EA201301180A1 - Основанная на bcma стратификация и терапия пациентов, страдающих множественной миеломой - Google Patents
Основанная на bcma стратификация и терапия пациентов, страдающих множественной миеломойInfo
- Publication number
- EA201301180A1 EA201301180A1 EA201301180A EA201301180A EA201301180A1 EA 201301180 A1 EA201301180 A1 EA 201301180A1 EA 201301180 A EA201301180 A EA 201301180A EA 201301180 A EA201301180 A EA 201301180A EA 201301180 A1 EA201301180 A1 EA 201301180A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- multiple myeloma
- cells
- bcma
- therapy
- patients suffering
- Prior art date
Links
- 206010035226 Plasma cell myeloma Diseases 0.000 title abstract 4
- 208000034578 Multiple myelomas Diseases 0.000 title abstract 3
- 238000013517 stratification Methods 0.000 title abstract 2
- 238000002560 therapeutic procedure Methods 0.000 title abstract 2
- 210000003719 b-lymphocyte Anatomy 0.000 abstract 5
- 102000006942 B-Cell Maturation Antigen Human genes 0.000 abstract 3
- 108010008014 B-Cell Maturation Antigen Proteins 0.000 abstract 3
- 230000003211 malignant effect Effects 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 2
- BGFTWECWAICPDG-UHFFFAOYSA-N 2-[bis(4-chlorophenyl)methyl]-4-n-[3-[bis(4-chlorophenyl)methyl]-4-(dimethylamino)phenyl]-1-n,1-n-dimethylbenzene-1,4-diamine Chemical compound C1=C(C(C=2C=CC(Cl)=CC=2)C=2C=CC(Cl)=CC=2)C(N(C)C)=CC=C1NC(C=1)=CC=C(N(C)C)C=1C(C=1C=CC(Cl)=CC=1)C1=CC=C(Cl)C=C1 BGFTWECWAICPDG-UHFFFAOYSA-N 0.000 abstract 1
- 238000011230 antibody-based therapy Methods 0.000 abstract 1
- 201000000050 myeloid neoplasm Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
- G01N33/57426—Specifically defined cancers leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3061—Blood cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Cell Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- General Physics & Mathematics (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- Food Science & Technology (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Mycology (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11163558 | 2011-04-21 | ||
| PCT/EP2012/057248 WO2012143498A1 (en) | 2011-04-21 | 2012-04-20 | Bcma-based stratification and therapy for multiple myeloma patients |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EA201301180A1 true EA201301180A1 (ru) | 2014-03-31 |
Family
ID=44343806
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201301180A EA201301180A1 (ru) | 2011-04-21 | 2012-04-20 | Основанная на bcma стратификация и терапия пациентов, страдающих множественной миеломой |
Country Status (19)
| Country | Link |
|---|---|
| US (3) | US20130101599A1 (enExample) |
| EP (1) | EP2699259B1 (enExample) |
| JP (1) | JP2014520248A (enExample) |
| KR (1) | KR20140031905A (enExample) |
| CN (1) | CN103608039A (enExample) |
| AP (1) | AP2013007178A0 (enExample) |
| AU (1) | AU2012244676A1 (enExample) |
| CA (1) | CA2832510A1 (enExample) |
| CL (1) | CL2013003031A1 (enExample) |
| CO (1) | CO6801644A2 (enExample) |
| EA (1) | EA201301180A1 (enExample) |
| IL (1) | IL228701A0 (enExample) |
| MA (1) | MA35056B1 (enExample) |
| MX (1) | MX2013012167A (enExample) |
| PE (1) | PE20140612A1 (enExample) |
| PH (1) | PH12013502147A1 (enExample) |
| SG (1) | SG194500A1 (enExample) |
| TN (1) | TN2013000412A1 (enExample) |
| WO (1) | WO2012143498A1 (enExample) |
Families Citing this family (84)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2013340799B2 (en) | 2012-11-01 | 2018-08-09 | Max-Delbruck-Centrum Fur Molekulare Medizin (Mdc) | An antibody that binds CD269 (BCMA) suitable for use in the treatment of plasma cell diseases such as multiple myeloma and autoimmune diseases |
| TW201425336A (zh) | 2012-12-07 | 2014-07-01 | Amgen Inc | Ｂｃｍａ抗原結合蛋白質 |
| US9243058B2 (en) | 2012-12-07 | 2016-01-26 | Amgen, Inc. | BCMA antigen binding proteins |
| EP2953974B1 (en) | 2013-02-05 | 2017-12-20 | EngMab Sàrl | Bispecific antibodies against cd3epsilon and bcma |
| EP2762497A1 (en) | 2013-02-05 | 2014-08-06 | EngMab AG | Bispecific antibodies against CD3epsilon and BCMA |
| EP2762496A1 (en) | 2013-02-05 | 2014-08-06 | EngMab AG | Method for the selection of antibodies against BCMA |
| US10126301B2 (en) * | 2013-02-08 | 2018-11-13 | Institute For Myeloma & Bone Cancer Research | Diagnostic, prognostic, and monitoring methods for multiple myeloma, chronic lymphocytic leukemia, and B-cell non-hodgkin lymphoma |
| KR102480433B1 (ko) | 2014-02-07 | 2022-12-21 | 맥마스터 유니버시티 | 3기능성 t 세포-항원 커플러 및 이의 제조 방법 및 용도 |
| KR102632731B1 (ko) * | 2014-04-30 | 2024-02-01 | 막스-델부뤽-센트럼 퓌어 몰레쿨라레 메디친 인 데어 헬름홀츠-게마인샤프트 | Ｃｄ269에 대한 인간화 항체 |
| EP2982692A1 (en) | 2014-08-04 | 2016-02-10 | EngMab AG | Bispecific antibodies against CD3epsilon and BCMA |
| EP3023437A1 (en) | 2014-11-20 | 2016-05-25 | EngMab AG | Bispecific antibodies against CD3epsilon and BCMA |
| EP3029068A1 (en) * | 2014-12-03 | 2016-06-08 | EngMab AG | Bispecific antibodies against CD3epsilon and BCMA for use in the treatment of diseases |
| EP3227432B1 (en) | 2014-12-05 | 2023-10-11 | Memorial Sloan Kettering Cancer Center | Chimeric antigen receptors targeting b-cell maturation antigen and uses thereof |
| KR102701479B1 (ko) | 2014-12-05 | 2024-09-03 | 메모리얼 슬로안 케터링 캔서 센터 | B-세포 성숙화 항원을 표적화하는 항체 및 사용 방법 |
| TWI703159B (zh) * | 2015-04-13 | 2020-09-01 | 美商輝瑞股份有限公司 | Bcma特異性治療性抗體及其用途 |
| HRP20200390T1 (hr) | 2015-08-03 | 2020-06-12 | Engmab Sàrl | Monoklonska antitijela protiv humanog antigena starenja b stanica (bcma) |
| UA127515C2 (uk) | 2015-08-17 | 2023-09-20 | Янссен Байотек, Інк. | Антитіло до всма, біспецифічна антигензв'язувальна молекула, що зв'язує всма і cd3, і їх використання |
| EP3368903A1 (en) * | 2015-10-30 | 2018-09-05 | GlaxoSmithKline Intellectual Property Development Limited | Prognostic method |
| ES2898329T3 (es) | 2016-01-12 | 2022-03-07 | Oncotracker Inc | Métodos mejorados para supervisar el estado inmunitario de un sujeto |
| CN116063503A (zh) | 2016-02-17 | 2023-05-05 | 思进股份有限公司 | Bcma抗体和其用以治疗癌症和免疫病症的用途 |
| WO2017223111A1 (en) | 2016-06-21 | 2017-12-28 | Teneobio, Inc. | Cd3 binding antibodies |
| MY200988A (en) | 2016-09-14 | 2024-01-27 | Teneobio Inc | CD3 Binding Antibodies |
| IL266424B2 (en) * | 2016-11-02 | 2023-09-01 | Engmab Sarl | A bispecific antibody against bcma and cd3 and an immunological drug for combined treatment in multiple myeloma |
| EP3559035A1 (en) * | 2016-12-21 | 2019-10-30 | TeneoBio, Inc. | Anti-bcma heavy chain-only antibodies |
| WO2018144535A1 (en) | 2017-01-31 | 2018-08-09 | Novartis Ag | Treatment of cancer using chimeric t cell receptor proteins having multiple specificities |
| WO2018151836A1 (en) | 2017-02-17 | 2018-08-23 | Fred Hutchinson Cancer Research Center | Combination therapies for treatment of bcma-related cancers and autoimmune disorders |
| US20200179511A1 (en) | 2017-04-28 | 2020-06-11 | Novartis Ag | Bcma-targeting agent, and combination therapy with a gamma secretase inhibitor |
| EP3615055A1 (en) | 2017-04-28 | 2020-03-04 | Novartis AG | Cells expressing a bcma-targeting chimeric antigen receptor, and combination therapy with a gamma secretase inhibitor |
| WO2018231944A1 (en) | 2017-06-13 | 2018-12-20 | Berenson James R | Diagnostic, prognostic, and monitoring methods for solid tumor cancers |
| US20200384130A1 (en) | 2017-06-14 | 2020-12-10 | Dana-Farber Cancer Institute, Inc. | B-cell maturation antigen (bcma)-directed nanoparticles |
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| CN118146370A (zh) | 2017-06-20 | 2024-06-07 | 特纳奥尼股份有限公司 | 仅有重链的抗bcma抗体 |
| WO2019035938A1 (en) | 2017-08-16 | 2019-02-21 | Elstar Therapeutics, Inc. | MULTISPECIFIC MOLECULES BINDING TO BCMA AND USES THEREOF |
| EP3692066A2 (en) * | 2017-09-14 | 2020-08-12 | GlaxoSmithKline Intellectual Property Development Limited | Combination treatment for cancer |
| JP7137619B2 (ja) * | 2017-09-29 | 2022-09-14 | モガム・インスティテュート・フォー・バイオメディカル・リサーチ | Ｂｃｍａに対して高い親和性を有する抗ｂｃｍａ抗体およびそれを含むがんの処置のための医薬組成物 |
| WO2019071358A1 (en) | 2017-10-12 | 2019-04-18 | Mcmaster University | Y182T MUTATION T CELL ANTIGEN COUPLEUR AND METHODS AND USES THEREOF |
| IL321733A (en) | 2017-10-18 | 2025-08-01 | Novartis Ag | Compositions and methods for selective degradation of proteins |
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| US11453723B1 (en) | 2021-06-25 | 2022-09-27 | Mcmaster University | BCMA T cell-antigen couplers and uses thereof |
| US20250000973A1 (en) | 2021-08-20 | 2025-01-02 | Novartis Ag | Methods of making chimeric antigen receptor-expressing cells |
| CA3237357A1 (en) | 2021-11-03 | 2023-05-11 | Janssen Biotech, Inc. | Methods of treating cancers and enhancing efficacy of bcmaxcd3 bispecific antibodies |
| WO2024025967A1 (en) * | 2022-07-28 | 2024-02-01 | Springworks Therapeutics, Inc. | Determination of bcma level on plasma cells by flow cytometry |
| WO2024089639A1 (en) | 2022-10-26 | 2024-05-02 | Novartis Ag | Lentiviral formulations |
| WO2024102954A1 (en) | 2022-11-10 | 2024-05-16 | Massachusetts Institute Of Technology | Activation induced clipping system (aics) |
| WO2025059162A1 (en) | 2023-09-11 | 2025-03-20 | Dana-Farber Cancer Institute, Inc. | Car-engager containing il-2 variants to enhance the functionality of car t cells |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0307434B2 (en) | 1987-03-18 | 1998-07-29 | Scotgen Biopharmaceuticals, Inc. | Altered antibodies |
| US20040002068A1 (en) | 2000-03-01 | 2004-01-01 | Corixa Corporation | Compositions and methods for the detection, diagnosis and therapy of hematological malignancies |
| AU2002238052A1 (en) | 2001-02-20 | 2002-09-04 | Zymogenetics, Inc. | Antibodies that bind both bcma and taci |
| CA2720682A1 (en) | 2008-04-25 | 2009-10-29 | Zymogenetics, Inc. | Levels of bcma protein expression on b cells and use in diagnostic methods |
| NZ594985A (en) * | 2009-03-10 | 2013-07-26 | Biogen Idec Inc | Anti-bcma (b-cell maturation antigen, cd269, tnfrsf17) antibodies |
| WO2010121093A2 (en) | 2009-04-17 | 2010-10-21 | Lpath, Inc. | Humanized antibody compositions and methods for binding lysophosphatidic acid |
-
2012
- 2012-04-19 US US13/450,716 patent/US20130101599A1/en not_active Abandoned
- 2012-04-20 PH PH1/2013/502147A patent/PH12013502147A1/en unknown
- 2012-04-20 MX MX2013012167A patent/MX2013012167A/es not_active Application Discontinuation
- 2012-04-20 PE PE2013002369A patent/PE20140612A1/es not_active Application Discontinuation
- 2012-04-20 CN CN201280029972.2A patent/CN103608039A/zh active Pending
- 2012-04-20 SG SG2013076930A patent/SG194500A1/en unknown
- 2012-04-20 KR KR1020137030684A patent/KR20140031905A/ko not_active Withdrawn
- 2012-04-20 WO PCT/EP2012/057248 patent/WO2012143498A1/en not_active Ceased
- 2012-04-20 JP JP2014505643A patent/JP2014520248A/ja active Pending
- 2012-04-20 EA EA201301180A patent/EA201301180A1/ru unknown
- 2012-04-20 CA CA2832510A patent/CA2832510A1/en not_active Abandoned
- 2012-04-20 EP EP12714730.4A patent/EP2699259B1/en not_active Revoked
- 2012-04-20 MA MA36351A patent/MA35056B1/fr unknown
- 2012-04-20 AU AU2012244676A patent/AU2012244676A1/en not_active Abandoned
- 2012-04-20 AP AP2013007178A patent/AP2013007178A0/xx unknown
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2013
- 2013-10-03 IL IL228701A patent/IL228701A0/en unknown
- 2013-10-11 TN TNP2013000412A patent/TN2013000412A1/fr unknown
- 2013-10-18 CL CL2013003031A patent/CL2013003031A1/es unknown
- 2013-10-24 CO CO13252985A patent/CO6801644A2/es not_active Application Discontinuation
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2014
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2016
- 2016-01-15 US US14/996,503 patent/US20160131655A1/en not_active Abandoned
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| Publication number | Publication date |
|---|---|
| US20130101599A1 (en) | 2013-04-25 |
| CA2832510A1 (en) | 2012-10-26 |
| KR20140031905A (ko) | 2014-03-13 |
| CO6801644A2 (es) | 2013-11-29 |
| CL2013003031A1 (es) | 2014-08-18 |
| EP2699259B1 (en) | 2016-07-27 |
| JP2014520248A (ja) | 2014-08-21 |
| MX2013012167A (es) | 2013-12-10 |
| TN2013000412A1 (en) | 2015-03-30 |
| AP2013007178A0 (en) | 2013-10-31 |
| IL228701A0 (en) | 2013-12-31 |
| PE20140612A1 (es) | 2014-06-07 |
| US20140193433A1 (en) | 2014-07-10 |
| WO2012143498A1 (en) | 2012-10-26 |
| US20160131655A1 (en) | 2016-05-12 |
| SG194500A1 (en) | 2013-12-30 |
| CN103608039A (zh) | 2014-02-26 |
| EP2699259A1 (en) | 2014-02-26 |
| MA35056B1 (fr) | 2014-04-03 |
| AU2012244676A1 (en) | 2013-10-24 |
| PH12013502147A1 (en) | 2014-01-13 |
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