EA201391605A1 - Способы очистки вирусов с использованием гельпроникающей хроматографии - Google Patents
Способы очистки вирусов с использованием гельпроникающей хроматографииInfo
- Publication number
- EA201391605A1 EA201391605A1 EA201391605A EA201391605A EA201391605A1 EA 201391605 A1 EA201391605 A1 EA 201391605A1 EA 201391605 A EA201391605 A EA 201391605A EA 201391605 A EA201391605 A EA 201391605A EA 201391605 A1 EA201391605 A1 EA 201391605A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- methods
- chromatography
- viruses
- gelproducting
- gel permeation
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- 241000700605 Viruses Species 0.000 title abstract 3
- 238000004587 chromatography analysis Methods 0.000 title 1
- 238000004140 cleaning Methods 0.000 title 1
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 abstract 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 abstract 1
- 229930006000 Sucrose Natural products 0.000 abstract 1
- 239000000872 buffer Substances 0.000 abstract 1
- 150000001768 cations Chemical class 0.000 abstract 1
- 239000003599 detergent Substances 0.000 abstract 1
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 abstract 1
- 239000012149 elution buffer Substances 0.000 abstract 1
- 238000000605 extraction Methods 0.000 abstract 1
- 238000005227 gel permeation chromatography Methods 0.000 abstract 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 239000002953 phosphate buffered saline Substances 0.000 abstract 1
- 239000005720 sucrose Substances 0.000 abstract 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/34—Size-selective separation, e.g. size-exclusion chromatography; Gel filtration; Permeation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/42—Selective adsorption, e.g. chromatography characterised by the development mode, e.g. by displacement or by elution
- B01D15/424—Elution mode
- B01D15/426—Specific type of solvent
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/02—Separating microorganisms from their culture media
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2720/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsRNA viruses
- C12N2720/00011—Details
- C12N2720/12011—Reoviridae
- C12N2720/12051—Methods of production or purification of viral material
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Virology (AREA)
- Immunology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Medicinal Preparation (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161480561P | 2011-04-29 | 2011-04-29 | |
| PCT/CA2012/000406 WO2012145837A1 (en) | 2011-04-29 | 2012-04-27 | Methods of purifying viruses using gel permeation chromatography |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EA201391605A1 true EA201391605A1 (ru) | 2014-02-28 |
Family
ID=47067091
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201391605A EA201391605A1 (ru) | 2011-04-29 | 2012-04-27 | Способы очистки вирусов с использованием гельпроникающей хроматографии |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20120273424A1 (enExample) |
| EP (1) | EP2702147B1 (enExample) |
| JP (1) | JP6029651B2 (enExample) |
| KR (2) | KR20140024406A (enExample) |
| CN (1) | CN103492557B (enExample) |
| AU (1) | AU2012248082B2 (enExample) |
| CA (1) | CA2832367A1 (enExample) |
| DK (1) | DK2702147T3 (enExample) |
| EA (1) | EA201391605A1 (enExample) |
| ES (1) | ES2822199T3 (enExample) |
| IL (1) | IL228491A (enExample) |
| MX (1) | MX337348B (enExample) |
| SG (1) | SG194449A1 (enExample) |
| TW (1) | TW201307561A (enExample) |
| WO (1) | WO2012145837A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2630012T3 (es) | 2010-12-02 | 2017-08-17 | Oncolytics Biotech Inc. | Formulaciones virales liofilizadas |
| EA201390810A1 (ru) * | 2010-12-02 | 2013-09-30 | Онколитикс Байотек Инк. | Жидкие вирусные составы |
| BR112015031541A2 (pt) | 2013-06-17 | 2017-07-25 | De Staat Der Nederlanden Vert Door De Mini Van Vws Miniie Van Volksgezondheid Welzijn En Sport | métodos para o impedimento da agregação de componentes virais |
| CN112384615A (zh) | 2018-07-04 | 2021-02-19 | 普罗拜奥根股份公司 | 用于纯化包膜病毒的方法 |
| CN111812313B (zh) * | 2020-06-22 | 2021-10-08 | 北京生物制品研究所有限责任公司 | 铝佐剂吸附型新型冠状病毒灭活疫苗中抗原的解离方法 |
| CN114544815B (zh) * | 2022-03-01 | 2023-10-27 | 中牧实业股份有限公司 | 一种山羊痘病毒的定量检测方法 |
| CN116718524B (zh) * | 2023-06-26 | 2025-11-07 | 西安交通大学 | 一种基于细胞膜色谱技术的病毒颗粒检测方法 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5096885A (en) * | 1988-04-15 | 1992-03-17 | Genentech, Inc. | Human growth hormone formulation |
| ATE148165T1 (de) * | 1989-07-24 | 1997-02-15 | Bayer Ag | Stabilisierung von hochgereinigten proteinen |
| BR9507657A (pt) * | 1994-05-16 | 1997-09-09 | Merck & Co Inc | Proteina isolada e purificada de papilomavirus recombinante capsideos particulas semelhantes a virus processos a virus processos para produzir a proteina para tratar ou prevenir a infecçao por papilomavirus para produzir uma proteina de capsideo de papilomavirus recombinante montada em um capsideo ou particula semelhante a virus e para induzir uma resposta imune em um animal vertebrado composiçoes farmacêuticas kit para a detecçao de papilomavirus ou anticorpos para papilomavirus e sistema sinte |
| CA2723040A1 (en) * | 1998-02-17 | 1999-08-19 | Schering Corporation | Compositions comprising viruses and methods for concentrating virus preparations |
| JP4087712B2 (ja) | 2001-03-16 | 2008-05-21 | オンコリティクス バイオテック， インコーポレイティッド | 細胞培養物からウイルスを抽出する方法 |
| ATE427990T1 (de) * | 2002-04-30 | 2009-04-15 | Oncolytics Biotech Inc | Verbesserte reinigungsmethode fur viren |
| US7901921B2 (en) * | 2004-10-22 | 2011-03-08 | Oncolytics Biotech Inc. | Viral purification methods |
| EP1878791A1 (en) * | 2006-07-11 | 2008-01-16 | Bia Separations D.O.O. | Method for influenza virus purification |
| JP5326155B2 (ja) * | 2006-08-07 | 2013-10-30 | 一般財団法人化学及血清療法研究所 | 痘瘡生ワクチンの製造方法 |
| DK2132315T3 (en) * | 2007-03-12 | 2015-10-19 | Oncolytics Biotech Inc | Reoviruses with modified sequences |
| CN102089324B (zh) * | 2007-11-12 | 2014-04-16 | 特罗科隆科学有限公司 | 用于对流行性感冒进行治疗以及诊断的组合物以及方法 |
| US8227577B2 (en) * | 2007-12-21 | 2012-07-24 | Hoffman-La Roche Inc. | Bivalent, bispecific antibodies |
| EA201390810A1 (ru) * | 2010-12-02 | 2013-09-30 | Онколитикс Байотек Инк. | Жидкие вирусные составы |
| ES2630012T3 (es) * | 2010-12-02 | 2017-08-17 | Oncolytics Biotech Inc. | Formulaciones virales liofilizadas |
-
2012
- 2012-04-27 ES ES12776970T patent/ES2822199T3/es active Active
- 2012-04-27 SG SG2013075569A patent/SG194449A1/en unknown
- 2012-04-27 WO PCT/CA2012/000406 patent/WO2012145837A1/en not_active Ceased
- 2012-04-27 KR KR1020137031292A patent/KR20140024406A/ko not_active Ceased
- 2012-04-27 KR KR1020197006419A patent/KR102151890B1/ko active Active
- 2012-04-27 CN CN201280020376.8A patent/CN103492557B/zh active Active
- 2012-04-27 US US13/457,642 patent/US20120273424A1/en not_active Abandoned
- 2012-04-27 CA CA2832367A patent/CA2832367A1/en not_active Abandoned
- 2012-04-27 JP JP2014506699A patent/JP6029651B2/ja active Active
- 2012-04-27 DK DK12776970.1T patent/DK2702147T3/da active
- 2012-04-27 AU AU2012248082A patent/AU2012248082B2/en active Active
- 2012-04-27 EA EA201391605A patent/EA201391605A1/ru unknown
- 2012-04-27 EP EP12776970.1A patent/EP2702147B1/en active Active
- 2012-04-27 MX MX2013012627A patent/MX337348B/es active IP Right Grant
- 2012-04-27 TW TW101115116A patent/TW201307561A/zh unknown
-
2013
- 2013-09-17 IL IL228491A patent/IL228491A/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| IL228491A0 (en) | 2013-12-31 |
| JP2014516515A (ja) | 2014-07-17 |
| CA2832367A1 (en) | 2012-11-01 |
| EP2702147B1 (en) | 2020-07-15 |
| WO2012145837A1 (en) | 2012-11-01 |
| AU2012248082B2 (en) | 2015-08-20 |
| US20120273424A1 (en) | 2012-11-01 |
| CN103492557A (zh) | 2014-01-01 |
| EP2702147A1 (en) | 2014-03-05 |
| KR102151890B1 (ko) | 2020-09-03 |
| JP6029651B2 (ja) | 2016-11-24 |
| MX337348B (es) | 2016-02-29 |
| IL228491A (en) | 2017-05-29 |
| CN103492557B (zh) | 2015-07-29 |
| EP2702147A4 (en) | 2014-11-05 |
| KR20190026059A (ko) | 2019-03-12 |
| SG194449A1 (en) | 2013-12-30 |
| ES2822199T3 (es) | 2021-04-29 |
| DK2702147T3 (da) | 2020-09-28 |
| AU2012248082A1 (en) | 2013-05-09 |
| KR20140024406A (ko) | 2014-02-28 |
| MX2013012627A (es) | 2014-05-13 |
| TW201307561A (zh) | 2013-02-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EA201391605A1 (ru) | Способы очистки вирусов с использованием гельпроникающей хроматографии | |
| MX392274B (es) | Cartuchos utiles en limpieza de soluciones de dialisis. | |
| MX2022012089A (es) | Anticuerpos que comprenden un dominio de union al antigeno dependiente de la concentracion ionica, variantes de la region fc, anticuerpos de union a interleucina 8 (il-8) y usos de los mismos. | |
| EA201791693A1 (ru) | Гетеродимерные иммуноглобулины | |
| SG10201902924RA (en) | Antibodies that bind ebola glycoprotein and uses thereof | |
| EA201101593A1 (ru) | КОМПОЗИЦИИ И СПОСОБЫ, ПРЕДНАЗНАЧЕННЫЕ ДЛЯ НАПРАВЛЕННОГО ВОЗДЕЙСТВИЯ АНТИТЕЛ НА БЕЛОК С3b СИСТЕМЫ КОМПЛЕМЕНТА | |
| MX358137B (es) | Composiciones del polipéptido de fusión tnfr: fc exentas de arginina y métodos de uso. | |
| CU20170039A7 (es) | Método de purificación del anticuerpo humanizado 9e4 | |
| MX2018000505A (es) | Anticuerpos especificos para tau hiperfosforilada y metodos de uso de los mismos. | |
| PH12014500866A1 (en) | Immunobinders directed against tnf | |
| EA201291039A1 (ru) | Антитела, связывающие cd27 человека, и их применение | |
| EP2691170A4 (en) | BIN-FREE ZEOLITIC ADSORPTION AGENTS, METHOD FOR PRODUCING BINDER-FREE ZEOLITIC ADSORPTION AGENTS, AND ADSORPTIVE SEPARATION PROCESSES USING BINDING-FREE ZEOLITE ADSORPTION AGENTS | |
| MX374811B (es) | Anticuerpos anti-tau y métodos de uso. | |
| MX2013003182A (es) | Purificacion de anticuerpos por cromatografia de lecho movil simulada. | |
| EA201591106A1 (ru) | Цеолитовые адсорбенты, способ их изготовления и их применение | |
| EA201591806A1 (ru) | Лечение и профилактика острой почечной недостаточности с применением анти-альфа-v-бета-5 антител | |
| MX367661B (es) | Anticuerpos anti-baff novedosos. | |
| AU2012249274A8 (en) | Neutralizing antibodies to Nipah and Hendra virus | |
| WO2016014434A3 (en) | Anti-cd74 antibodies, compositions comprising anti-cd74 antibodies and methods of using anti-cd74 antibodies | |
| EA201591791A1 (ru) | Антитела pac1 человека | |
| MX2016001601A (es) | Separacion de anticuerpos biespecificos y subproductos de produccion de anticuerpos biespecificos utilizando cromatografia de hidroxiapatita. | |
| EA201301107A1 (ru) | Моноклональные антитела против ингибитора пути тканевого фактора (tfpi) | |
| MX379312B (es) | Anticuerpos especificos para fcrn. | |
| TN2015000277A1 (en) | Bmp-6 antibodies | |
| EA201990593A1 (ru) | Непрерывный способ для снижения гетерогенности терапевтического белка |