EA201370118A1 - Производные 4-(5-цианопиразол-1-ил)пиперидина в качестве модуляторов gpr 119 - Google Patents
Производные 4-(5-цианопиразол-1-ил)пиперидина в качестве модуляторов gpr 119Info
- Publication number
- EA201370118A1 EA201370118A1 EA201370118A EA201370118A EA201370118A1 EA 201370118 A1 EA201370118 A1 EA 201370118A1 EA 201370118 A EA201370118 A EA 201370118A EA 201370118 A EA201370118 A EA 201370118A EA 201370118 A1 EA201370118 A1 EA 201370118A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- cyanopyrazol
- gpr
- modulators
- piperidine
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/12—Ophthalmic agents for cataracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Neurosurgery (AREA)
- Hematology (AREA)
- Physical Education & Sports Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Obesity (AREA)
- Ophthalmology & Optometry (AREA)
- Psychiatry (AREA)
- Urology & Nephrology (AREA)
- Reproductive Health (AREA)
- Hospice & Palliative Care (AREA)
- Gynecology & Obstetrics (AREA)
- Immunology (AREA)
- Emergency Medicine (AREA)
- Vascular Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41644110P | 2010-11-23 | 2010-11-23 | |
| PCT/IB2011/054996 WO2012069948A1 (en) | 2010-11-23 | 2011-11-09 | 4- (5-cyano-pyrazol-1-yl) -piperidine derivatives as gpr 119 modulators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EA201370118A1 true EA201370118A1 (ru) | 2013-12-30 |
Family
ID=45418722
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201370118A EA201370118A1 (ru) | 2010-11-23 | 2011-11-09 | Производные 4-(5-цианопиразол-1-ил)пиперидина в качестве модуляторов gpr 119 |
Country Status (26)
| Country | Link |
|---|---|
| EP (1) | EP2643310A1 (es) |
| JP (1) | JP2013543885A (es) |
| KR (1) | KR20130083915A (es) |
| CN (1) | CN103298801A (es) |
| AP (1) | AP2013006809A0 (es) |
| AR (1) | AR088121A1 (es) |
| AU (1) | AU2011333427A1 (es) |
| BR (1) | BR112013011865A2 (es) |
| CA (1) | CA2814231A1 (es) |
| CL (1) | CL2013001054A1 (es) |
| CO (1) | CO6801716A2 (es) |
| CR (1) | CR20130139A (es) |
| CU (1) | CU20130059A7 (es) |
| DO (1) | DOP2013000102A (es) |
| EA (1) | EA201370118A1 (es) |
| EC (1) | ECSP13012630A (es) |
| GT (1) | GT201300135A (es) |
| MA (1) | MA34805B1 (es) |
| MX (1) | MX2013004083A (es) |
| NI (1) | NI201300044A (es) |
| PE (1) | PE20140409A1 (es) |
| SG (1) | SG189830A1 (es) |
| TW (1) | TWI433843B (es) |
| UY (1) | UY33742A (es) |
| WO (1) | WO2012069948A1 (es) |
| ZA (1) | ZA201302362B (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6463631B2 (ja) | 2011-06-09 | 2019-02-06 | ライゼン・ファーマシューティカルズ・エスアー | Ｇｐｒ−１１９のモジュレータとしての新規化合物 |
| CN104780915A (zh) | 2012-07-11 | 2015-07-15 | 埃尔舍利克斯治疗公司 | 包含他汀、双胍和用于减小心脏代谢风险的其它药剂的组合物 |
| JP2017119628A (ja) * | 2014-05-09 | 2017-07-06 | 日産化学工業株式会社 | 置換アゾール化合物及び糖尿病治療薬 |
| CN104892517A (zh) * | 2015-02-13 | 2015-09-09 | 佛山市赛维斯医药科技有限公司 | 酰肼类化合物、其制备方法及用途 |
| CN104610151A (zh) * | 2015-02-13 | 2015-05-13 | 佛山市赛维斯医药科技有限公司 | 含酰肼和烷氧苯类结构的化合物、其制备方法及用途 |
| CN104592120A (zh) * | 2015-02-13 | 2015-05-06 | 佛山市赛维斯医药科技有限公司 | 一种环丙基酰肼和甲氧苯类gpr119激动剂、制备方法及其用途 |
| EP3416959B1 (en) | 2016-02-18 | 2021-05-12 | Syngenta Participations AG | Pesticidally active pyrazole derivatives |
| CN106631992B (zh) * | 2017-01-05 | 2019-01-18 | 桑迪亚医药技术（上海）有限责任公司 | 一种4-氧-3,4-二氢-2h-吡啶-1-甲酸叔丁酯的合成方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2185544B1 (en) * | 2007-07-19 | 2014-11-26 | Cymabay Therapeutics, Inc. | N-azacyclic substituted pyrrole, pyrazole, imidazole, triazole and tetrazole derivatives as agonists of the rup3 or gpr119 for the treatment of diabetes and metabolic disorders |
| TW201002705A (en) * | 2008-03-31 | 2010-01-16 | Metabolex Inc | Oxymethylene aryl compounds and uses thereof |
| NZ596467A (en) * | 2009-06-05 | 2014-01-31 | Pfizer | L- ( piperidin-4-yl) -pyrazole derivatives as gpr 119 modulators |
-
2011
- 2011-11-09 JP JP2013540458A patent/JP2013543885A/ja active Pending
- 2011-11-09 CA CA2814231A patent/CA2814231A1/en not_active Abandoned
- 2011-11-09 MA MA35928A patent/MA34805B1/fr unknown
- 2011-11-09 MX MX2013004083A patent/MX2013004083A/es unknown
- 2011-11-09 AU AU2011333427A patent/AU2011333427A1/en not_active Abandoned
- 2011-11-09 BR BR112013011865A patent/BR112013011865A2/pt not_active IP Right Cessation
- 2011-11-09 SG SG2013023189A patent/SG189830A1/en unknown
- 2011-11-09 CN CN2011800550665A patent/CN103298801A/zh active Pending
- 2011-11-09 AP AP2013006809A patent/AP2013006809A0/xx unknown
- 2011-11-09 KR KR1020137013064A patent/KR20130083915A/ko not_active Application Discontinuation
- 2011-11-09 WO PCT/IB2011/054996 patent/WO2012069948A1/en active Application Filing
- 2011-11-09 EA EA201370118A patent/EA201370118A1/ru unknown
- 2011-11-09 PE PE2013001058A patent/PE20140409A1/es not_active Application Discontinuation
- 2011-11-09 EP EP11802149.2A patent/EP2643310A1/en not_active Withdrawn
- 2011-11-21 UY UY0001033742A patent/UY33742A/es unknown
- 2011-11-22 AR ARP110104351A patent/AR088121A1/es not_active Application Discontinuation
- 2011-11-22 TW TW100142804A patent/TWI433843B/zh not_active IP Right Cessation
-
2013
- 2013-03-22 CR CR20130139A patent/CR20130139A/es unknown
- 2013-04-02 ZA ZA2013/02362A patent/ZA201302362B/en unknown
- 2013-04-16 CL CL2013001054A patent/CL2013001054A1/es unknown
- 2013-04-23 CU CU2013000059A patent/CU20130059A7/es unknown
- 2013-05-09 DO DO2013000102A patent/DOP2013000102A/es unknown
- 2013-05-13 NI NI201300044A patent/NI201300044A/es unknown
- 2013-05-20 EC ECSP13012630 patent/ECSP13012630A/es unknown
- 2013-05-21 GT GT201300135A patent/GT201300135A/es unknown
- 2013-05-23 CO CO13127143A patent/CO6801716A2/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| MA34805B1 (fr) | 2014-01-02 |
| NI201300044A (es) | 2013-08-01 |
| CA2814231A1 (en) | 2012-05-31 |
| SG189830A1 (en) | 2013-06-28 |
| PE20140409A1 (es) | 2014-03-23 |
| UY33742A (es) | 2012-06-29 |
| AU2011333427A1 (en) | 2013-04-11 |
| CR20130139A (es) | 2013-06-28 |
| EP2643310A1 (en) | 2013-10-02 |
| DOP2013000102A (es) | 2013-07-15 |
| KR20130083915A (ko) | 2013-07-23 |
| CU20130059A7 (es) | 2013-06-28 |
| GT201300135A (es) | 2015-02-19 |
| MX2013004083A (es) | 2013-06-13 |
| WO2012069948A1 (en) | 2012-05-31 |
| TWI433843B (zh) | 2014-04-11 |
| AP2013006809A0 (en) | 2013-04-30 |
| CO6801716A2 (es) | 2013-11-29 |
| BR112013011865A2 (pt) | 2016-08-23 |
| AR088121A1 (es) | 2014-05-14 |
| TW201300373A (zh) | 2013-01-01 |
| CN103298801A (zh) | 2013-09-11 |
| ZA201302362B (en) | 2014-06-25 |
| CL2013001054A1 (es) | 2013-09-27 |
| JP2013543885A (ja) | 2013-12-09 |
| ECSP13012630A (es) | 2013-07-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EA201190280A1 (ru) | Производные l-(пиперидин-4-ил)пиразола в качестве модуляторов gpr 119 | |
| EA201370118A1 (ru) | Производные 4-(5-цианопиразол-1-ил)пиперидина в качестве модуляторов gpr 119 | |
| EA201001329A1 (ru) | Соединения и композиции в качестве модуляторов активности gpr119 | |
| EA201590590A1 (ru) | Модуляторы рецептора андрогенов и их применение | |
| EA201001332A1 (ru) | Соединения и композиции в качестве модуляторов активности gpr119 | |
| CY1119518T1 (el) | Τροποποιημενα αντιγονα φυματιωσης | |
| EA201590881A1 (ru) | Терапевтические соединения и композиции и их использование в качестве модуляторов пк-m2 | |
| EA201791007A2 (ru) | Соединения и их применения для модуляции гемоглобина | |
| BRPI0808775A2 (pt) | compostos e composições como moduladores de atividade de gpr119 | |
| EA200971077A1 (ru) | Гетероциклические модуляторы киназы | |
| EA201001330A1 (ru) | Соединения и композиции в качестве модуляторов активности gpr119 | |
| EA201591426A1 (ru) | Соединения и их применения для модуляции гемоглобина | |
| EA201170349A1 (ru) | Модуляторы mif | |
| EA201370066A1 (ru) | Модуляторы эстрогеновых рецепторов и их применение | |
| EA201591432A1 (ru) | Соединения и их применения для модуляции гемоглобина | |
| EA201590292A1 (ru) | Соединения, которые являются sip-модулирующими агентами и/или atx-модулирующими агентами | |
| BR112012021296A2 (pt) | imunoconjugados e anticorpos de receptor de folato 1 e usos dos mesmos. | |
| UA111579C2 (uk) | ГЕТЕРОЦИКЛІЧНІ ПОХІДНІ 2-АМІНОБЕНЗО[d]ОКСАЗОЛУ, ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ НА ЇХ ОСНОВІ ТА ЇХ ЗАСТОСУВАННЯ ДЛЯ ЛІКУВАННЯ ЗАХВОРЮВАННЯ, ПОВ'АНОГО З РІ3-КІНАЗОЮ | |
| EA201491161A1 (ru) | Фторированные модуляторы рецепторов эстрогенов и их применение | |
| EA200901157A1 (ru) | Конденсированные кольцевые гетероциклические модуляторы киназы | |
| EA201591427A1 (ru) | Соединения и их применения для модуляции гемоглобина | |
| EA201390506A1 (ru) | Полипептиды, которые связывают компонент с5 комплемента человека | |
| EA201201658A1 (ru) | Производные пиперидина и их применение для лечения метаболических нарушений | |
| EA201491610A1 (ru) | Модуляторы x рецепторов печени | |
| EA201491609A1 (ru) | Модуляторы x рецепторов печени |