EA201270409A1 - Способ производства промежуточных продуктов артемизинина - Google Patents

Способ производства промежуточных продуктов артемизинина

Info

Publication number
EA201270409A1
EA201270409A1 EA201270409A EA201270409A EA201270409A1 EA 201270409 A1 EA201270409 A1 EA 201270409A1 EA 201270409 A EA201270409 A EA 201270409A EA 201270409 A EA201270409 A EA 201270409A EA 201270409 A1 EA201270409 A1 EA 201270409A1
Authority
EA
Eurasian Patent Office
Prior art keywords
manufacture
acid
artemisinin
interim articles
products
Prior art date
Application number
EA201270409A
Other languages
English (en)
Other versions
EA021061B1 (ru
Inventor
Фолькер Крафт
Герхард Кретцшмар
Кай Россен
Original Assignee
Санофи
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Санофи filed Critical Санофи
Publication of EA201270409A1 publication Critical patent/EA201270409A1/ru
Publication of EA021061B1 publication Critical patent/EA021061B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/36—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by hydrogenation of carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/26—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/303—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by hydrogenation of unsaturated carbon-to-carbon bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/608—Esters of carboxylic acids having a carboxyl group bound to an acyclic carbon atom and having a ring other than a six-membered aromatic ring in the acid moiety
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/12—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
    • C07D493/18—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/12—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
    • C07D493/20—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/14—All rings being cycloaliphatic
    • C07C2602/26—All rings being cycloaliphatic the ring system containing ten carbon atoms
    • C07C2602/28—Hydrogenated naphthalenes

Abstract

Заявка относится к способу получения (2R)-дигидроартемизининовой кислоты, или сложных эфиров (2R)-дигидроартемизининовой кислоты из артемизининовой кислоты, или сложных эфиров артемизининовой кислоты соответственно дииминовой гидрогенизацией экзоциклической СС-двойной связи и применению указанного способа в производстве противомалярийного лекарственного средства артемизинина.
EA201270409A 2009-09-11 2010-09-10 Способ производства промежуточных продуктов артемизинина EA021061B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24174409P 2009-09-11 2009-09-11
PCT/IB2010/002566 WO2011030223A2 (en) 2009-09-11 2010-09-10 Process for the production of artemisinin intermediates

Publications (2)

Publication Number Publication Date
EA201270409A1 true EA201270409A1 (ru) 2012-12-28
EA021061B1 EA021061B1 (ru) 2015-03-31

Family

ID=43567786

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201270409A EA021061B1 (ru) 2009-09-11 2010-09-10 Способ производства промежуточных продуктов артемизинина

Country Status (20)

Country Link
US (1) US8334392B2 (ru)
EP (1) EP2475635B1 (ru)
JP (1) JP5711745B2 (ru)
KR (1) KR20120065395A (ru)
CN (1) CN102612507B (ru)
AU (2) AU2010293907B2 (ru)
BR (1) BR112012005345A2 (ru)
CA (1) CA2773007C (ru)
DK (1) DK2475635T3 (ru)
EA (1) EA021061B1 (ru)
ES (1) ES2634940T3 (ru)
HR (1) HRP20171139T1 (ru)
HU (1) HUE035319T2 (ru)
IL (2) IL218483A (ru)
LT (1) LT2475635T (ru)
MX (1) MX2012003001A (ru)
MY (1) MY155952A (ru)
PT (1) PT2475635T (ru)
SI (1) SI2475635T1 (ru)
WO (1) WO2011030223A2 (ru)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2565197A1 (en) 2011-08-29 2013-03-06 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Method and device for the synthesis of artemisinin
AP3831A (en) * 2011-08-29 2016-09-30 Max Planck Gesellschaft Method and device for the synthesis of artemisinin
EP2660234A1 (en) * 2012-05-02 2013-11-06 Sanofi Process for the production of artemisinin intermediates
CN103087074A (zh) * 2012-12-14 2013-05-08 湖南科源生物制品有限公司 一种青蒿素的半合成方法
CN103755550B (zh) * 2013-11-28 2016-03-02 湖南科源生物制品有限公司 一种二氢青蒿酸的合成方法
CN112538010B (zh) * 2019-09-20 2023-08-11 凯特立斯（深圳）科技有限公司 一种青蒿素类化合物合成关键中间体的制备方法
DE102020120218A1 (de) 2020-07-31 2022-02-03 KBHB Consult GmbH Gegen das ribosomale Protein rpL35/uL29 gerichtete Moleküle zur Verwendung in der Behandlung von Erkrankungen, insbesondere Epidermolysis bullosa (EB)

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4992561A (en) 1990-05-11 1991-02-12 The United States Of America As Represented By The Secretary Of The Army Simple conversion of artemisinic acid into artemisinin
IN184682B (ru) 1995-12-29 2000-09-23 Council Scient Ind Res
JP3148136B2 (ja) 1996-12-26 2001-03-19 高砂香料工業株式会社 新規なキラルジホスフィン化合物、その製造中間体、該ジホス フィン化合物を配位子とする遷移金属錯体並びに該錯体を含む 不斉水素化触媒
US5995084A (en) * 1997-01-17 1999-11-30 Tritech Microelectronics, Ltd. Touchpad pen-input and mouse controller
IN188174B (ru) 1997-03-17 2002-08-31 Council Scient Ind Res
JP3549390B2 (ja) 1998-03-23 2004-08-04 高砂香料工業株式会社 ルテニウム−ホスフィン錯体及びその製造方法
US20060270863A1 (en) * 2005-05-27 2006-11-30 Amyris Biotechnologies Conversion of amorpha-4,11-diene to artemisinin and artemisinin precursors
CN1900081A (zh) * 2005-07-22 2007-01-24 中国科学院上海药物研究所 水溶性青蒿素衍生物、制法、药物组合物及用途
WO2009088404A1 (en) * 2007-12-30 2009-07-16 Amyris Biotechnologies, Inc. Processes for the preparation of artemisinin an its precursors

Also Published As

Publication number Publication date
EP2475635A2 (en) 2012-07-18
CN102612507B (zh) 2015-04-22
HRP20171139T1 (hr) 2017-10-06
EA021061B1 (ru) 2015-03-31
US8334392B2 (en) 2012-12-18
IL218483A0 (en) 2012-04-30
WO2011030223A2 (en) 2011-03-17
AU2010293907A1 (en) 2012-04-26
EP2475635B1 (en) 2017-04-26
JP5711745B2 (ja) 2015-05-07
JP2013504557A (ja) 2013-02-07
CA2773007C (en) 2017-04-25
MY155952A (en) 2015-12-31
CA2773007A1 (en) 2011-03-17
AU2010293907B2 (en) 2016-03-03
HUE035319T2 (en) 2018-05-02
KR20120065395A (ko) 2012-06-20
SI2475635T1 (sl) 2017-08-31
BR112012005345A2 (pt) 2016-03-22
ES2634940T3 (es) 2017-09-29
IL246336A0 (en) 2016-08-31
AU2016203676A1 (en) 2016-06-16
IL218483A (en) 2016-07-31
LT2475635T (lt) 2017-07-25
US20110230669A1 (en) 2011-09-22
CN102612507A (zh) 2012-07-25
WO2011030223A3 (en) 2011-05-19
PT2475635T (pt) 2017-07-10
DK2475635T3 (en) 2017-07-03
MX2012003001A (es) 2012-07-17

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU