EA201301082A1 - Способ изготовления инкапсулированных терапевтических продуктов и их применение - Google Patents
Способ изготовления инкапсулированных терапевтических продуктов и их применениеInfo
- Publication number
- EA201301082A1 EA201301082A1 EA201301082A EA201301082A EA201301082A1 EA 201301082 A1 EA201301082 A1 EA 201301082A1 EA 201301082 A EA201301082 A EA 201301082A EA 201301082 A EA201301082 A EA 201301082A EA 201301082 A1 EA201301082 A1 EA 201301082A1
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- EA
- Eurasian Patent Office
- Prior art keywords
- encapsulation
- barrier
- incapsulated
- manufacturing
- application
- Prior art date
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/32—Bones; Osteocytes; Osteoblasts; Tendons; Tenocytes; Teeth; Odontoblasts; Cartilage; Chondrocytes; Synovial membrane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/37—Digestive system
- A61K35/39—Pancreas; Islets of Langerhans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/37—Digestive system
- A61K35/407—Liver; Hepatocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/20—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/64—Animal cells
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Cell Biology (AREA)
- Zoology (AREA)
- Developmental Biology & Embryology (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- Virology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Gastroenterology & Hepatology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Transplantation (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Dermatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Endocrinology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Botany (AREA)
- Urology & Nephrology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Ophthalmology & Optometry (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Inorganic Chemistry (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Obesity (AREA)
Abstract
Изобретение относится к способам инкапсуляции, включающим микроинкапсуляцию на базе альгината для обеспечения иммунной защиты и долговременного функционирования биологического материала или терапевтических средств. Биологический материал или терапевтические средства окружают мембраной, сформированной превращением в гель полимера альгината. Более конкретно, но ни в коей мере не исключительно, система инкапсуляции предназначена для использования в области алло- и ксенотрансплантации. Мембрана представляет собой барьер, защищающий инкапсулированный материал, обеспечивающий долговечность и предотвращающий нежелательные воздействия с внешней стороны барьера, такие как воспалительные реакции или иммунные ответные реакции. Изобретение также ориентировано на способы изготовления и предоставления инкапсулированных продуктов для применения в клеточной терапии. Терапевтические продукты, полученные способом инкапсуляции, могут составлять метод облегчения или лечения ряда состояний.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP11160298 | 2011-03-29 | ||
PCT/EP2012/053868 WO2012130567A1 (en) | 2011-03-29 | 2012-03-07 | Method for encapsulated therapeutic products and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
EA201301082A1 true EA201301082A1 (ru) | 2014-01-30 |
Family
ID=44455573
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201301082A EA201301082A1 (ru) | 2011-03-29 | 2012-03-07 | Способ изготовления инкапсулированных терапевтических продуктов и их применение |
Country Status (12)
Country | Link |
---|---|
US (1) | US20140017304A1 (ru) |
EP (1) | EP2691084A1 (ru) |
JP (1) | JP2014509617A (ru) |
KR (1) | KR20140051161A (ru) |
CN (1) | CN103619328A (ru) |
AU (1) | AU2012237375A1 (ru) |
BR (1) | BR112013024402A2 (ru) |
CA (1) | CA2831184A1 (ru) |
EA (1) | EA201301082A1 (ru) |
MX (1) | MX2013011040A (ru) |
SG (1) | SG193615A1 (ru) |
WO (1) | WO2012130567A1 (ru) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SG11201602232UA (en) | 2013-09-24 | 2016-04-28 | Giner Inc | System for gas treatment of a cell implant |
CN107645952B (zh) * | 2015-03-23 | 2022-03-18 | 加利福尼亚大学董事会 | 薄膜细胞包囊装置 |
CN105274084A (zh) * | 2015-10-15 | 2016-01-27 | 深圳爱生再生医学科技有限公司 | 脱乙酰几丁质/海藻酸钠干细胞微囊及其制备和培养方法 |
WO2017175065A2 (en) * | 2016-04-04 | 2017-10-12 | Beta-O2 Technologies Ltd. | Implantable device for implantation of cells having anti-inflammatory and vascularization capabilities and methods of making thereof |
AU2017317607B2 (en) * | 2016-10-19 | 2018-05-17 | Beta Cell Technologies Pty Ltd | Cell population seeding in dermal matrices for endocrine |
RU2019114817A (ru) | 2016-11-15 | 2020-11-16 | Джинер Лайф Сайенс, Инк. | Устройство чрезкожной диффузии газов, подходящее для применения с подкожным имплантатом |
JP7121005B2 (ja) * | 2016-11-23 | 2022-08-17 | メイヨ・ファウンデーション・フォー・メディカル・エデュケーション・アンド・リサーチ | 生物学的製剤の粒子媒介送達 |
RU2019131719A (ru) * | 2017-04-06 | 2021-05-06 | Сераксис, Инк. | Макроинкапсулированные терапевтические клетки и способы их применения |
CA3062412A1 (en) | 2017-05-04 | 2018-11-08 | Giner Life Sciences, Inc. | Robust, implantable gas delivery device and methods, systems and devices including same |
KR101952762B1 (ko) * | 2017-05-08 | 2019-02-27 | 강원대학교산학협력단 | 알긴산과 콜라겐의 조합으로 생성된 줄기세포를 캡슐화하는 미세캡슐 조성물 및 그 제조방법 |
WO2019246416A1 (en) * | 2018-06-21 | 2019-12-26 | Yale University | Bioartificial vascular pancreas |
US20210196646A1 (en) * | 2018-08-15 | 2021-07-01 | Wake Forest University Health Sciences | Improved formulations for pancreatic islet encapsulation |
CN109316464B (zh) * | 2018-11-01 | 2020-12-11 | 长春万成生物电子工程有限公司 | 包含胰岛样细胞团的制剂 |
US11596913B2 (en) * | 2021-07-16 | 2023-03-07 | Clearh2O, Inc. | Methods of high throughput hydrocolloid bead production and apparatuses thereof |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4663286A (en) | 1984-02-13 | 1987-05-05 | Damon Biotech, Inc. | Encapsulation of materials |
US5116747A (en) * | 1989-08-11 | 1992-05-26 | University Of Waterloo | Immobilization of biologically active material in capsules prepared from a water-soluble polymer and chitosan acetate |
WO1991009119A1 (en) * | 1989-12-13 | 1991-06-27 | Trancel Corporation | Improved alginate microcapsules, methods of making and using same |
US5084350A (en) | 1990-02-16 | 1992-01-28 | The Royal Institution For The Advance Of Learning (Mcgill University) | Method for encapsulating biologically active material including cells |
IL102785A (en) * | 1991-08-20 | 1998-06-15 | Univ Leicester | Method for removing protein from a water- soluble gum and a method of making biocompatible capsules using said gum |
US5762959A (en) * | 1992-05-29 | 1998-06-09 | Vivorx, Inc. | Microencapsulation of cells |
DE19904785A1 (de) * | 1999-02-05 | 2000-08-10 | Ulrich Zimmermann | Verfahren zur Herstellung von stabilem Alginatmaterial |
ES2299417T3 (es) | 2000-04-12 | 2008-06-01 | Beta-Cell N.V. | Metodo para producir preparaciones de celulas endocrinas pancreaticas madura e inmaduras, preparacion de las celulas y su utilizacion para el tratamiento de la diabetes mellitus. |
ITMI20032115A1 (it) * | 2003-11-03 | 2005-05-04 | Uni Degli Dustdi Di Pavia | Allestimento di sistemi di coltura tridimensionale in |
IL160095A0 (en) * | 2004-01-28 | 2004-06-20 | Yissum Res Dev Co | Formulations for poorly soluble drugs |
CA2625875C (en) * | 2005-10-21 | 2013-12-24 | Living Cell Products Pty Limited | Encapsulation system |
ATE444741T1 (de) * | 2006-05-10 | 2009-10-15 | Biocompatibles Uk Ltd | Glp-1 peptide enthaltende kugelförmige mikrokapseln, deren produktion und deren verwendung |
IT1392356B1 (it) * | 2008-12-19 | 2012-02-28 | Università degli Studi di Perugia | Procedimento di microincapsulamento di cellule del sertoli, microcapsule ottenute e loro impiego per la prevenzione e la cura del diabete mellito di tipo 1. |
-
2012
- 2012-03-07 US US14/008,290 patent/US20140017304A1/en not_active Abandoned
- 2012-03-07 CN CN201280016970.XA patent/CN103619328A/zh active Pending
- 2012-03-07 MX MX2013011040A patent/MX2013011040A/es unknown
- 2012-03-07 EP EP12707321.1A patent/EP2691084A1/en not_active Withdrawn
- 2012-03-07 BR BR112013024402A patent/BR112013024402A2/pt not_active Application Discontinuation
- 2012-03-07 KR KR1020137028360A patent/KR20140051161A/ko not_active Application Discontinuation
- 2012-03-07 JP JP2014501513A patent/JP2014509617A/ja active Pending
- 2012-03-07 WO PCT/EP2012/053868 patent/WO2012130567A1/en active Application Filing
- 2012-03-07 EA EA201301082A patent/EA201301082A1/ru unknown
- 2012-03-07 SG SG2013071832A patent/SG193615A1/en unknown
- 2012-03-07 AU AU2012237375A patent/AU2012237375A1/en not_active Abandoned
- 2012-03-07 CA CA2831184A patent/CA2831184A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP2691084A1 (en) | 2014-02-05 |
US20140017304A1 (en) | 2014-01-16 |
CA2831184A1 (en) | 2012-10-04 |
KR20140051161A (ko) | 2014-04-30 |
SG193615A1 (en) | 2013-11-29 |
BR112013024402A2 (pt) | 2016-12-13 |
AU2012237375A1 (en) | 2013-10-10 |
MX2013011040A (es) | 2014-08-22 |
WO2012130567A1 (en) | 2012-10-04 |
JP2014509617A (ja) | 2014-04-21 |
CN103619328A (zh) | 2014-03-05 |
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