EA201300902A1 - Гранулы гамма-гидроксимасляной кислоты - Google Patents

Гранулы гамма-гидроксимасляной кислоты

Info

Publication number
EA201300902A1
EA201300902A1 EA201300902A EA201300902A EA201300902A1 EA 201300902 A1 EA201300902 A1 EA 201300902A1 EA 201300902 A EA201300902 A EA 201300902A EA 201300902 A EA201300902 A EA 201300902A EA 201300902 A1 EA201300902 A1 EA 201300902A1
Authority
EA
Eurasian Patent Office
Prior art keywords
gamma
acid
hydroximatic
gramulas
active substance
Prior art date
Application number
EA201300902A
Other languages
English (en)
Other versions
EA026403B1 (ru
Inventor
Паскаль Сюпли
Сильви Лекусте
Original Assignee
Дебрежа Э Ассосье Фарма
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Дебрежа Э Ассосье Фарма filed Critical Дебрежа Э Ассосье Фарма
Publication of EA201300902A1 publication Critical patent/EA201300902A1/ru
Publication of EA026403B1 publication Critical patent/EA026403B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0007—Effervescent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0065—Forms with gastric retention, e.g. floating on gastric juice, adhering to gastric mucosa, expanding to prevent passage through the pylorus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/501—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse

Abstract

Изобретение касается гранулы, содержащей твердое ядро, на которое нанесено действующее вещество, где указанное действующее вещество выбрано из гамма-гидроксимасляной кислоты или одной из ее фармацевтически приемлемых солей, где указанная гранула дополнительно содержит в нанесенном на твердое ядро виде одно или более соединений, которые могут генерировать газ, один или несколько разбавителей, при этом данная гранула имеет покрывающую мембрану и твердое ядро составляет от 15 до 50 вес.% от общего веса гранулы.
EA201300902A 2011-02-11 2012-02-03 Гранулы гамма-гидроксимасляной кислоты EA026403B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR1100433A FR2971422B1 (fr) 2011-02-11 2011-02-11 Granules d'acide gamma-hydroxybutyrique
PCT/FR2012/000046 WO2012107652A1 (fr) 2011-02-11 2012-02-03 Granules effervescents d'acide gamma - hydroxybutyrique

Publications (2)

Publication Number Publication Date
EA201300902A1 true EA201300902A1 (ru) 2014-01-30
EA026403B1 EA026403B1 (ru) 2017-04-28

Family

ID=45819229

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201300902A EA026403B1 (ru) 2011-02-11 2012-02-03 Гранулы гамма-гидроксимасляной кислоты

Country Status (30)

Country Link
US (2) US9943488B2 (ru)
EP (1) EP2672961B1 (ru)
JP (1) JP5869004B2 (ru)
KR (1) KR101799620B1 (ru)
CN (1) CN103347503B (ru)
AR (1) AR085360A1 (ru)
AU (1) AU2012215252C1 (ru)
BR (1) BR112013020412B1 (ru)
CA (1) CA2825053C (ru)
CL (1) CL2013002243A1 (ru)
CY (1) CY1120655T1 (ru)
DK (1) DK2672961T3 (ru)
EA (1) EA026403B1 (ru)
ES (1) ES2680638T3 (ru)
FR (1) FR2971422B1 (ru)
HK (1) HK1185007A1 (ru)
HR (1) HRP20181338T1 (ru)
HU (1) HUE039484T2 (ru)
IL (1) IL227631A (ru)
LT (1) LT2672961T (ru)
MA (1) MA34886B1 (ru)
MX (1) MX362613B (ru)
PL (1) PL2672961T3 (ru)
PT (1) PT2672961T (ru)
RS (1) RS57615B1 (ru)
SI (1) SI2672961T1 (ru)
TR (1) TR201811120T4 (ru)
TW (1) TWI533865B (ru)
UA (1) UA113506C2 (ru)
WO (1) WO2012107652A1 (ru)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2663466C1 (ru) * 2017-03-20 2018-08-06 Общество с ограниченной ответственностью "МБА-групп" Композиция для профилактики и/или лечения вич-инфекции

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US20120076865A1 (en) 2010-03-24 2012-03-29 Jazz Pharmaceuticals, Inc. Controlled release dosage forms for high dose, water soluble and hygroscopic drug substances
US10398662B1 (en) 2015-02-18 2019-09-03 Jazz Pharma Ireland Limited GHB formulation and method for its manufacture
FR3049463B1 (fr) 2016-04-01 2019-07-05 Debregeas Et Associes Pharma Doses unitaires a liberation immediate de ghb ou de l'un de ses sels therapeutiquement acceptables administrees par voie orale et leur utilisation pour maintenir l'abstinence alcoolique
US11000498B2 (en) 2016-07-22 2021-05-11 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US11504347B1 (en) 2016-07-22 2022-11-22 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
UY37341A (es) 2016-07-22 2017-11-30 Flamel Ireland Ltd Formulaciones de gamma-hidroxibutirato de liberación modificada con farmacocinética mejorada
US11602513B1 (en) 2016-07-22 2023-03-14 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US11602512B1 (en) 2016-07-22 2023-03-14 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US20180263936A1 (en) 2017-03-17 2018-09-20 Jazz Pharmaceuticals Ireland Limited Gamma-hydroxybutyrate compositions and their use for the treatment of disorders
AU2018357886B2 (en) * 2017-11-02 2024-04-18 Zambon S.P.A. Pharmaceutical compositions comprising safinamide
CA3086153A1 (en) 2017-12-18 2019-06-27 Tris Pharma, Inc. Modified release drug powder composition comprising gastro-retentive raft forming systems having trigger pulse drug release
WO2019126214A1 (en) 2017-12-18 2019-06-27 Tris Pharma, Inc. Pharmaceutical composition comprising ghb gastro-retentive raft forming systems having trigger pulse drug release
US11666546B2 (en) 2017-12-18 2023-06-06 Tris Pharma, Inc GHB pharmaceutical compositions comprising a floating interpenetrating polymer network forming system
WO2019123269A1 (en) * 2017-12-20 2019-06-27 Flamel Ireland Limited Packaged modified release gamma-hydroxybutyrate formulations having improved stability
AU2019383389A1 (en) 2018-11-19 2021-05-06 Jazz Pharmaceuticals Ireland Limited Alcohol-resistant drug formulations
CA3127871A1 (en) 2019-03-01 2020-09-10 Flamel Ireland Limited Gamma-hydroxybutyrate compositions having improved pharmacokinetics in the fed state
EP4167966A1 (en) 2020-06-18 2023-04-26 XWPharma Ltd. Pharmaceutical granulations of water-soluble active pharmaceutical ingredients
WO2022020621A1 (en) 2020-07-24 2022-01-27 XWPharma Ltd. Pharmaceutical compositions and pharmacokinetics of a gamma-hydroxybutyric acid derivative
TW202228665A (zh) * 2020-10-05 2022-08-01 凱瑞康寧生技股份有限公司 γ－羥基丁酸衍生物之修飾釋放組合物
TW202300139A (zh) 2021-03-19 2023-01-01 凱瑞康寧生技股份有限公司 γ-羟基丁酸衍生物的聯合釋放製劑的藥代動力學
WO2022218364A1 (en) * 2021-04-16 2022-10-20 Nanjing Nutrabuilding Bio-Tech Co., Ltd. Coated beta hydroxybutyric acid crystal and methods for producing the same
US11583510B1 (en) 2022-02-07 2023-02-21 Flamel Ireland Limited Methods of administering gamma hydroxybutyrate formulations after a high-fat meal
US11779557B1 (en) 2022-02-07 2023-10-10 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics

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IT1266565B1 (it) 1993-07-22 1997-01-09 Ct Lab Farm Srl Composizioni farmaceutiche a rilascio controllato a base di uno o piu' sali farmaceuticamente accettabili dell'acido gamma-idrossi-butirrico.
ITMI20011446A1 (it) * 2001-07-06 2003-01-06 Altergon Sa Composizioni farmaceutiche di principi attivi suscettibili di somministrazione illecita
US8193211B2 (en) * 2004-09-30 2012-06-05 Supernus Pharmaceuticals, Inc. Controlled release compositions of gamma-hydroxybutyrate
FR2938432B1 (fr) * 2008-11-14 2011-05-20 Debregeas Et Associes Pharma Nouveau procede de preparation de granules de principes actifs, et granules tels qu'obtenus
FR2938431B1 (fr) * 2008-11-14 2013-12-20 Debregeas Et Associes Pharma Nouvelle composition a base d'acide gamma-hydroxybutyrique
FR2949062B1 (fr) * 2009-08-12 2011-09-02 Debregeas Et Associes Pharma Nouvelles formulations pharmaceutiques contre le mesusage des medicaments

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2663466C1 (ru) * 2017-03-20 2018-08-06 Общество с ограниченной ответственностью "МБА-групп" Композиция для профилактики и/или лечения вич-инфекции

Also Published As

Publication number Publication date
LT2672961T (lt) 2018-09-10
AU2012215252A1 (en) 2013-08-15
EA026403B1 (ru) 2017-04-28
JP5869004B2 (ja) 2016-02-24
FR2971422B1 (fr) 2016-05-20
TW201309285A (zh) 2013-03-01
SI2672961T1 (sl) 2018-10-30
CY1120655T1 (el) 2019-12-11
HUE039484T2 (hu) 2019-01-28
PT2672961T (pt) 2018-10-19
EP2672961A1 (fr) 2013-12-18
IL227631A (en) 2017-08-31
US20140004202A1 (en) 2014-01-02
AR085360A1 (es) 2013-09-25
RS57615B1 (sr) 2018-11-30
EP2672961B1 (fr) 2018-06-06
CN103347503B (zh) 2016-06-01
US9943488B2 (en) 2018-04-17
HK1185007A1 (zh) 2014-02-07
IL227631A0 (en) 2013-09-30
CA2825053A1 (fr) 2012-08-16
CN103347503A (zh) 2013-10-09
TWI533865B (zh) 2016-05-21
HRP20181338T1 (hr) 2018-10-19
JP2014505094A (ja) 2014-02-27
KR101799620B1 (ko) 2017-11-20
NZ613206A (en) 2015-07-31
CA2825053C (fr) 2019-04-02
PL2672961T3 (pl) 2018-11-30
FR2971422A1 (fr) 2012-08-17
TR201811120T4 (tr) 2018-08-27
DK2672961T3 (en) 2018-09-17
ES2680638T3 (es) 2018-09-10
KR20140051118A (ko) 2014-04-30
CL2013002243A1 (es) 2014-01-31
BR112013020412B1 (pt) 2021-12-07
WO2012107652A1 (fr) 2012-08-16
MX2013008299A (es) 2013-12-16
BR112013020412A2 (pt) 2016-10-25
AU2012215252C1 (en) 2017-05-25
MA34886B1 (fr) 2014-02-01
MX362613B (es) 2019-01-28
UA113506C2 (uk) 2017-02-10
US20180193277A1 (en) 2018-07-12
AU2012215252B2 (en) 2017-01-19

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): KG TJ TM