海济煜医药科技有限公司 一类含杂环结构化合物的制备方法及作为抗菌剂的应用
CN117069693A (zh) * 2022-05-16 2023-11-17 上海济煜医药科技有限公司 一类含胺基结构化合物的制备方法及作为抗菌剂的应用
CN115007323B (zh) * 2022-06-17 2024-01-23 中南大学 一种抑制矿物中黄铁矿浮选的方法

Family Cites Families (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8301699D0 (en) * 1983-01-21 1983-02-23 Pfizer Ltd Antifungal agents
GB8304282D0 (en) * 1983-02-16 1983-03-23 Pfizer Ltd Antifungal agents
DE3313073A1 (de) * 1983-04-12 1984-10-18 Bayer Ag, 5090 Leverkusen 1-azolyl-3-pyrazolyl-2-propanol-derivate, verfahren zu ihrer herstellung und ihre verwendung als fungizide
US4921475A (en) 1983-08-18 1990-05-01 Drug Delivery Systems Inc. Transdermal drug patch with microtubes
US5087240A (en) 1983-08-18 1992-02-11 Drug Delivery Systems Inc. Transdermal drug patch with conductive fibers
ATE33982T1 (de) * 1983-12-20 1988-05-15 Ciba Geigy Ag Mikrobizide.
GB8506619D0 (en) * 1985-03-14 1985-04-17 Pfizer Ltd Triazole antifungal agents
US4738851A (en) 1985-09-27 1988-04-19 University Of Iowa Research Foundation, Inc. Controlled release ophthalmic gel formulation
US5163899A (en) 1987-03-20 1992-11-17 Drug Delivery Systems Inc. Transdermal drug delivery system
US5312325A (en) 1987-05-28 1994-05-17 Drug Delivery Systems Inc Pulsating transdermal drug delivery system
GB8804164D0 (en) 1988-02-23 1988-03-23 Tucker J M Bandage for administering physiologically active compound
US4882150A (en) 1988-06-03 1989-11-21 Kaufman Herbert E Drug delivery system
GB8819308D0 (en) * 1988-08-13 1988-09-14 Pfizer Ltd Triazole antifungal agents
US5206364A (en) * 1988-08-13 1993-04-27 Pfizer Inc. Triazole antifungal agents
US5008110A (en) 1988-11-10 1991-04-16 The Procter & Gamble Company Storage-stable transdermal patch
US5088977A (en) 1988-12-21 1992-02-18 Drug Delivery Systems Inc. Electrical transdermal drug applicator with counteractor and method of drug delivery
US5521222A (en) 1989-09-28 1996-05-28 Alcon Laboratories, Inc. Topical ophthalmic pharmaceutical vehicles
DE69009946T2 (de) 1989-12-04 1994-11-03 Searle & Co System zur transdermalen Albuterol Applikation.
US5077033A (en) 1990-08-07 1991-12-31 Mediventures Inc. Ophthalmic drug delivery with thermo-irreversible gels of polxoxyalkylene polymer and ionic polysaccharide
JP2594486B2 (ja) 1991-01-15 1997-03-26 アルコン ラボラトリーズ インコーポレイテッド 局所的眼薬組成物
GB9121456D0 (en) * 1991-10-10 1991-11-27 Pfizer Ltd Triazole antifungal agents
US5352456A (en) 1991-10-10 1994-10-04 Cygnus Therapeutic Systems Device for administering drug transdermally which provides an initial pulse of drug
EP0617665B1 (en) 1991-12-18 1999-03-31 Minnesota Mining And Manufacturing Company Multilayered barrier structures
EP0553769B1 (de) 1992-01-29 1996-01-03 FRANZ VÖLKL GmbH & CO. SKI UND TENNIS SPORTARTIKELFABRIK KG Ballspielschläger, insbesondere Tennisschläger
JP3452213B2 (ja) * 1994-07-05 2003-09-29 エーザイ株式会社 抗真菌剤及びその製造方法
IL114193A (en) 1994-06-20 2000-02-29 Teva Pharma Ophthalmic pharmaceutical compositions based on sodium alginate
ES2094688B1 (es) 1994-08-08 1997-08-01 Cusi Lab Manoemulsion del tipo de aceite en agua, util como vehiculo oftalmico y procedimiento para su preparacion.
GB9512961D0 (en) * 1995-06-26 1995-08-30 Pfizer Ltd Antifungal agents
CN1189162A (zh) 1995-06-26 1998-07-29 辉瑞研究开发公司 三唑抗真菌剂
FI102788B (fi) * 1995-09-14 1999-02-15 Nokia Telecommunications Oy Yhteisen levydatan hallinta kahdennetussa tietokoneyksikössä
IT1283911B1 (it) 1996-02-05 1998-05-07 Farmigea Spa Soluzioni oftalmiche viscosizzate con polisaccaridi della gomma di tamarindo
GB9605705D0 (en) * 1996-03-19 1996-05-22 Pfizer Ltd Therapeutic agents
US5800807A (en) 1997-01-29 1998-09-01 Bausch & Lomb Incorporated Ophthalmic compositions including glycerin and propylene glycol
US6261547B1 (en) 1998-04-07 2001-07-17 Alcon Manufacturing, Ltd. Gelling ophthalmic compositions containing xanthan gum
US6197934B1 (en) 1998-05-22 2001-03-06 Collagenesis, Inc. Compound delivery using rapidly dissolving collagen film
JP2000344744A (ja) * 1999-06-04 2000-12-12 Ss Pharmaceut Co Ltd アセトフェノン誘導体およびその製法
GB0227558D0 (en) * 2002-11-26 2002-12-31 Syngenta Ltd Fungicides
CN100422153C (zh) 2005-02-06 2008-10-01 沈阳化工研究院 N-(2-取代苯基)-n-甲氧基氨基甲酸酯类化合物及其制备与应用
BRPI0501146A (pt) * 2005-03-16 2006-10-31 Fmc Quimica Do Brasil Ltda composição fungicida/inseticida/herbicida/nematicida, uso de derivados de imidazóis e/ou trazóis no combate de pragas agrìcolas, método para preparação da referida composição, bem como método para controle de doenças/insetos/ácaros/nematóides e plantas daninhas, particularmente de doenças foliares e/ou de solos
EP2073741A4 (en) 2006-10-18 2013-07-24 Bnl Biotech Co Ltd ENDODONTIC INSTRUMENT FOR SHUTDOWN OF RADICULAR CHANNEL AND HEATED END SUITABLE FOR THIS INSTRUMENT
CA2669887A1 (en) * 2006-11-21 2008-05-29 Viamet Pharmaceuticals, Inc. Metallo-oxidoreductase inhibitors using metal binding moieties in combination with targeting moieties
WO2008124131A1 (en) * 2007-04-05 2008-10-16 The John Hopkins University Antifungal agents as neuroprotectants
US8221057B2 (en) 2008-06-25 2012-07-17 General Electric Company Method, system and controller for establishing a wheel space temperature alarm in a turbomachine
EA024341B1 (ru) * 2010-04-24 2016-09-30 Ваймет Фармасьютикалс, Инк. Соединения, ингибирующие металлоферменты
WO2011134911A2 (en) 2010-04-28 2011-11-03 Bayer Cropscience Ag Fungicide hydroximoyl-tetrazole derivatives
EP2522683B1 (en) 2011-05-10 2013-12-11 Hüttenes-Albertus Chemische-Werke GmbH Silicic ester modified phenol/formaldehyde novolaks and their use for the production of resin coated substrates
WO2012177608A1 (en) * 2011-06-19 2012-12-27 Viamet Pharmaceuticals, Inc. Metalloenzyme inhibitor compounds
JP6247632B2 (ja) * 2011-06-19 2017-12-13 ヴィアメット ファーマスーティカルズ，インコーポレイテッド メタロ酵素阻害剤化合物
KR101964195B1 (ko) 2011-06-23 2019-04-01 비아멧 파마슈티컬즈(엔씨), 인코포레이티드 금속효소 억제제 화합물
WO2013090210A1 (en) * 2011-12-11 2013-06-20 Viamet Pharmaceuticals, Inc. Metalloenzyme inhibitor compounds
KR102061137B1 (ko) * 2012-01-20 2019-12-31 마이코비아 파마슈티컬즈, 인코포레이티드 금속효소 억제제 화합물
WO2014043376A1 (en) * 2012-09-12 2014-03-20 Dow Agrosciences Llc Metalloenzyme inhibitor compounds

Also Published As

Publication number Publication date
IN2014MN00093A (c_deeref_Disk_and_Scratch_Disk_Pools_and_Their_Defaults.html) 2015-06-19
EP2721021B1 (en) 2019-01-23
BR102012015199A2 (pt) 2014-05-13
JP6122846B2 (ja) 2017-04-26
CA2839769A1 (en) 2012-12-27
EP2721020B1 (en) 2019-01-23
US20140350003A1 (en) 2014-11-27
PH12013502624A1 (en) 2014-02-17
CL2013003639A1 (es) 2014-10-10
CA2838909A1 (en) 2012-12-27
US20150099750A1 (en) 2015-04-09
JP2014518219A (ja) 2014-07-28
US20130005729A1 (en) 2013-01-03
WO2012177608A1 (en) 2012-12-27
CO6940433A2 (es) 2014-05-09
ECSP14013153A (es) 2014-04-30
EA201490036A1 (ru) 2014-06-30
US9221791B2 (en) 2015-12-29
US9556143B2 (en) 2017-01-31
EP2721021A4 (en) 2015-09-30
CN103842355A (zh) 2014-06-04
AR086988A1 (es) 2014-02-05
KR101912850B1 (ko) 2018-10-30
EP2721020A4 (en) 2015-09-23
US8901121B2 (en) 2014-12-02
AU2012273161B9 (en) 2017-07-06
KR20140040235A (ko) 2014-04-02
CN103764646A (zh) 2014-04-30
WO2012177603A2 (en) 2012-12-27
WO2012177603A3 (en) 2013-04-25
MX2013015160A (es) 2015-01-14
JP2014517044A (ja) 2014-07-17
AU2012273161B2 (en) 2017-04-20
UY34146A (es) 2013-01-31
EP2721020A2 (en) 2014-04-23
US20130005719A1 (en) 2013-01-03
AU2012273166A1 (en) 2014-01-23
US8809378B2 (en) 2014-08-19
CR20140024A (es) 2014-07-02
EA024385B1 (ru) 2016-09-30
JP6159318B2 (ja) 2017-07-05
EP2721021A1 (en) 2014-04-23
KR20140048935A (ko) 2014-04-24
AU2012273161A1 (en) 2014-01-16
HK1198651A1 (en) 2015-05-22

Similar Documents

Publication Publication Date Title
EA201490088A1 (ru) Соединения, ингибирующие металлоферменты
EA201490038A1 (ru) Соединения, ингибирующие металлоферменты
EA201291107A1 (ru) Соединения, ингибирующие металлоферменты
EA201491385A1 (ru) Соединения, ингибирующие металлоферменты
EA201491151A1 (ru) Соединения, ингибирующие металлоферменты
UA114090C2 (uk) Сполуки, що інгібують металоферменти
EA201690007A1 (ru) Соединения, ингибирующие металлоферменты
EA201390704A1 (ru) Соединения, ингибирующие металлоферменты
EA201891539A1 (ru) Соединения, ингибирующие металлоферменты
EA201891833A1 (ru) Комбинация для лечения амиотрофического бокового склероза или родственных болезней
EA201390711A1 (ru) Гидроксиамидные соединения пиримидина в качестве ингибиторов деацетилаз белков и способы их применения
EA201500362A1 (ru) Ингибиторы rho-киназы
GB201103062D0 (en) Method
EA201490423A1 (ru) СПОСОБЫ И КОМПОЗИЦИИ, ОТНОСЯЩИЕСЯ К p62, ДЛЯ ЛЕЧЕНИЯ И ПРОФИЛАКТИКИ РАКА
WO2011082245A3 (en) Metalloenzyme inhibitor compounds
UA108878C2 (ru) Ингибиторы протеинтирозинкиназной активности
MX2022012386A (es) Compuestos inhibidores de metaloenzimas.
WO2012058529A3 (en) Metalloenzyme inhibitor compounds
EA201390876A1 (ru) Соединения, ингибирующие металлоферменты
WO2013033004A3 (en) Metalloenzyme inhibitor compounds
EA201400970A1 (ru) Новые композиции для лечения амиотрофического бокового склероза