EA201300092A1 - Замещенные производные оксадиазола - Google Patents
Замещенные производные оксадиазолаInfo
- Publication number
- EA201300092A1 EA201300092A1 EA201300092A EA201300092A EA201300092A1 EA 201300092 A1 EA201300092 A1 EA 201300092A1 EA 201300092 A EA201300092 A EA 201300092A EA 201300092 A EA201300092 A EA 201300092A EA 201300092 A1 EA201300092 A1 EA 201300092A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- oxadiazol derivatives
- substituted oxadiazol
- substituted
- derivatives
- inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4245—Oxadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Neurology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Dermatology (AREA)
- Gastroenterology & Hepatology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10168833 | 2010-07-08 | ||
| US36274610P | 2010-07-09 | 2010-07-09 | |
| PCT/EP2011/061372 WO2012004287A1 (en) | 2010-07-08 | 2011-07-06 | 5-(biphenyl-4-yl)-3-phenyl-1,2,4-oxadiazolyl derivatives as ligands on the sphingosine 1-phosphate (s1p) receptors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EA201300092A1 true EA201300092A1 (ru) | 2013-06-28 |
Family
ID=42341535
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201300092A EA201300092A1 (ru) | 2010-07-08 | 2011-07-06 | Замещенные производные оксадиазола |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US9029405B2 (https=) |
| EP (1) | EP2590956B1 (https=) |
| JP (1) | JP6014589B2 (https=) |
| KR (1) | KR20140003379A (https=) |
| CN (1) | CN103097365B (https=) |
| AR (1) | AR082132A1 (https=) |
| AU (1) | AU2011275854B2 (https=) |
| CA (1) | CA2804473C (https=) |
| EA (1) | EA201300092A1 (https=) |
| ES (1) | ES2586145T3 (https=) |
| IL (1) | IL224071B (https=) |
| MX (1) | MX2012015021A (https=) |
| SG (1) | SG186872A1 (https=) |
| TW (1) | TW201206429A (https=) |
| WO (1) | WO2012004287A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102250035A (zh) * | 2011-06-10 | 2011-11-23 | 北京富卡生物技术有限公司 | 二芳基取代-1，3，4-噁二唑化合物的合成方法和其药物用途 |
| CN107857760A (zh) * | 2017-11-21 | 2018-03-30 | 南京天翔医药科技有限公司 | 鞘氨醇‑1‑磷酸受体调节剂及其应用 |
| MX2022007846A (es) * | 2019-12-23 | 2022-07-19 | Sitryx Therapeutics Ltd | Derivados carboxi con propiedades antiinflamatorias. |
| EP4126827B1 (en) * | 2020-03-27 | 2024-11-20 | Receptos LLC | Sphingosine 1 phosphate receptor modulators |
| US20240228448A1 (en) * | 2021-03-31 | 2024-07-11 | Washington University | Compositions for binding sphingosine-1-phosphate receptor 1 (s1p1), imaging of s1p1, and processes for preparation thereof |
| CN117203189A (zh) * | 2021-04-14 | 2023-12-08 | 株式会社Lg化学 | 制备用于合成鞘氨醇-1-磷酸酯受体激动剂的中间体的方法 |
| US12571867B2 (en) | 2022-04-14 | 2026-03-10 | United States Pharmacopeial Convention | Nuclear magnetic resonance analysis systems and methods |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0711792B1 (de) | 1994-11-05 | 1999-03-10 | BASF Aktiengesellschaft | Melaminharze |
| EP1697333A4 (en) * | 2003-12-17 | 2009-07-08 | Merck & Co Inc | (3,4-DISUBSTITUTED) PROPANE ACID BOXYLATES AS AGONISTS OF THE S1P (EDG) RECEPTOR |
| US20060223866A1 (en) * | 2004-08-13 | 2006-10-05 | Praecis Pharmaceuticals, Inc. | Methods and compositions for modulating sphingosine-1-phosphate (S1P) receptor activity |
| WO2006131336A1 (en) | 2005-06-08 | 2006-12-14 | Novartis Ag | POLYCYCLIC OXADIAZOLES OR I SOXAZOLES AND THEIR USE AS SlP RECEPTOR LIGANDS |
| GB0511684D0 (en) * | 2005-06-08 | 2005-07-13 | Novartis Ag | Organic compounds |
| TWI404706B (zh) * | 2006-01-11 | 2013-08-11 | Actelion Pharmaceuticals Ltd | 新穎噻吩衍生物 |
| GB0601744D0 (en) * | 2006-01-27 | 2006-03-08 | Novartis Ag | Organic compounds |
| JP2009269819A (ja) * | 2006-08-25 | 2009-11-19 | Asahi Kasei Pharma Kk | アミン化合物 |
| CN101522646A (zh) * | 2006-09-29 | 2009-09-02 | 诺瓦提斯公司 | 具有抗炎和免疫抑制特性的二唑衍生物 |
| MX2010003612A (es) * | 2007-10-04 | 2010-04-30 | Merck Serono Sa | Derivados de oxadiazol. |
| TW201000099A (en) * | 2008-06-20 | 2010-01-01 | Amgen Inc | S1P1 receptor agonists and use thereof |
| EP2241558A1 (en) | 2009-04-03 | 2010-10-20 | Merck Serono SA | Oxadiazole derivatives |
-
2011
- 2011-07-01 TW TW100122179A patent/TW201206429A/zh unknown
- 2011-07-06 SG SG2012096533A patent/SG186872A1/en unknown
- 2011-07-06 WO PCT/EP2011/061372 patent/WO2012004287A1/en not_active Ceased
- 2011-07-06 EA EA201300092A patent/EA201300092A1/ru unknown
- 2011-07-06 CA CA2804473A patent/CA2804473C/en not_active Expired - Fee Related
- 2011-07-06 KR KR20137003335A patent/KR20140003379A/ko not_active Withdrawn
- 2011-07-06 ES ES11729318.3T patent/ES2586145T3/es active Active
- 2011-07-06 US US13/809,013 patent/US9029405B2/en not_active Expired - Fee Related
- 2011-07-06 EP EP11729318.3A patent/EP2590956B1/en not_active Not-in-force
- 2011-07-06 MX MX2012015021A patent/MX2012015021A/es not_active Application Discontinuation
- 2011-07-06 AU AU2011275854A patent/AU2011275854B2/en not_active Ceased
- 2011-07-06 CN CN201180033823.9A patent/CN103097365B/zh not_active Expired - Fee Related
- 2011-07-06 JP JP2013517372A patent/JP6014589B2/ja not_active Expired - Fee Related
- 2011-07-08 AR ARP110102449 patent/AR082132A1/es not_active Application Discontinuation
-
2012
- 2012-12-31 IL IL224071A patent/IL224071B/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| SG186872A1 (en) | 2013-02-28 |
| WO2012004287A1 (en) | 2012-01-12 |
| JP6014589B2 (ja) | 2016-10-25 |
| IL224071B (en) | 2018-06-28 |
| US20130116289A1 (en) | 2013-05-09 |
| EP2590956A1 (en) | 2013-05-15 |
| US9029405B2 (en) | 2015-05-12 |
| CA2804473C (en) | 2019-04-02 |
| AU2011275854A1 (en) | 2013-02-21 |
| AR082132A1 (es) | 2012-11-14 |
| AU2011275854B2 (en) | 2015-08-27 |
| TW201206429A (en) | 2012-02-16 |
| EP2590956B1 (en) | 2016-05-04 |
| CN103097365B (zh) | 2016-02-24 |
| KR20140003379A (ko) | 2014-01-09 |
| MX2012015021A (es) | 2013-04-03 |
| JP2013530202A (ja) | 2013-07-25 |
| CN103097365A (zh) | 2013-05-08 |
| CA2804473A1 (en) | 2012-01-12 |
| ES2586145T3 (es) | 2016-10-11 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EA201400412A1 (ru) | ЗАМЕЩЕННЫЕ БЕНЗИЛИНДАЗОЛЫ ДЛЯ ПРИМЕНЕНИЯ В КАЧЕСТВЕ ИНГИБИТОРОВ Bub1 КИНАЗЫ ДЛЯ ЛЕЧЕНИЯ ГИПЕРПРОЛИФЕРАТИВНЫХ ЗАБОЛЕВАНИЙ | |
| EA201400735A1 (ru) | Производные альфа-амино бороновой кислоты, селективные ингибиторы иммунопротеасомы | |
| EA201490596A1 (ru) | Новые производные дигидрохинолин-2-она | |
| EA201390766A1 (ru) | БЕНЗОКСАЗЕПИНЫ КАК ИНГИБИТОРЫ PI3K/mTOR И СПОСОБЫ ИХ ИСПОЛЬЗОВАНИЯ И ПОЛУЧЕНИЯ | |
| EA201490474A1 (ru) | Аминохиназолины в качестве ингибиторов киназ | |
| EA201300684A1 (ru) | Производные 6-амино-2-фениламино-1н-бензимидазол-5-карбоксамида и их применение в качестве ингибиторов микросомной простагландин-е2-синтазы-1 | |
| UA110612C2 (uk) | Похідні 1-аміно-2-циклопропілетилборонової кислоти | |
| EA201291143A1 (ru) | Пиразолилхиназолиновые ингибиторы киназы | |
| EA201201677A1 (ru) | Производные гетероарилимидазолона в качестве ингибиторов jak | |
| EA201301209A1 (ru) | Производные пирролотриазинона в качестве ингибиторов p13k | |
| EA201590748A1 (ru) | Противовирусные соединения против rsv | |
| EA201391072A1 (ru) | Производные фтор-пиридинона, полезные в качестве антибактериальных агентов | |
| EA201001680A1 (ru) | Соединения бензолсульфонамидтиазола и оксазола | |
| EA201592199A1 (ru) | Производные бипиразола в качестве ингибиторов jak | |
| EA201490042A1 (ru) | Азетидинил-фенил-, пиридил- или пиразинилкарбоксамидные производные как ингибиторы jak | |
| EA201390214A1 (ru) | Гетероарилы и их применение | |
| EA201100447A1 (ru) | Органические соединения | |
| EA201270149A1 (ru) | Ингибиторы bace | |
| EA201491012A1 (ru) | Гетероциклические ингибиторы глютаминазы | |
| EA201101182A1 (ru) | Новые аминоазагетероциклические карбоксамиды | |
| EA201490471A1 (ru) | Пиридазиноновые соединения и их применение в качестве ингибиторов daao | |
| EA201290184A1 (ru) | Бензодиазепиновый ингибитор бромодомена | |
| EA201071264A1 (ru) | Аминодигидротиазиновые производные в качестве ингибиторов bace для лечения болезни альцгеймера | |
| EA201590224A1 (ru) | Имидазотриазинкарбонитрилы, используемые в качестве ингибиторов киназы | |
| EA201071100A1 (ru) | Пиридилсодержащие ингибиторы передачи сигнала через белок hedgehog |