EA201400365A1 - Новые тиопроизводные лактамов в качестве высокоактивных ингибиторов hdac и их применение в качестве лекарственных средств - Google Patents

Новые тиопроизводные лактамов в качестве высокоактивных ингибиторов hdac и их применение в качестве лекарственных средств

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EA201400365A1
EA201400365A1 EA201400365A EA201400365A EA201400365A1 EA 201400365 A1 EA201400365 A1 EA 201400365A1 EA 201400365 A EA201400365 A EA 201400365A EA 201400365 A EA201400365 A EA 201400365A EA 201400365 A1 EA201400365 A1 EA 201400365A1
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new
thyroduct
lacts
medicines
application
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EA201400365A
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EA023171B1 (ru
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Джузеппе Джаннини
Вальтер Кабри
Джанфранко Баттистуцци
Давиде Виньола
Никола Фанто'
Клаудио Пизано
Лоредана Веши
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Сигма-Тау Индустрие Фармасьютике Риуните С.П.А.
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Publication of EA201400365A1 publication Critical patent/EA201400365A1/ru
Publication of EA023171B1 publication Critical patent/EA023171B1/ru

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    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic

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Abstract

Настоящее изобретение относится к новым амидным соединениям формулы (I) и к их применению в качестве противоопухолевых и проапоптотических агентов. Изобретение включает применение указанных соединений в медицине в отношении раковых заболеваний, а также других заболеваний, чувствительных к ингибированию HDAC, и фармацевтическую композицию, содержащую указанные соединения.
EA201400365A 2011-09-19 2012-09-17 Тиопроизводные лактамов в качестве высокоактивных ингибиторов hdac и их применение в качестве лекарственных средств EA023171B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP11181832 2011-09-19
PCT/EP2012/068230 WO2013041480A1 (en) 2011-09-19 2012-09-17 New thio derivatives bearing lactams as potent hdac inhibitors and their uses as medicaments

Publications (2)

Publication Number Publication Date
EA201400365A1 true EA201400365A1 (ru) 2014-06-30
EA023171B1 EA023171B1 (ru) 2016-04-29

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EA201400365A EA023171B1 (ru) 2011-09-19 2012-09-17 Тиопроизводные лактамов в качестве высокоактивных ингибиторов hdac и их применение в качестве лекарственных средств

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US (1) US8927533B2 (ru)
EP (1) EP2758371B1 (ru)
JP (1) JP6053795B2 (ru)
KR (1) KR101929774B1 (ru)
CN (1) CN103732577B (ru)
AU (1) AU2012311640B2 (ru)
BR (1) BR112014006600B1 (ru)
CA (1) CA2843211C (ru)
DK (1) DK2758371T3 (ru)
EA (1) EA023171B1 (ru)
ES (1) ES2579321T3 (ru)
HU (1) HUE029687T2 (ru)
IL (1) IL230717A (ru)
MX (1) MX369508B (ru)
NZ (1) NZ620336A (ru)
PL (1) PL2758371T3 (ru)
PT (1) PT2758371T (ru)
UA (1) UA111231C2 (ru)
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ZA (1) ZA201402790B (ru)

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BR112016012561A2 (pt) 2013-12-03 2017-08-08 Acetylon Pharmaceuticals Inc Combinações de inibidores da histona desacetilase e fármacos imunomoduladores
KR102359214B1 (ko) 2014-04-04 2022-02-07 델 마 파마슈티컬스 폐의 비소세포 암종 및 난소암을 치료하기 위한 디안하이드로갈락티톨 및 이의 유사체 또는 유도체
WO2016201374A1 (en) * 2015-06-11 2016-12-15 University Of Florida Research Foundation, Incorporated Sulfanide adenosine derivatives and uses thereof

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IT1231477B (it) * 1989-07-12 1991-12-07 Sigma Tau Ind Farmaceuti (pirrolidin-2-one-1-il) acetammidi quali attivatori dei processi di apprendimento e della memoria e composizioni farmaceutiche comprendenti tali composti
IT1244507B (it) * 1991-04-11 1994-07-15 Sigma Tau Ind Farmaceuti Derivati dell'acido piroglutammico quali attivatori dei processi di apprendimento e della memoria e composizioni farmaceutiche comprendenti tali composti
CN1378450A (zh) * 1999-09-08 2002-11-06 斯隆-凯特林癌症研究院 新型细胞分化剂和组蛋白脱乙酰基酶抑制剂及其使用方法
ITRM20010464A1 (it) * 2001-07-31 2003-01-31 Sigma Tau Ind Farmaceuti Derivati retinoidi ad attivita' antiangiogenica, antitumorale e pro-apoptotica.
US7163937B2 (en) * 2003-08-21 2007-01-16 Bristol-Myers Squibb Company Cyclic derivatives as modulators of chemokine receptor activity
US20080004290A1 (en) * 2003-11-28 2008-01-03 The University Of Queensland Anti-Cancer Agents
CA2550352A1 (en) * 2003-12-19 2005-07-14 Jerini Ag Compounds for the inhibition of undesired cell proliferation and use thereof
JP2007238452A (ja) 2006-03-03 2007-09-20 Nippon Kayaku Co Ltd ヒストン脱アセチル化酵素を阻害する新規化合物
EP2100879A1 (en) * 2008-03-13 2009-09-16 4Sc Ag Novel N-substituted tetrahydroisoquinoline/isoindoline hydroxamic acid compounds

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AU2012311640A1 (en) 2014-02-13
BR112014006600A2 (pt) 2017-03-28
UA111231C2 (ru) 2016-04-11
ZA201402790B (en) 2015-12-23
ES2579321T3 (es) 2016-08-09
DK2758371T3 (en) 2016-08-01
JP6053795B2 (ja) 2016-12-27
NZ620336A (en) 2015-07-31
CN103732577B (zh) 2017-04-05
WO2013041480A1 (en) 2013-03-28
KR20140066993A (ko) 2014-06-03
CA2843211C (en) 2019-03-12
EP2758371A1 (en) 2014-07-30
EP2758371B1 (en) 2016-06-15
CN103732577A (zh) 2014-04-16
HUE029687T2 (en) 2017-03-28
PT2758371T (pt) 2016-07-13
EA023171B1 (ru) 2016-04-29
AU2012311640B2 (en) 2017-04-13
JP2014531441A (ja) 2014-11-27
IL230717A0 (en) 2014-03-31
PL2758371T3 (pl) 2017-01-31
IL230717A (en) 2017-01-31
CA2843211A1 (en) 2013-03-28
KR101929774B1 (ko) 2018-12-18
BR112014006600B1 (pt) 2022-04-19
US8927533B2 (en) 2015-01-06
MX2014003334A (es) 2014-05-21
MX369508B (es) 2019-11-11
US20140200205A1 (en) 2014-07-17

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