EA201270566A1 - Противомикробные соединения и способы их получения и применения - Google Patents

Противомикробные соединения и способы их получения и применения

Info

Publication number
EA201270566A1
EA201270566A1 EA201270566A EA201270566A EA201270566A1 EA 201270566 A1 EA201270566 A1 EA 201270566A1 EA 201270566 A EA201270566 A EA 201270566A EA 201270566 A EA201270566 A EA 201270566A EA 201270566 A1 EA201270566 A1 EA 201270566A1
Authority
EA
Eurasian Patent Office
Prior art keywords
methods
production
application
antimicrobial compounds
compounds
Prior art date
Application number
EA201270566A
Other languages
English (en)
Russian (ru)
Inventor
Эрин М. Даффи
Ашоке Бхаттачарджи
Хардвин О'Доуд
Марко Девиво
Зольтан Ф. Канио
Яцек Г. Мартинов
Ик-Хиеон Пайк
Мэттью Х. Шейдемен
Сандра Сиништаж
Брайан Т. Вимберли
Юйшэн У
Original Assignee
Риб-Экс Фармасьютикалз, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Риб-Экс Фармасьютикалз, Инк. filed Critical Риб-Экс Фармасьютикалз, Инк.
Publication of EA201270566A1 publication Critical patent/EA201270566A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
    • A61F2250/0067—Means for introducing or releasing pharmaceutical products into the body

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Materials For Medical Uses (AREA)
EA201270566A 2009-10-16 2010-10-15 Противомикробные соединения и способы их получения и применения EA201270566A1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US25247809P 2009-10-16 2009-10-16
US31428710P 2010-03-16 2010-03-16
US35820110P 2010-06-24 2010-06-24
PCT/US2010/052922 WO2011047319A2 (fr) 2009-10-16 2010-10-15 Composés anti-microbiens et procédés permettant de fabriquer et d'utiliser ces composés

Publications (1)

Publication Number Publication Date
EA201270566A1 true EA201270566A1 (ru) 2012-11-30

Family

ID=44343888

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201270566A EA201270566A1 (ru) 2009-10-16 2010-10-15 Противомикробные соединения и способы их получения и применения

Country Status (15)

Country Link
US (2) US9193731B2 (fr)
EP (2) EP2488525B1 (fr)
JP (1) JP6267863B2 (fr)
KR (2) KR20190044136A (fr)
CN (1) CN102712647B (fr)
AU (3) AU2010306646B2 (fr)
CA (1) CA2777734A1 (fr)
DK (1) DK2488525T3 (fr)
EA (1) EA201270566A1 (fr)
ES (1) ES2675798T3 (fr)
IL (2) IL219133A (fr)
MX (2) MX349718B (fr)
NZ (1) NZ599291A (fr)
PH (1) PH12016502092A1 (fr)
WO (1) WO2011047319A2 (fr)

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US10934295B2 (en) * 2016-05-06 2021-03-02 BioVersys AG Antimicrobials and methods of making and using same
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MA47120A (fr) 2016-12-22 2021-04-28 Incyte Corp Dérivés pyridine utilisés en tant qu'immunomodulateurs
TW201904970A (zh) 2017-06-19 2019-02-01 美商梅林塔療法公司 抗微生物劑及製造及使用方法
US20210403473A1 (en) * 2018-02-21 2021-12-30 BioVersys AG Antimicrobial compounds and methods of making and using the same
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WO2019234508A1 (fr) 2018-06-06 2019-12-12 BioVersys AG Agents de biodéfense
US20210253589A1 (en) 2018-06-06 2021-08-19 BioVersys AG Aminomethylamidine and methylamidine antimicrobial compounds
CA3103304A1 (fr) * 2018-06-15 2019-12-19 Galapagos Nv Nouveaux composes et compositions pharmaceutiques associees pour le traitement de maladies
US20240239800A1 (en) * 2018-12-07 2024-07-18 BioVersys AG Pyrrolo[2,3-d]pyrimidin-2-one antimicrobial compounds
WO2021030162A1 (fr) 2019-08-09 2021-02-18 Incyte Corporation Sels d'un inhibiteur de pd-1/pd-l1
KR20220075382A (ko) 2019-09-30 2022-06-08 인사이트 코포레이션 면역조절제로서의 피리도[3,2-d]피리미딘 화합물
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JP6317669B2 (ja) 2011-04-15 2018-04-25 メリンタ セラピューティクス インコーポレイテッド 抗菌化合物ならびにそれを作製および使用する方法

Also Published As

Publication number Publication date
PH12016502092A1 (en) 2017-08-30
EP2488525A2 (fr) 2012-08-22
CA2777734A1 (fr) 2011-04-21
US9193731B2 (en) 2015-11-24
KR101972992B1 (ko) 2019-04-29
CN102712647B (zh) 2018-04-24
JP2013508297A (ja) 2013-03-07
KR20190044136A (ko) 2019-04-29
EP2488525A4 (fr) 2013-07-03
AU2010306646A1 (en) 2012-05-03
KR20170132900A (ko) 2017-12-04
WO2011047319A3 (fr) 2011-08-18
JP6267863B2 (ja) 2018-01-24
AU2016266048B2 (en) 2018-07-19
US20160031893A1 (en) 2016-02-04
EP2488525B1 (fr) 2018-04-25
WO2011047319A2 (fr) 2011-04-21
AU2016266048A1 (en) 2016-12-22
IL219133A (en) 2017-10-31
MX349718B (es) 2017-08-10
IL255097A0 (en) 2017-12-31
US20120220566A1 (en) 2012-08-30
CN102712647A (zh) 2012-10-03
ES2675798T3 (es) 2018-07-12
AU2010306646B2 (en) 2016-09-01
DK2488525T3 (en) 2018-08-06
AU2018204628A1 (en) 2018-07-12
EP3406613A1 (fr) 2018-11-28
MX2012004340A (es) 2012-11-23
WO2011047319A8 (fr) 2011-10-27
IL219133A0 (en) 2012-06-28
NZ599291A (en) 2014-06-27

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