EA201370099A1 - Терапия на основе лигандов хемосенсорных рецепторов - Google Patents

Терапия на основе лигандов хемосенсорных рецепторов

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Publication number
EA201370099A1
EA201370099A1 EA201370099A EA201370099A EA201370099A1 EA 201370099 A1 EA201370099 A1 EA 201370099A1 EA 201370099 A EA201370099 A EA 201370099A EA 201370099 A EA201370099 A EA 201370099A EA 201370099 A1 EA201370099 A1 EA 201370099A1
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EA
Eurasian Patent Office
Prior art keywords
peptide
glp
glucagon
chemosensor
ligands
Prior art date
Application number
EA201370099A
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English (en)
Inventor
Элейн Д. Бэрон
Мартин Р. Браун
Кристофер Р.Г. Джонс
Марк С. Файнман
Original Assignee
Элселикс Терапьютикс, Инк.
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Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=45934655&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201370099(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Элселикс Терапьютикс, Инк. filed Critical Элселикс Терапьютикс, Инк.
Publication of EA201370099A1 publication Critical patent/EA201370099A1/ru

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    • A61K31/7016—Disaccharides, e.g. lactose, lactulose
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    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
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    • A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
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    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
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    • A61K31/201—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having one or two double bonds, e.g. oleic, linoleic acids
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Abstract

В настоящей заявке предложены способы модулирования концентрации гормона у субъекта, включающие введение композиции, содержащей лиганд хемосенсорного рецептора, причем указанная композиция приготовлена с возможностью доставки указанного лиганда в одну или более областей кишечника указанного субъекта. Также предложены способы, направленные на модулирование циркулирующих концентраций одного или более из глюкагоноподобного пептида-1 (ГПП-1) (общего), ГПП-1 (активного), глюкагоноподобного пептида-2 (ГПП-2), оксинтомодулина, пептида YY (PYY) (общего), PYY 3-36, холецистокинина (ХЦК), желудочного ингибиторного полипептида (ГИП), инсулина, С-пептида, глицентина, урогуанилина, амилина, грелина (общего), грелина (активного) и глюкагона.
EA201370099A 2010-10-19 2011-10-18 Терапия на основе лигандов хемосенсорных рецепторов EA201370099A1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US39471610P 2010-10-19 2010-10-19
US201161430914P 2011-01-07 2011-01-07
PCT/US2011/056766 WO2012054523A2 (en) 2010-10-19 2011-10-18 Chemosensory receptor ligand-based therapies

Publications (1)

Publication Number Publication Date
EA201370099A1 true EA201370099A1 (ru) 2013-11-29

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EA201370099A EA201370099A1 (ru) 2010-10-19 2011-10-18 Терапия на основе лигандов хемосенсорных рецепторов

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Country Link
US (1) US9486463B2 (ru)
EP (1) EP2630491A4 (ru)
JP (1) JP2013540156A (ru)
KR (1) KR20140114736A (ru)
CN (1) CN104220875A (ru)
AU (1) AU2011317140A1 (ru)
BR (1) BR112013009635A2 (ru)
CA (1) CA2815024A1 (ru)
CL (1) CL2013001085A1 (ru)
EA (1) EA201370099A1 (ru)
IL (1) IL225845A0 (ru)
MX (1) MX2013004364A (ru)
SG (1) SG189444A1 (ru)
WO (1) WO2012054523A2 (ru)
ZA (1) ZA201303335B (ru)

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CA2990230A1 (en) 2015-06-19 2016-12-22 University Of Southern California Compositions and methods for modified nutrient delivery
SG11201800675PA (en) * 2015-07-27 2018-02-27 Suntory Holdings Ltd Composition containing cyclic dipeptide and sweetening agent
US20190224214A1 (en) * 2016-08-16 2019-07-25 Syracuse University Human ghrelin o-acyltransferase inhibitors
WO2018132768A1 (en) * 2017-01-13 2018-07-19 Sanna Pietro P Methods and compositions for treating hpa hyperactivity
MX2020007167A (es) * 2018-01-09 2020-11-06 Gila Therapeutics Inc Composiciones y metodos para tratar enfermedades metabolicas.
CN111302942B (zh) * 2020-04-09 2022-03-01 中国热带农业科学院热带生物技术研究所 具有ptp1b抑制活性的化合物及其应用
CN113599382B (zh) * 2021-08-20 2023-01-03 兰州大学 喹啉类衍生物在制备治疗糖尿病及其并发症药物中的应用

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